Choi, Noorie;Chang, Ji Hyun;Kim, Suzy;Kim, Hak Jae
Radiation Oncology Journal
/
v.35
no.2
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pp.144-152
/
2017
Purpose: The role of radiotherapy (RT) was largely deserted after the introduction of platinum-based chemotherapy, but still survival rates are disappointingly low. This study focuses on assessing the clinical efficacy of RT in relation to chemotherapy resistance. Materials and Methods: From October 2002 to January 2015, 44 patients were diagnosed with epithelial ovarian cancer (EOC) and treated with palliative RT for persistent or recurrent EOC. All patients received initial treatment with optimal debulking surgery and adjuvant platinum-based chemotherapy. The biologically effective dose (BED) was calculated with ${\alpha}/{\beta}$ set at 10. Ninety-four sites were treated with RT with a median BED of 50.7 Gy (range 28.0 to 79.2 Gy). The primary end-point was the in-field local control (LC) interval, defined as the time interval from the date RT was completed to the date any progressive or newly recurring disease within the RT field was detected on radiographic imaging. Results: The median follow-up duration was 52.3 months (range 7.7 to 179.0 months). The 1-year and 2-year in-field LC rates were 66.0% and 55.0%, respectively. Comparisons of percent change of in-field tumor response showed similar distribution of responses among chemoresistant and chemosensitive tumors. On multivariate analysis of predictive factors for in-field LC analyzed by sites treated, $BED{\geq}50Gy$ (hazard ratio, 0.4; confidence interval, 0.2-0.9; p = 0.025) showed better outcomes. Conclusion: Regardless of resistance to platinum-based chemotherapy, RT can be a feasible treatment modality for patients with persistent of recurrent EOC. The specific role of RT using updated approaches needs to be reassessed.
Lee, Ji Hoon;Kim, Sung Woo;Jeon, Ga Won;Sin, Jong Beom
Clinical and Experimental Pediatrics
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v.58
no.6
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pp.224-229
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2015
Purpose: Thyroid dysfunction is common in preterm infants. Congenital hypothyroidism causes neurodevelopmental impairment, which is preventable if properly treated. This study was conducted to describe the characteristics of thyroid dysfunction in very low birth weight infants (VLBWIs), evaluate risk factors of hypothyroidism, and suggest the reassessment of thyroid function with an initially normal thyroid-stimulating hormone (TSH) as part of a newborn screening test. Methods: VLBWIs (January 2010 to December 2012) were divided into two groups according to dysfunction-specific thyroid hormone replacement therapy, and associated factors were evaluated. Results: Of VLBWIs, 246 survivors were enrolled. Only 12.2% (30/246) of enrolled subjects exhibited thyroid dysfunction requiring thyroid hormone replacement. Moreover, only one out of 30 subjects who required thyroid hormone treatment had abnormal thyroid function in the newborn screening test with measured TSH. Most of the subjects in the treatment group (22/30) exhibited delayed TSH elevation. Gestational age, Apgar score, antenatal steroids therapy, respiratory distress syndrome, patent ductus arteriosus, sepsis, intraventricular hemorrhage, postnatal steroids therapy, and duration of mechanical ventilation did not differ between the two groups. Birth weight was smaller and infants with small for gestational age were more frequent in the treatment group. Conclusion: Physicians should not rule out suggested hypothyroidism, even when thyroid function of a newborn screening test is normal. We suggest retesting TSH and free thyroxine in high risk preterm infants with an initially normal TSH level using a newborn screening test.
The purpose of this study was to find the effects of the dynamic lumbar stabilization exercise on functional recovery of low back pain patients. The subjects were consisted of sixty patients who had nonspecific subacute low back pain. All subjects randomly assigned to dynamic lumbar stabilization exercise group. Williams exercise group and modalities treatment group. The dynamic lumbar stabilization exercise group received modalities treatment with dynamic lumbar stabilization exercise. Williams exercise group received modalities treatment with Williams flexion exercise and modalities treatment group received modalities treatment without exercise. The Oswestry low back pain disability questionnaire was used to measure disability of low back pain. Assessment was carried out before treatment fur obtain baseline measurement of low back pain and reassessment were carried out at after 20 and 40 treatment sessions. The results of this study were as following: 1. The Oswestry low back pain disability questionnaire scores were significantly decreased after 20th and 40th treatment in dynamic lumber stabilization exercise group(p<.05). 2. The Oswestry low back pain disability questionnaire scores were significantly decreased after 20th and 40th treatment in Williams exercise group(p<.05). 3. The Oswestry low back pain disability questionnaire scores were significantly decreased after 20th and 40th treatment in modalities treatment group(<.05). 4. There were no statistical difference between the 3 groups at pre-treatment with Oswestry low back pain disability questionnaire scores(p>.05). 5. There were no statistical difference between the 3 groups after 20th treatment with Oswestry low back pain disability questionnaire scores(p>.05). 6. There were statistical difference between the 3 groups after 40th treatment with Oswestry low back pain disability questionnaire scores(p<.05). 7. The Oswestry low back pain disability questionnaire scores were significantly decreased after 40th treatment in all 3 groups and the decrement were greater in order of dynamic lumbar stabilization exercise group. Williams exercise group and modalities treatment group.
This study explores reasonable alternatives to internet interconnection policy. Due to the development of information and communication technology, patterns of the Internet usage are changing rapidly, including increase of video streaming services. For this reason, there is a lively discussion of the Internet interconnection policy, which integrates various Internet service operators into one ecosystem. We conducted an Analytic Hierarchy Process(AHP) analysis with 16 experts in government/public, and academic sectors, and alternative selection criteria and their corresponding alternatives and detailed tasks were evaluated. According to the results, the most important alternative selection criteria was a "fair charge against foreign service operators", and the most desirable alternative was "partial revise". Moreover, the experts responded that "reassessment of the principle of the charge" is the most urgent task to improve the Internet interconnection policy.
Kwak, Sung-Jin;Bhattrai, Bal Dev;Kim, Eun-Jung;Lee, Chang-Keun;Lee, Hyeong-Jin;Heo, Woo-Myung
Korean Journal of Ecology and Environment
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v.45
no.1
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pp.62-71
/
2012
Lake Doam watershed was surveyed to evaluate non-point source discharge characteristics and discharge load including several water quality parameters in Song Stream from July 2009 to July 2011. Concentrations of water pollutants were high during the rainfall period, especially, SS, TP and COD showed increasing tendencies toward cumulative water discharge but TN did not show much difference. SS, TP and COD had an initial flush effect of over 50 mm rainfall event but there was no clear tendency for rainfalls below that level. Event mean concentration (EMC) regarding the rainy and dry period showed large differences. Especially rainy season EMC (SS, TP, COD) demonstrated an increasingly high tendency. EMCs of COD, SS, TN and TP measured for twelve rain events were as high as 26.1, 866.0, 4.68 and 0.605 mg $L^{-1}$, respectively. COD, SS, TN and TP loadings from the highland agricultural region of the Song Stream watershed were 34,263, 1,250,254, 2,673 and 933 kg $yr^{-1}\;km^{-2}$, respectively, which were relatively higher than the results of other stream systems. Therefore, it is strongly recommended that long-term monitoring and non-point pollution reduction programs for the highland agricultural area to continue. Furthermore, this non-point source pollution loading research acquired from the highland agricultural area could be the base for reassessment.
Some Korean terminologies on reproductive structures of seed plants in plant morphology, written incorrectly in many books, were analysed to propose accurately expressed terminologies. 31 books in areas such as general biology, plant biology, plant morphology, and biological dictionaries and glossaries were selected to analyse the accuracy of the terminologies for reproductive structures in gymnosperms, e.g., cone or strobilus, seed (or ovulate) cone and pollen cone, and conifer(s) or coniferous plants, and for flower structures in angiosperms, e.g., corolla, anther, filament, pistillate (or female) flower and staminate (or male) flower, apocarpous, and syncarpous. The definition and etymology of the terminologies were traced in 4 textbooks of plant anatomy and 2 dictionaries of biology and botany written in English. On the basis of the definition, etymology, and principles for terminology formation according to the International Organization for Standardization (ISO 704:2000), reasonably expressed Korean terminologies were proposed. All of the 8 terminologies examined in this study were included in the glossary of biological terminologies, published by the Korean Association of Biological Sciences in 2005, and designated as an editorial source for science and biology textbooks for middle and high schools by Ministry of Education in 2007. However, the only 1 of the 8 terminologies described in the glossary were consistent with the proposed expression in the present study. These inconsistencies indicated the need for a reassessment of this glossary of biological terminologies. The newly proposed terminologies would facilitate mutual understanding between teachers and students of plant biology.
Korean terminologies on stem structures in plant morphology, written incorrectly in many books, were analysed to propose accurately expressed terminologies. 35 books in areas such as general biology, plant biology, plant morphology, and biological dictionaries and glossaries were selected to analyse the accuracy of the terminologies for seed structures, e.g., shoot and shoot system, rhizome, apical dominance, anticlinal and periclinal divisions, and intercalary and lateral meristems. The definition and etymology of the terminologies were traced in 4 textbooks of plant anatomy and 2 dictionaries of biology and botany written in English. On the basis of the definition, etymology, and principles for terminology formation according to the International Organization for Standardization (ISO 704:2000), reasonably expressed Korean terminologies were proposed. All of the 8 terminologies examined in this study were included in the glossary of biological terminologies, published by the Korean Association of Biological Sciences in 2005, and designated as an editorial source for science and biology textbooks for middle and high schools by Ministry of Education in 2007. However, the only 1 of the 8 terminologies described in the glossary were consistent with the proposed expression in the present study. These inconsistencies indicated the need for a reassessment of this glossary of biological terminologies. The validity of the proposed Korean terminologies was tested in a questionnaire sent to 17 professors teaching plant morphology or/and taxonomy at universities. A mean of 91.9% of the total respondents agreed with the Korean expressions proposed in this study. The new, proposed terminologies would facilitate mutual understanding between teachers and students of plant biology.
Park, Se-Moon;Yoon, Bong-Yo;Kim, Dae-Jung;Park, Joo-Wan;Kim, Chang-Lak
Nuclear Engineering and Technology
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v.38
no.6
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pp.575-584
/
2006
As the development of total management systems for sites along with site environmental information is becoming standard, the system known as the Site Information and Total Environmental database management System (SITES) has been developed over the last two years. The first result was a database management system for storing data obtained from facilities, and a site characterization in addition to an environmental assessment of a site. The SITES database is designed to be effective and practical for use with facility management and safety assessment in relation to Geographic Information Systems. SITES is a total management program, which includes its database, its data analysis system required for site characterization, a safety assessment modeling system and an environment monitoring system. It can contribute to the institutional management of the facility and to its safety reassessment. SITES is composed of two main modules: the SITES Database module (SDM) and the Monitoring & Assessment (M&A) module [1]. The M&A module is subdivided into two sub-modules: the Safety Assessment System (SAS) and the Site Environmental Monitoring System (SEMS). SAS controls the data (input and output) from the SITES DB for the site safety assessment, whereas SEMS controls the data obtained from the records of the measuring sensors and facilities. The on-line site and environmental monitoring data is managed in SEMS. The present paper introduces the procedure and function of the M&A modules.
In the traditional subsistence farming era in Korea, most of small farmer's housing plots in the rural villages had their boundary barriers of which materials being the natural ones provided from nearby places. However, during the rapid industrialization period from 1960s, a traditional type of boundary barriers in the rural villages had been replaced mostly by low-cost factory-made ones, which means absolute loss of their amenity values as a linear part of villagescape. In spite of many study efforts on boundary barriers of traditional rural houses, detailed historical dating on them after 1960s have not tried up to now, which provoked to try this study. Through the direct and in-depth interviews to rural villagers sampled from 21 case villages, it was found that original boundary barriers structure in most of farm houses was made of natural materials like stone, soil, trees and bamboo, but, replaced by cement block structures mostly during Saemaeul Project period. However, although being relatively minority, traditional ones have been preserved up to now mainly in remote mountainous and seashore villages, but was in very low condition. In the overall view, for more than half a century, boundary barriers of farm houses had been left without public or private improvement efforts. In order to enhance their amenity values, more research works should be carried out on positive reassessment of the traditional ones harmonized with multifunctionalities for modern village life.
The computed tomogrpahy(CT) provides a high quality in images of human body but contributes to the relatively high patient dose. The frequency of CT examination is increasing and, therefore, the concerns about the patient dose are also increasing. In this study the experimental determination of patient dose was performed by using a physical anthropomorphic phantom and thermoluminescent dosimeter(TLD). The measurements were done for the both axial and spiral scan mode. As a result the effective doses for each scan mode were 17.78mSv and 10.01 mSv respectively and the fact that the degree of the reduction in the patient dose depends on the pitch scan parameter was confirmed. The measurement methods suggested in this study can be applied for the reassessment of the patient dose when the technique in CT equipment is developed or the protocol for CT scanning is changed.
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