• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2095-2100
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• 2014

Objective: Most patients with advanced breast cancer experience resistance to endocrine treatment and eventual disease progression. This meta-analysis was designed to compare the efficacy and tolerability of fulvestrant 250mg with anastrozole 1mg in postmenopausal women with advanced breast cancer. Methods: Electronic literature databases (Cochrane Library, Medline, and Embase) were searched for randomized controlled trials (RCTs) published prior to August 2013. Only RCTs that compared fulvestrant 250mg to anastrozole 1mg in postmenopausal women with advanced breast cancer were selected. The main outcomes were time to treatment failure (TTF), time to progression (TTP), duration of response (DOR), clinical benefit rate, and tolerability. Results: Four RCTs covering 1,226 patients (fulvestrant, n=621; anastrozole, n=605) were included in the meta-analysis. Fulvestrant increased the DOR compared to anastrozole (HR =1.31, 95% confidence interval [CI] 1.13-1.51). There was no statistically significant difference between fulvestrant and anastrozole in terms of TTF (HR=1.02, 95%CI 0.89-1.17), complete response (RR=1.79, 95%CI, 0.93-3.43), and partial response (RR=0.91, 95%CI 0.69-1.21). As for safety, there was no statistical significance between the two groups for common adverse events. Conclusion: Fulvestrant 250mg is as effective and well-tolerated as anastrozole 1mg treatment for advanced breast cancer in postmenopausal women whose disease progressed after prior endocrine treatment. Thus, fulvestrant may serve as a reasonable alternative to anastrozole when resistance is experienced in breast cancer cases.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2723-2729
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• 2013

Background: To investigate the internal validity of a food-frequency questionnaire (FFQ) developed for use in Chinese women and to compare habitual dietary intakes between population and hospital controls measured by the FFQ. Materials and Methods: A quantitative FFQ and a short food habit questionnaire (SFHQ) were developed and adapted for cancer and nutritional studies. Habitual dietary intakes were assessed in 814 Chinese women aged 18-81 years (407 outpatients and 407 population controls) by face-to-face interview using the FFQ in Shenyang, Northeast China in 2009-2010. The Goldberg formula (ratio of energy intake to basal metabolic rate, EI/BMR) was used to assess the validity of the FFQ. Correlation analyses compared the SFHQ variables with those of the quantitative FFQ. Differences in dietary intakes between hospital and population controls were investigated. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using conditional logistic regression analyses. Results: The partial correlation coefficients were moderate to high (0.42 to 0.80; all p<0.05) for preserved food intake, fat consumption and tea drinking variables between the SFHQ and the FFQ. The average EI/BMR was 1.93 with 88.5% of subjects exceeding the Goldberg cut-off value of 1.35. Hospital controls were comparable to population controls in consumption of 17 measured food groups and mean daily intakes of energy and selected nutrients. Conclusions: The FFQ had reasonable validity to measure habitual dietary intakes of Chinese women. Hospital outpatients provide a satisfactory control group for food consumption and intakes of energy and nutrients measured by the FFQ in a Chinese hospital setting.

• 한국통신학회논문지
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• 제30권10B호
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• pp.676-688
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• 2005

본 연구는 인터넷전화의 서비스적 특성과 기존음성전화서비스간의 경쟁관계 분석을 통해 전화망과 If Phone망간 합리적인 정산방안의 비교결과를 제시하고 있다. 연구방법론은 양방향(two-way) 상호정산체계에 따라 전화망과 IP Phone망간 정산방식을 무정산방식, 정액제방식, 정률제방식의 세가지 대안으로 나누어 검토하였으며, 정산유형별로 상호정산식을 도출하여 최적기본요금 및 통화요금을 사회후생적 차원에서 비교, 분석하였다. 연구결과 인터넷전화의 요금 정산식은 인터넷사업자의 시장점유율과 함께 가변적으로 변동하는 함수이며 소비자후생에 매우 직접적인 영향을 끼치고 있음을 알 수 있었다. 각 대안들의 특징, 국내 통신 산업에서의 적용가능성, 국내 인터넷전화의 시장상황 및 경쟁상황, 이용대가 산정의 공정성 및 투명성의 관점에서 현 시점에서는 정액제의 사용이 권장될 수 있다. 그러나 향후 인터넷 전화 소비자의 평균통화량이 지금 수준보다 현저히 높아질 경우, 그리고 인터넷 전화의 시장 점유율이 지금보다 훨씬 증가해서 기간통신의 대체율이 높아질 경우에 소비자 후생과 망투자비용의 효과적인 활용을 위해 정률제로의 전환을 고려해야 한다.

• KIEAE Journal
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• 제12권1호
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• pp.3-10
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• 2012

Recently, the increase of impervious area has been pointed out as a major cause of climate change and biotop area deterioration]. Therefore, quantitative indicators for environmental housing design and planning have been needed especially to control the impervious area. The Biotop Area Ratio(BAR) as the mostly applied environmental planning control instrument in Korea verifying the possibility of utilizing has been used effectively in various aspects. However, the fact that the space types are based on two dimension and ecological functions of spaces are simplified has shown the limitations of this planning instrument in the use as planning and evaluation indicator. In this study, classification criteria and the weighting of the space types in similar indicators Biotopflaechenfaktor (BFF, Berlin), Seattle Green Factor (SGF, Seattle), and Green Area Factor (GAF, Malmo) were analyzed. These indicators are similar in the sense that they apply weights to calculate the area and express a percentage of land area. The findings are as follows: The basic method that can estimate the vegetation volume is proposed to overcome the limitation of the BAR. It also was proven that the introduction of three-dimensional volume rate of biotops area was possible. Finally, the framework of space type classification criteria is proposed through linkages with relevant laws and regulations. With the improvement of the space types, the BAR is expected to be reasonable indicator in outdoor space evaluation in housing project.

• 한국구조물진단유지관리공학회 논문집
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• 제19권1호
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• pp.128-138
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• 2015

탄산화는 지하구조물과 같이 이산화탄소의 농도가 높고 강우로부터 보호되는 콘크리트 구조물에 매우 심각한 열화현상이다. 탄산화 깊이 및 수화물의 변화를 평가하기 위해 많은 연구가 진행되고 있으나 해석모델의 복잡성, 이산화탄소 확산계수 모델링 등의 어려움으로 인해 실제 탄산화 거동을 제한적으로 모사하고 있다. 본 연구에서는 기존의 탄산화 모델링 (Ducom)에 대하여 확산계수 모델링, 공극률 감소 모델, 이산화탄소의 장기반응률 등을 개선하여 개선된 탄산화 모델을 제시하였다. 검증을 위하여 온도변화를 고려한 촉진탄산화 시험. 공극률 평가 시험 (수은압입법)을 수행하였으며, 탄산화 깊이를 개선되기 전/후의 모델과 비교하였다. 또한 수산화칼슘의 중량변화와 실태조사결과를 이용하여 낮은 이산화탄소에 노출된 콘크리트 구조물의 탄산화 깊이를 제안된 모델과 비교하였다. 제안된 모델은 확산계수 감소성, 공극률 감소성을 적절하게 반영하여 기존의 모델에 비해 합리적인 결과 (수산화칼슘 소모량, 탄산화 깊이)를 나타내었다.

• 한국산업보건학회지
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• 제9권1호
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• pp.173-186
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• 1999

To utilize diffuse sampling of formaldehyde in air, a new sampler was designed. A glass fiber filter was impegnated with 2,4-dinitrophenylhydrazine(DNP) and phosphoric acid and mounted 37mm cassette. The formaldehyde vapor was sampled in the dynamic chamber and measured by high performance liquid chromatograph and compared with solid sorbent tube. The results were as follows ; 1. The desorption efficiencies of diffusive sampler between 97.0% and 100%. 2. the sampling rate is constant as in $58{\sim}61.8m{\ell}/min$ when sampling times are between 120 and 360 min. 3. There was a significant relationship between concentrations of diffusive samples and active samples with the coefficient of determination(R2) of 0.92. 4. Desorbed amount of formaldehyde diffusive sampler was increased by high relative humidity. 5. Wheth diffusive samplers were stored at room temperature or at refrigerator there was no statistically significant difference in the accuracy of result. 6. When the diffusive samplers, which collected formaldehyde vapor, were exposed to clean air for three hours, there was no significant loss of formaldehyde due to reverse diffusion. In conclusion, this study suggest that developed diffusive samplers will be a reasonable substitute for the solid sorbent tube for sampling formaldehyde and practical comparative study of developed diffusive sampler should be performed at workplaces of manufacturing industry.

• 한국진공학회지
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• 제12권2호
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• pp.112-117
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• 2003

MgO 박막은 PDP(plasma display panels)분야에서 널리 사용되어 왔다. 본 연구에서는, 기존에 사용되고 있는 e-beam evaporation, reactive magnetron sputtering법과 arc deposition법으로 MgO 보호막을 증착하여 구조적 · 광학적 특성을 비교하였다. 반응 가스인 산소 가스의 유입량을 변화시켜 Mg metal target을 이용하여 vacuum arc deposition equipment 의해 유리 기판 위에 증착하였다. Ellipsometer를 이용하여 치밀도를 측정하고, MgO보호막의 마모율(erosion rate)를 측정하기 위해 가속 실험 방법을 도입, Ar+ 이온빔에 의한 erosion test를 시행하여 내마모성을 알아보았다. 또한, XPS와 UV test를 사용하여 MgO보호막의 광투과도에 미치는 수분의 영향을 조사한 결과, arc evaporation 법이 광투과도 90%이상을 유지하여 수분의 영향에 둔감한 것을 알 수 있었다. 한편, XRD와 AFM을 이용하여 MgO 박막의 구조와 표면 형상에 대해 조사하였다.

• 한국물환경학회지
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• 제34권3호
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• pp.308-315
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• 2018

SWMM-LID was calibrated with flow monitoring data in LHI to evaluate runoff after LID application. The flow rate in the B basin was estimated to be 0.94 and 6.15 for O/S and $D_v$, respectively. In the A and C basins, the difference between the observed and simulated data was greater than in the B basin. As a result of runoff reduction efficiency by the application of LID facilities, the change of infiltration increased from 34.6 % to 45.8 % in the entire watershed, and the runoff decreased from 58.8 % to 46.3 %. In the runoff reduction of each LID facility, rain garden E showed the highest effect with 99.9 % and bioretention B showed the lowest effect with 27.5 %. In order to evaluate the efficiency of each LID facility, a comparison is made between the pore volume (V) of the LID and the catchment area (A). The runoff showed a runoff reduction effect of about 70 % above the 0.1 volume/area (V/A) value. As a result of examining the runoff reduction with LID facilities by the LID module of SWMM, a reasonable design is possible by reflecting the appropriate LID volume to drainage area.

• 보건행정학회지
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• 제6권1호
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• pp.144-162
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• 1996

This study was conducted to identify the problems related to operation of the committee system in university hospitals and to propose the direction for reforming it. Data were collected by surveying 138 working-level administration managers of committees from 12 university hospitals in Seoul in October, 1995. The results were as follows: 1. The purposes of the committee were to promote the reasonable dicision making in the hospitals, to satisfy the requirement of Hospital Accreditation Program and, to execute the administrational instructions in due order. The sort of job which was charged of chairmen and the majority of committee member was doctor. 2. The committees which were to be held the meeting frequently in a year were general management committees(8.25 times/year). But in case of operation rate, medical care-related committees showed the most frequent meeting(90.15%). Most of committees made the regulations and reported the results of their meeting to the CEO of their hospitals by written documents. 3. Most doctors thought the medical care-related committees useful. Medical technicians regarded education and research-related committees as useful, while administrators favored the general management committees. 4. The factors related to the perceived performance of the committee were the kind of job, the class of job and the kind of committee. Also, the perceived performance of the committee was positively related to the usefulness in efficient management of work, and negatively to uncertainties in responsibility and a nominal role of the committee. 5. Most of the respondnts thought that the concern of the top manager about the committee was the most important factor for the improvement of committee system at hospitals. They also regarded that formalization of the objectives and regulation rule and composition of committees with members which work in various fields as essential. Further studies on the organizational and operational cjharacteristics which include general hospitals in various areas are required.

• 한국잠사곤충학회지
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• 제5권
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• pp.63-66
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• 1965

본 연구는 우리나라산 작잠견에 대한 합리적인 제사법 구명하기 위한 연구로서 결과를 얻었다. 1. 작잠사비율에 있어서 추견의 왕사구는 8.02% 좌조구는 7.44% 이었고, 춘견의 왕사구는 7.23% 좌조구는 6.79%로서 종래의 6.00% 내외보다는 현저한 경향을 보았다. 2. 작잠견의 관계사량비율에 있어서는 추견 63∼68% 춘견 66∼70%로서 춘견이 추견보다 2∼3% 증가를 보이었다. 이것은 궁견당시의 기후형태에 영향되리라고 본다. 3. 조사능률에 있어서 대 1인 1시간당 조사량은 70g 내외이었다. 4. 작잠견의 강신도에 있어서 강력은 3g/D 내외었고 신도는 26% 내외로서 강력은 생사보다 약하였고, 신도는 생사보다 컷다. 5. 이상의 연구결과는 작견조사의 기업화를 가능케 하여 작잠업을 새로운 수출산업으로 발전할 수 있게 되었으므로 외화획득상 정부의 적극시책이 요구된다.