• Journal of the Institute of Electronics Engineers of Korea SD
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• v.49 no.8
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• pp.63-72
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• 2012

In this paper, we proposed a parallel architecture of line & block edge filter for high-performance H.264/AVC deblocking filter for Quad Full High Definition(Quad FHD) video real time processing. To improve throughput, we designed 4-parallel block edge filter with 16 line edge filter. To reduce internal buffer size and processing cycle, we scheduled 4-parallel zig-zag scan order as deblocking filtering order. To avoid data conflicts we placed 1 delay cycle between block edge filtering. We implemented interleaving buffer, as internal buffer of block edge filter, to sharing buffer for reducing buffer size. The proposed architecture was simulated in 0.18um standard cell library. The maximum operation frequency is 108MHz. The gate count is 140.16Kgates. The proposed H.264/AVC deblocking filter can support Quad FHD at 113.17 frames per second by running at 90MHz.

• Tuberculosis and Respiratory Diseases
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• v.79 no.2
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• pp.85-90
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• 2016

Background: Lung cancer is the most common cause of cancer related death. Alterations in gene sequence, structure, and expression have an important role in the pathogenesis of lung cancer. Fusion genes and alternative splicing of cancer-related genes have the potential to be oncogenic. In the current study, we performed RNA-sequencing (RNA-seq) to investigate potential fusion genes and alternative splicing in non-small cell lung cancer. Methods: RNA was isolated from lung tissues obtained from 86 subjects with lung cancer. The RNA samples from lung cancer and normal tissues were processed with RNA-seq using the HiSeq 2000 system. Fusion genes were evaluated using Defuse and ChimeraScan. Candidate fusion transcripts were validated by Sanger sequencing. Alternative splicing was analyzed using multivariate analysis of transcript sequencing and validated using quantitative real time polymerase chain reaction. Results: RNA-seq data identified oncogenic fusion genes EML4-ALK and SLC34A2-ROS1 in three of 86 normal-cancer paired samples. Nine distinct fusion transcripts were selected using DeFuse and ChimeraScan; of which, four fusion transcripts were validated by Sanger sequencing. In 33 squamous cell carcinoma, 29 tumor specific skipped exon events and six mutually exclusive exon events were identified. ITGB4 and PYCR1 were top genes that showed significant tumor specific splice variants. Conclusion: In conclusion, RNA-seq data identified novel potential fusion transcripts and splice variants. Further evaluation of their functional significance in the pathogenesis of lung cancer is required.

• Imaging Science in Dentistry
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• v.49 no.4
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• pp.301-306
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• 2019

Purpose: This report presents a procedure for performing power Doppler ultrasound-guided sialography using the phenomenon of increased blood flow and illustrates its application to practical patient cases. Materials and Methods: The salivary gland was scanned using ultrasound equipment (GE LOGIQ5 Expert^® device; GE Medical Systems, Milwaukee, WI, USA) to identify pathological findings related to the patient's chief complaint. To identify the orifice of the main duct, it should be cannulated using a lacrimal dilator. After inserting the catheter into the cannulated main duct, the position of the catheter within the duct was confirmed by ultrasound. A contrast agent was injected until the patient felt fullness, and ultrasound (B-mode) was used to confirm whether the contrast agent filled the main canal and secondary and tertiary ducts. Then, power Doppler ultrasound was performed to determine whether the salivary gland had increased blood flow. Results: In 2 cases in this report, a power Doppler ultrasound scan showed a significant increase in blood flow after contrast medium injection, which was not observed on a preoperative scan. Conclusion: Power Doppler ultrasound was found to be a simple, safe, and effective tool for real-time sialography monitoring.

• Journal of the Korean Society for Nondestructive Testing
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• v.24 no.2
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• pp.180-185
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• 2004

Conventional ultrasonic examination to detect micro and small surface cracks is based on the pulse-echo technique using a normal immersion focused transducer with high frequency, or an angle-beam transducer generating surface waves. It is difficult to make an automatic ultrasonic system that can detect micro and small surface cracks and position in a large structure like steel and ceramic rolls, because of the huge data of inspection and the ambiguous position data of the transducer. In this study, a high-precision scanning acoustic microscope with a 10MHz large-aperture transducer has been used to assess the existence, position and depth of a surface crack from the real-time A, B, C scans obtained by exploiting the ultrasonic diffraction. The ultrasonic method with large aperture transducer has improved the accuracy of the crack depth assessment and also the scanning speed by ten times, compared with the conventional ultrasonic methods.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.44 no.5
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• pp.58-65
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• 2007

As multimedia portable devices become popular, the amount of computation for processing data including video compression has significantly increased. Various researches for low power consumption of the mobile devices and real time processing have been reported. Motion Estimation is responsible for 67% of H.264 encoder complexity. In this research, a new circuit is designed for motion estimation. The new circuit uses motion prediction based on approximate SAD, Alternative Row Scan (ARS), DAU, and FDVS algorithms. Our new method can reduce the amount of computation by 75% when compared to multi-frame motion estimation suggested in JM8.2. Furthermore, optimal number and size of reference frame blocks are determined to reduce computation without affecting the PSNR. The proposed Motion Estimation method has been verified by using the hardware and software Co-Simulation with iPROVE. It can process 30 CIF frames/sec at 50MHz.

• Journal of Korean Society on Water Environment
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• v.28 no.6
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• pp.843-850
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• 2012

Due to the fast response to algae bloom issue in drinking water treatment plant, very fast determination methodology for algal toxin is required. In this study, column switching technique based online preconcentration method was combined with high resolution full scan mass spectrometer to save sample preparation time and to obtain fast and accurate result. After parameter optimization of online preconcentration, 1mL filtered sample was directly injected to trap column with switching valve system. Next, target toxins are eluted by 98% acetonitrile and analysed with 150 - 1,100 amu scan range at 50,000 resolving power. Method detection limit (MDL) for microcystin-LR, the most toxic isomer, was 0.1 ng/mL and others such as microcystin-YR, microcystin-RR and nodularin were 0.08, 0.03 and 0.04 ng/mL, respectively. This is the best improved sensitivities with 1mL volume in the literature. Furthermore, due to the use of ultra pressure HPLC (UPLC), the whole method run was completed in 4 min. Real sample applications for 173 sample including 55 surface water and 118 treatment plant samples for raw and treated water could be done within 16 hours. In our calculation, this methodology is roughly 80% faster than the previous manual solid-phase extraction with LC-MS/MS method.

• Proceedings of the Korean Society of Food Hygiene and Safety Conference
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• 1996.06a
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• pp.33-33
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• 1996

Interests in the field of rapid methods and automation in microbiology have been growing steadily on an international scale in recent years. International meetings concerned this problem have been held in elsewhere in the world countries since the past twenty years. But, unfortunately in the field of microbial examination in food hygiene, this problem have not yet been developed so much as in the field of clinical microbiology. Today, I would like to introduce you here present aspects of rapid and automation technologies, those which are manly carrying in milk and meats industries. My illustration will be given recent improved technologies using automatic apparatus and instruments along with process of microbial count procedure. Recent direct microbiological counting system (ChemeScan \ulcorner) as real time ultrasensitive analysis created by Cheminex Ltd., France is now most evolutional instrument to provide direct microbial counts, down to one cell, within 30 minutes. The results from these evaluations how a good correlation between the ChemScan system and the standard plate count method. This system will be successful application for not only in the field of pharmacology but also food microbiology. In addition, current identification of microbes by sophisticated instruments suitable for food microbiology, one of which Biology is manual system (BIOLOG\ulcorner), provides reference-level capability at a modes price. For the manual system, the color reactions in the microplate are read by eye and manually keyed into personal computer. Species identification appears on the computer screen within seconds, along with biotype patterns, a list of closely related species, and other useful statistics. In present this is useful application for microbial ecology and epidemiological survey. RiboPrinter system newly produced by DuPont is now focusing among microbiologists in the world, and is one of the biggest microbial characterization system using a DNA-based approach. The technology analyzer is bacterial culture for its genetic fingerprint or riboprint pattern. Finally Bio-cellTracer system for automatic measurement of fungal growth and Fukitori-Maseter, a Surface Hygiene Monitoring Kit by using swabe procedure in food processing environment are briefly illustrated in this presentation.

• The Korean Journal of Nuclear Medicine Technology
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• v.13 no.1
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• pp.57-62
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• 2009

Purpose: Brain SPECT study is more sensitive to motion than other studies. Especially, when applying 1-day subtraction method for Diamox SPECT, it needs shorter study time in order to prevent reexamination. We were required to have new study condition and analysing method on dual detector system because triple head camera in Seoul National University Hospital is to be disposed. So we have tried to increase image quality and make the dual and triple head to have equivalent study time by using a new analysing program. Materials and Methods: Using IEC phantom, we estimated contrast, SNR and FWHM. In Hoffman 3D brain phantom which is similar with real brain, we were on the supposition that 5% of injected doses were distributed in brain tissue. To compare with existing FBP method, we used fan-beam collimator. And we applied 15 sec, 25 sec/frame for each SEPCT studies using LEHR and LEUHR. We used OSEM2D and Onco-flash3D reconstruction method and compared reconstruction methods between applied Gaussian post-filtering 5mm and not applied as well. Attenuation correction was applied by manual method. And we did Brain SPECT to patient injected 15 mCi of $^{99m}Tc$-HMPAO according to results of Phantom study. Lastly, technologist, MD, PhD estimated the results. Results: The study shows that reconstruction method by Flash3D is better than exiting FBP and OSEM2D when studied using IEC phantom. Flowing by estimation, when using Flash3D, both of 15 sec and 25 sec are needed postfiltering 5 mm. And 8 times are proper for subset 8 iteration in Flash3D. OSEM2D needs post-filtering. And it is proper that subset 4, iteration 8 times for 15sec and subset 8, iteration 12 times for 25sec. The study regarding to injected doses for a patient and study time, combination of input parameter-15 sec/frame, LEHR collimator, analysing program-Flash3D, subset 8, iteration 8times and Gaussian post-filtering 5mm is the most appropriate. On the other hands, it was not appropriate to apply LEUHR collimator to 1-day subtraction method of Diamox study because of lower sensitivity. Conclusions: We could prove that there was also an advantage of short study time effectiveness in Dual camera same as Triple gamma camera and get great result of alternation from existing fan-beam collimator to parallel collimator. In addition, resolution and contrast of new method was better than FBP method. And it could improve sensitivity and accuracy of image because lesser subjectivity was input than Metz filter of FBP. We expect better image quality and shorter study time of Brain SPECT on Dual detector system.

• Journal of KIISE:Databases
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• v.29 no.5
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• pp.381-392
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• 2002

This paper deals with the problem of shape-based retrieval in time-series databases. The shape-based retrieval is defined as the operation that searches for the (sub)sequences whose shapes are similar to that of a given query sequence regardless of their actual element values. In this paper, we propose an effective and efficient approach for shape-based retrieval of subsequences. We first introduce a new similarity model for shape-based retrieval that supports various combinations of transformations such as shifting, scaling, moving average, and time warping. For efficient processing of the shape-based retrieval based on the similarity model, we also propose the indexing and query processing methods. To verify the superiority of our approach, we perform extensive experiments with the real-world S&P 500 stock data. The results reveal that our approach successfully finds all the subsequences that have the shapes similar to that of the query sequence, and also achieves significant speedup up to around 66 times compared with the sequential scan method.

• Journal of Biomedical Engineering Research
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• v.23 no.5
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• pp.351-364
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• 2002

Conventional 3D ultrasound imaging using mechanical ID arrays suffers from poor elevation resolution due to the limited depth-of-focus (DOF). On the other hand, 3D imaging systems using 2D phased arrays have a large number of active channels and hence require a very expensive and bulky beamforming hardware. To overcome these limitations, a new real-time volumetric imaging method using curved 2-D arrays is presented, in which a small subaperture, consisting of 256 elements, moves across the array surface to scan a volume of interest. For this purpose, a 2-D curved array is designed which consists of 90$\times$46 elements with 1.5λ inter-element spacing and has the same view angles along both the lateral and elevation directions as those of a commercial mechanical 1-D array. In the proposed method, transmit and receive subapertures are constructed by cutting the four corners of a rectangular aperture to obtain a required image qualify with a small number of active channels. In addition the receive subaperture size is increased by using a sparse array scheme that uses every other elements in both directions. To suppress the grating lobes elevated due to the increase in clement spacing, fold-over array scheme is adopted in transmit, which doubles the effective size of a transmit aperture in each direction. Computer simulation results show that the proposed method can provide almost the same and greatly improved resolutions in the lateral and elevation directions, respectively compared with the conventional 3D imaging with a mechanical 1-D array.