• Korean Journal of Clinical Pharmacy
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• v.28 no.2
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• pp.81-87
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• 2018

Objective: There have been many cases of spontaneous adverse drug reactions to fentanyl at a regional pharmacovigilance center in the hospital. To assess the factors causing the adverse drug reactions reported in patients receiving fentanyl patient-controlled analgesia (PCA) monotherapy or in combination with fentanyl transdermal therapeutic system (TTS) for acute post-operative pain management. Methods: We conducted a retrospective cohort study with all patients prescribed fentanyl PCA for pain management after orthopedic surgery at a single university hospital from June 2012 to May 2013. We analysed the factors causing adverse drug reactions reported by a spontaneous reporting system in patients receiving fentanyl PCA monotherapy and those receiving fentanyl TTS in combination with fentanyl PCA. Results: Based on the spontaneous adverse drug reaction reporting, the risk ratio for the incidence rate of adverse drug reaction in the fentanyl TTS combination therapy group was 3.04 (95 % CI: 2.4-4.00, P < 0.0001), which was approximately 3-fold higher than that reported for fentanyl PCA monotherapy. Only 60 % of the adverse drug reactions were reported. Conclusion: It is inappropriate to add fentanyl TTS to fentanyl PCA to manage post-operative acute pain. There is a need to improve adverse drug reaction reporting. We expect that regular analysis of adverse drug reactions reported at regional pharmacovigilance centre would aid in appropriate drug utilization by patients.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.3D
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• pp.231-240
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• 2010

As majority of the traffic accidents in intersections is caused by human factor, a close examination is required on its contributing factors through measuring the psychological and physiological response according to the driving characteristics of the drivers and the road conditions. In this study, for the safety evaluation of individual intersection considering human factors of the drivers, electroencephalography reaction was measured utilizing cutting-edge measuring equipment and survey on drivers' cognitive characteristics in ordinary times and while driving test was conducted. The relationship between the electroencephalography response when approaching the intersection and cognitive evaluation survey data in driving test was clarified, and individual intersection safety evaluation model was built considering cognitive evaluation factor and the reaction of a bio-response electroencephalography data. As a result, I could find out that cognitive evaluation was made through the reaction of a bio-response (Electroencephalography) process because electroencephalography reaction of a bio-response showed differently by the physical characteristics of the intersection and cognitive evaluation had a difference.

• Korean Journal of Clinical Pharmacy
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• v.29 no.2
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• pp.125-132
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• 2019

Objective: To examine the perceptions and attitudes toward spontaneous adverse drug reaction (ADR) reporting system among community pharmacists and identify factors that influence reporting, by implementing a survey. Methods: A structured questionnaire was developed and distributed online. Request for the survey was posted on the website of pharmacy's billing program, and the survey was conducted for 8 days. We collected the participants' response on their work environment, experience of ADR reporting, and their perception and attitude on the reporting system. Multivariate logistic regression was used to evaluate factors influencing ADR reporting. Results: A total of 382 pharmacists participated in the survey. Significant contributing factors for reporting level were age (odds ratio [OR], 0.90; 95% confidence interval [CI], 0.84-0.96), knowledge of reporting method (OR, 53.56; 95% CI, 9.10-315.41), installation of reporting program (OR, 31.92; 95% CI, 4.16-244.75), and encouragement from the Korean pharmaceutical association (OR, 4.13; 95% CI, 1.11-15.35). Regarding the attitude toward spontaneous ADR reporting system, 'lack of time for reporting' (OR, 0.29; 95% CI, 0.15-0.53) and 'complexity of reporting procedure' (OR, 0.51; 95% CI, 0.31-0.84), were associated with a low likelihood of reporting. Conclusion: Our results indicated that the knowledge of ADR reporting method, installation of the reporting program, and encouragement from the Korean Pharmaceutical Association contribute to active reporting. It is necessary to simplify the reporting method, make the ADR reporting program user-friendly, and provide educational interventions to increase participation in spontaneous reporting by the community pharmacists.

• Applied Chemistry for Engineering
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• v.26 no.2
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• pp.184-192
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• 2015

Characteristics of Char-$CO_2$ gasification for petroleum coke, biomass and mixed fuels were compared in the temperature range of $1,100{\sim}1,400^{\circ}C$ using TGA (Thermogravimetric analyzer). Kinetic constants with respect to reaction temperature were determined by using different gas-solid reaction models. Also activation energy (Ea) and pre-exponential factors ($K_0$) in each models were calculated by using Arrhenius equation and then were compared with experimental values to determine reaction rate equation for char-$CO_2$ gasification. Reaction time for $CO_2$ gasification decreased with an increase of reaction temperature. Also, the activation energy of $CO_2$ gasification reaction for mixture with petroleum coke and biomass decreased with increasing biomass contents. This indicates that mixing with biomass could bring synergy effects on $CO_2$ gasification reaction.

• Korean Chemical Engineering Research
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• v.56 no.3
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• pp.315-319
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• 2018

Fenton reaction is widely used as a out of cell method for evaluating the membrane electrochemical durability of Proton Exchange Fuel Cell (PEMFC). In this study, we investigated the factors affecting the Fenton reaction. In order to estimate the degree of the reaction, it is necessary to analyze the radicals as a product in the Fenton reaction. However, since the radicals are difficult to analyze, the degree of the reaction was measured by analyzing the concentration of hydrogen peroxide. The activation energy was calculated from the rate of hydrogen peroxide change with temperature. The activation energy was 24.9 kJ/mol at 180 min. The Fenton reaction rate was affected by the iron ion concentration. At $80^{\circ}C$, 200 rpm, and $Fe^{2+}$ 80 ppm, the concentration of hydrogen peroxide was decreased more than 20% even for 1 hour, which shows that frequent solution replacement increases the membrane degradation rate.

• Nutrition Research and Practice
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• v.11 no.4
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• pp.334-339
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• 2017

BACKGROUND/OBJECTIVES: Telomere length is a useful biomarker for determining general aging status. Some studies have reported an association between alcohol consumption and telomere length in a general population; however, it is unclear whether the alcohol flush reaction, which is an alcohol-related trait predominantly due to acetaldehyde dehydrogenase deficiency, is associated with telomere length. This cross-sectional study aimed to evaluate the associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length (LTL). SUBJECTS/METHODS: The study included 1,803 Korean adults. Participants provided blood specimens for LTL measurement assay and reported their alcohol drinking status and the presence of an alcohol flush reaction via a questionnaire-based interview. Relative LTL was determined by using a quantitative polymerase chain reaction. Statistical analysis used multiple linear regression models stratified by sex and age groups, and potential confounding factors were considered. RESULTS: Age-specific analyses showed that heavy alcohol consumption (> 30 g/day) was strongly associated with a reduced LTL in participants aged ${\geq}65years$ (P < 0.001) but not in younger participants. Similarly, the alcohol flush reaction was associated with a reduced LTL only in older participants who consumed > 15 g/day of alcohol (P < 0.01). No significant alcohol consumption or alcohol flush reaction associations with LTL were observed in the sex-specific analyses. CONCLUSIONS: The results suggest that older alcohol drinkers, particularly those with the alcohol flush reaction, may have an accelerated aging process.

• Resources Recycling
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• v.12 no.3
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• pp.13-24
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• 2003

The production characteristics of activated carbon from waste walnut shell have been investigated by taking activation temperature, activation time, amount of activating agent, and kind of activating agent as the major influential factors. The adsorption capacity of the activated carbon which was produced using phosphoric acid as the activating agent increased with activation temperature and showed its greatest value at about $550^{\circ}C$. Yield for activated carbon was observed to decrease continuously as the activation temperature was raised. The optimal activation time for the highest adsorption capacity was found to be about 2 hr, and as the activation time increased the yield for activated carbon was showed to decrease continuously. The increase in the amount of activating agent resulted in the increase of the yield for activated carbon, however, excessive amount of activating agent deteriorated its adsorption capacity reversely. The variations of the microstructure of activated carbon observed by SEM with several influential factors, correlated very well with its changes in the adsorbability with the same factors and the kind of activating agent was found to play an important role in the determination of the adsorption capacity of activated carbon. To investigate the adsorption characteristics of the produced activated carbon, the adsorption reactions of $Cu^{2+}$ ion were examined using the produced activated carbon as the adsorbent. In general, the kinetics of the adsorption of $Cu^{2+}$ ion was observed to follow a 2nd-order reaction and the rate constant for adsorption reaction increased as the initial concentration of adsorbate was diminished. The equilibrium adsorption of $Cu^{2+}$ was explained well with Freundlich model and its adsorption reaction was found to be endothermic. The activation energy for adsorption was calculated to be 13.07 kcal/mol, which implied that the adsorption reaction was very irreversible, and several thermodynamic parameters of adsorption reaction were estimated using van't. Hoff equation and thermodynamic relationships.

• Journal of the Korean Applied Science and Technology
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• v.38 no.3
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• pp.762-770
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• 2021

The purpose of this study was to analyze the effect on the vertical ground reaction force, the elapsed time, and the center of pressure factors during gait by maepsi exercise program, which is a whole body exercise, to middle-aged women for 8 weeks. A total of 25 subjects participated in this study, 13 in the exercise group(age, 41±4.4 years; heigh, 162.5±5.8cm; weight, 57.8±6.7kg; body mass, 21.9±2.4kg/m2) and 12 in the control group(age, 41.1±5.6 years; height, 160.9±5.5 cm; weight, 576.2±8.1 kg; body mass, 21.7±2.9 kg/m2). In the exercise group, the maepsi exercise program consisting of 7 areas, 23 types and 77 movements, was conducted 3 times a week for 8 weeks. Two-way repeated measures ANOVA was performed to verify the ground reaction force factors during gait, and the post-test was analyzed with bonferroni adjustment(a=.05). In the exercise group, compared to the control group, the exercise group showed higher values than the control group in the elapsed time to FMWA and FPO, vertical ground reaction force at FMWA and FPO, and RMS factors of COP in the AP direction. Therefore, it was found that the 8-week maepsi exercise program improved the acceleration and deceleration exercise functions of middle-aged women who performed gait.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.1 no.2
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• pp.173-191
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• 1994

This descriptive-correlational study was conducted to exam if there were relation between noise level and reaction to noise of inpatient. The purpose of this study was to provide a basic data for comfort of patient hospitalized. The hypotheses of the study are : 1. The higher perceived noise level of inpatient, the higher reaction level to noise. 2. The higher perceived noise level of inpatient, physiological reaction level to noise. 3. The higher perceived noise level of inpatient, the higher emotional reaction level to noise. The participant were 153 patients hospitalized in one general hospital. The research instruments used for this study were noise scale and reaction of patient scale developed by the author. Data was collected over a period of 10 days from the 9th of July to the 18th of July, 1994. Statistical analysis of the data included percentage, t-test, ANOVA and Scheffe test. Examination of the hypotheses was done by use of pearson correlation coefficient. The results are summarized as follows ; 1. The mean score of noise level was 2.24. Among noise factors reported by the subjects, that which ranked highest was 'Conversation of Visitors'(2.82). Next were 'noise of handling receptacle'(2.73), 'the others noise from outside'(2.73) and 'Conversation of supporter'(2.71). 2. The mean score of reaction level to noise was 2.19, physiological reaction level 2.04 and emotional reaction level 2.37. Among Physiological reaction to noise reported by the subjects, that which ranked highest was 'tired'(2.39). Next were 'sweating'(2.22) and 'headache'(2.20). Among emotional reaction to noise reported by the subjects, that which ranked highest was 'to irritate nerve'(2.53). Next were 'disturbing rest'(2.51) and 'to disturb sleep'(2.46). 3. The relationship between perceived noise level of inpatient and reaction to noise was statically significant (r=0.599, p=.0001). The relationship between perceived noise level of inpatient and physiological reaction to noise was statically significant (r=0.554, p=.0001). The relationship between perceived noise level of inpatient and emotional reaction to noise was statically significant(r=0.535, p=.0001). Thus hypothese 1, 2, 3 were supported. 4. There were significant differences between noise level of inpatient, admission periods, mobility of physical condition and exposure level to noise. 5. There were significant differences between physiological reaction level to noise, admission periods, mobility of physical condition and operation Yes or No. 6. There were significant difference between emotional reaction level to noise, admission periods, mobility of physical condition and exposure level to noise.

• Physical Therapy Korea
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• v.25 no.2
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• pp.1-12
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• 2018

Background: It is very difficult for hemiplegic patients to effectively perform the sit-to-stand (STS) movements independently because of several factors. Moreover, the analysis of STS motion in hemiplegic patients has been thus far confined to only muscle strength evaluation with little information available on structural and environmental factors of varying chair height and foot conditions. Objects: This study aimed to analyze the change in biomechanical factors (ground reaction force, center of mass displacement, and the angle and moment of joints) of the joints in the lower extremities with varying chair height and foot conditions in hemiplegic patients while they performed the STS movements. Methods: Nine hemiplegic patients voluntarily participated in this study. Their STS movements was analyzed in a total of nine sessions (one set of three consecutive sessions) with varying chair height and foot conditions. The biomechanical factors of the joints in the lower extremities were measured during the movements. Ground reaction force was measured using a force plate; and the other abovementioned parameters were measured using an infra-red camera. Two-way repeated analysis of variance was performed to determine the changes in biomechanical factors in the lower extremities with varying chair height and foot conditions. Results: No interaction was found between chair height and foot conditions (p>.05). All measured variables with varying chair height showed a significant difference (p<.05). Maximum joint flexion angle, maximum joint moment, and the displacement of the center of mass in foot conditions showed a significant difference (p<.05); however the maximum ground reaction force did not show a significant difference (p>.05). Conclusion: The findings suggest that hemiplegic patients can more stably and efficiently perform the STS movement with increased chair height and while they are bare-foot.