Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length in Korean adults

  • Wang, Hyewon (Department of Foods and Nutrition, College of Science and Technology, Kookmin University) ;
  • Kim, Hyungjo (Department of Foods and Nutrition, College of Science and Technology, Kookmin University) ;
  • Baik, Inkyung (Department of Foods and Nutrition, College of Science and Technology, Kookmin University)
  • Received : 2017.03.30
  • Accepted : 2017.05.29
  • Published : 2017.08.01
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Abstract

BACKGROUND/OBJECTIVES: Telomere length is a useful biomarker for determining general aging status. Some studies have reported an association between alcohol consumption and telomere length in a general population; however, it is unclear whether the alcohol flush reaction, which is an alcohol-related trait predominantly due to acetaldehyde dehydrogenase deficiency, is associated with telomere length. This cross-sectional study aimed to evaluate the associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length (LTL). SUBJECTS/METHODS: The study included 1,803 Korean adults. Participants provided blood specimens for LTL measurement assay and reported their alcohol drinking status and the presence of an alcohol flush reaction via a questionnaire-based interview. Relative LTL was determined by using a quantitative polymerase chain reaction. Statistical analysis used multiple linear regression models stratified by sex and age groups, and potential confounding factors were considered. RESULTS: Age-specific analyses showed that heavy alcohol consumption (> 30 g/day) was strongly associated with a reduced LTL in participants aged ${\geq}65years$ (P < 0.001) but not in younger participants. Similarly, the alcohol flush reaction was associated with a reduced LTL only in older participants who consumed > 15 g/day of alcohol (P < 0.01). No significant alcohol consumption or alcohol flush reaction associations with LTL were observed in the sex-specific analyses. CONCLUSIONS: The results suggest that older alcohol drinkers, particularly those with the alcohol flush reaction, may have an accelerated aging process.

Keywords

References

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