• Journal of KIISE:Databases
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• v.36 no.2
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• pp.150-167
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• 2009

XML has become the new standard for storing, exchanging, and publishing of data over both the internet and the ubiquitous data stream environment. As demand for efficiency in handling XML document grows, labeling scheme has become an important topic in data storage. Recently proposed labeling schemes reflect the dynamic XML environment, which itself provides motivation for the discovery of an efficient labeling scheme. However, previous proposed labeling schemes have several problems: 1) An insertion of a new node into the XML document triggers re-labeling of pre-existing nodes. 2) They need larger memory space to store total label. etc. In this paper, we introduce a new labeling scheme called a Circle Labeling Scheme. In CLS, XML documents are represented in a circular form, and efficient storage of labels is supported by the use of concepts Rotation Number and Parent Circle/Child Circle. The concept of Radius is applied to support inclusion of new nodes at arbitrary positions in the tree. This eliminates the need for re-labeling existing nodes and the need to increase label length, and mitigates conflict with existing labels. A detailed experimental study demonstrates efficiency of CLS.

• 대한핵의학회:학술대회논문집
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• 1999.05a
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• pp.193-195
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• 1999

There is considerable interest in $^{188}Re$ due to its favorable properties as a therapeutic radionuclide $^{188}Re$ and $^{99m}Tc$ act as a matched pair because of their similar chemical properties, and therefore methods of labeling with $^{99m}Tc$ can be applied to the labeling with $^{188}Re$. With appropriately chosen agents as carriers of $^{188}Re$, the labeling can be readily carried out using $^{188}ReO_4^-$ in the presence of a reducing agent. $^{188}Re$ radio-pharmaceuticals based on $^{99m}Tc$ complexes have been synthesized and are currently being studied for clinical use. Some of them are shown to be suitable for therapeutic use and promising for radiotherapy in nuclear medicine.

• The Korean Journal of Nuclear Medicine
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• v.34 no.4
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• pp.344-352
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• 2000

Purpose: Re-188-Hydroxyethylidene diphosphonate (HEDP) is a new cost-effective agent for systemic radioisotope therapy of metastatic bone pain. We investigated the influence of carrier for labeling and biodistribution of Re-188-HEDP using HEDP kit with or without carrier ($KReO_4$). Materials and Methods: The kits (HEDP 15 mg, gentisic acid 4 mg and $SnCl_2.2H_2O_2$ 4.5 mg) with or without carrier ($KReO_4$ 0.1 mg) were labeled with Re-188 solution, made available from an in-house generator by boiling for 15 min. We compared the labeling efficiency and stability of carrier-added and carrier-free preparations of Re-188-HEDP Biodistribution and imaging studies of each preparation were performed in ICR mice ($1.85{\sim}3.7MBq/0.1ml$) and SD rats ($74.1{\sim}85.2MBq/0.5ml$). Results: The carrier-added preparation showed high labeling efficiency (95% at pH 5) and high stability in serum (88%, 3 hr). However, the carrier-free preparation showed low labeling efficiency (59% at pH 5) and low stability (43%, 3 hr). The carrier-added preparation showed high uptake in bone and low uptake in stomach and kidneys. However, the carrier-free preparation showed lower uptake in bone and higher uptake in both stomach and kidneys, which is supposed to be due to released perrhenate. The carrier-added preparation also showed better images with higher skeletal accumulation, lower uptake in other organs and lower soft tissue uptake than the carrier-free preparation. Conclusion: The results of these studies clearly demonstrate that addition of carrier perrhenate is required for high labeling efficiency, stability, bone uptake and good image quality of Re-188-HEDP.

• The Korean Journal of Nuclear Medicine
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• v.33 no.1
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• pp.84-93
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• 1999

Purpose: We investigated the direct labeling method of antibody with $^{99m}Tc$ and $^{188}Re$ and examined the stability and function of these labeled compounds in in vitro and in vivo. Materials and Methods: Disulfide bond of nonspecific human IgG was reduced to -SH group by 2-mercaptoethanol. Stannous ion was used to reduce $^{99m}Tc$ and $^{188}Re$. The stability of $^{99m}Tc$-IgG and $^{188}Re$-IgG was estimated upto 24 hrs. Biodistribution was evaluated in abscess bearing rats at 4 and 24 hr post-injection of $^{99m}Tc$ or $^{188}Re$ labeled IgG. Results: The number of -SH group per reduced IgG molecule was 2.34. The labeling yield of $^{99m}Tc$-IgG and $^{188}Re$-IgG were 90% and 95%, respectively The stability of $^{99m}Tc$-IgG at 1, 4, 6 and 24 hr was 91%, 83%, 78%, 7% and that of $^{188}Re$-IgG at 1, 4, 16 and 24 hr was 94%, 80%, 47%, 42%, respectively. At 4 hr post-injection of $^{99m}Tc$-IgG, high uptake was found on kidney, blood, stomach and abscess ($9.42{\pm}0.68,\;1.43{\pm}0.24,\;0.86{\pm}0.18,\;0.72{\pm}0.10$ %ID/g, respectively). The uptakes at 24 hr were kidney, abscess,.itomach, and blood in descending order. In case of $^{188}Re$-lgG, high uptake at 4 hr post injection appeared on kidney, blood, abscess and stomach ($3.92{\pm}0.62,\;1.32{\pm}0.08,\;0.88{\pm}0.01,\;0.26{\pm}0.06$, respectively). The uptakes at 24 hr were kidney, abscess, blood and stomach in descending order. The abscess to blood uptake ratio of $^{99m}Tc$-IgG was 0.5 at 4 hr and 2.02 at 24 hr and that of $^{188}Re$-IgG was 0.67 and 1.29. Conclusion: $^{99m}Tc$-IgG and $^{188}Re$-IgG canbe labeled efficiently with direct labeling method. However, $^{99m}Tc$-IgG and $^{188}Re$-IgG, labeled with direct method, was unstable. Further study is needed to enhance the stability of the antibody labeling.

• The Korean Journal of Nuclear Medicine
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• v.31 no.4
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• pp.427-432
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• 1997

Re-188 is useful candidate for therapeutic radionuclide because it has a physical half life of 17 hours, contains beta emissions suitable for therapy(maximum energy 2.12MeV) and emits a gamma ray that is suitable for quantitative diagnostic scanning(155keV). To use Re-188 as a radionuclide compound of angioplasty balloon radiotherapy, we investigated the labelling method and biodistribution of Re-188-DTPA We postulated that labeled Re-188-DTPA is preferable because it would be excreted via urinary system more easily than other compounds. To label Re-188 with DTPA, 1ml of 222MBq(6mCi) of Re-188 was added to DTPA solution(DTPA 20mg, $SnCl_2{\cdot}2H_2O$ 10mg, pH 3.5) and boiled at $100^{\circ}C$ for 120min in water bath. pH was adjusted to 5 with 2.3% sodium acetate. Labeling efficiency was measured using TLC-SG(acetone, saline). We evaluated biodistribution of Re-188-DTPA in sacrificed mice at 10 and 60 minutes after injection. We acquired images of kidneys, and drew time-activity curves in normal dogs and rats and calculated Tmax and Tl/2 in rats. The labelling efficiency was 95.7% on average. Labelling of Re-188-DTPA was.stable(90% after 5hours) in vitro at room temperature. According to time-activity curves of dogs and rats, it took 15 to 20 minutes after injection for Re-188-DTPA to be washed out through kidneys. In conclusion, Re-188-DTPA was successfully labeled, Re-188-DTPA was stable in vitro and was excreted early via kidneys in animals. We could recommend Re-188-DTPA as radionuclide of potential use in angioplasty balloon radiotherapy.

• Proceedings of the Korean Nuclear Society Conference
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• 1998.10a
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• pp.347-347
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• 1998

• Proceedings of the Korean Information Science Society Conference
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• 2004.10b
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• pp.79-81
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• 2004

범위 기반 레이블링 스킴(range-based labeling scheme)을 이용하면 임의의 두 노드에 대한 조상-자손 관계를 쉽게 판별할 수 있으므로, XPath나 XQuery 형태의 질의를 효율적으로 처리할 수 있다. 그러나 노드의 삽입이 일어나는 동적인 상황에서는 불가피하게 전체 또는 일부의 레이블을 다시 할당(re-labeling)할 가능성이 있다는 문제점이 있다. 본 논문에서는 Dietz 레이블링 스킴을 개선한 EP2(extended preorder ＆amp; postorder) 레이블링 스킴을 제안한다. 제안하는 스킴은 동일한 저장 공간상에서 범위 기반 레이블링 스킴에 비해 동적인 갱신에 유리하며, 기존의 구조 조인 알고리즘(structural join algorithm)을 이용하여 효율적으로 구조 질의(structural query)를 처리할 수 있다.

• Journal of Microbiology and Biotechnology
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• v.16 no.10
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• pp.1491-1498
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• 2006

The feasibility of pullulan acetate nanoparticles (PAN) with ionic strength (IS) sensitivity as a radioisotope carrier to inhibit tumor growth is demonstrated. PAN was radiolabeled with rhenium 188 (Re-188) without any chelating agents. The labeling efficiency of Re-188 into PAN (Re-188PAN) was $49.3{\pm}4.0%$ as determined by TLC. The tumor volumes of mice treated with 0.45 mCi of Re-188-PAN were measured and compared with that of free Re-188 after 5 days of intratumoral injection. For the histological evaluation of apoptotic nuclei of tumor cells, hematoxylin and eosin (H&E), and terminal deoxynucleotidyl transferase biotinylated deoxyuridine triphosphate nick end labeling (TUNEL) staining were performed. The mean tumor volume of the Re-188-PAN-treated group was decreased by 36% after 5 days, whereas that the free Re-188-treated group was decreased by only 15% (P<0.05). The mean number of TUNEL-positive cells in Re-188-PAN-treated tumors at $144.3{\pm}79.9$ cells/section was significantly greater than the control ($26.7{\pm}7.9$ cells/section, P=0.03). The numbers of leukocyte and lymphocyte were decreased in both free Re-188- and Re-188-PAN-treated mice. These results indicated that the intratumoral injection of Re-188-PAN effectively inhibits the tumor growth by prolonging Re-188 retention time in tumor site induced by the IS sensitivity.

• The Journal of the Convergence on Culture Technology
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• v.9 no.3
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• pp.835-843
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• 2023

Given the structure of XML data, path and tree pattern matching algorithms play an important role in XML query processing. To facilitate decisions or relationships between nodes, nodes in an XML tree are typically labeled in a way that can quickly establish an ancestor-descendant on relationship between two nodes. However, these techniques have the disadvantage of re-labeling existing nodes or recalculating certain values if insertion occurs due to sequential updates. Therefore, in current labeling techniques, the cost of updating labels is very high. In this paper, we propose a new labeling technique called Fast XML encoding, which supports the update of order-sensitive XML documents without re-labeling or recalculation. It also controls the length of the label by reusing deleted labels at the same location in the XML tree. The proposed reuse algorithm can reduce the length of the label when all deleted labels are inserted in the same location. The proposed technique in the experimental results can efficiently handle order-sensitive queries and updates.

• Journal of Korean Tunnelling and Underground Space Association
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• v.21 no.3
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• pp.419-432
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• 2019

Most of deep learning model training was proceeded by supervised learning, which is to train labeling data composed by inputs and corresponding outputs. Labeling data was directly generated manually, so labeling accuracy of data is relatively high. However, it requires heavy efforts in securing data because of cost and time. Additionally, the main goal of supervised learning is to improve detection performance for 'True Positive' data but not to reduce occurrence of 'False Positive' data. In this paper, the occurrence of unpredictable 'False Positive' appears by trained modes with labeling data and 'True Positive' data in monitoring of deep learning-based CCTV accident detection system, which is under operation at a tunnel monitoring center. Those types of 'False Positive' to 'fire' or 'person' objects were frequently taking place for lights of working vehicle, reflecting sunlight at tunnel entrance, long black feature which occurs to the part of lane or car, etc. To solve this problem, a deep learning model was developed by simultaneously training the 'False Positive' data generated in the field and the labeling data. As a result, in comparison with the model that was trained only by the existing labeling data, the re-inference performance with respect to the labeling data was improved. In addition, re-inference of the 'False Positive' data shows that the number of 'False Positive' for the persons were more reduced in case of training model including many 'False Positive' data. By training of the 'False Positive' data, the capability of field application of the deep learning model was improved automatically.