• 상하수도학회지
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• 제17권4호
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• pp.519-527
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• 2003

Cake layer in crossflow microfiltration(CFMF) can be reduced by coagulation, enhancing membrane flux. This is because enlarging particle size by coagulation increases shear-induced diffusivity and the back-transport of rejected particles. However it is known that the enlarged particles are disaggregated by the shear force of the pump while passing through it. This study is to look at the disaggregation in relation with cake layer reducation. Kaolin and polysulfon hollow fiber microfilter are used for experiment. The reduction of cake resistance by coagulation is observed in a range of 17% to 53% at the various coagulation conditions. The particle size analysis results of the experiments show that aggregated particles in feed are completely disaggregated by pump but re-aggregation of particles occurs in membrane. This suggestes that the re-aggregation of particles is critical to cake reduction and flux enhancement, since the aggregated particles are completely broken. The mechanisms for re-aggregation in membrane are the same with those for coagulation in feed tank. Charge neutralization is better for CCFMF than sweep flocculation although it has two drawbacks in operation.

• Applied Biological Chemistry
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• 제29권2호
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• pp.198-206
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• 1986

정제인삼(精製人蔘)사포닌의 수용액을 분자투석막(分子透析膜)(분자량(分子量) 12000)을 통(通)하여 투석(透析)하거나 Bio-Gel P-2(분자량(分子量) $200{\sim}2000$)gel을 통과시켜 분취(分取)하고 HPLC로 ginsenoside를 분석(分析)하였다. Ginsenoside는 분자결합양상(分子結合樣相)과 분자내(分子內) 친수성기(親水性基)의 공간배열(空間配列)에 따라 3군(群)으로 분류(分類)되었다. 제(第) I 군(群)은 거대(巨大)미셀 형성자(形成者)로 결합분자수(結合分子數)가 10이상이며 I면친수기형(面親水基形)이고 panaxadiol인 $Ginsenoside\;Rb_1$, $Rb_2$, Rc 및 Rd가 포함된다. 제(第)II군(群)은 소(小)미셀형성자(形成者)로 결합분자수(結合分子數)가 10이상(以上)에서 1까지이고 불완전(不完全) 양면친수기형(兩面親水基形)이며 triol인 $Rg_2$와 Rf 및 diol인 $Rg_3$가 포함된다. 제(第)III군(群)은 단분자(單分子)로 존재(存在)하며 양면친수기형(兩面親水基形)이고 triol인 Re와 $Rg_1$을 포함한다.

• Korea-Australia Rheology Journal
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• 제16권3호
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• pp.129-134
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• 2004

The aggregation characteristics of red blood cells (RBCs) were measured using a newly developed light-transmission slit rheometer. Conventional methods of RBC disaggregation such as the rotational Couette system were replaced with a pressure-driven slit flow system with a vibrational mechanism. Using a vibration generator, one can disaggregate the RBC aggregates stored in the slit. While shear stress decreases exponentially, instantaneous pressure and the transmitted light intensity were measured over time. Applying an abrupt shearing flow after disaggregation caused a rapid elongation of the RBCs followed by loss of elongation with the decreasing shear stress. While the shear stress is further decreasing, the RBCs start to re-aggregate and the corresponding transmitted intensity increases with time, from which the aggregation indices can be obtained using a curve-fitting program.

• 한국분말재료학회지
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• 제20권6호
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• pp.479-486
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• 2013

In the present work, physicochemical treatments were introduced for de-aggregation and stable dispersion of detonation nanodiamonds (DND) in polar solvents. The DNDs in water exhibited a particle size of 138 nm and high dispersion stability without particular treatment. However, the DNDs in ethanol were severely aggregated to several micrometers in size and showed poor dispersion stability with time. To break down aggregates of DNDs and enhance the dispersion stability of them in ethanol, mechanical force and chemical surfactant were introduced as functions of zirconia ball size, kind of surfactant and amount of surfactant added. From the analyses of average particle size and Turbiscan results, it was suggested that the size of DNDs in ethanol can be reduced by only mechanical force; however, the DNDs were re-aggregated due to high surface activity. The long-term dispersion stability can be achieved by applying mechanical force to break down the aggregates of DNDs and by preventing re-aggregation of them using proper surfactant.

• Korea-Australia Rheology Journal
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• 제20권4호
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• pp.253-260
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• 2008

A method based on transient shear flow dynamics of red cell aggregates was developed to investigate reversible re-aggregation processes with decreasing shear flow. In the microchannel-flow aggregometry, the aggregated red blood cells that are subjected to continuously decreasing shear stress in microchannel flow were measured with the use of a laser-scattering technique. Both the laser-backscattered intensity and pressure were simultaneously measured with respect to time, resulting in shear stress ranging from $0{\sim}35\;Pa$ for a time period of less than 30 seconds. The time dependent recording of the backscattered light intensity (syllectogram) yielded an upward convex curve with a peak point, which reflected the transition threshold of aggregation in the RBC suspensions. Critical-time and critical-shear stress corresponding to the peak point were examined by varying the initial pressure-differential and the micro channel depth, and these results showed good potential for being used as new aggregation indices. In the present study, these newly proposed indices were also validated by differentiating the effect of fibrinogen on RBC aggregation and then these indices were compared to the conventional indices that were measured by a rotational aggregometer.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 춘계학술대회
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• pp.1678-1681
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• 2004

The light-transmission technique has been applied to a slit rheometer for measuring red blood cell aggregation as well as blood viscosity over a range of shear rates. For measurement of blood viscosity and aggregation, instantaneous pressure and transmit-light intensity are measured with time. Using a precision pressure measurement, one can determine the shear stress and shear rate. In addition, a transmitted light through a blood sample indicates degree of RBC aggregation. With abruptly flowing with high shear rate, RBCs rapidly disaggregate and the intensity of the transmitted light becomes low. When continuously flowing with decreasing shear rate, RBCs tend to re-aggregate and the corresponding transmit-intensity gradually increases with time. The light intensity as a degree of RBC aggregation is plotted against shear rate and compared with blood viscosity. The advantages of this design are dual measurement at a time, simplicity, i.e., ease of operation and no moving parts, low cost, short operating time, and the disposable kit which is contacted with blood sample.

• 한국통신학회논문지
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• 제35권9B호
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• pp.1295-1304
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• 2010

본 논문에서는 에너지 효율적이고 신뢰성있는 데이터수집을 제공하는 고장감내형 데이터병합을 제안한다. 기존 데이터병합 기법은 패킷 손실에 대응하지 못하거나 대응 하더라도 에너지 소모가 매우 크다. 고장감내형 데이터병합은 적응적 타임아웃 데이터병합 기법에 트랙 토폴로지를 이용한 캐싱 및 재전송 기법을 적용하여 중요 이벤트에 대해 신뢰성있는 데이터수집을 제공한다. 고장감내형 데이터병합은 이벤트 가능성이 없는 평상시에는 기존의 트리 기반의 단일경로 데이터수집을 함으로써 에너지 소모를 줄인다. 하지만 이벤트 가능성이 감지되면 트랙 토폴로지를 이용한 패킷 손실 감지 및 재전송을 통해 데이터병합 결과의 정확도를 높인다. 실험 결과에서 고장감내형 데이터병합은 평균 소모 에너지 측면에서 TAG에 비해 약 8% 에너지 소모가 감소하였고, 이벤트 발생 가능성이 있을 경우 데이터 정확도 측면에서 TAG에 비해 41%정도 우수한 성능을 보였다. 그리고 평균 소모 에너지 측면에서 PERLA에 비해 약 53% 정도 에너지 소모가 감소하였으며, 이벤트 발생 가능성이 있을 경우 데이터 정확도 측면에서는 성능 저하가 거의 없었다.

• 방송공학회논문지
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• 제20권2호
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• pp.300-309
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• 2015

IEEE 802.11n 무선랜에서 높은 처리율을 지원하기 위하여 미디어 접근 제어(MAC) 계층은 A-MSDU(Aggregate-MAC Service Data Unit)와 A-MPDU(Aggregate-MAC Protocol Data Unit)을 채택하고 있다. 일반적으로, A-MPDU는 선택적 재전송 기능을 사용하기 때문에 A-MSDU보다 높은 처리율 성능을 보이고 있다. 그러나 A-MPDU가 선택적 재전송 기능을 사용할지라도 A-MPDU 내부의 MPDU의 크기가 최소 MPDU 시작 간격 크기보다 작은 MPDU의 경우에는 더미(dummy) MPDU인 구분자(delimiter)의 추가로 인한 재전송 오버헤드 때문에 처리율의 저하현상이 발생하게 된다. 따라서 상기의 문제점을 해결하기 위하여 A-MPDU 내부의 MPDU의 크기가 최소 MPDU 시작 간격 크기보다 작은 경우에 A-MPDU 내부의 MPDU가 구분자로 채워지는 것이 아니라 A-MSDU로 채워지는 2-레벨(two-level) 집적 방식이 소개되었다. 상기의 2-레벨 집적방식에서, 기존 재전송 방법은 오직 A-MPDU에 대해서만 재전송을 수행하고 있지만 본 논문에서 제안하는 재전송 방법에서는 재전송 데이터의 크기가 최소 MPDU 시작 간격 크기보다 작은 경우에 신규 MSDU들과 재전송 MSDU들을 함께 집적하여 재전송을 수행한다. 따라서 제안한 재전송 방법이 기존의 재전송 방법보다 더 좋은 처리율 성능을 가진다.

• 한국위성정보통신학회논문지
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• 제10권3호
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• pp.53-56
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• 2015

최근 스마트폰과 태블릿 PC 등의 무선 랜(WLAN: Wireless Local Area Networks)을 지원하는 디바이스가 급증하고, 이를 이용한 모바일 서비스가 기하급수적으로 빠르게 보급되었다. 이런 상황에 따라 무선 랜은 더 빠른 속도의 데이터 전송에 대하여 요구하였고, 이를 만족하기 위하여 IEEE 802.11n의 표준이 확정되었다. 특히, IEEE 802.11n의 표준에서 A-MPDU(Aggregation MAC Protocol Data Unit)이라는 핵심적인 기술을 발표하였다. 이는 데이터를 전송할 때 발생하는 오버헤드를 감소하여 전송속도 향상에 도움을 주었다. 본 논문에서는 이 A-MPDU 전송하는 데이터 중 TCP 트래픽을 전송할 때 발생하는 문제점에 대하여 논하고, 해결 방안도 제시한다. A-MPDU 방식으로 TCP 데이터를 전송할 때, 특정 MPDU 데이터가 전송이 실패하는 경우 TCP Duplicate ACK을 발생하여 불필요한 TCP 재전송이 발생하게 된다. 이에 TCP가 갖고 있는 TCP cumulative ACK을 이용하여 불필요하게 발생하는 TCP duplicate ACK 생성을 막고 전송효율을 높이는 방안을 해결책으로 제시한다. 이 해결 방안은 여러 개의 TCP ACK을 집적하여 보내는 대신 시퀀스 번호가 가장 높은 TCP ACK을 하나만 대표하여 보내어 불필요한 오버헤드를 감소할 수 있다. 이 방식을 이용하면 기존 표준에서 제안된 방식에 비해 최대 20% 이상의 전체 처리율 향상을 볼 수 있다.

• BMB Reports
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• 제38권3호
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• pp.259-265
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• 2005

Proteins must fold into their correct three-dimensional conformation in order to attain their biological function. Conversely, protein aggregation and misfolding are primary contributors to many devastating human diseases, such as prion-mediated infections, Alzheimer's disease, type II diabetes and cystic fibrosis. While the native conformation of a polypeptide is encoded within its primary amino acid sequence and is sufficient for protein folding in vitro, the situation in vivo is more complex. Inside the cell, proteins are synthesized or folded continuously; a process that is greatly assisted by molecular chaperones. Molecular chaperones re a group of structurally diverse and mechanistically distinct proteins that either promote folding or prevent the aggregation of other proteins. With our increasing understanding of the proteome, it is becoming clear that the number of proteins that can be classified as molecular chaperones is increasing steadily. Many of these proteins have novel but essential cellular functions that differ from that of more 'conventional' chaperones, such as Hsp70 and the GroE system. This review focuses on the emerging role of molecular chaperones in protein quality control, i.e. the mechanism that rids the cell of misfolded or incompletely synthesized polypeptides that otherwise would interfere with normal cellular function.