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Efficacy and Safety of COVID-19 Vaccines in Adolescents: Systematic Review of Randomized Controlled Studies and Observational Studies

  • Soo-Han Choi;Su-Yeon Yu;Jimin Kim;Miyoung Choi;Youn Young Choi;Jae Hong Choi;Ki Wook Yun;Young June Choe
    • Pediatric Infection and Vaccine
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    • v.31 no.1
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    • pp.12-24
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    • 2024
  • The number of pediatric coronavirus disease 2019 (COVID-19) cases worldwide are increasing compared to the early phase of the pandemic, along with highly transmissible severe acute respiratory syndrome coronavirus variant and the increase in adult COVID-19 vaccination. We conducted a rapid systematic review and meta-analysis of published randomized clinical trials (RCTs) of the COVID-19 vaccines and the observational retrospective studies on adverse events after COVID-19 vaccination in adolescents. Seventeen studies were finally included in this systematic review. Meta-analysis showed that although vaccination in adolescents was significantly effective to prevent COVID-19 infection in retrospective studies (risk ratio [RR], 0.29; 95% confidence interval [CI], 0.22-0.37; I2 =100%), however the effect of preventing COVID-19 infection was lower than in RCTs (RR, 0.05; 95% CI, 0.01-0.27). In five retrospective studies, the pooled estimated proportion of participants with myocarditis and/or pericarditis was 2.33 per 100,000 of the population (95% CI, 0.97-5.61 per 100,000). Sub-group analysis with sex and vaccine doses showed that male (5.35 per 100,000) and the second dose (9.71 per 100,000) had significantly higher incidence of myocarditis and/or pericarditis than female (1.09 per 100,000) and the first dose (1.61 per 100,000), respectively. Our study showed that mRNA COVID-19 vaccines in adolescent recipients were favorable and effective against COVID-19 in RCT as well as observational studies. The safety findings of BNT162b2 vaccine in adolescents were explored and we found the difference of safety according to sex and vaccine doses. The occurrence of adverse events after mRNA COVID-19 vaccination should be monitored.

Effect of Root Zone Cooling Using the Air Duct on Temperatures and Growth of Paprika During Hot Temperature Period (공기순환 덕트를 이용한 근권부 냉방이 고온기 파프리카 재배에서 온도와 생육에 미치는 영향)

  • Choi, Ki Young;Jang, Eun Ji;Rhee, Han Cheol;Yeo, Kyung-Hwan;Choi, Eun Young;Kim, Il Seop;Lee, Yong-Beom
    • Journal of Bio-Environment Control
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    • v.24 no.3
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    • pp.243-251
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    • 2015
  • This study aimed to determine the effects of root zone cooling using air duct on air temperature distribution and root zone and leaf temperatures of sweet pepper (Capsicum annum L. 'Veyron') grown on coir substrate hydroponic system in a greenhouse. When the air duct was laid at the passage adjacent the slab, the direction of air blowing was upstream at $45^{\circ}$. The cooling temperature was set at $20^{\circ}C$ for day and $18^{\circ}C$ for night. For cooing timing treatments, the cooling air was applied at all day (All-day), only night time (5 p.m. to 1 a.m.; Night), or no cooling (Control). The air temperature inside the greenhouse at a height of 40 and 80cm above the floor, and substrate and leaf temperatures, fruit characteristics, and fruit ratio were measured. Under the All-day treatment, the air temperature was decreased about $4.4{\sim}5.1^{\circ}C$ at the height of 40cm and $2.1{\sim}3.1^{\circ}C$ at the height of 80cm. Under the Night treatment, the air temperature was decreased about $3.4{\sim}3.8^{\circ}C$ at the height of 40cm and $2.2{\sim}2.7^{\circ}C$ at the height of 80cm. The daily average temperature in the substrate was in the order of the Control ($27.7^{\circ}C$) > Night ($24.1^{\circ}C$) > All-day ($22.8^{\circ}C$) treatment. Cooling the passage with either upstream blowing at $45^{\circ}$ or horizontal blowing at $180^{\circ}$ was effective in lowering the air temperature at a height of 50cm; however, no difference at a height of 100cm. Cooling the passage with perpendicular direction at $90^{\circ}$ was effective in lowering the air temperature at the height between 100 and 200cm above the floor; however, no effect on the temperature at the height of 50cm. A greater decrease in leaf temperature was found at 7 p.m. than that at 9. a.m. under both All-day and Night treatments. Fresh weight partitioning of fruit was in the order of the All-day (48.6%) > Night (45.6%) > Control (24.4%) treatment. A higher fruit production was observed under the All-day treatment, in which the accumulated average temperature was the lowest, and it may have been led to a higher proportion of photosynthate distributed to fruit than other treatments.

Pathogenic Classification and Clinical Characteristics of Nontuberculous Mycobacterial Pulmonary Disease in a National Tuberculosis Hospital (일개 국립결핵병원에서 경험한 비결핵성 마이코박테리아 폐질환의 원인균과 임상상)

  • Choi, Sun-Pil;Lee, Bong-Keun;Min, Jin-Hong;Kim, Jin-Hee
    • Tuberculosis and Respiratory Diseases
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    • v.59 no.6
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    • pp.606-612
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    • 2005
  • Background : It has been reported that nontuberculosis mycobacterium(NTM) isolates account for approximately 10% of patients with a positive Acid-Fast Bacilli(AFB) smear. Therefore, it is necessary to consider NTM pulmonary disease when such a positive test is encountered. The aim of this study was to evaluate the etiologies and clinical characteristics of patients with NTM pulmonary disease who had been treated at a national tuberculosis hospital. Methods : The NTM isolates were recovered from the sputum or bronchial washing specimens submitted to a clinical laboratory of National Masan TB Hospital from August 2002 to July 2003. All samples were identified using a polymerase chain reaction-restriction fragment length polymorphism analysis method, which amplifies the rpoB gene. The patients were diagnosed with NTM disease according to the American Thoracic Society diagnostic criteria. Results : One hundred NTM isolates were recovered from 57 patients. Of the 100 isolates, M. avium complex(MAC) was the most common species, which was found 55%(n=55) of patients, followed by M. abscessus(n=25), and M. fortuitum( n=9). 26(45.6%) patients had NTM disease. Twenty-six (45.6%) patients had NTM disease according to The American Thoracic Society classification. The main organisms involved in NTM disease were MAC(n=19, 73.1%) and M. abscessus(n=5, 19.2%). The pathogenic potential was 67.9% in M. intracellulare and 41.7% in M. abscessus. The predictive factors related to NTM disease were a positive sputum smear (OR 6.4, p=0.02) and the isolation of either MAC or M. abscessus(OR 6.9, p=0.007). Fifteen patients(57.7%) were cured. There were no significant factors associated with the treatment success. Conclusion : There was a relatively high proportion of NTM disease in NTM isolates and the common species were MAC and M. abscessus. The predictive factors for NTM disease were a positive sputum smear and the isolation of either MAC or M. abscessus.

Study on the Anchovy Boat Seine - II - On The Hydrodynamic Resistance and Performance of Patti-net (기선권현망의 연구 II - 파치망의 유체저항과 그물꼴에 관하여 -)

  • Lee, Byoung-Gee;Su, Young-Tae;Han, Hi-Soo
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.14 no.2
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    • pp.63-68
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    • 1978
  • A boat seine has been used as a major fishing gear for catching anchovy (Engraulis japonica) in the southern coastal waters of Korea since the 1920s. Since the 1950s some improvement from the original seine has been made; powered boats equipped with net hauler has been used instead of rowing boats with hand-driven capstan, and the seining method has been changed into the trawling method. But even now, there are many problems to be solved in the view point of decreasing man power without decreasing catching efficiency. For the purpose, patti-net has been introduced from Japan and experimented on the commercial base since 1972, and it was known that the patti-net could be operated with man power as half as needed in the coventional net, but catching efficiency was not so desirable. Therefore, the study on the characteristics of it were required. The authors carried out a model experiment with a Qne-twentieth scale model net towed by a powered boat on the sea. The obtained results run as follows: 1. Hydrodynamic resistance of the model net can be explained as $R_p=69.6 V_{I.66}$ $R_h=37 v^2$ where $R_p$ and $R_b$ denote the resistance of the whole gear and the cod end in kg respectively, and v the towing speed in mlsec. 2. Performance of wing and cod end showed no deformation such as observed at the conventional net. 3. The ratio of opening at the entrance of bag net to that of cod end showed about 2: 1. Therefore, when we intend to enlarge the net to be able to operate in the deep fishing ground, the cod end should be enlarged in the same proportion and increased towing power is needed .. Then, it will be better to increase the ratio for increasing fishing efficiency without increasing towing power.

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Impact of the Silicate Polymerization on the Formation of Insoluble Aluminium Silicate (수 중 존재하는 실리케이트의 존재형태가 불용성 알루미늄실리케이트 형성에 미치는 영향)

  • Gwon, Eun-Mi;Hong, Seung-Kwan;Kim, Ji-Hyong;Jung, Wook-Jin;Yoo, Myung-Jin
    • Journal of Korean Society of Environmental Engineers
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    • v.29 no.6
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    • pp.654-661
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    • 2007
  • The goal of this research was to identify the impact of silicate polymerization on the formation of insoluble aluminiumsilicate salts which could be a cause of irreversible fouling in the membrane process by lab-scale test. For this, the amount and characteristics of precipitates that were formed in six samples with different Al and Si concentration were analyzed. And the particles was also observed by SEM-EDS(Scanning Electron Microscope - Electron Dispersion Spectrophotometer) to compare morphology and ratio of Al and Si in each precipitates. Finally the reactive and nonreactive silicate contents in the solution and precipitates were analyzed to calculate silicate form content in each fraction. The amount of precipitates was in proportion to the total concentration of both element in solution. And the amount of insoluble particle that was not dissolved in the acid solution was recorded the highest in the sample 2 of which Si concentration was lower than the saturation concentration, 50 mg/L. The content of reactive silicate in precipitates was also recorded the highest value in sample 2 of which almost silicate form was reactive. When the silicate concentration is same, that value was recorded the highest in the sample with highest Al concentration. The SEM morphology of the precipitates was similar to that of Aluminiumhydroxide and the insoluble precipitates was not dissolved in acidic solution with pH 2.7 was able to observed only in sample 2. The ratio of Al and Si in the precipitates was ranged $0.48\sim3.14$, thai of sample 2 was recorded the highest value, 3.14. It is concluded that the insoluble aluminiumsilicate could be easily formed in the solution of which silicate exist as a reactive form and coexisting Al is sufficient.

Factors Influencing the Pros and Opposite of Life-Sustaining Treatment in the Elderly: Focusing on the Values of Cohabitation with Children and the Cost of Living in Old Age (노인의 연명의료에 대한 찬반 의견에 영향을 미치는 요인: 자녀동거와 노후생활비에 대한 가치관을 중심으로)

  • Mee-Ae Lee
    • Journal of Industrial Convergence
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    • v.21 no.3
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    • pp.159-169
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    • 2023
  • This study analyzed the factors affecting the opinions of life-sustaining treatment among the elderly in Korea. The study subjects were 10,097 people who responded to the survey on the condition of the elderly (2020), and using the SPSS 25.0 program, first, the demographic characteristics of the research subjects were identified through descriptive statistics and the average and normality of major variables were identified. Second, the chi-square was analyzed by conducting a cross-analysis of opinions on life-sustaining treatment according to the characteristics of the elderly. Third, a correlation analysis was performed to analyze the correlation between major variables. Fourth, the relative influence on the life-sustaining treatment of the elderly was identified through multiple regression analysis. The main research findings are as follows. First, 8,565 (84.8%) of the elderly were opposed to medical treatment (life-sustaining treatment) to save them even if they were unconscious or difficult to live. Second, as a result of cross-analysis on life-sustaining treatment for the elderly, the 𝑥2 values of education level, health status, living together with children, and cost of living in old age were found to be significant. Third, the educational level of the elderly, living together with children, and the cost of living in old age were found to have statistically significant negative effects on life-sustaining treatment. Such research results indicate that the elderly with a high level of education oppose life-sustaining treatment compared to those with a low level of education. In addition, in the case of the elderly with traditional values who responded that one of their children should live with the elderly (parents), the ratio of people in favor of life-sustaining treatment was high, and in the case of the elderly with modern values who responded that they did not have to live together, the ratio of opposition to life-sustaining treatment was high. appeared to be high. In addition, in the case of the elderly with traditional values who responded that the burden of living expenses in old age should be shared between the state and society and their children, the proportion in favor of life-sustaining treatment was high. This high figure expressed the desire for well-dying. Based on these research results, the value system was re-examined as a factor influencing the elderly's opinion on life-sustaining treatment, and basic data for welfare policies for the elderly were provided.

Effects of Mustard Seeds and Powder on In vitro Ruminal Fermentation Characteristics and Methane Production (겨자종자와 겨자분의 첨가가 반추위 발효성상과 메탄생성에 미치는 영향)

  • Lee, Kang Yeon;Kim, Kyoung Hoon;Baek, Youl Chang;Ok, Ji Un;Seol, Yong Joo;Han, Ki Jun;Park, Keun Kyu;Ryu, Ho Tae;Lee, Sang Suk;Jeon, Che Ok;Oh, Young Kyoon
    • Journal of Animal Science and Technology
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    • v.55 no.1
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    • pp.25-32
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    • 2013
  • The purpose of this study was to investigate the effects of mustard, which contains allyl isothiocyanate, on ruminal fermentation and methane emission in vitro. To this end, diluted ruminal fluid(30ml) was incubated anaerobically at $39^{\circ}C$ or 6, 12, and 24 h with or without seeds or powdered mustard. Either mustard seed or powdered mustard was weighed and serially (0, 3.33, 5.00, 6.67, and 8.33 g/L) mixed with ruminal fluid. Ammonia-N was increased (P < 0.05) by mustard treatment in a dose dependent manner. Regardless of concentration or form, mustard increased (P < 0.05) total VFA content but decreased (P < 0.01) pH compared to control group. Molar proportion of acetate (A) was decreased (P < 0.05) whereas propionate (P) was increased (P < 0.05) by mustard treatment, thereby A:P ratio was decreased (P < 0.05) compared to control group. Total gas production was increased (P < 0.01) in a linear manner by mustard treatment compared to control group. There was no effect of mustard powder, except 8.33 g/L level at 6 h, on methane emission. However, at 24 h, methane emission was reduced (P < 0.05) by 4.77% and 11.54% with 6.67 g/L and 8.33 g/L of mustard seeds supplementation, respectively. Altogether, these results suggest that mustard seeds containing allyl isothiocyanate may reduce methane production without disturbing ruminal fermentation.

Inheritance Study of Male Sterile Transformants Containing Pollen-specific Promoter and Diphtheria Toxin A Gene (수술특이프로모터와 디프테리아 독성 유전자에 의한 웅성불임 형질전환체의 후대 유전분석)

  • Park, Young-Doo;Kim, Hyun-Uk;Park, Beom-Seok;Jin, Yong-Moon
    • Horticultural Science & Technology
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    • v.18 no.3
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    • pp.342-347
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    • 2000
  • The objectives of this study were to investigate the genetic and phenotypic features of male sterile transformants by pollen-specific expression of diphtheria toxin gene and to find out inheritance patterns of transgene to the next generation. When backcrossed (BC) progenies were tested for expression of kanamycin resistance ($Km^R$), 9 lines out of 13 lines, except 4 lines ($BC_{1}5-13,\;BC_{1}5-23,\;BC_{1}5-28,\;BC_{1}5-32$), showed the ratio of $Km^R$ to kanamycin sensitive ($Km^S$), from 1:30 to all $Km^S$. As a result, they were much lower than Mendelian segregation of a dominant gene. To determine whether male sterility is a heritable and stable trait, 5 male sterile plants ($BC_{1}5-13,\;BC_{1}5-14,\;BC_{1}5-23,\;BC_{1}5-32,\;BC_{1}5-33$ lines) which had different transgene copy numbers were backcrossed as female parents with pollens from wild type. To confirm the existence of the DTx-A gene in the genome of the progenies, PCR was conducted using specific primers of the DTx-A coding region. A PCR band of 428 bp was obtained from each generation, which is the predicted size of the DTx-A gene fragment. Trangenes were inherited to the next $BC_4T_0$ progenies and showed male sterility, however, based on the copy numbers of DTx-A gene male sterile plants did not show predicted ratio. When male sterile plants were backcrossed with fertile plants, fruit capsule sizes and seed settings were relatively reduced from those of selfing wild type plants. The fruit sizes and seed settings were reduced in proportion to the increase in the copy number of DTx-A gene.

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Anaerobic Co-Digestion Characteristics of Food Waste Leachate and Sewage Sludge (BMP test를 통한 음폐수와 하수슬러지의 병합소화 특성 평가)

  • Lee, Suyoung;Yoon, Young-Sam;Kang, Jun-Gu;Kim, Ki-Heon;Shin, Sun Kyoung
    • Journal of the Korea Organic Resources Recycling Association
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    • v.24 no.1
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    • pp.21-29
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    • 2016
  • We mix food waste leachate and sewage sludge by the proportion of 1:9, 3:7 and 5:5. It turns out that they produced 233, 298 and 344 $CH_4{\cdot}mL/g{\cdot}VS$ of methane gas. The result suggests that as the mixing rate of food waste leachate rises, the methane gas productions increases as well. And more methane gas is made when co-digesting sewage sludge and food waste leachate based on the mixing ratio, rather than digesting only sewage sludge alone. Modified Gompertz and Exponential Model describe the BMP test results that show how methane gas are produced from organic waste. According to the test, higher the mixing rate of food waste leachate is, higher the methane gas productions is. The mixing ratio of food waste leachate that produces the largest volume of methane gas is 3:7. Modified Gompertz model and Exponential model describe the test results very well. The correlation values($R^2$) that show how the results of model prediction and experiment are close is 0.92 to 0.98.

The Influence of organic Matter on Soil Aggregation in Forest Soils (삼림토양내(森林土壤內)의 유기물함량(有機物含量)이 토양입단화(土壤粒團化)에 미치는 영향(影響))

  • Park, Gwan Soo;Lee, Soo Wook
    • Journal of Korean Society of Forest Science
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    • v.79 no.4
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    • pp.367-375
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    • 1990
  • In order to determine the effects of bedrock, organic matter, calcium and iron oxide on the soil aggregation, this research has performed with soils from bedrock regions of Limestone, Granite and Granite gneiss. This research was also to estimate how organic matter, calcium and iron oxide influence on soil aggregation under different forest conditions in various bedrock regions. And it also had a purpose to rate physical factors relevant to soil aggregation, their characteristics and aggregate diameter which closely relates to stabilities in the process of soil erosion. The following conclusions have been drawn in response to the overall research objectives. The rates of the soil aggregation on different bedrock regions were 21% in Limestone bedrock, 19.8% in Granite bedrock and 9.9% in Granite gneiss bedrock. A main factor in soil aggregation was the orgainc matter content in soils and the rate of soil aggregation increased in the constant proportion with the organic matter content. The relation could be formulated into Y=4.31X-4.37(Y : aggregation ratio X : organic matter content). The soil aggregation ratio under the deciduous forests eras higher than that under the coniferous forests. It was considered that this resulted from differences in organic matter content. Soil aggregates with larger diameter than 0.5mm were found more in Limestone bedrock than other smaller size soil aggregates of 0.25mm diameter were more distributed in Granite gneiss bedrock. Granite bedrock region had normal distribution in soil aggregate sizes with the highest frequency of 0.5mm diameter. Calcium and iron oxides had only partial influences on the soil aggregation in some specific conditions. But in Limestone bedrock region calcium influenced on the soil aggregation with the organic matter content.

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