• 대한불안의학회지
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• 제10권2호
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• pp.128-136
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• 2014

Objective : This study aimed to examine impact of anxiety and demographic factors on relationship between severity of depressive symptom and quality of life and disability. Methods : One hundred ninety five patients who met DSM-IV-TR criteria for depressive disorder were enrolled. It includes "Hamilton Rating Scale for Depression (HRSD)", "State-Trait Anxiety Inventory-State (STAI-S)", "General Health Questionnaire/Quality of Life-12 (GHQ/QL-12)", and "Sheehan Disability Scale (SDS)". Correlation analysis was used to see the correlations of each variable. Hierarchical regression analysis was used to see mediating effect of anxiety in the relationship. Sobel test was used to verify mediating effect. Multiple regression analysis was used to see moderating effect of demographic factors in the relationship. Results : There was partial mediating effect of anxiety on the relationship between severity of depressive symptoms and decreased quality of life (z=-11.68, p<.001)/increased disability (z=10.42, p<.001). Only religion was found to be moderating effect on the relationship between depressive symptoms and decreased quality of life. Conclusion : Rapid relief of anxiety along with depressive symptom had important implications for the treatment of patients with depression.

• 자동차안전학회지
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• 제8권4호
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• pp.12-17
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• 2016

NHTSA (National Highway Traffic Safety Administration) has offered consumers the vehicle safety information on their car since 1978. NHTSA believes that they contribute auto makers to develop safer vehicle for customers, which will result in even lower numbers of deaths and injuries resulting from motor vehicle crashes. NHTSA has been studied why people are still dying in frontal test despite of the use of many restraints system and they understand that current test does not reflect real world crash data such as oblique and corner impact test. As a result, NHTSA announced that a new test method will be introduced to use of enhanced biofidelic dummy and new crash avoidance technology evaluation from 2019. New and refined injury criteria will be applied to Head / Neck / Chest / Lower Leg. BrIC(Brain Injury Criterion)value in NHTSA test results using THOR dummy from 2014 to 2015 was average 0.91 and 1.24 in driver and passenger dummies. IIHS 64kph SOF test is the most likely to new frontal oblique test in an aspect of offset impact which is being studied by NHTSA. In this paper, we focused on head injury, especially brain injury - BrIC and conducted IIHS 64kph SOF (Small Offset Front) test with Hybrid III dummy to evaluate the injury for BrIC. Based on the test results, these data can be predicted BrIC level and US NCAP rating with current vehicle.

• 생물정신의학
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• 제18권4호
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• pp.210-216
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• 2011

Subsyndromal depression (SSD) is found to be more prevalent than major depressive disorder (MDD) and minor depressive disorder (MnDD). SSD is also associated with adverse clinical outcomes, increased risk of suicide, increased social dysfunction and disability, increased risk for future mood disorders, and increased uses of medical and mental health services. DSM-IV diagnostic criteria are not suitable for capturing SSD. Although there is no agreement on gold standard to define SSD so far, three definitions of SSD are available. First, SSD is defined as having two or more current depressive symptoms without core depressive symptoms (depressive mood or loss of interest) and with time threshold (most of the day and nearly every day over at least two weeks). Second, SSD is defined as having two or more current depressive symptoms with core depressive symptoms and without time threshold. Third, SSD is defined by using cutoff points of depression rating scales. SSD may represent a prodromal, residual, or interepisode symptomatic state in the course of MDD and MnDD. More than a half of SSD patients became any type of depressive disorders (SSD, MnDD and MDD) at 1 year. SSD may represent a discrete category of its own, without prior or consequent episodes of MDD. Considering clinical significance of SSD such as its high prevalence, significant psychosocial impairment and chronicity and serious outcomes, researchers and clinicians should be more vigilant in capturing and caring for patients with SSD.

• 대한암한의학회지
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• 제21권2호
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• pp.63-74
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• 2016

Objective : The purpose of this study is to report the effects of radio-frequency hyperthermia cancer treatment in conjunction with Sorafenib on hepatocellular carcinoma patient. Method : The patient was diagnosed with hepatocellular carcinoma at S6/7 and treated with right posterior sectionectomy. After 4 months, tumor recurrence was found at S4, 5 and 8. After transarterial chemoembolization, the patient was prescribed Sorafenib (proprietary name $Nexavar^{(R)}$ ) as well as proceeding with radio-frequency hyperthermia. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (AFP, PIVKA-II), natural killer (NK) cell activity, and numeric rating scales (NRS). Results : After the treatment, tumor size was decreased accompanying by reducing the level of tumor markers (AFP, PIVKA-II). Major clinical symptoms were improved with increasing NK cell activity. There were no adverse events based on National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. Conclusion : This case suggests that radio-frequency hyperthermia has synergistic effect for the treatment of hepatocellular carcinoma patient in conjunction with Sorafenib.

• Clinical and Experimental Pediatrics
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• 제60권6호
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• pp.189-195
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• 2017

Purpose: The purpose of this study was to investigate the effects of lamotrigine for the treatment of attention-deficit hyperactivity disorder (ADHD) symptoms in children with epilepsy. Methods: Pediatric patients newly diagnosed with epilepsy (n=90 [61 boys and 29 girls]; mean age, $9.1{\pm}3.4years$) were enrolled. All patients were evaluated with the Korean ADHD rating scale (K-ARS)-IV before treatment with lamotrigine and after doses had been administered. The mean interval of ADHD testing was approximately 12.3 months. The initial dosage of lamotrigine was 1 mg/kg/day (maximum 25 mg/day for the first 2 weeks), and increased by 1 mg/kg every 2 weeks until titrated up to 7 mg/kg/day (or maximum 200 mg/day). Results: The mean ADHD test score of the 90 subjects was $17.0{\pm}1.8$ at baseline. It was slightly reduced to $15.6{\pm}1.7$ after lamotrigine monotherapy (P>0.01). Prior to treatment, a total of 31 patients (34.4%) met the diagnostic criteria for ADHD according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision, Of these 31 patients, 27 (87.1%) had significantly improved ADHD scores with lamotrigine monotherapy ($28.0{\pm}1.6$ reduced to $18.1{\pm}2.6$, P<0.001). Among these 27 patients, 25 (92.6%) showed normalized electroencephalogram (EEG) and 26 (96.3%) achieved total freedom from seizures within 12 months of the initiation of lamotrigine monotherapy. Conclusion: The results from our study show that lamotrigine had a positive effect in pediatric epilepsy patients by reducing ADHD symptoms, preventing seizures, and normalizing EEG. However, further research is required to determine whether lamotrigine is efficacious against ADHD symptoms independent of its effects on epileptic seizures.

• 동의생리병리학회지
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• 제30권5호
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• pp.327-337
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• 2016

The objective of this study was to review the current clinical studies about the effect of herbal medicine for Parkinson's disease in China over the last 5 years and then to suggest the foundation for treatment and further studies. We had searched for studies in China National Knowledge Infrastructure(CNKI, http://www.cnki.net) and PubMed from January 2010 to December 2014. Key words were the various combinations of '帕金森', '湯', '丸', '散', '中醫藥', 'Parkinson's disease', and 'herbal medicine'. Total 53 clinical studies were selected and analyzed. The most frequently used diagnostic criteria of Parkinson's disease was the Unified Parkinson's Disease Rating Scale(UPDRS). The most frequently used medical herb was Paeoniae Radix alba(白芍藥) more 30 times and the highest amount was Astragali radix(黃芪) 100g per day. The most frequent syndrome differentiation was liver kidney yin deficiency(肝腎陰 虛). We found out there are many clinical studies of herbal medicine for Parkinson's disease in China. These studies would be able to provide the basis of clinical research on Parkinson's disease, and also applied to the treatment of Parkinson's disease in Korea.

• 영재교육연구
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• 제20권1호
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• pp.257-287
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• 2010

본 연구는 교육청 산하 영재학급의 영재선발에 적용되는 관찰과 추천에 의한 영재판별모형의 개발을 목적으로 한다. 이를 위해서 영재 판별의 정의와 가능성, 현재의 영재선발, 영재판별의 방법에 대해 조사하였다. 관찰 추천 영재판별모형은 모두 4단계로 구성되었다. 1단계는 다양한 정보들의 수집이고, 2단계는 포트폴리오 구성과 그 내용을 루브릭으로 평정하는 것이고, 3단계는 2단계에서 선발된 학생들을 대상으로 수업과 면접을 실시하여 학생들의 문제해결능력과 정의적 특성을 알아본 다음, 4단계인 영재선정심사위원회에서 최종적으로 영재선발을 결정한다. 본 영재판별모형은 영재프로그램에 배치되고 나서도 영재에 대한 지속적인 관찰을 통하여 영재의 재배치나 상위 영재기관에의 추천 근거자료로 사용하도록 되어 있다. 본 모형은 현재 영재성을 발휘하거나 앞으로 발휘할 가능성이 높은 잠재적인 영재의 선발에 도움을 주며, 특히 소외계층의 영재선발에 일익을 담당할 것으로 보인다.

• 척추신경추나의학회지
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• 제5권1호
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• pp.111-124
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• 2010

Objectives: The purpose of this study is to report clinical effects of oriental medicine w~h conservative treatments including acupuncture, Chuna treatment and herbal medicine on a patient with low back pain and lower limb numbness caused by HIVD and schwannoma. Methods: The patient was diagnosed with HIVD and schwannoma through the MRI scan. This case was treated with acupuncture, Chuna treatment and herbal medicine during the whole admission period. We evaluated the progress of the symptoms with objective criteria such as NRS(Numerical Rating Scale), SLRT(Straight Leg Raising Test), ODI(Oswestry Disability Index) score and MMT(Manual Muscle Testing). Results and Conclusions: After weeks of conducting conservative treatment on patient with low back pain and lower limb numbness caused by HIVD and schwannoma occurred at the lumbar spine, significant improvements of the symptoms were seen. These results suggest that in the case of low back pain and lower limb numbness caused by HIVD and schwannoma, conservative treatments can be considered as one of the options of treating the symptoms beside surgical way.

• 한국컴퓨터정보학회논문지
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• 제15권12호
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• pp.227-235
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• 2010

이 논문은 RFM 기법과 연관성 분석을 이용한 개인화된 전자상거래 추천 시스템을 제안한다. 제안된 전자상거래 추천시스템은 사용자의 평가 자료에 의존하지 않고 묵시적인(Implicity)방법을 이용하여 고객정보와 구매이력 정보를 기반으로 RFM(Recency, Frequency, Monetary) 기법을 이용한 고객 세분화와 교차판매(cross-sell)관계를 찾는 연관성 분석을 이용한 개선된 시스템이다. 또한 고객군별 구매특성 분석을 통하여 효율적인 마케팅 전략과 고객관계관리(CRM: Customer Relationship Management)방법을 제시한다. 현업에서 사용하는 데이터 셋을 구성하여 실험 및 평가를 통해서 효용성을 입증 및 평가하여 일대일 웹 마케팅을 실현하였다.

• 한국전자통신학회논문지
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• 제8권11호
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• pp.1733-1740
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• 2013

교육에서 중요한 요소는 신뢰성 있는 교육의 질을 확보하는 문제이다. 교육의 질을 확보하는 기준에는 다양한 방법들이 있다. 노동부의 계좌제교육, 보건의료종사자의 보수교육에서의 질 관리는 출석관리가 중요한 평가기준이기 때문에 신뢰성 높은 출석관리가 요구된다. 노동부에서 교육생의 출석 신뢰도를 높이기 위해서 최근에 신용카드형태의 출석체크 시스템을 도입하였다. 이에 비해 보건의료종사자의 보수교육은 형식적으로 이루어지는 출석관리로 교육의 질 문제가 제기되어왔다. 최근 개발된 USN기반의 출석관리시스템들은 효과는 있지만 적은규모의 교육이 다수의 지역에서 동시에 진행되는 경우에 관리자 측면에서는 비용적인 문제와 이동성 문제 그리고 시스템 운용의 문제 그리고 교육생의 출석관리의 신뢰도 문제가 해결해야 할 과제로 남게 되었다. 이러한 요구를 해결하기 위해서 본 연구는 바코드와 PC카메라 기반의 저비용 출석관리시스템을 설계 및 구현하였다. 개발된 시스템을 실제 보수교육현장에서 테스트를 실시한 결과 관리자 측면에서는 98%만족도를 보였고 교육생 측면에서도 95%의 만족도를 보였다.