• Biomedical Science Letters
• /
• v.25 no.4
• /
• pp.302-312
• /
• 2019

The aim of this work was to investigate the effect of black tea extract (BTE) on collagen -induced platelet aggregation. In this study, BTE (10~500 ㎍/mL) was shown to inhibit platelet aggregation via thromboxane A₂ (TXA₂) down-regulation by blocking cyclooxygenase-1 (COX-1) activity. Also, BTE decreased intracellular Ca²⁺ mobilization ([Ca²⁺]_i). Additionally, BTE enhanced the levels of both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which are aggregation-inhibiting molecules. BTE inhibited the phosphorylation of phospholipase C (PLC) γ2 and syk activated by collagen. BTE regulated platelet aggregation via cAMP-dependent phosphorylation of vasodilator-stimulated phosphoprotein (VASP) Ser¹⁵⁷. The anti-platelet effects of BTE in high fat diet (HFD)-induced obese rats were evaluated. After eight weeks of BTE treatment (300 and 600 mg/kg), the platelet aggregation rate in the treated groups was significantly less than that in the HFD-fed control group. Also, BTE exhibited a hepatoprotective effect and did not exert hepatotoxicity. Therefore, these data suggest that BTE has anti-platelet effects on collagen-stimulated platelet aggregation and may have therapeutic potential for the prevention of platelet-mediated thrombotic diseases.

• Computers and Concrete
• /
• v.2 no.6
• /
• pp.499-516
• /
• 2005

A composite model is used to represent the heterogeneity of plain concrete consisting of coarse aggregates, mortar matrix and the mortar-aggregate interface. The composite elements of plain concrete are modeled using triangular finite element units which have six interface nodes along the sides. Fracture is captured through a constitutive single branch softening-fracture law at the interface nodes, which bounds the elastic domain inside each triangular unit. The inelastic displacement at an interface node represents the crack opening or sliding displacement and is conjugate to the internodal force. The path-dependent softening behaviour is developed within a quasi-prescribed displacement control formulation. The crack profile is restricted to the interface boundaries of the defined mesh. No re-meshing is carried out. Solutions to the rate formulation are obtained using a mathematical programming procedure in the form of a linear complementary problem. An event by event solution strategy is adopted to eliminate solutions with simultaneous formation of softening zones in symmetric problems. The composite plain concrete model is compared to experimental results for the tensile crack growth in a Brazilian test and three-point bending tests on different sized specimens. The model is also used to simulate wedge-type shear-compression failure directly under the loading platen of a Brazilian test.

• Advances in environmental research
• /
• v.2 no.4
• /
• pp.261-277
• /
• 2013

The degradation of alachlor has been investigated using sonolysis (US), photocatalysis (UV) and sonophotocatalysis (US/UV) using three photocatalyst viz. $TiO_2$ (mixture of anatase and rutile), $TiO_2$ (anatase) and ZnO. The effect of photocatalyst loading on the extent of degradation of alachlor has been investigated by varying $TiO_2$ (both types) loading over the range of 0.01 g/L to 0.1 g/L and ZnO loading over the range of 0.05 g/L to 0.3 g/L. The optimum loading of the catalyst was found to be dependent on the type of operation i.e., photocatalysis alone or the combined operation of sonolysis and photocatalysis. All the combined processes gave complete degradation of alachlor with maximum rate of degradation being obtained in the case of sonophotocatalytic process also showing synergistic effect at optimized loading of photocatalyst. About 50% to 60% reduction in TOC has been obtained using the combined process of sonophotocatalysis depending on the operating conditions. The alachlor degradation fitted first order kinetics for all the processes under investigation. It has been observed that the $TiO_2$ (mixtrure of anatase and rutile) is the most active photocatalyst among the three photocatalysts studied in the current work. The effect of addition of radical enhancers and scavengers on sonophotocatalytic degradation of alachlor has been investigated in order to decipher the controlling mechanism. The alachlor degradation products have been identified using LC-MS method.

• Proceedings of the KSME Conference
• /
• 2004.04a
• /
• pp.348-352
• /
• 2004

Recently the steel parts used for automiles and trains are required to be used under higher stress than ever before in need of the weight down. However, threr are a lot of problems with developing such of fatigue strength and fatigue life are mainly focused on by adopting residual stress. And got the following characteristics from crack growth test carried out stress ratio. Fatigue life shows more improvement in the Un-peening material. And Compressive residual stress of surface on the Shot-peening processed operate resistance force of fatigue. So we cam obtain fallowings. (1) The fatigue crack growth rate on stage II is conspicuous with the size of compressive residual stress and is dependent of Paris equation. (2) Although the maximum compressive residual stress is deeply and widely formed from surface, fatigue life does not improve than when maximum compressive residual stress is formed in surface. (3) The threshold stress intensity factor range is increased with increasing compressive residual stress.

• Journal of Magnetics
• /
• v.8 no.3
• /
• pp.108-112
• /
• 2003

We report the experimental finding that there exists a transition of magnetization reversal process with varying the applied field in Co/Pd multilayer. We have measured the wall-motion speed V and the nucleation rate R during magnetization reversal via time-resolved direct domain observation, where the magnetization reversal process of Co/Pd multilayer is found to take a transition from thermal activation process to viscous process at the critical field of about 1.87 H$\_$C/ (coercivity). In the thermal activation regime, we find that the field dependences of two activation volumes for the wall-motion process and the nucleation process are different with each other, which reveals that the wall-motion and nucleation experience completely different interactions. In the viscous regime, we find that the wall-mobility is much smaller than a typical value for the sandwiched Co films, which implies that the Co/Pd interfaces in multilayer substantially contribute to the dynamic dissipation.

• Journal of Plant Biology
• /
• v.30 no.4
• /
• pp.299-309
• /
• 1987

The seasonal pattern and the annual magnitude of the internal (or biochemical) and plant-soil cycles of phophorus in adjacent three different herb plant populations-Helianthus tuberosus L., Artemisia princeps Pampan and Phalaris anundinacea L.-in an old field of the basin in the Mt. Geumoh were investigated. A lot of the phosphorus demand for the three populations was supplied by the withdrawal from below-ground organ in early growing period, by the absorption from soil in mid-growing period and by the withdrawal from stem in later growing period. But in the A. princeps and P. arundianacea populations, a great deal of phosphorus seemed to be absorbed prior to the first withdrawal. The annual amount of the phosphorus flowing throughthe internal cycle was about 59% of the total hosphorus flow on theorgan level in the H. tuberosus population, 41% in the A. princeps population and 32% in the P. arundinacea population, indicating that the tuber plant had the most developed internal cycle system. The annual amount of phosphorus which took part in the plant-soil cycle in the stand of the three populations was in the range of 4.49-5.65 gPm-2, corresponding to only 3-8% of the extractable phosphorus contained in the soil of 0-20 cm depth. The fact that the H. tuberosus population is higher in the extent fo internal cycle but smaller in the magnitude of plant-soil cycle and lower in the turnover rate of phsophorus than the other two populations suggests that the growth of H. tuberosus population may be less dependent on soil phosphorus availability than those of the other two populations.

• Korean Journal of Plant Resources
• /
• v.27 no.6
• /
• pp.601-609
• /
• 2014

In this study, the effect of plant extract on the senescence action and cell survival rate in two types of cells, in which aging was derived by adriamycin, was analyzed to find the materials for suppressing cell senescence from natural resources. The results are as follows. For human umbilical vein endothelial cells (HUVECs), the fruit of Physalis angulata L. and the aerial part of Synurus deltoides (Aiton) Nakai showed excellent cell-senescence inhibition activities in a treatment concentration-dependent manner, demonstrating the high possibility for utilization as a material for prevention and treatment for vascular diseases. The water extract from the root of Polygonatum odoratum var. pluriflorum for variegatum Y. N. Lee showed potent cell-senescence inhibitory effect for human dermal fibroblasts (HDFs). Thus it is considered that the additional study on the plant needs for elucidating the possible utilization as material for skin health improvement.

• Archives of Pharmacal Research
• /
• v.20 no.3
• /
• pp.239-246
• /
• 1997

In the present study, liver regeneration rate (%) was increased up to 70% 3 days after partial hepatectomy (PH). Nitric oxide synthase (NOS) activity in liver tissue as well as serum nitrite/ nitrate content had no timed response, revealing no significant difference between shamoperated and partially hepatectomized rat liver. Contents of free methylarginines in liver tissue were increased biphasically in a time-dependent manner after PH. However, those in serum did not exhibit the same patterns as in liver. Taken together, the results suggest that $N^{G}$-monomethyl-L-arginine (MMA) and $ N^{G}, N^{G}$-dimethylarginine (DMA) play a role in inhibiting nitric oxide (NO) synthesis in regenerating rat liver because the increase of their contents was synchronized with NOS expression.

• Journal of the Society of Naval Architects of Korea
• /
• v.35 no.4
• /
• pp.46-54
• /
• 1998

In this paper, the erect of notch geometries on dynamic stress concentration was investigated by using the dynamic photoelasticity and the drop weight loading system Dynamic stress fields arisen by elastic wave through the loading system around various types of notch geometries were captured by using $10^6/sec$ frame rate Cranz-Shardin camera system with 12 photographic frames. We found that dynamic stress concentrations around the notch tip and comer were highly dependent on the change in notch geometries. The elders of dynamic stress singularity ware determined with respect to varying geometries of notches and we explained dynamic stress concentration in terms of the orders of dynamic stress singularity.

• Journal of the Korean Chemical Society
• /
• v.14 no.4
• /
• pp.287-296
• /
• 1970

The varation of potential and completeness of reaction in an oxidation-reduction titration of Red$_1$ ($a\;Ox_1+N_1e{\leftrightarrow}b\;Red_1)\;by\;Ox_2\;(C\;Ox_2+n_2e{\leftrightarrow}d\;Red_2)$ is analyzed on the basis of general expressions. It is shown that the reaction deficiency as well as the rate of variation of the potential with titration fraction change in proportion to the $[n_2(a-b)-n_1(c-d)]$ th power of the concentration of the reagents. In particular, at the equivalence point, the expression of the potential contains a concentration dependent term that is proportional to ac-bd. Thus, the equivalence-point potential varies with the concentration of the reagents unless ac=bd is satisfied. It is also shown that the sharpness of the potentiometric titration curve is shown to occur either prior to or after the equivalence point depending upon whether $n_1cn_2b$, the deviation being the same order of magnitude as the relative deficiency at the equivalence point.