Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Changes of Nitric Oxide Synthase Activity and Free Methylarginines Contents in Regenerating Rat Liver after Partial Hepatectomy

  • Lee, Young-Jin (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
  • Nam, Suk-Woo (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
  • Seo, Dong-Wan (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
  • Ahn, Seong-Hoon (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
  • Ko, Young-Kwon (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
  • Sung, Dae-Suk (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
  • Han, Jeung-Whan (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
  • Hong, Sung-Youl (Department of Genetic Engineering, College of Life Science and Natural Resources, Sungkyunkwan University) ;
  • Lee, Hyang-Woo (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University)
  • Published : 1997.06.01
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Abstract

In the present study, liver regeneration rate (%) was increased up to 70% 3 days after partial hepatectomy (PH). Nitric oxide synthase (NOS) activity in liver tissue as well as serum nitrite/ nitrate content had no timed response, revealing no significant difference between shamoperated and partially hepatectomized rat liver. Contents of free methylarginines in liver tissue were increased biphasically in a time-dependent manner after PH. However, those in serum did not exhibit the same patterns as in liver. Taken together, the results suggest that $N^{G}$-monomethyl-L-arginine (MMA) and $ N^{G}, N^{G}$-dimethylarginine (DMA) play a role in inhibiting nitric oxide (NO) synthesis in regenerating rat liver because the increase of their contents was synchronized with NOS expression.

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