• 대한한의학회지
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• 제31권5호
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• pp.12-32
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• 2010

Objective: This study aimed to review herbal remedy-based RCTs on cancer patients in order to produce helpful information for clinical study of herbal medicine in the future. Methods: We collected all RCTs using herbal remedies on cancer patients from Pubmed and Cochrane databases until November 1st, 2009. Elementary information such as nation where performed, clinical question, design, randomization, double-blinding and allocation concealment were analyzed. Results: 153 RCTs were finally selected. 119 RCTs were conduced in China while only 2 were done in Korea. The most frequent targeted cancer was lung cancer as 29 RCTs. The main clinical questions included improvement of quality of life, elongation of survival rate and regression of tumor being 83, 62 and 55 respectively. 112 RCTs used herbal remedies with western therapy. Adequate methods for randomization and allocation concealment were found in 37% and 10% of trials respectively. Conclusions: We found that herbal remedies are used on cancer patients in aspects of both caring for the human body and tumor treatment itself. The study might provide us useful data for cancer-related clinical study using herbal remedies in the future.

• Communications for Statistical Applications and Methods
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• 제28권5호
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• pp.411-424
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• 2021

Inference following two-stage adaptive designs (also known as two-stage randomization designs) with survival endpoints usually focuses on estimating and comparing survival distributions for the different treatment strategies. The aim is to identify the treatment strategy(ies) that leads to better survival of the patients. The objectives of this study were to assess the performance three commonly cited methods for estimating survival distributions in two-stage randomization designs. We review three non-parametric methods for estimating survival distributions in two-stage adaptive designs and compare their performance using simulation studies. The simulation studies show that the method based on the marginal mean model is badly affected by high censoring rates and response rate. The other two methods which are natural extensions of the Nelson-Aalen estimator and the Kaplan-Meier estimator have similar performance. These two methods yield survival estimates which have less bias and more precise than the marginal mean model even in cases of small sample sizes. The weighted versions of the Nelson-Aalen and the Kaplan-Meier estimators are less affected by high censoring rates and low response rates. The bias of the method based on the marginal mean model increases rapidly with increase in censoring rate compared to the other two methods. We apply the three methods to a leukemia clinical trial dataset and also compare the results.

• Journal of Acupuncture Research
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• 제29권5호
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• pp.109-118
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• 2012

Objectives : The aim of this study was to evaluate the effectiveness and safety of acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue. Methods : A randomized, controlled pilot trial was conducted. Twenty-four participants were randomized into one of the two groups: an acupuncture group(n=12) and wait-list group(n=12). The treatment group received 12 sessions of acupuncture over 4 weeks. Eight points($GV_{20}$; bilateral GB20, $BL_{11}$, $BL_{13}$, $BL_{15}$, $BL_{18}$, $BL_{20}$, and $BL_{23}$) were selected for needling. The control group did not receive acupuncture treatment during study period and follow-up were done in the $5^{th}$ and $9^{th}$ weeks after randomization in both groups. The primary outcome was fatigue severity scale(FSS) and the secondary outcomes included a short form of stress response inventory(SRI-short form), beck depression inventory(BDI), and insomnia severity index(ISI). Safety was assessed at every visit. Results : There were statistically significant differences in the between group values of FSS at $5^{th}$ weeks after randomization(p=0.0002), SRI-short form, BDI, and ISI at $5^{th}$, $9^{th}$ weeks after randomization(p<0.01). There were no adverse events. Conclusions : The results suggest that acupuncture is associated with benefits on the short-term outcomes in chronic fatigue syndrome and idiopathic chronic fatigue.

• 한국수학교육학회지시리즈A:수학교육
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• 제38권2호
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• pp.165-172
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• 1999

$\sub$e/$\^$2/, that were results from those three sources of such imperfection. Especially to eliminate the differences in severity among many raters the randomization procedure of raters sample was very effective in enhancing the reliability of ratings with comparatively small groups of examinees and raters. And we also introduced the new rating methods, i.e. the 2-step diagnostic procedures to check the sizes of the reliability stability of raters and the sore adjustment method to enumerate the optimal mean values in rating the examinees.

• 한국통계학회:학술대회논문집
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• 한국통계학회 2000년도 추계학술발표회 논문집
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• pp.241-246
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• 2000

A simple random sample is taken from a population and a particular survey item is subject to nonresponse that corresponds to random subsampling of the sampled values within adjustment cells. Our object is to estimate Bayesian probability interval of the population mean.

• 한국경영과학회지
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• 제22권2호
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• pp.1-12
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• 1997

We consider an M/M/2 queue with two servers placed in series. System performance measures that we present in closed expressions are the first and the second moments for the system size, the queue walting time and the sojourn time. We also present an algorithm for computing the queue waiting time distribution function based on the randomization method. As an application, we analyze the double tollbooth system and compare its performance with the conventional single tollbooth system's.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 1997년도 춘계학술대회논문집
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• pp.233-239
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• 1997

The effect of the cross-rolling on the evolution of the deformation texture and the subsequent annealing texture was studied in 5182 aluminium alloy. The orientation density near {011}<110>. The weak ${\beta}$-fiber orientations in the deformation texture lead to the randomization of the annealing texture, whereas the strong ${\beta}$-fiber orientations lead to the strong Cube orientation in the annealing texture. The development of the strong rotated Cube orientation in the annealing texture seemed to be related with the decrease in the R-value.

• Communications for Statistical Applications and Methods
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• 제8권1호
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• pp.219-227
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• 2001

Another approach (multi-parameter measurement method) of interlaboratory studies of test methods is presented. When the unrestricted normal likelihood for the fixed latent variable model is unbounded, we propose a me쇙 of restricting the parameter space by formulating realistic alternative hypothesis under which the likelihood is bounded. A simulation study verified the claim of conservatism of level of significance based on assumptions about central chi-square distributed test statistics and on Bonferroni approximations. We showed a randomization approach that furnished empirical significance levels would be better than a Bonferroni adjustment.

• 산업기술연구
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• 제31권A호
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• pp.27-31
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• 2011

In many industrial experiments, some practical constraints often force factors in an experiment to be much harder to change than others. Such an experiment involves randomization restrictions and it can be thought of as split-plot experiment. This paper investigates the path of steepest ascent/descent within a split-plot structure. A method is proposed for calculating the coordinates along the path.

• 한국데이터정보과학회:학술대회논문집
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• 한국데이터정보과학회 2001년도 추계학술대회
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• pp.67-75
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• 2001

A completely randomized growth curve model was defined by Zerbe(1979). We propose the fully significant difference procedure for multiple comparisons of completely randomized growth curve model. The standard F test is useful tool to multiple comparisons of the completely randomized growth curve model. The proposed method is applied to experimental data.