• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6267-6271
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• 2013

Objective: To determine clinical efficacy, safety and prognostic factors of pemetrexed plus platinum as first-line treatment in patients with advanced non-small cell lung cancer (NSCLC). Materials and Methods: Clinical characteristics, short-term efficacy, survival and adverse reactions of 47 advanced non-squamous NSCLC patients who had received pemetrexed plus platinum as first-line treatment in Shanghai Pulmonary Hospital from January 2009 to June 2011 were retrospectively analyzed. The Chi-squared test was applied to statistically analyze the overall response rate (ORR), disease control rate (DCR) and toxicity reactions in both groups, while survival data wereanalyzed by Kaplan-Meier and logrank methods, and the COX proportional hazards model was adopted for a series of multi-factor analyses. Results: Only two patients were lost to follow-up. The ORR, DCR, medium progression-free survival time (PFS) and medium overall survival (OS) were 31.9%, 74.5%, 5 months and 15.2 months, while 1- and 2-year survival rates were 63.8% (30/47) and 19.2% (9/47), respectively. Single-factor analysis showed that tumor pathological patterns and efficacy were in association with medium PFS (P<0.05), whereas tumor pathological patterns, smoking history and efficacy were closely connected with medium OS (P<0.05). Multi-factor analyses demonstrated that pathological patterns and efficacy were independent factors influencing OS (P<0.05). The rate of toxicity reactions in degree III/IV was low, including hematologic toxicity marked by decline in white blood cell count and decrease in the platelet count (PLT), and non-hematologic toxicity manifested by gastrointestinal reactions, such as nausea and vomiting. Conclusions: Pemetrexed plus platinum as first-line treatment has excellent efficacy and slight adverse reactions with favorable drug-tolerance in patients with advanced non-squamous NSCLC.

• 한국항행학회논문지
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• 제24권1호
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• pp.1-8
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• 2020

본 연구에서는 항공기에 장착하여 S/C대역의 신호를 장거리 표적으로 방사하기 위한 장치를 개발하였다. 장치는 요구된 실효 등방성 복사전력을 충족시키기 위해 대역별 송신기와 광대역 안테나로 RF 인터페이스를 구성하였다. 장치의 외형은 항공기 연료탱크와 동일한 포드(pod) 형상으로 설계했고, 측정된 장치의 중량은 119.8 kg, 무게중심은 1391.35 mm 그리고 관성 모멘트는 46.07 ± 0.05(I_yy) kg·㎡과 45.36 ± 0.09(I_zz) kg·㎡로 모두 항공기 장착을 위한 요구도를 충족함을 확인하였다. 비행 안전을 확인하기 위해 전자기 간섭 시험(RE102, CE102), 환경시험(고온/저온 운용, 고도), 체계 내 전자기 적합성 시험 그리고 인체 전자기 복사 위해도 시험을 수행하였으며, 모든 항목의 시험 결과가 요구사항을 충족함을 확인하였다. 장치는 요구되는 전기적/기계적으로 요구되는 사항을 모두 충족함으로써 항공기 장착이 가능함을 확인하였다.

• Archives of Plastic Surgery
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• 제37권1호
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• pp.91-94
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• 2010

Purpose: The purpose of this study is to describe the usefulness of intraoperative mobile CT scans in the reduction of zygomatic arch fracture. Method: Two patients with zygomatic arch fractures were selected who were indications of closed reduction by Gilles' approach. After the reduction was done in the operating room with zygomatic arch elevator, intraoperative CT scan was done to check the extent of reduction. Additional reduction was performed according to the obtained images from the intraoperative mobile CT scan. Examination of the preoperative CT, intraoperative CT after the reduction, and postoperative plain X-ray films were done for documentation and analysis. Results: Reduction was carried out successfully to the patients without any complications. Both patients were satisfied with the postoperative cosmetic and functional outcome. Revisional surgery was not necessary during the 6 months follow up. Conclusion: The advantage of this method is that it is easier to obtain three dimensional relationships of the fracture site. Furthermore, the operator is less exposed to radiation hazards compared to other methods that obtain intraoperative images such as the C-arm. In conclusion, intraoperative mobile CT scan can be a useful surgical aid in the reduction of zygomatic arch fractures.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2004년도 한국우주과학회보 제13권2호
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• pp.231-234
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• 2004

Electrical grounding is defined as referencing an electrical circuit or a common reference plane for preventing shock hazards and for enhancing operability of the circuit and EMI control. In order to realize the best electrical grounding system of korean space launch vehicle, we should design the electrical grounding architecture of korean space launch vehicle of system-level at the earliest point in design procedure. To minimize the electrical grounding loop and the unnecessary electromagnetic interference or radiation among the electronic subsystems, we should establish the electrical grounding rules of the all electrical interfaces. The electrical interfaces among the electronic subsystems are generally classified into the electrical power and signal interfaces. Because of using the primary and secondary power system architecture in the korean space launch vehicle system such as the common space launch vehicle systems, we need to establish the electrical grounding rules between the primary and secondary power system. We also need to establish the electrical signal grounding interface rules among the electronic subsystems. In this paper, we will describe the grounding schemes of the common space launch vehicle system and propose a conceptual design for the electrical grounding architecture of korean space launch vehicle system.

• 한국군사과학기술학회지
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• 제22권2호
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• pp.224-232
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• 2019

This paper presents guidelines for the verification test on electromagnetic environmental effects of a commercial derivative military aircraft. To prove the safety-of-flight of a renovated aircraft and appropriate working of electronic system/device, E3 test and analysis at the system level should be performed prior to its operations on real warfare. For the aircraft modified with Falcon 2000S, we concentrate on intra-system EMC, EMRADHAZ (Electromagnetic Radiation Hazards), electrical bonding, P-Static as test and lightning as analysis from a airworthiness certification point of view based on MIL-STD-464, MIL-HDBK-516. As a result, it is verified that the modified aircraft has enough electromagnetic compatibility capabilities under EME(Electromagnetic Environment). In the process, test and analysis methods considering shielding effectiveness(SE) are applied.

• 대기
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• 제33권5호
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• pp.519-530
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• 2023

Deep convection can make adverse effects on safe and efficient aviation operations by causing various weather hazards such as convectively-induced turbulence, icing, lightning, and downburst. To prevent such damage, it is necessary to accurately predict spatiotemporal distribution of deep convective area near the airport and airspace. This study developed a new index, the Aviation Convective Index (ACI), for deep convection, using the operational global Unified Model of the Korea Meteorological Administration. The ACI was computed from combination of three different variables: 3-hour maximum of Convective Available Potential Energy, averaged Outgoing Longwave Radiation, and accumulative precipitation using the fuzzy logic algorithm. In this algorithm, the individual membership function was newly developed following the cumulative distribution function for each variable in Korean Peninsula. This index was validated and optimized by using the 1-yr period of radar mosaic data. According to the Receiver Operating Characteristics curve (AUC) and True Skill Score (TSS), the yearly optimized ACI (ACI_YrOpt) based on the optimal weighting coefficients for 1-yr period shows a better skill than the no optimized one (ACI_NoOpt) with the uniform weights. In all forecast time from 6-hour to 48-hour, the AUC and TSS value of ACI_YrOpt were higher than those of ACI_NoOpt, showing the improvement of averaged value of AUC and TSS by 1.67% and 4.20%, respectively.

• 한국식품영양과학회지
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• 제35권3호
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• pp.383-387
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• 2006

호남지역 병원 6곳의 급식시설 및 부식류 등에 대한 미생물학적 안정성이 평가되어졌다. 조사된 병원급식시설의 공중낙하균 평가에서는 식탁, 조리장 및 냉동고에서 미생물균수가 비교적 높게 측정되어 이러한 시설에 대한 미생물학적 오염에 대한 철저한 관리가 요구됨을 보여 주었다. 또한 조리기구 및 용기 표면의 미생물학적 안정성 측정에서는 도마, 칼, 식판 등의 일반세균수는 비교적 높았으나 유의적인 수준은 아니었으며 대장균군, 황색포도상구균, 대장균 등의 수준도 일반적인 미생물 오염기준 미만으로 나타나 미생물학적 안정성은 양호하였다. 하지만 이들 급식시설에서 제공되는 부식류에 대한 미생물학적 안정성 평가에서는 대체적으로 가열조리식품의 미생물학적 오염은 기준 미만으로 나타났으나 기준을 초과한 부식에 대해서는 철저한 미생물학적 안전 관리가 이루어져야 할 것으로 판단되었다.

• 비파괴검사학회지
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• 제35권4호
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• pp.239-244
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• 2015

생체 조직은 세포 배열이나 조직 형태 등 다양한 차이에 의해 각각 고유의 전기적 특성을 가지며, 생물학적 변화가 일어나면 고유의 전기적 특성이 변한다. 본 연구는 방사선 피폭에 따른 생체 조직의 전기적 특성 변화를 측정하기 위한 선행연구로 측정 과정에서 방사선 피폭 우려가 있으므로, 실험자의 방사선 장애를 방지하기 위해 LabVIEW를 이용하여 자동제어 측정 시스템을 개발한 후 생체 조직의 특성을 평가하고자 하였다. 생체 조직의 전기적 특성 측정전 후 형태학적 변화를 관찰한 결과 조직 변화는 관찰되지 않았으며, 유사한 양상이었다. Impedance/Gain-phase analyzer로 생체 조직의 임피던스를 반복 측정한 결과 변동계수가 10% 미만으로 측정값은 재현성이 있었다. 주파수 변화에 따른 생체 조직의 전기적 특성 중에서 위상차 변화는 거의 없었으며, 조직은 저항성을 나타내었고, 임피던스 크기는 주파수에 비례하여 일정하게 감소하였다. 본 연구를 통해 생체 조직의 전기적 특성 변화를 측정할 수 있는 자동제어 시스템을 개발하였으며, 생체 조직의 전기적 특성을 이해할 수 있었다.

• 한국광물학회지
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• 제23권4호
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• pp.347-356
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• 2010

알루미늄과 수산화알루미늄을 제조하는 (주)KC에서 사용하는 보오크사이트는 '자연기원방사성물질(NORM)'에, 가공 중 발생하는 폐기물 또는 부산물인 red mud는 '인위적으로 농축된 자연기원방사성물질(TENORM)'에 해당된다. 이 연구는 NORM의 대량사용시설인 (주)KC 공장 내부 및 주변 지역의 지질특성, 토양에 대한 광물학적 및 지화학적 분석을 수행하여 향후 작업장과 그 주변 지역의 방사능 피복량을 측정하고 방호하기 위한 과학적인 기초자료를 제공하고자 한다. (주)KC 공장 내부 및 인근지역 토양의 광물조성은 석영, 장석, 운모, 고령토, 깁사이트, 세피올라이트 등 모암으로부터 유래된 광물조성과 적철석, 보에마이트, 방해석 등 원광석인 보오크사이트로부터 유래된 광물조성으로 혼화되어 있다. 이 지역 토양의 평균 U 함량은 4.7 ppm, Th 함량은 23.6 ppm으로서 Th 함량이 다소 높게 나타난다. 토양의 $^{40}K$의 농도는 100~1,433 Bq/kg, $^{226}Ra$의 농도는 8.4~179 Bq/kg이고 $^{232}Th$의 농도는 13.5~300 Bq/kg으로서 높은 농도는 보이지 않으나 상대적으로 높은 $^{226}Ra$ 농도는 red mud 적재장 주변에서 확인된다. 토양시료의 외부 위해지수 범위는 0.10~1.66이며 평균 0.63으로서 전체적으로 는 위해 기준치로 제시되는 1.0 이하이지만 41개 지점 중 4개 지점이 1.0 이상을 나타난다.

• Korean Journal of Radiology
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• 제24권3호
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• pp.235-246
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• 2023

Objective: It is difficult to predict the treatment response of tissue after stereotactic radiosurgery (SRS) because radiation necrosis (RN) and tumor recurrence can coexist. Our study aimed to predict tumor recurrence, including the recurrence site, after SRS of brain metastasis by performing a longitudinal tumor habitat analysis. Materials and Methods: Two consecutive multiparametric MRI examinations were performed for 83 adults (mean age, 59.0 years; range, 27-82 years; 44 male and 39 female) with 103 SRS-treated brain metastases. Tumor habitats based on contrast-enhanced T1- and T2-weighted images (structural habitats) and those based on the apparent diffusion coefficient (ADC) and cerebral blood volume (CBV) images (physiological habitats) were defined using k-means voxel-wise clustering. The reference standard was based on the pathology or Response Assessment in Neuro-Oncologycriteria for brain metastases (RANO-BM). The association between parameters of single-time or longitudinal tumor habitat and the time to recurrence and the site of recurrence were evaluated using the Cox proportional hazards regression analysis and Dice similarity coefficient, respectively. Results: The mean interval between the two MRI examinations was 99 days. The longitudinal analysis showed that an increase in the hypovascular cellular habitat (low ADC and low CBV) was associated with the risk of recurrence (hazard ratio [HR], 2.68; 95% confidence interval [CI], 1.46-4.91; P = 0.001). During the single-time analysis, a solid low-enhancing habitat (low T2 and low contrast-enhanced T1 signal) was associated with the risk of recurrence (HR, 1.54; 95% CI, 1.01-2.35; P = 0.045). A hypovascular cellular habitat was indicative of the future recurrence site (Dice similarity coefficient = 0.423). Conclusion: After SRS of brain metastases, an increased hypovascular cellular habitat observed using a longitudinal MRI analysis was associated with the risk of recurrence (i.e., treatment resistance) and was indicative of recurrence site. A tumor habitat analysis may help guide future treatments for patients with brain metastases.