• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.10021-10025
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• 2014

Background: The study aimed to describe the age distribution of breast cancer diagnosis among Chinese females for comparison with the United States and the European Union, and provide evidence for the screening target population in China. Materials and Methods: Median age was estimated from hospital databases from 7 tertiary hospitals in China. Population-based data in China, United States and European Union was extracted from the National Central Cancer Registry, SEER program and GLOBOCAN 2008, respectively. Age-standardized distribution of breast cancer at diagnosis in the 3 areas was estimated based on the World Standard Population 2000. Results: The median age of breast cancer at diagnosis was around 50 in China, nearly 10 years earlier than United States and European Union. The diagnosis age in China did not vary between subgroups of calendar year, region and pathological characteristics. With adjustment for population structure, median age of breast cancer at diagnosis was 50~54 in China, but 55~59 in United States and European Union. Conclusions: The median diagnosis age of female breast cancer is much earlier in China than in the United States and the European Union pointing to racial differences in genetics and lifestyle. Screening programs should start at an earlier age for Chinese women and age disparities between Chinese and Western women warrant further studies.

• 대한전자공학회논문지SP
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• 제49권4호
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• pp.10-15
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• 2012

사람 특히 얼굴 및 피부색은 칼라 영상의 화질 평가에 있어서 중요한 요소이다. 그러므로 칼라를 적용하는 장치에는 효과적으로 피부색을 보정하는 방법이 필요하다. 이전의 방법은 선호 피부색 영역의 중심 값을 기준으로 피부색을 보정하였다. 하지만 피부색에 대한 관찰자의 주관적인 평가를 통하여 선호 피부색을 조사한 결과 가장 선호하는 피부색이 선호 피부색 영역의 중심과 일치하지 않으며 또한 하나의 우세한 값을 가지지 않는다. 따라서 본 논문에서는 각 인종에 대한 다중의 선호색을 이용하여 선호 피부색으로 보정하는 방법을 제안한다. 먼저, 각 인종에 대하여 밝기에 따른 다중의 선호 피부색을 결정한다. 그 후 피부색 영역을 검출하고 각 인종의 평균 피부색과 검출된 각 피부색 영역의 평균 값의 차이를 이용하여 검출된 피부색 영역에 대한 인종을 선택한다. 다음으로 각 선택된 영역에 대하여 다중의 선호피부색 중 하나의 대응되는 선호 피부색을 결정한다. 마지막으로 입력 피부색은 부드러운 피부색 재현을 위해 선택된 선호 피부색과의 차이에 비율적으로 보정된다. 실험을 통하여 제안한 방법과 이전 방법을 비교하였고, 주관적 평가에서 제안한 방법이 우수한 성능을 나타내었다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제30권7_8호
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• pp.773-779
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• 2003

얼굴 영역의 정확한 위치를 정확히 찾는 것은 얼굴 인식을 위한 핵심적인 전처리 과정이다. 본 논문에서는 조명조건, 표정, 배경의 변화에 무관하게 얼굴의 구성요소를 검출할 수 있는 강건한 기법을 제안한다. 수평 방향의 상대적으로 어두운 화소값을 갖는 눈썹, 눈, 입 둥과 같은 독립된 얼굴 요소를 검출하기 위해 형상 분해 국부 최적 임계치 기법을 적용하며 얼굴을 구성하는 간단한 기하학적 조건을 만족하는 얼굴 요소의 그룹을 검색함으로써 순수 얼굴영역을 검출한다. AR-face 데이타베이스의 영상에 적용한 결과, 두꺼운 안경테에 의해 눈썹이 가리워진 특수한 경우를 제외한 거의 모든 영상에 대해 정확한 얼굴 영역을 검출할 수 있었고, 얼굴의 대칭성을 이용해 회전과 이동 변화를 보상할 수 있으므로 강건한 얼굴 인식의 전처리 과정으로 사용할 수 있다.

• 대한구순구개열학회지
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• 제7권1호
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• pp.17-24
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• 2004

Cleft lip and palate are most common congenital defomity to affect the orofacial region. Cleft lip and palate are caused by abnormal development of primary and secondary palate. Its causative mechanism is not completely understood, but genetic and environmental factors play important roles. Lots of epidemiologic surveys have been done extensively about incidence, racial influence, sex ratio, parent age, associated syndrome and genetic factors. These researches are useful to dissolve many problems in prevention and treatment of cleft lip and palate. We performed epidemiologic survey of cleft lip and palate who visited the department of Oral and Maxillofacial Surgery, Guro hospital of Korea University from 1995 to 2004.

• 대한의생명과학회지
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• 제27권3호
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• pp.177-181
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• 2021

Allergy is an immune response that appears in certain people, and reactions such as coughing, shortness of breath, and hives occur. The immune system plays an important role in homeostasis and host defense, and allergies cause hypersensitivity reactions when an imbalance of immunity occurs. Mutations in the TLR genes are associated with autoimmune conditions such as allergies and asthma. It has been reported that a locus in the TLR1-TLR6-TLR10 region may be associated with atopic sensitization or allergy. Therefore, the purpose of this study was to select an allergy patient group and a healthy control group to determine how the genetic mutation of TLR1 affects the onset of disease. This study was conducted in 709 patients and 5,025 control groups out of 10,956 patients with data from KARE and HEXA cohorts. As a result of logistic regression analysis of 6 SNPs selected from the TLR1 gene, only rs117033348 showed a statistically significant correlation (P = 0.002356). The influence of rs117033348 was examined using PolyPhen-2, and a significant result was shown. Therefore, it can be predicted that the G base in rs117033348 will have an influence on the human body. In addition, Geography of Genetic Variants browser was used to confirm the geographical distribution of allele frequencies for the TLR1 gene. Although it was found that there was a large racial difference in the prevalence of TLR1 SNP, it could be confirmed that the polymorphism of rs117033348 conducted in this study was only specific in East Asia when compared with each race.

• Korean Circulation Journal
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• 제53권2호
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• pp.69-91
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• 2023

Cardio-oncology is an emerging multi-disciplinary field, which aims to reduce morbidity and mortality of cancer patients by preventing and managing cancer treatment-related cardiovascular toxicities. With the exponential growth in cancer and cardiovascular diseases in Asia, there is an emerging need for cardio-oncology awareness among physicians and country-specific cardio-oncology initiatives. In this state-of-the-art review, we sought to describe the burden of cancer and cardiovascular disease in Asia, a region with rich cultural and socio-economic diversity. From describing the uniqueness and challenges (such as socio-economic disparity, ethnical and racial diversity, and limited training opportunities) in establishing cardio-oncology in Asia, and outlining ways to overcome any barriers, this article aims to help advance the field of cardio-oncology in Asia.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3129-3132
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• 2014

Aims: Genome-wide association studies (GWAS) have identified several risk variants for prostate cancer (pCa) mainly in Europeans, which need to be further verified in other racial groups. We selected six previously identified variants as candidates and to define the association with PCa in Northern Han Chinese. Methods: 749 subjects from Beijing and Tianjin in Northern China were included. Six variants (rs10505474, rs7837328, rs4242384, rs7813, rs486907 and rs1058205) were genotyped by high resolution melting (HRM) assays. The individual and cumulative contribution for of the risk of PCa and clinical covariates were analyzed. Results: Among the six candidate variants, onlyrs10505474, and rs7837328, both locating at 8q24 region, were associated with PCa in our population.rs10505474 (A) was associated with PCa ($OR_{recessive}=1.56$, p=0.006); and rs7837328 (A) was associated with PCa ($OR_{dominant}=1.38$, p=0.042/$OR_{recessive}=1.99$, p=0.003). Moreover, we observed a cumulative effects between them ($p_{trend}=2.58{\times}10^{-5}$). The joint population attributable risk showed the two variants might account for 71.85% of PCa risk. In addition, we found the homozygotes of rs10505474 (A) and rs7837328 (A) were associated with PCa clinical covariants (age at onset, tumor stage, respectively) ($p_{age}=0.046$, $P_{tumorstage}=0.048$). Conclusion: rs10505474 (A) and rs7387328 (A) at 8q24 are associated with PCa and cumulatively confer risk, suggesting the two variations could determine susceptibility to PCa in the Northern Chinese Han population.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6357-6362
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• 2014

Background: Globally, the overall incidence of cancer is increasing as a result of ageing populations and changing lifestyles. Cancer is one of the leading causes of death, especially in the developed nations. Cancers affecting the young population are generally considered uncommon. This study assessed the demography and trends of cancers of the young in Brunei Darussalam, a small and developing Southeast Asia nation. Materials and Methods: All patients diagnosed with cancers between 2000 and 2012 were identified from the cancer registry maintained by the State Histopathology Laboratory. Cancers of the young was defined as any cancers diagnosed under the age of 40 years. Demographic data and the type of cancers were collected and analysed using SPSS Statistics 17.0. Results: Among the 6,460 patients diagnosed with cancer over the study period, 18.7% (n=1,205) were categorized as young with an overall decline in the proportion from 26.6% in 2000 to 18.8% in 2012 (p<0.001 for trend). Among all cancers of the young, the most common systems affected were gynecological (24.1%), hematological/lymphatic (15.8%), subcutaneous/dermatological/ musculoskeletal (10.5%), breast (10.5%) and gastrointestinal (9.9%). Overall, among the different systems, neurological (54.9%) had the highest proportion of cancers of the young followed by gynecological/reproductive (30.6%), hematological/lymphatic (39.9%), endocrine (38.7%), subcutaneous/dermatological/ musculoskeletal (22.3%) and the head and neck region (20.1%). There was a female predominance (66.9%) and the incidence was significantly higher among the Malays (20.1%) and expatriates (25.1%) groups compared to the Chinese (10.7%) and indigenous (16.8%) groups (p<0.001 for trend). Conclusions: Cancers of the young (<40 years) accounted for almost a fifth of all cancers in Brunei Darussalam with certain organ systems more strongly affected. There was a female preponderance in all racial groups. Over the years, there has been a decline in the overall proportion of cancers of the young. Selective screening programs should nevertheless be considered.

• 한국의류학회지
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• 제31권11호
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• pp.1554-1564
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• 2007

In apparel industry, the production of clothing for the global market, has it#s origin in its characteristics depending on hands on working style, according to the globalization of a fashion industry. These days, however, the globalized production is unable to keep pace with the short cycle of production due to the unpredictable change of the taste or demands in the local area, as a result, the industry has come to take a focus on the production and consumption in the circumscribed region. In this stream, the northeastern area, specially, Dalian which is renowned for a center of fashion was designated as a city of this study as a representative. The cultural, racial and geographical uniqueness, asks for the analysis, based on the individual local area on the part of Korean fashion company desiring to launch into China fashion market. The purpose of this thesis is to analyse the style, color, and items of street fashion in Dalian. I would contribute to the understanding the preference of fashion in northeastern area, thereby, affording a fundamental resources for designing strategies for Korean fashion brands in China. The period of investigation is about 5 weeks from 14 May 2006 until 18 June 2006, with combined use of camcorder and digital camera. The site was Victory Shopping Plaza, in center of city, also with Mycal, Ansung, Dasang department store situated in the Economic Development area. The result of this study are as follows: 1. Preferred clothing styles are casual styles(68%) rather than formal styles(32%). In the casual styles, sports casual(36.0%), character casual(29.5%), jean casual(2.6%) were listed. All kinds of clothes are tightly fitted due to the stretched fabric and knit fabric. 2. Preferred colors are white(31.1%), red(16.6%), black(15.8%) khaki(7.8%) and blue(7.6%) for tops, and black(34.6%), blue(27.2%), white(15.4%), brown(14.6%) for bottoms. 3. Preferred clothing items are T-shirt(36.5%), jumper(33.6%), jacket(20.0%), blouse(8.7%), etc.(1.2%) for tops, pants(91.4%), skirts(8.6%) for bottoms. In the pants, cigarette pants(34.6%), bell bottom pants(21.0%), cargo pants(19.9%), straight pants(15.9%) were listed respectively. In the skirts, flare skirt(3.9%), tight skirt(2.2%), semi tight skirt(1.7%), pleats skirt(0.8%) were listed.

• 한국엔터테인먼트산업학회논문지
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• 제14권3호
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• pp.323-331
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• 2020

신한류의 장기화와 유의미한 도약을 위해서 해외에서 음악성과 대중성을 인정받은 국악퓨전밴드인 잠비나이, 씽씽 밴드, 악단광칠을 중심으로 세계화 과정에 밴드의 특징을 분석해 신한류로서의 가능성을 찾아보았다. 첫째, 같은 아시아권에서는 한국의 전통음악이 동질감으로 받아져 새로움을 부여하지 않지만 서구지역에서는 동양적인 이질감이 오히려 더 강한 경쟁력이 된 것으로 보인다. 신한류가 다양한 지역으로 확대됨에 지역 특화의 레퍼토리를 구성하여 시도해 보아야 할 것이다. 둘째, 세 밴드의 특징은 한국 전통음악의 고유성을 한 축으로 하면서 다양한 장르와 융합을 시도한 점이다. 신한류는 동아시아 스탠다드가 글로벌 스탠다드로 변환되는 과정에서 문화의 고유성을 지킴과 동시에 다양성과 차이를 수용하는 방식으로 나아가야 할 것이다. 셋째, 국악인이 주체가 되어 전통음악의 세계를 구축하고 대중화와 세계화를 가능케 하는 특징을 통해 신한류와의 융합에 타당성을 찾아보았다. 국악에 반영된 음색, 구성, 연출 기법 등의 효과나 음악적 요소에 대한 분석적인 연구를 통해 한국의 전통 문화적 가치를 부각시킬 필요성이 있다. 국악이 제공하는 고유성과 한국적 가치는, 아시아에서는 동질감으로, 유럽과 미국에서는 이질감으로 작용하여 신한류 콘텐츠의 가능성을 제시하고 한류의 장기화에 이바지할 것이다.