• 대한족부족관절학회지
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• 제17권3호
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• pp.203-208
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• 2013

Purpose: We analyzed retrospectively the effect of pyridoxine in the treatment of peripheral nerve related foot pain because we have seen favorable clinical results from it as a monotherapy. Materials and Methods: We analyzed the clinical results of 200 cases of peripheral nerve related foot pain, treated with pyridoxine from March 2009 to February 2012. We devided them into three groups, peripheral neuritis, Morton's neuroma and posttraumatic neuralgia and recorded percentage of improvement of pain, compared to initial pain level at 2 weeks and 6 weeks. Results: There were 127 peripheral neuritis cases, 22 Morton's neuroma and 51 posttraumatic neuralgia. At 2 weeks after treatment, 135 cases(67.5%) showed pain relief. At 6 weeks, 36 cases(21%) showed complete improvement of pain, 81 cases(47%) showed more than 50 % of improvement, 22 cases(13%) showed less than 50% of improvement and 33 cases(19%) showed no improvement. There are 4 cases of gastrointestinal discomfort and 2 cases of aggravation of nervy pain. Conclusion: Pyridoxine was effective drug in the treatment of peripheral neuropathic pain in terms of pain relief, safety and cost effectiveness. So it can be an available first line drug before adding other drugs.

• Annals of Clinical Neurophysiology
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• 제10권1호
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• pp.74-78
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• 2008

Pyridoxine has been known as an essential cofactor in many important biological reactions of tissue metabolism including blood, skin, and central nervous system. Nowadays, vitamins are widely consumed because of the belief that they provide health benefits with no harm. We report a patient with sensory ataxia who had a 3-year history of excessive vitamin $B_6$ intake. Her clinical and electrodiagnostic findings were characteristic of sensory neuronopathy, which were probably caused by pyridoxine intoxication. Physicians should be aware of the toxicities of megavitamin therapy.

• Journal of Nutrition and Health
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• 제18권3호
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• pp.242-248
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• 1985

Weanling female Sprague Dawley rats were fed diets containing 22mg pyridoxine HCI/kg diet(control diet) and 1.2mg pyridoxine HCI/kg diet(deficient diet). One deficient group and one control group were fed their diets throughout the period of growth, gestation and lactation. After the pups were born and weaned, the deficient group was divided into two groups. Therefore, one(DC) switched to control diet and the other continued the same deficient diet until 10 week-old. Analysis of chemical composition of fatty acid in the total brain lipid was conducted in the pups of 5, 10, 15, 21, 35, 50 days of age. Arachidonic acid content was significantly decreased in the deficient group at 5 days compared to the control, but at almost all ages, there were no significant differences in fatty acid contens among all the groups. The fatty acid compositions of the brain phospholipids were determined on pups at 1, 14, 21, 35, 70 days of age. The content of $C_{20}\;_{4}$ in the brain phosphatidylcholine birth and contents of $C_{22}\;_{4}$ and $C_{22}\;_{5}$ at birtd, and $C_{22}\;_{5}$ and $C_{22}\;_{6}$ at 14 days in the phosphatidylethanolamine were depressed in the deficient group. These changes were not consistent with ages. Therefore, it may reflect that the major part of the changes occuring in the pyridoxine depleted rats depends, not so much on the pyridoxine depletion itself, as on the age or development of the rats.

• Clinical and Experimental Pediatrics
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• 제49권11호
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• pp.1223-1226
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• 2006

철적모구성 빈혈은 heme 대사의 이상으로 혈청철의 증가와 소구성 저색소성 빈혈을 보이며, 골수 소견에서 적혈구계 과다형성과 함께 환상 철적모구가 많이 나타나는 것이 특징이다. 저자들은 2세 남아에서 드문 질환인 철적모구성 빈혈과 승모판 탈출증에 의한 승모판 역류가 동시에 있는 증례를 경험하였다. 환아는 철적모구성 빈혈에 의해 수혈에 따른 철분의 과잉 침착과 만성 빈혈에 의한 심계 항진에 의한 심근 기능 장애가 발생할 가능성이 있는데다, 동반된 승모판 탈출증으로 심기능의 장애의 위험이 증가할 것으로 사료된다. 현재 환아는 pyridoxine 투약 후 전신 상태와 혈색소 수치가 안정적으로 유지되고 있다.

• 한국식품과학회지
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• 제47권1호
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• pp.95-102
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• 2015

본 연구는 분유모델시스템에 $\small{L}$-carnitine, pyridoxine hydrochloride, $\small{DL}$-${\alpha}$-tocopheryl acetate를 첨가하여 Maillard 반응에 의해 생성된 MRPs를 저감화 시키기 위한 최적조건을 찾기 위해 RSM의 CCD를 이용하였다. $\small{L}$-Carnitine ($X_1$), pyridoxine hydrochloride($X_2$), $\small{DL}$-${\alpha}$-tocopheryl acetate ($X_3$)의 농도를 독립변수로 하고 형광도와 HMF 함량을 종속변수로 각각 설정하였다. 종속변수 회귀식의 결정계수($R^2$)는 각각 0.942, 0.861로 반응표면분석 모델에 적합하였다. 형광도와 HMF 함량은 $\small{L}$-carnitine과 pyridoxine hydrochloride의 농도가 낮을 때 $\small{DL}$-${\alpha}$-tocopheryl acetate의 농도가 감소할수록 그 값이 급격히 감소하였다. $\small{L}$-Carnitine의 농도가 높을 때 pyridoxine hydrochloride의 농도가 $20{\mu}M$ 이하로 감소할수록 형광도가 감소하였고 HMF 함량은 $\small{L}$-carnitine의 농도에 관계없이 pyridoxine hydrochloride의 농도가 $20{\mu}M$ 이하로 감소할수록 감소하는 경향을 나타냈다. 본 실험에서 분유모델시스템에서 생성된 MRPs를 저감화 할 수 있는 최적조건으로 $\small{L}$-carnitine, pyridoxine hydrochloride, $\small{DL}$-${\alpha}$-tocopheryl acetate의 농도는 각각 2.26, 15.77, $20.63{\mu}M$이었다. 이때 형광도는 77.4%였고 HMF 함량은 248.7 ppb로 각각 유단백질-유당 마이얄 반응생성물(LC, lactose+sodium caseinate)대비 MRPs를 22.6, 23.1% 감소시킬 수 있다고 예측할 수 있었다. 또한, RSM을 통해 찾은 최적 조건의 실험값으로 형광도는 79.3%였고 HMF 함량은 247.6 ppb로 각각 LC대비 MRPs를 20.7, 17.8% 감소 시켰다. 따라서, $\small{L}$-carnitine, pyridoxine hydrochloride, $\small{DL}$-${\alpha}$-tocopheryl acetate의 최적화된 혼합을 통하여 분유 제조 시 MRPs 생성을 저감화 시킬 수 있을 것으로 생각된다.

• 한국응용곤충학회지
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• 제12권2호
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• pp.71-78
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• 1973

목련흰비단병균 Sclerotium rolfsii의 균사생장 및 균핵형성에 대한 thianine, biotin, nicotinic acid, Pyrido-xine, inositol과 DNA 및 RNA의 영향을 조사한 바 그 결과를 요약하면 다음과 같다. 1. 공시균은 thiamine 결핍균으로서 균사생장 최적 thiamine 농도는 20r/l이고 이농도를 초과하면 오히려 균사생장이 억제되어 150r/l에서는 무첨가구와 거이 비슷한 균사생장을 하였다. 2. 공시균의 생장에 있어서 thiamine의 첨가에 따른 질소원 이용도는 $NH_4NO_3>(NH_4)_2SO_4>asparagine>KNO_3$의 순위이며 질소원별 thiamine 최적요구량은 $KNO_3$인 경우 12r/l, asparagine인 경우는 16r/l정도였다. 균핵형성량에 있어서는 $KNO_3>NH_4NO_3>asparagine>(NH_4)_2SO_4$의 순위로 질소원별 thiamine 최적량은 $KNO_3,\;NNO_3,\;NH_4NO_3$가 8r/l에서 균핵의 대부분이 형성되나 asparagine은 16r/l정도였다. 3. 배양액의 pH는 공시균이 생장을 개시하자마자 3.5정도로 급격히 떨어지나 그 이후로는 생장량이 증가함에 따라 완만하게 떨어졌다. 그러나 pH2.2 이하로는 내려가지 않았다. 4. Nicotinic acid는 공시균의 생장 및 균핵형성에 아무런 효과가 없었다. 그러나 thiamine 10r/l와의 공존하에서는 다소의 효과가 있는 것으로 nicotinic acid 7-10mg/l에서 가장 생장이 좋았고 그 이상에서는 생육이 억제되었다. 5. Pyridoxine, biotin 및 inositol은 배지의 질소원이 $(NH_4)_2SO_4$나 asparagine인 경우 모두 공시균의 균사생장 및 균핵형성에 아무런 효과가 없었다. 6. 공시균의 균사생 장에 대한 각종 vitamin의 상호효과는 thiamine, biotin, Pyridoxine, inositol의 4가지 combination에 의해서도 thiamine이 첨가되지 않으면 거이 효과가 나타나지 않았다. 그러나 thiamine+pyridoxine, thiamine + inositol, thiamine + biotin + pyrid oxine, thiamine + biotin + pyridoxine + inositol 구에 있어서는 thiamine단독첨가구와 동등 혹은 그 이상이지만 thiamine+biotin과 thianline+biftin+inositol구는 오히려 떨어졌다. 균핵형성에 있어서는 thiamine단독구에 비하여 각구 모두 약간씩 증가하였다. 7. 공시균의 균사생장에 대한 DNA와 RNA의 효과는 무첨가구에 비하여 다소 인정되는데 DNA보다는 RNA가 좀더 효과적이었다. RNA는 2-6mg/l에서 DNA는 6mg/l에서 가장 좋았다. 균핵형성에 있어서는 효과가 없 었다. 8. RNA의 농도가 증가함에 따라 또 thiamine의 농도가 증가함에 따라 균사생장량이 증가하는 것으로 thiamine의 존재하에 RNA의 효과가 뚜렷하게 나타났다. 그러나 균핵형성에는 효과가 없었다.

• Archives of Pharmacal Research
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• 제14권1호
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• pp.73-77
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• 1991

The effects of pyridoxine (PN) on rifampicin (RMF) toxicity were investigated by both in vivo and in vitro methods. RMF (30 mg/kg) was injected intraperitoneally and PN(150 mg/kg) was administered orally to rats for 10 consecutive days. After treatment, clinical chemistry and hematologic profiles were measured. RMF and PN plus RMF did not show any adverse effects at this in vivo experimental condition. Thymidine incorporations of mice bone marrow cells were examined in vitro. RMF showed a decrease in thymidine uptake in a dose-dependent manner, but PN showed a reversal of the thymidine uptake suppression caused by RMF (p<0.01). On the other hand, PN showed a decrease in thymidine uptake at a high concentration level.

• 약학회지
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• 제30권4호
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• pp.185-192
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• 1986

Authors developed the computer application program (language: APPLE SOFT BASIC) for derivative spectrophotometry. By means of this program, derivative of spectral absorbance with respect to wavelength is recorded versus wavelength. To try this program in connection with spectrophotometer system, the authors have done the simultaneous quantitation of pyridoxine center dot HCl and nicotinamide in the mixture, and the result was compared with that of absorbance method.

• 한국가금학회:학술대회논문집
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• 한국가금학회 2004년도 제21차 정기총회 및 학술발표회
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• pp.95-96
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• 2004

An experiment was conducted to investigate the effects of dietary supplementation of feather meal (FM its) digests on the performance of broiler chicks and taurine content in broiler meat. A total of 1,000 broiler chickens were assigned to five dietary treatments : Control, FM diet(FM), FM+pyridoxine(FM+Pyridox), H$_2$O$_2$ treated FM diet(H$_2$O$_2$-FM) and enzyme treated FM diet (Enzyme-FM). Treated diets were supplemented with FM or FM digests at the level of 5 % to the control diet. During the stater period, weight gain of chicks fed FM+Pyridox was significantly higher(P<0.05) than those of the other FM or FM digest treatments but was not different from the control. Weight gam of overall period were not significantly different among treatments. Feed intake of the control was greater than that of FM or FM digest treatments. Feed conversion ratio(feed intake/gain) of chicks fed FM and H$_2$O$_2$-FM were significantly higher than those of Enzyme-FM and FM+Pyridox, but were not significantly different from the control. Taurine contents of leg and breast mucle were significantly (P<0.01) different among treatments but those of liver were not significantly different. Taurine content of FM+Pyridox was highest in both leg and breast muscle. It was 85 % higher in leg muscle and 15 % higher in breast muscle than that of the control. Sensory evaluation data showed significant but not consistant responses in various parameters. FM + Pyridox treatment showed highest score in aroma of raw leg muscle of male and in juiciness and tenderness of broiled breast muscle of male chickens. Control group showed highest color score in raw leg muscle of female and lowest overall acceptability score in broiled breast and leg muscle of male chicken. It is concluded that taurine can be enriched especially in broiler leg meat by 5 % FM diet supplemented with pyridoxine.

• Journal of Nutrition and Health
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• 제27권9호
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• pp.930-939
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• 1994

Vitamin B-6 nutrition has been shown to be inadequate in many population groups including pregnant and lactating women, and in infants. Vitamin B-6 intake was measured in 98 pregnant mothers and a total of 172 cord blood samples of their and other new born infants were analyzed for erythrocyte alanine aminotransferase(EALAT) activities with or without the addition of pyridoxal-5-phosphate to assess vitamin B-6 status of the infants. The average daily vitamin B-6 intake of the pregnant mothers was 1.79mg$\pm$0.88(81.4% of the Recommended Dietary Allowances ; RDA) and vitamin B-6 to protein intake ration was 0.017mg vitamin B-6/g protein. Thirty-eight percent of the pregnant women consumed diets which provided less than the RDA for vitamin B-6 during pregnancy. Seventy-two percent of the dietary pyridoxine intake was provided by the plant food source whose bioavailability was reported to be lower when compared to that of the animal food. The average activity coefficient(AC) values of the cord blood EALAT was 1.41$\pm$0.11, and 32% of the blood samples had EALATAC values greater than 1.25, suggesting that vitamin B-6 status of the newborns might be less than adequate.