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안구건조증의 침 치료에 대한 최근 임상 연구 동향 분석 - 2010년 이후 Pubmed, Cochrane Library 검색 중심으로

  • Ji-One Im;Ji-Young Choi;Seon-Young Jee;Min Hwangbo
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.36 no.2
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    • pp.10-25
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    • 2023
  • Objectives : The purpose of this review is to validate the effectiveness of acupuncture treatment on dry eye syndrome. Methods : Through foreign online databases(Pubmed, Cochrane Library) and domestic online databases(Science On, OASIS) we only searched for Randomized controlled trials(RCTs) that performed acupuncture for dry eye syndrome from January 2010 to December 2022. Results : The most commonly used acupoints were 風池(GB20), 贊竹(BL2) and the most commonly used meridian was the gall bladder meridian of foot-shaoyang. The most commonly used evaluation criteria was Tear Break Up Time(TBUT) followed by Schirmer Test and Ocular Surface Disease Index(OSDI). In most of 8 studies, acupuncture treatment showed significant therapeutic effects. Conclusions : According to this study results, acupuncture can be suggested to effective way for treating dry eye syndrome. More clinical studies are needed to prove the effectiveness of the acupuncture on dry eye syndrome.

Myocardial Protective Effects of Shenfu Injection after Mitral Valve Replacement Surgery; A Systematic Review and Meta Analysis. (승모판의 인공판막 치환술후 삼부주사액의 심근보호효과에 관한 체계적 문헌고찰 및 메타분석)

  • Bong-Jin Shin;Ji-Ho Kim;Mu-Hyeok Ahn;Jung-Nam Kwon
    • The Journal of Korean Medicine
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    • v.43 no.3
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    • pp.164-180
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    • 2022
  • Objectives: The purpose of this study was to evaluate the effects of shenfu injection on myocardial protective effects after mitral valve replacement surgery. Methods: We searched four international databases (PUBMED, Embase, Web of Science and CNKI) and three domestic electronic databases (OASIS, RISS and NDSL) for relevant studies. We used following keywords 'shenfu', 'valve replacement', 'mitral valve' at PUBMED, Embase and Web of Science; '二尖瓣', '参附注射液', '瓣膜' at CNKI and '이첨판', '판막', '삼부' at domestic databases. The search range included randomized controlled trials. When appropriate, meta-analyses were performed. Results: Seven randomized controlled trials were selected. All studies used Shenfu injection after mitral valve replacement surgery. We analyzed myocardial damage, cardiac function, patients' recovery rate, with various evaluation indicators. We also used meta-analysis for CK-MB, cTnI, MDA and voluntary recovery of heartbeat. CK-MB was analyzed in two subgroups: 8 hours and 24 hours after surgery. Std was -2.34(95% CI -4.10, -0.58) for 8 hours and -1.95(95% CI -4.79 to 0.88) for 24 hours. 8 hours showed statistically significant difference. cTnI appeared significant decrease with Std of -2.13(95% CI -2.60, -1.66). MDA showed significant decrease with Std of -0.95(95% CI -1.43 to -0.47). Voluntary recovery of heartbeat significantly increased with the odd ratio of 4.34(95% CI 1.76, 10.70). Conclusions: We suggest that Shenfu injection after Mitral valve replacement surgery may have significant myocardial protective effects in terms of reducing myocardial damages, reactive oxygen species, increasing cardiac function and patients' recovery after surgery. However, the evidence is limited, further research is required.

Factors related to infection management performance of health workers at Long-Term Care Hospitals in Korea: systemic review and meta analysis (국내 요양병원 종사자의 감염관리 수행도 관련요인 연구: 체계적 고찰 및 메타분석)

  • Kim, Eun Kyung;Park, Heeok
    • Journal of Digital Convergence
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    • v.20 no.5
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    • pp.857-866
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    • 2022
  • The current study is a meta analysis study to identify the factors related to infection management performance and the effect size according to the factors. Data collection was included from the data of KMBASE, RISS, KISS, DBpia, National Library of Korea, Pubmed, and EMBASE. R3.5.1 was used for the data analysis. A total of 22 factors were identified. The meta analysis showed the effect size as follows: gender(.16), age(.30), education(.32), beds(.28), needs of education in infection management(.44), participating in education of infection management(.25), recognition/knowledge in infection management(.70). Based on the findings, evidence based programs need to be provided to improve the infection management performance of health workers at Long-Term Care Hospitals.

Experimental study trends on the prevention and treatment effects of herbal medicine for gastroesophageal reflux disease (GERD) - based on Pubmed (천연물의 위식도역류질환 예방, 치료 효과에 대한 실험연구 현황 – Pubmed를 중심으로)

  • YongBin Kim;Young-Sik Kim
    • Herbal Formula Science
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    • v.31 no.4
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    • pp.389-413
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    • 2023
  • Objectives : This study aimed to review the current trends in experimental studies on the use of natural products for treatment of gastroesophageal reflux disease (GERD). Methods : Experimental studies assessing the efficacy of natural products against GERD were searched on PubMed. Articles were selected based on predefined inclusion and exclusion criteria and then analyzed for experimental methods, interventions, and result analysis techniques. Results : A total 37 studies were included in this review. Predominantly, in vivo experiments were conducted to induce GERD through surgery, involving the ligation of the pylorus and the transitional junction between the corpus and the forestomach using 7-week-old male Sprague-Dawley rats. The acute induction model, sacrificing animals after a single administration following GERD induction, was mainly used.The utilization of cell experiments was relatively infrequent, with a focus on assessing antioxidant and anti-inflammatory effects via the treatment of the RAW 264.7 cell line with lipopolysaccharides treatment. Glycyrrhizae Radix et Rhizoma, Pinelliae Tuber, Ginseng Radix and Zingiberis Rhizoma were used as single ingredients, and herbal formula, STW-5 (iberogast), Rikkunshito (六君子湯), Banhasasim-tang (半夏瀉心湯), and Hewei Jiangni granule (和胃降逆湯) were used. Outcome analysis methods encompassed Macroscopic evaluation, esophageal function assessment, blood biomarker analysis, histological examination, protein analysis, gene expression analysis, and gastric juice analysis. Proton pump inhibitors were predominantly employed as positive controls. Conclusions : This study revealed the current trends in non-clinical research evaluating natural products for GERD. Based on the results of this study, we expect that non-clinical research on clinically effective natural products will be revitalized.

Review of Research Trends and Evaluation Tools for Clinical Studies of Neck Pain and Cervical Spondylosis : Using the Pubmed Database (Pubmed분석을 통한 경추통과 경추 척추증의 임상연구 최신동향 및 평가도구에 관한 고찰)

  • Kim, Myung Kwan;Kim, Young-Il;Kim, Eun Seok;Jung, In Chul;Park, Yang-Chun;Jeon, Ju Hyun
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.32 no.4
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    • pp.232-246
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    • 2018
  • The purpose of this research is to contribute to clinical researches on neck pain and cervical spondylosis by reviewing the latest research trends and evaluation tools through the analyses of clinical studies on neck pain and cervical spondylosis over the last 5 years. 70 papers satisfying the selection conditions among the RCT papers that had been searched as "neck pain" or "cervical spondylosis" at Pubmed(https://www.ncbi.nlm.nih.gov/pubmed) from March 2011 to February 2016 were targeted. Papers were numbered in order of their publication dates and analyzed by classifying their contents into 1) pain classification, 2) treatment type, 3) treatment duration, 4) treatment time, 5) number of participants, 6) evaluation tools and methods of research, and 7) evaluation duration. 55 papers targeted chronic neck pain, 6 papers acute and subacute neck pain, and 2 papers subacute and chronic neck pain. In comparison by intervention, 43 papers corresponded to physical therapy, 3 papers to acupuncture, 1 to herbal fomentation, 5 to medication, and 18 papers corresponded to multilateral comparisons comparing the efficacy by various interventions. In research period, there were 50 papers based on treatment period, 16 papers based on the number of treatments, and 4 papers based on different periods depending on each group. In treatment duration, the cases from 1 month or more to less than 3 months were most, followed by the cases of less than 1 month, and the cases from 3 months or more to less than 6 months. In treatment frequency, the number of treatments of the treatment group was the same as that of the control group in 51 papers, and many treatments were conducted by the methods of acupuncture, manual therapy, and injection therapy in cases of once or twice of treatments, and physical therapy and electroacupuncture corresponded mainly to the cases from 3 times or more to less than 10 times of treatments, and retrospective observation and exercise programs corresponded mainly to the cases of more than 30 times of treatments. In the number of subjects of the researches, the cases from 50 or more to less than 100 were most, followed by the cases from 20 or more to less than 50. There were 7 evaluation tools cited 10 times or more: VAS, NRS, PPT, NDI, NPQ, CROM, and SF-36. In evaluation period, 37 papers evaluated only during the treatment period, and 33 papers conducted follow-up. In follow-up period, the cases of less than 3 months were most, followed by the cases from 6 months or more to less than 1 year, and the cases from 3 months or more to less than 6 months. When planning clinical researches on cervical pain in the future, appropriate intervention methods, frequency and duration of treatment, period of follow-up, appropriate number of subjects and selection of evaluation tools for objective validity will have to be considered. In addition, randomization, double-blind, etc. will have to be considered for researches with high basis level.

Review of Effect of the Mechanical Stress on Muscle (근육에 대한 역학적 스트레스의 영향)

  • Kang, Jong-Ho;Kim, Jin-Sang
    • PNF and Movement
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    • v.6 no.2
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    • pp.51-57
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    • 2008
  • Purpose : Mechanical stress activates signaling cascades and leading to a specific response of a network of signaling pathways. The purpose of this study is to review the effect of mechanical stress-induced adaptation in skeletal muscle involves a biological mechanisms. Methods : This is literature study with Pubmed, Medline and books. Results : Skeletal muscle tissue demonstrates a malleability and may adjust its metabilic response, vascularization and neuromuscular characteristic makeup in response to alteration in functional demands. The adaptation in skeletal muscle involoves a multitude of signalling mechanisms related with insuline-like growth factor, vascular endothelial growth factor, neurotrophins. Conclusions : The identification of the basic relationships underlying the malleability of skeletal muscle tissue is likely to be of relevance for our understanding with PNF technique.

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Brain Plasticity and Stroke Rehabilitation (뇌가소성과 뇌졸중 재활)

  • Kim, Sik-Hyun
    • PNF and Movement
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    • v.6 no.2
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    • pp.39-50
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    • 2008
  • Purpose : This article reviewed the advances in the understanding of the effect of motor rehabilitation and brain plasticity on functional recovery after CNS damage. Methods : This is literature study with Pubmed, Medline and Science journal. Results : The inability of CNS neurons to regenerate is largely associated with nonneuronal aspects of the CNS environment. Especially, this neuronal growth inhibition is mediated by myelin associated glycoprotein, olygodendrocyte-myelin glycoprotein, and NOGO. Enriched environment, motor learning, forced limb use have been utilized in scientific studies to promote functional reorganization and brain plasticity. Especially, enriched environment and motor enrichment may prime the brain to respond more adaptively to injury, in part by expressed neurotrophic factors. Conclusions : These reviews suggest that activity-induced neural plasticity occur in damaged brain areas in order to functional reorganization, where it could contribute to motor recovery, and represent a target for stroke rehabilitation.

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Systematic Review of Acupoint Catgut Embedding Therapy for Climacteric Hot Flush (갱년기 안면홍조에 대한 매선치료 : 체계적 문헌고찰)

  • Song, Mi-Hwa;Hong, Ka-Kyung;Choi, Chang-Min
    • The Journal of Korean Obstetrics and Gynecology
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    • v.30 no.2
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    • pp.71-80
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    • 2017
  • Objectives: The purpose of this systematic review was to overview and evaluate the effectiveness of acupoint catgut embedding for climacteric hot flush. Methods: We searched articles from CNKI, Pubmed CENTRAL, Koreantk, Oasis online databases. After searching the articles, we performed quality assessment using Cochrane risk of bias (RoB) tools. Results: Among the 20 articles were searched, one radomized controlled clinical trial (RCT) was selected. 1 Study showed that Acupoint catgut embedding treatment has significant effect on climacteric hot flush in terms of the effectiveness rate. Conclusions: This study found encouraging but limited evidence of aupoint catgut embedding theragpy for climacteric hot flush.

Correlation Analysis of Cancer Biomarkers and COPD Using the Word Embedding (워드 임베딩을 이용한 COPD와 암 관련 바이오마커의 상관관계 분석)

  • Yoon, Byeong-Hun;Kim, Yu-Seop
    • Annual Conference on Human and Language Technology
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    • 2017.10a
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    • pp.251-254
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    • 2017
  • 본 연구에서는 COPD와 기존에 연관이 있는 것으로 알려진 바이오마커 이외의 새로운 바이오마커를 찾고자 한다. Pubmed Data에서 선정한 암 관련 바이오마커를 추출하여 COPD와 암 관련 바이오마커의 관계를 파악하는 데이터로 사용한다. 그리고 워드 임베딩 모델 중 Word2vec을 사용하여 워드 임베딩 한다. 워드 임베딩한 K차원의 COPD와 암 관련 바이오마커를 t-SNE를 사용하여 시각화한다. 또한 코사인 유사도를 이용하여 COPD와 암 관련 바이오마커의 유사도를 측정한다. 그리고 코사인 유사도와 t-SNE 결과를 이용하여 COPD와 암 관련 바이오마커와의 상관관계를 파악할 수 있으며, 암 관련 바이오마커와 COPD 관련 바이오마커를 비교 하여 기존의 COPD와 연관이 있다고 알려진 바이오마커 이외의 새로운 바이오마커를 찾을 수 있다.

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Correlation Analysis of Cancer Biomarkers and COPD Using the Word Embedding (워드 임베딩을 이용한 COPD와 암 관련 바이오마커의 상관관계 분석)

  • Yoon, Byeong-Hun;Kim, Yu-Seop
    • 한국어정보학회:학술대회논문집
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    • 2017.10a
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    • pp.251-254
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    • 2017
  • 본 연구에서는 COPD와 기존에 연관이 있는 것으로 알려진 바이오마커 이외의 새로운 바이오마커를 찾고자 한다. Pubmed Data에서 선정한 암 관련 바이오마커를 추출하여 COPD와 암 관련 바이오마커의 관계를 파악하는 데이터로 사용한다. 그리고 워드 임베딩 모델 중 Word2vec을 사용하여 워드 임베딩 한다. 워드 임베딩한 K차원의 COPD와 암 관련 바이오마커를 t-SNE를 사용하여 시각화한다. 또한 코사인 유사도를 이용하여 COPD와 암 관련 바이오마커의 유사도를 측정한다. 그리고 코사인 유사도와 t-SNE 결과를 이용하여 COPD와 암 관련 바이오마커와의 상관관계를 파악할 수 있으며, 암 관련 바이오마커와 COPD 관련 바이오마커를 비교 하여 기존의 COPD와 연관이 있다고 알려진 바이오마커 이외의 새로운 바이오마커를 찾을 수 있다.

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