• The Korean Journal of Physiology and Pharmacology
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• v.28 no.5
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• pp.393-401
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• 2024

Large language models (LLMs) are rapidly transforming medical writing and publishing. This review article focuses on experimental evidence to provide a comprehensive overview of the current applications, challenges, and future implications of LLMs in various stages of academic research and publishing process. Global surveys reveal a high prevalence of LLM usage in scientific writing, with both potential benefits and challenges associated with its adoption. LLMs have been successfully applied in literature search, research design, writing assistance, quality assessment, citation generation, and data analysis. LLMs have also been used in peer review and publication processes, including manuscript screening, generating review comments, and identifying potential biases. To ensure the integrity and quality of scholarly work in the era of LLM-assisted research, responsible artificial intelligence (AI) use is crucial. Researchers should prioritize verifying the accuracy and reliability of AI-generated content, maintain transparency in the use of LLMs, and develop collaborative human-AI workflows. Reviewers should focus on higher-order reviewing skills and be aware of the potential use of LLMs in manuscripts. Editorial offices should develop clear policies and guidelines on AI use and foster open dialogue within the academic community. Future directions include addressing the limitations and biases of current LLMs, exploring innovative applications, and continuously updating policies and practices in response to technological advancements. Collaborative efforts among stakeholders are necessary to harness the transformative potential of LLMs while maintaining the integrity of medical writing and publishing.

• Journal of Korean Society of Environmental Engineers
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• v.39 no.11
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• pp.634-640
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• 2017

Toxicity and fate assessment is necessary in the evaluation of the environmental, health and safety risks of engineered nanomaaterials (ENMs). Therefore, in order to ensure the reproducibility, reliability and relevance of ENMs toxicity results, stable and monomodal dispersion protocols in toxicity test media are needed. Zinc oxide nanoparticles (nZnO) are widely used in various products such as cosmetic products, paper, paints etc. In this study, nZnO dispersions in ecotoxicity test media were produced by following a series of steps of modified National Institute of Standards and Technology (NIST) Special publication 1200-5. In addition, natural organic matter (humic acid (HA)) was used as a stabilizing agent to disperse nZnO in the test media. The hydrodynamic diameters (HDD) of the nZnO in dispersion ranged between 150 and 200 nm according to the dynamic light scattering (DLS) measurement. Based on these dispersions in ecotoxicity test using ecological species (Oryzias latipes, Daphnia magna, Pseudokirchneriella subcapitata and Chironomusus riparius), dispersion protocol was found to have a considerable potential in ecotoxicity test of ENMs.

• Child Health Nursing Research
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• v.9 no.2
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• pp.149-161
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• 2003

Purpose: The purpose of this study is to identified patterns and trend of studies and to analyzed the nursing research related to the mother-child interaction in Korea and to improve direction of nursing research in mother-child interaction in Korea. Method: The research studies related to the mother-child interaction were selected from the Korean Nurses Academic Society Journal, and from dissertation, which were conducted between 1961 and 2002 with the consideration of the condition and the cultural specialty of Korea. The total numbers of the studies were 34. These studies were classified according to 1)time of publication or presentation, 2)research design, 3)type of interaction objects, 4)measurement tool, and 5)chief content of studies. Ressult: 1) Until 1984, there was no research studies related to mother-child interaction. The number of studies on the mother-child interaction on the mother-child interaction has been increased rapidly after 1985. The mother-child interaction studies were 13(38.2％) from the doctoral dissertation, 4(11.8％) from the Master's theses and 17(50％) other papers were published in academic journals. 2) Experimental studies of research design was used in these research studies was 13(38.2％). Descriptive studies was 8(23.6％), correlational studies was 4(11.8％) and comparative studies was 4(11.8％). Qualitative study was just one(2.9％) and literature review was 4(11.8％). Especially experimental studies has been increased. 3) Participants of these studies were mother and infant 29(85.5％), father and infant 2(5.9％), mother and fetus 2(5.9％) and nurse and infant 1(2.9％) 4) Utilization of instruments as follows: 13 studies used Walker et al(1986)'s MIPIS (Mother-Infant Play Interaction Scale), 6 studies used Barnard(1978)'s NCAFS (Nursing Child Assessment Feeding Scale), 4 studies used NCATS(Nursing child Assessment Teaching Scale) for assessing mother-infant interaction. 3 studies used Stainton(1981)'s Parent-Infant Interaction Scale. Choi(1987), Kim(1999) and Kim and Son(1997) used measurement tool researcher made which was modified from NCATS (Nursing child Assessment Teaching Scale) and AMIS(Assessment of Mother-Infant Sensitivity Scale). Other tools used to survey influencing factors of interaction. 5) Content of the research studies were classified 3 different types, such as ① studies about the mother-child interactions' pattern, ② studies about influencing factors of the mother-child interaction, ③ studies about effect of nursing intervention program to improve the mother-child interaction. Conclusion: Therefore we make following suggestions which are made based on the above research analysis : 1) In the future research studies need to compare with other area of discipline in mother-child interaction. 2) More attention and in depth research is needed to validate in terms of research design and statistical data analysis. 3) It is important to develop the instruments which is culturally acceptable in Korea society. 4) The results of correlational studies and experimental studies needs to the integrated by meta analysis.

• Journal of Acupuncture Research
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• v.27 no.2
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• pp.123-142
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• 2010

Objectives : The knee pain is the main reason of getting acupuncture treatment. In order to have confidence in the results of a study, it is necessary to establish that questionnaire is both valid and reliable in questionnaire related study. The aim of this study was to review the instruments that are currently in sue for assessing the knee joint. Methods : A literature study was performed to choose appropriate scales for assessment for pain and the function of the knee. Theoretically based scales were selected for review. Therefore, 18 scales for knee and 9 scale for pain were reviewed. the status of scales involved in knee treatment of acupuncture throughout several countries was evaluated. Results & Conclusion : Lysholm Knee Scoring Scale, Cincinnati knee rating system(CKRS) are adequate for ligament injury in knee. International Knee Documentation Committee scoring system(IKDC) may become a publication requirement for journals in view of the international standing of the committee. The available outcome measure for use in osteoarthritis are Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC), Lequesne Functional Severity Index(LFI) and Knee Injury and Osteoarthritis Outcome Score(KOOS), and in rheumatoid arthritis are McMaster-Toronto Arthritis patient function preference questionnaire(MACTAR), Quality of Life-Rheumatoid Arthritis Scale(QoL-RA Scale). Visual analog scale(VAS), verbal rating scale(VRS) are commonly used for the standard pain scale. For long term follow-up study The Medical Outcomes Study Short Form-36(SF-36), Arthritis Impact Measurement Scales(AIMS), Health Assessment Questionnaire(HAQ) should be included. Each measurement has its own composition and characteristics. Their validity, reliability, responsiveness and practical characteristics were already evaluated. We found 20 domestic and 28 overseas papers about knee treatment using acupuncture assessed with knee scales.

• Journal of Korean Medicine for Obesity Research
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• v.17 no.1
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• pp.37-45
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• 2017

Recently the global epidemic problem of obesity has stimulated intense interest in the study of physiological mechanisms using animal models as a way to gain crucial data required for translation to human studies. Panax ginseng has been reported to have anti-obesity or antidiabetic effects in many animal studies; however, there have been few studies investigating human obesity. Herein, we will assess and examine the evidence supporting the anti-obesity effect of Panax ginseng in animal models with respect to anthropometric and metabolic outcomes. We will include controlled, comparative studies assessing the effect of Panax ginseng in preclinical studies of obesity. Panax ginseng will be administered during or following the induction of experimental obesity. The primary outcome measure will be anthropometric assessment and the secondary outcome measures will include adipose tissue weight, total amount of food consumed and metabolic parameters. We will search MEDLINE, Embase, PubMed, Web of Science, and Scopus without language, publication date, or other restrictions. Ethical approval will not be necessary as the data collected in this study will not be individual patient data, consequently there will be no concerns about violations of privacy. After finishing the whole procedure, the results will be disseminated by publication in a peer-reviewed journal or presented at a relevant conference. This protocol has been registered on the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) website (http://www.camarades.info).

• 한국노년학
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• v.37 no.2
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• pp.431-444
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• 2017

This study identified effect size of cognition improvement programs developed for normal elderly in Korea. By searching four databases, 9,624 studies published from 2000 to 2016 were identified. Finally, 14 studies which satisfied the inclusion criteria were selected for meta-analysis. Quality assessment of included studies was conducted using controlled trial checklist of Scottish Intercollegiate Guidelines Network. R version 3.3.2 (2016-10-31) with "meta" and "metafor" package was used to calculate effect sizes, identify the reasons of heterogeneity, and check publication bias. Total effect size of cognition improvement program was middle (SMD=0.759, p<.001, $I^2=34%$). For heterogeneity, moderator analysis was executed and combined program with exercise had the largest effect size (SMD=1.231, p<.001, $I^2=40.8%$). Publication bias was exist by funnel plot and Egger 's regression test, but trim and fill analysis showed that there was no serious error to reverse study results. Therefore, Combined program with exercise for the normal elderly was expected to improve the cognitive function of the normal elderly.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4305-4309
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• 2012

Background: Previous studies on the association between the TP53 Arg72Pro polymorphism and hepatocellular carcinoma (HCC) risk obtained controversial findings. This study aimed to quantify the strength of the association by meta-analysis. Methods: We searched PubMed and Wangfang databases for published studies on the association between the TP53 Arg72Pro polymorphism and HCC risk, using the pooled odds ratio (OR) with its 95% confidence intervals (95% CI) for assessment. Results: 10 studies with a total of 2,026 cases and 2,733 controls were finally included into this meta-analysis. Overall, the TP53 Arg72Pro polymorphism was not associated with HCC risk (all P values greaterth HCC risk in Caucasians in three genetic models (For Pro versus Arg, OR = 1.20, 95%CI 1.03-1.41; For ProPro versus ArgArg, OR = 1.74, 95%CI 1.23-2.47; For ProPro versus ArgPro/ArgArg, OR = 1.85, 95%CI 1.33-2.57). However, there was no significant association between the TP53 Arg72Pro polymorphism and HCC risk in East Asians (all P values greater than 0.10). No evidence of publication bias was observed. Conclusion: Meta-analyses of available data suggest an obvious association between the TP53 Arg72Pro and HCC risk in Caucasians. However, the TP53 Arg72Pro polymorphism may have a race-specific effect on HCC risk and further studies are needed to elucidate this possible effect.

• Journal of Preventive Medicine and Public Health
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• v.32 no.1
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• pp.72-79
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• 1999

Objectives. The purpose of this study was to evaluate the quality of abstracts of original articles. Methods. This subjects selected total 63 abstracts of the original articles of the Korean Journal of Preventive Medicine in 1997. The quality of abstracts was measured against a checklist of evaluation criteria, which were divided into eight categories and the numbers of inappropriate words (including grammar) according to criterionbased survey. A score for each abstract was obtained by dividing the number of criteria presented by the number applicable. The overall mean score was also determined. Results. The overall mean score of abstract quality was 0.55 out of 1. Of the abstracts subject selection 83% didn't include specific technical descriptors. Of those that gave conclusions 92% didn't address study limitations and 78% made no recommendations for future study. The overall mean number of inappropriate usage of words (including grammar) per abstract was 14.1. The overall mean number of English words was 283. In the multiple regression analyses, the research career of the first author and the number of English words to the number of inappropriate usage of words were statistically significant. Also, in the secondary regression model, the number of English words to the quality score of abstract was only statistically significant. Conclusions. Most of the abstracts provided some information pertaining to each evaluation criterion. However, they did not provide sufficient details to enhance the reader's understanding of the article. On the basis of the study the abstracts need improvement in its description of the reported subject selection, statements of limitations and recommendations, etc. The Korean Society for Preventive Medicine will recommend a proposal for more informative abstracts in Korean J Prey Med and will take into consideration the introduction of foreign review of abstracts. Future studies should address these issues and compare the quality of abstracts between different journals and their time of publication.

• Journal of Radiation Protection and Research
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• v.41 no.1
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• pp.1-6
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• 2016

Background: It is very difficult to set a regulatory guidance or criteria for the protection of non-human species from the ionizing radiation, because there are no generally or internationally accepted methods for demonstrating the compliance with such criteria. It is needed that Korea develop the primary dose rate standards for the protection of both aquatic and terrestrial biota in the near future. Materials and Methods: The potential dose rates due to both external and internal radiation exposures to marine organisms such as plaice/flounder, gray mullet, and brown seaweed collected within territorial seas around the Korean Peninsula were estimated. Results and Discussion: The total dose rates to plaice/flounder, gray mullet and brown seaweed due to $^{40}K$, a primordial radionuclide in marine environment, were found to be 0.2%, 0.08% and 0.3% of approximately the values of the Derived Consideration Reference Levels (DCRLs, i.e. $1-10mGy{\cdot}d^{-1}$), respectively, as suggested by the International Commission on Radiological Protection (ICRP) publication 124. The total dose rates to marine fishes and brown seaweed due to anthropogenic radionuclides such as $^{90}Sr$, $^{137}Cs$ and $^{239+240}Pu$ were considered to be negligible compared to the total dose rate due to $^{40}K$. The external exposure to benthic fish due to all radionuclides was much higher than that of pelagic fish. Conclusion: From this study, it is recommended that the further study is required to develop a national regulatory guidance for the evaluation of doses to non-human species.

• The Journal of Korean Medicine
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• v.36 no.4
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• pp.80-103
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• 2015

Background: This study investigated current research trends in bee venom acupuncture in Korea. Materials and methods: The literature in Korea was reviewed using the search engines Science and Technology Society Village, Korean Studies Information Service System, National Discovery for Science Leaders, and Oriental Medicine Advanced Searching Integrated System. The keywords searched were "bee venom," "apitoxin," "apitherapy," and "bee sting." We selected 412 studies, which included Korean literary studies, experimental studies, and clinical studies. Results: We classified them by publication year, research type, disease and topic, and quality assessment. Among bee venom-related studies, clinical studies (235 studies) outnumbered experimental studies (149 studies) and literary studies (28 studies). Nineteen experimental studies concentrated on the theme of "anticancer." In the type analysis of clinical studies, lumbar disorders comprised 45 of 235 studies, followed by the effect on body. Forty-two randomized controlled trials (RCTs) have been published from 2003 to date (2015). Twenty-two studies used appropriate randomization methods. Fourteen studies had a Jadad score of 4-5 points; 15 studies, 1-3 points; and 13 studies, 0 points. Conclusions: Bee venom treatment is based on Korean traditional medicine theory. Numerous research studies suggest its effectiveness. Effort and academic approach on bee venom are expected to receive a positive evaluation.