• Journal of Chest Surgery
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• 제18권3호
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• pp.383-390
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• 1985

108 cases of open heart surgery were done at our department in 1984. There were 58 male and 50 female patients ranging in age from 20 months to 52 years. 75 cases were congenital heart disease, and 33 cases were acquired heart disease. There were 75 congenital heart anomalies with 5 operative deaths [6.7%], consisting of 62 acyanotic cases with 2 deaths [3.2%] and 13 cases of cyanotic cases with 3 deaths [23.1]. In 33 patients of acquired valvular disease, 29 valves were implanted; 20 mitral valve replacement with 2 death [10%], 2 aortic valve replacement with 1 death [50%], 2 double valve replacement [MVR+AVR] and 2 open mitral commissurotomy plus aortic valve replacement with no death. Postoperative, Warfarin sodium was medicated with checking prothrombin time. Finally, the operative mortality was 9.2% in congenital anomaly, and 9.1% in acquired heart disease, overall mortality rate was 9.3%.

• Journal of Nutrition and Health
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• 제33권4호
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• pp.374-385
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• 2000

The purpose of the present study was to investigate the effect of Korea leek on plasm lipids and platelet aggregation in hypercholesterolemic rats fed different dietary fat. Sprague-Dawley rats were fed with hyperlipidemic diet for 4 weeks in order to induce hyperlipidemia, followed by the feeding of experimental diets for additonal 4 weeks. We used three kinds of lipid(perilla oil, corn oil and lard). Korean leek of experimental diets was prepared by drying and milling. Powdered Cellulose and powdered Korean leek were added to experimental diets at the level of 5% (w/w). Serum concentrations of total lipid, total triglyceride, total cholesterol and LDL-cholesterol decreased in the order of perilla oil, corn oil and lard. Korean leek significantly decreased total lipid, total cholesterol, LDL-cholesterol, platelet count, prothrombin time, and platelet aggregation in rats fed a lard diet. The present observation indicates that Korean leek might be helpful for the prevention and threapy of hyperlipidemia and platelet aggregation.

• 한국임상수의학회지
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• 제35권5호
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• pp.218-221
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• 2018

A 12-year-old, intact female Jindo was referred to our clinic due to the enlargement of all lymph nodes, as well as severe dyspnea. All palpatible lymph nodes were highly swelling and enlargement. The dog was diagnosed as end stage of multicentric lymphoma with multi-organ metastasis. In addition, the dog was diagnosed as having a pulmonary thromboembolism via computed tomography (CT) and D-dimer concentrations and prothrombin time (PT) results. This case report describes that lymphoma can be associated with pulmonary thromboembolism which is life threatening complication in dogs. The present case was managed successfully with chemotherapy and antithrombotic treatment.

• 대한한방내과학회지
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• 제16권2호
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• pp.136-145
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• 1995

In order to investigate the effect of Dohongsamultang and Dansameum upon restrain of thorombus formation through the experimental study, following conclusion has been obtained; 1. The number of plateletes was increased in the trial group compared with the control group, revealed significance in both of trial groups. 2. Fibrinogen was increased in trial group compared with control group, but the significance was revealed only in Sample I group of Dohongsamultang. 3. Prothrombin time was shortened in both of trial groups, but the significance was revealed in Sample I group of Dohongsa-multang. 4. FDP was decreased in both of trial groups, but the significance was revealed in Sample I group of Dohongsamultang.

• 사상체질의학회지
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• 제3권1호
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• pp.173-183
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• 1991

These studies were conducted about the effects of Ferric oxide in the aspect of the basic pharmacology through experimental animals with the investigation of its clinical effects on oriental medical literatures of Ferric oxide. The results were as follows: 1. The analgenic effects induced by acetic acid were significant. 2. The anticonvulsive effects induced by ECT unit were significant. 3. The sedative effects in Rotor rod method were significant. 4. The number of platelets was increased but not significantly. 5. Prothrombin time was decreased significantly. 6. Fibrinogen was increased but not significantly. 7. The degree of concentration of FDP was decreased significantly. According to the above results, it is considered that Ferric oxide retains effectiveness on the treatment of cerebral stroke.

• Journal of Chest Surgery
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• 제26권2호
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• pp.158-159
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• 1993

The hemorragic episode is the major problem of mechanical prosthesis, because of the necessity for anticoagulant therapy to prevent complication of thromboembolism. Double valve replacement was performed to 42 year old male due to aortic stenoinsufficiency and mitral stenosis. For anticoagulant therapy, the patient has been given wafarin under the control of prothrombin time 0.5-2 times of normal) in the our hospital. The patient was injuried the right pelvic area by waves in the beach 4 years after double valve replacement. Pelvic MRI scan showed huge hematoma in the right pelvic cavity. The patient was operated removal of intrapelvic hematoma.

• Journal of Chest Surgery
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• 제21권1호
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• pp.62-69
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• 1988

In the department of chest surgery of WonKwang university hospital, mechanical valve replacement was performed in 51 cases from June 1985 to September 1987. Among these, 32 cases were mitral valve replacement, 4 cases were aortic valve replacement, and 15 cases were double valve replacement. 26 cases were male and 25 cases were female and age distribution ranged from 16 years old to 63 years old. Early death within 30 days after operation was 2 cases [3.9%] and causes of death were right heart failure [1] and right ventricular wall rupture [1]. Among 49 early survivors, 2 cases of late death were developed and the causes of death were cardiomyopathy [1] and ventricular arrhythmia [1] Anticoagulant therapy was done with warfarin sodium to the level of 1.5-2 times of normal prothrombin time [20-40%] in 47 survivors. Symptomatically, 93.6% of preoperative NYHA functional class III or IV were converted to the NYHA functional class I or II during follow up.

• 대한의생명과학회지
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• 제18권3호
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• pp.237-243
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• 2012

This study was undertaken to know the effect of fat diet (for eight weeks) on changes of inflammatory markers [tumor necrosis factor (TNF-${\alpha}$) and prostaglandin $E_2$ ($PGE_2$)] and blood coagulation system [platelet aggregation function (PAF), prothrombin time (PT), activated partial thromboplastin time (aPTT)] in rats. Serum TNF-${\alpha}$, $PGE_2$, biochemical markers, PAF, PT, aPTT, and body weight were measured and compared between the control (normal diet-rats) and the fat group (fat diet-rats). The weights in the fat group were higher than those of the control group. TNF-${\alpha}$, $PGE_2$, glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and creatinine levels were greater in the fat group compared with the control group. The degree of platelet aggregation was lower, whereas PT and aPTT levels were longer in the fat group than in the control group. These findings have shown that fat diet may cause inflammatory response, diabetes, liver and renal dysfunction, and disturbances of fibrinolysis and coagulation system.

• BMB Reports
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• 제29권3호
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• pp.225-229
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• 1996

Effects on thrombin by an amphipathic cation, dequalinium, which has been recognized as an anticarcinoma agent were investigated with small chromogenic substrates such as Na-benzoyl-DL-argininep-nitroanilide (BApNA), H-D-phenylalanyl-L-pipecoyl-L-arginine-p-nitroanilide (S-2238), and Na-p-tosyl-L-arginine methyl ester (TAME). Among them, only TAME hydrolysis due to an esterase activity of the enzyme was significantly activated to 81% at 20 ${\mu}M$ dequalinium in the absence of NaCl. This stimulation became even higher in the presence of 0.2 M NaCl to 3.5-fold at 60 ${\mu}M$ dequalinium. This specific activation of thrombin was well correlated with the results of in vitro coagulation tests measuring the activated partial thromboplastin time (APTT) and the prothrombin time (PT) It is pertinent. therefore, to suggest that the esterase activity should be examined in addition to the effects on 5-2238 hydrolysis when especially any regulators not directed to an active site of thrombin need to be studied. We also expect that dequalinium could be a useful tool for studying structure-function relationship of thrombin and blood coagulation.

• Mycobiology
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• 제48권3호
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• pp.228-232
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• 2020

Cordyceps is a genus of ascomycete fungi and is well known as one of the important medical fungi in Chinese, Korea, and other Asian countries, because of its various beneficial effects on human health. The pharmacological activities of Cordyceps extract are mainly focused on anti-cancer, anti-metastatic, and immune modulating effects. In the present study, we investigated whether the antiplatelet effect of ethanol extract of cultured Cordyceps militaris (CMEE) with FeCl₃-induced arterial thrombosis model. We observed that CMEE exhibited a significant inhibitory effect against ADP and collagen-induced platelet aggregation. However, there were no significant differences in prothrombin time (PT) and activated partial thromboplastin time (aPTT). These results suggest that antithrombotic activity of CMEE is related to antiplatelet effect rather than anticoagulation effect, and CMEE may be a positive effect on improving blood circulation against vessel injury and occlusion.