• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2009년도 9th International Meeting on Information Display
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• pp.173-176
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• 2009

We suggest a new protective layer for PDP consists of SrO and MgO double layer. This double layer structure protects SrO layer from the contamination by $H_2O$ or $CO_2$ in the air and enable SrO to play as the main cathode material. It was confirmed that the high secondary electron emission characteristics of SrO by Xe ion can bring considerable driving voltage reduction and improvement of luminance and luminous efficacy in PDP.

• 대한정형외과스포츠의학회지
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• 제3권1호
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• pp.31-35
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• 2004

스포츠 인구의 증가와 함께 인라인 스케이트로 인한 부상의 빈도가 증가하고 있다. 이 논문의 목적은 인라인 스케이트의 종류와 기본 기술, 보호 장구 사용, 그리고 부상과 관련된 예상 인자 또는 기여 인자를 확인하는 것이다. 조정 미숙과 경험 부족이 부상의 요인이었다. 스케이트를 타는 동안 보호 장구의 사용 역시 미비 하였다. 결론적으로 안전한 교육 과정, 인라인 스케이트 타는 법과 보호 장구의 최적의 디자인과 효과가 추후 연구를 통해 규명되어야 할 것이다.

• Journal of Preventive Medicine and Public Health
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• 제15권1호
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• pp.33-46
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• 1982

1975년(年)부터 1980년(年)까지 6년간(年間) 대구시내(大邱市內) 3개(個) 종합병원(綜合病院)에 입원(入院)되어 결핵(結核)으로 확진(確診)된 14세이하(歲以下) 환자(患者) 416중(中) BCG접종여부(接種與否)가 명확(明確)한 314명(名)을 대상(對象)으로 대조군(對照群)의 성별(性別), 년령별(年齡別) BCG접종율(接種率)을 기준(基準)삼아 BCG효과를 평가(評價)한 결과(結果) 그 성적(成績)을 요약(要約)하면 다음과 같다. 총(總) 314명(名)의 결핵환자(結核患者)에 대하여 BCG의 결핵방지효과를 평가(評價)한 결과(結果) BCG비접종군(非接種群)이 접종군(接種群)에 비하여 결핵(結核)에 걸릴 위험도(危險度)가 3.5배(倍)나 높았으며, BCG의 발병방지효과는 71.8%로 나타났다. 결핵성뇌막염(結核性腦膜炎)의 경우 BCG비접종군(非接種群)이 접종군(接種群)보다 비교위험도(比較危險度)가 3.9배(倍) 높으며, BCG효과면에서는 74.3%의 발병방지효과를 나타내었다. 여아군(女兒群)이 남아군(男兒群)에 비하여 BCG효과가 높음을 인정(認定)할 수 있었다(p<0.05). 조립결핵(粟粒結核)을 동반(同伴)한 결핵성뇌막염(結核性腦膜炎)의 경우 비교위험도(比較危驗度)는 6.9이었으며 BCG효과는 85.6%로 나타났다. 폐결핵(肺結核)을 동반(同伴)한 결핵성뇌막염(結核性腦膜炎)의 경우 비교위험도(比較危驗度)는 7.4이였으며 발병방지효과는 86.5%로 나타났고, 남아군(男兒群)이 여아군(女兒群)보다 그 효과가 현저(顯著)히 높았다(p<0.05). 조립결핵(粟粒結核)의 경우 비교위험도(比較危驗度)는 2.1이며 발병방지효과는 51.9%였으며, 폐결핵(肺結核)의 경우는 각각(各各) 2.2 및 54.7%로 나타났다. 폐결핵(肺結核)을 제외한 전결핵(全結核)의 경우 비교위험도(比較危驗度)는 4.1, BCG효과는 75.3%로 나타났으며,폐결핵(肺結核)에 비하여 결핵성뇌막염(結核性腦膜炎) 및 타결핵(他結核)을 동반(同伴)한 결핵성뇌막염(結核性腦膜炎)에서 발병방지효과가 현저(顯著)하게 높았다(p<0.05). 이상을 종합(綜合)하면 BCG효과에 부정적(否定的)인 역할(投割)을 할 여러가지 방해요인(妨害要因)이 있음에도 불구하고 질적(質的)으로 중증(重症)인 결핵성뇌막염(結核性腦膜炎)에서는 거의 80%의 예방력(豫防力), 조립결핵(粟粒結核) 및 폐결핵(肺結核)에서는 약 50%의 발병방지효과를 관찰(觀察)할 수 있었다. 따라서 결핵관리사업(結核管理事業)으로 BCG접종(接種)의 권장(勸奬)이 계속(繼續) 요망(要望)된다.

• Journal of Microbiology and Biotechnology
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• 제28권1호
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• pp.136-144
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• 2018

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Bacillus Calmette-$Gu\acute{e}rin$ (BCG) vaccine is the only TB vaccine currently available, but it is not sufficiently effective in preventing active pulmonary TB or adult infection. With the purpose of developing an improved vaccine against TB that can overcome the limitations of the current BCG vaccine, we investigated whether adjuvant formulations containing de-O-acylated lipooligosaccharide (dLOS) are capable of enhancing the immunogenicity and protective efficacy of TB subunit vaccines. The results revealed that the dLOS/dimethyl dioctadecyl ammonium bromide (DDA) adjuvant formulation significantly increased both humoral and Th1-type cellular responses to TB subunit vaccine that are composed of three antigens, Ag85A, ESAT-6, and HspX. The adjuvanted TB vaccine also effectively induced the Th1-type response in a BCG-primed mouse model, suggesting a potential as a booster vaccine. Finally, the dLOS/DDA-adjuvanted TB vaccine showed protective efficacy against M. tuberculosis infection in vitro and in vivo. These data indicate that the dLOS/DDA adjuvant enhances the Th1-type immunity and protective efficacy of the TB subunit vaccine, suggesting that it would be a promising adjuvant candidate for the development of a booster vaccine.

• Journal of Microbiology and Biotechnology
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• 제27권8호
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• pp.1539-1548
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• 2017

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen that commonly causes fatal infections in cystic fibrosis and burn patients as well as in patients who are hospitalized or have impaired immune systems. P. aeruginosa infections are difficult to treat owing to the high resistance of the pathogen to conventional antibiotics. Despite several efforts, no effective prophylactic vaccines against P. aeruginosa are currently available. In this study, we investigated the activity of the CIA06 adjuvant system, which is composed of alum and de-O-acylated lipooligosaccharide, on a P. aeruginosa outer membrane protein (OMP) antigen vaccine in mice. The results indicated that CIA06 significantly increased the antigen-specific IgG titers and opsonophagocytic activity of immune sera against P. aeruginosa. In addition, the antibodies induced by the CIA06-adjuvanted vaccine exhibited higher cross-reactivity with heterologous P. aeruginosa strains. Finally, mice immunized with the CIA06-adjuvanted vaccine were effectively protected from lethal P. aeruginosa challenge. Based on these data, we suggest that the CIA06 adjuvant system might be used to promote the immunogenicity and protective efficacy of the P. aeruginosa OMP vaccine.

• The Plant Pathology Journal
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• 제26권4호
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• pp.360-366
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• 2010

In the course of a searhing environmental friendly antifungal compounds, we found that mixture of methyl esters of fatty acids obtained from soybean oil had potent control efficacy against barley powdery mildew (Blumeria graminis f. sp. hordei). In this study, ten alkyl fatty acid esters (AFAEs) were tested for in vivo antifungal activity against five plant diseases such as rice blast, rice sheath blight, tomato gray mold, tomato late blight and barley powdery mildew. Some AFAEs showed the most control efficacy against barley powdery mildew among the tested plant diseases. By 5-hr protective and 1-day curative applications, six AFAEs ($3,000\;{\mu}g/ml$), including methyl and ethyl palmitates, methyl and ethyl oleates, methyl linoleate, and methyl linolenate demonstrated both curative and protective activities against barley powdery mildew. In contrary, methyl laurate strongly controlled the development of powdery mildew on barley plants by curative treatment at a concentration of $333\;{\mu}g/ml$, but did not show protective activity even at $3,000\;{\mu}g/ml$. Under greenhouse conditions, the seven AFAEs ($1,000\;{\mu}g/ml$) except for methyl and ethyl stearates, and methyl caprylate also effectively controlled cucumber powdery mildew caused by Podosphaera xanthii. Among them, methyl and ethyl palmitates ($333\;{\mu}g/ml$) represented the most control activity of more than 68% against the disease. The results are the first report on the antifungal activity of methyl and ethyl esters of fatty acids against plant pathogenic fungi.

• IMMUNE NETWORK
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• 제12권1호
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• pp.8-17
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• 2012

Background: Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract diseases in infancy and early childhood. Despite its importance as a pathogen, there is no licensed vaccine against RSV yet. The attachment glycoprotein (G) of RSV is a potentially important target for protective antiviral immune responses. Recombinant baculovirus has been recently emerged as a new vaccine vector, since it has intrinsic immunostimulatory properties and good bio-safety profile. Methods: We have constructed a recombinant baculovirus-based RSV vaccine, Bac-RSV/G, displaying G glycoprotein, and evaluated immunogenicity and protective efficacy by intranasal immunization of BALB/c mice with Bac-RSV/G. Results: Bac-RSV/G efficiently provides protective immunity against RSV challenge. Strong serum IgG and mucosal IgA responses were induced by intranasal immunization with Bac-RSV/G. In addition to humoral immunity, G-specific Th17- as well as Th1-type T-cell responses were detected in the lungs of Bac-RSV/G-immune mice upon RSV challenge. Neither lung eosinophilia nor vaccine-induced weight loss was observed upon Bac-RSV/G immunization and subsequent RSV infection. Conclusion: Our data demonstrate that intranasal administration of baculovirus-based Bac-RSV/G vaccine is efficient for the induction of protection against RSV and represents a promising prophylactic vaccination regimen.

• 동의생리병리학회지
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• 제24권6호
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• pp.1042-1052
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• 2010

This study aimed to evaluate the protective effects of Mundongcheongpye-eum (MCE) on elastase-induced lung injury. The extract of MCE was treated to A549 cells and elastase-induced lung injury mice model. Then, various parameters such as cell-based cyto-protective activity and histopathological finding were analyzed. MCE showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, protein level of cyclin B1, Cdc2, and Erk1/2, and gene expression of TNF-${\alpha}$ and IL-$1{\beta}$ in A549 cells. MCE treatment also revealed the protective effect on elastase-induced lung injury in mice model. This effect was evidenced via histopathological finding including immunofluence stains against elastin, collagen, caspase 3, and protein level of cyclin B1, Cdc2, and Erk1/2 in lung tissue. These data suggest that MCE has a pharmaceutical properties on lung injury. This study would provide an scientific evidence for the efficacy of MCE for clinical application to patients with chronic obstructive pulmonary disease.

• 전기학회논문지
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• 제61권2호
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• pp.243-250
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• 2012

In this study, we attempted to reduce firing voltage of AC-PDP by alloying MgO protective Layer with CaO. Also, spray coating of single crystal MgO powder has been used to improving Exo-electron emission characteristics and reducing the statistical discharge delay in plasma displays. The properties of discharge depending upon the single crystal MgO powder are investigated. Plasma display having powder coated MgCaO Protective Layer shows lower driving voltage and higher efficacy than of uncoated, conventional panel.

• 대한의생명과학회지
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• 제28권4호
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• pp.307-311
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• 2022

The extract of EA lacks studies showing its efficacy other than that it contains caffeic acid, an active compound that has antioxidant and neuroprotective effects on nerve cells. Therefore, in this study, we attempted to determine the effectiveness of EA extraction. In this study, we performed a DPPH assay to determine the antioxidant potential of EA. And then, the cytotoxic concentration of EA in HaCaT keratinocytes was determined, and the antioxidant effect was determined by measuring the malondialdehyde (MDA). The results of DPPH, a chemical antioxidant assay, clearly demonstrated the antioxidant capacity of EA extracted with distilled water. In addition, cell-based assays provide useful information on the protective effect of EA on oxidative stress-induced apoptosis.