• Journal of Physiology & Pathology in Korean Medicine
• /
• v.29 no.1
• /
• pp.58-65
• /
• 2015

This study is designed to investigate the protective effects of fermented Red Ginseng (FRG) against photoaging in vitro and in vivo. UVB was irradiated to the human keratinocyte HaCaT cell and dorsal skin of SKH-1 mice for the induction of photoaging. After treatment of non-fermented red ginseng (NRG), fermented red ginseng (FRG), and fortified fermented red ginseng (FFRG) to the UVB irradiated HaCaT cell, ROS production and activity of MMP-9 were examined by DCFC-DA assay and gelatin zymographic assay respectively. UVB irradiated SKH-1 mice were treated with NRG, FRG, and FFRG via oral(300 mg/Kg B.W./day) and topical($100{\mu}{\ell}/mouse/day$) route.All of NRG, FRG, and FFRG had significantly reduced the intracellular ROS production elicited by UVB, among them FRG slightly more reduced the ROS production than NRG and FFRG. FFRG had slightly more reduced the MMP-9 activity in UVB irradiated HaCaT cells than NRG and FFRG in high dose. Oral and topical treatment of NRG, FRG, and FFRG had decreased the expression of matrix metalloproteinase-2, -3, and -9 in dorsal skin of UVB irradiated mice. Among them, inhibitory effect of FRG on the expression of MMP-2 was apparent. We speculate that FRG has therapeutic potentials on the UVB irradiated photoaging.

• Food Science and Biotechnology
• /
• v.15 no.3
• /
• pp.380-384
• /
• 2006

Sprague-Dawley rats (n=32) were fed a diet containing basal (control), cellulose (5%), or alcohol insoluble residue (AIR) (5%) extracted from the stem and root barks of elm (Ulmus davidiana var. japonica Nakai) for 4 weeks. The effects of the diets, on gastrointestinal functions and morphology were evaluated. The weight gains, food intake, and food efficiencies for the cellulose and AIR diet-fed groups were not significantly different from those of the AIR-free (basal) diet. The gastrointestinal transit times of the stem and root bark AIR diets were significantly reduced (p<0.01) compared to the basal diet, and were slower than those of the cellulose diet. The fecal weights of the stem and root bark AIR diets were significantly increased (p<0.01) up to 4-fold compared to those of the basal diet. The height of the mucosal villi, and mucosal and muscle layer thicknesses of the colon were greater and more developed in the stem and root bark AIR diets (p<0.01) than in the basal diet. The villus heights in the jejunum and the colon mucosal goblet cells were more developed in the order of cellulose > stem bark AIR > root bark AIR diets.

• Journal of Biomedical Engineering Research
• /
• v.24 no.6 s.81
• /
• pp.501-507
• /
• 2003

Medical devices for helping the rehabilitation of the patients such as orthoses and prostheses should be designed to be strong enough. For the strength design, operational load should be identified first. Furthermore. medical devices are susceptible to dynamic load or shock frequently due to its characteristics. These type of the load may be identified by installing the sensors directly. However, it can modify the natural properties of the structures. Therefore, operational load should be identified indirectly from the system characteristics and responses such as vibrations. In this paper, the basic formulation of the indirect load identification is reviewed and the problems of conventional approach are checked. Then, the new approach based upon the principal component analysis is proposed and the validity of the proposed method is demonstrated using experiments.

• Journal of Biomedical Engineering Research
• /
• v.21 no.4
• /
• pp.385-390
• /
• 2000

The alignment of the prosthetics is very important in an amputee's gait. In the present study. a static prosthesis-alignment device was developed. It consisted of a force plate with four load cells, a laser beam controlled by a step motor, and a control part programmed by PCBASIC. Using the static prosthesis-alignment device, we measured the distance between the load line and various joints of 24 normal volunteers in three standing postures. such as neutral, forward leaning, and backward leaning. Only neutral postures were evaluated on four trans-tibial amputees. The load line for the normal person's neutral position located anterior to the ankle, the knee, and the greater trochanter, but posterior to the shoulder joint. Forward and backward leaning of the normal person resulted in a significant anterior and posterior movements of the load line, respectively. The load line for the amputated side of the trans-tibial amputee also located anterior to the ankle, the extremity prostheses, providing a good relative locations of the load line with respect to various joints.

• Archives of Plastic Surgery
• /
• v.46 no.4
• /
• pp.303-310
• /
• 2019

Background Prosthetic hands with a myoelectric interface have recently received interest within the broader category of hand prostheses, but their high cost is a major barrier to use. Modern three-dimensional (3D) printing technology has enabled more widespread development and cost-effectiveness in the field of prostheses. The objective of the present study was to evaluate the clinical impact of a low-cost 3D-printed myoelectric-interface prosthetic hand on patients' daily life. Methods A prospective review of all upper-arm transradial amputation amputees who used 3D-printed myoelectric interface prostheses (Mark V) between January 2016 and August 2017 was conducted. The functional outcomes of prosthesis usage over a 3-month follow-up period were measured using a validated method (Orthotics Prosthetics User Survey-Upper Extremity Functional Status [OPUS-UEFS]). In addition, the correlation between the length of the amputated radius and changes in OPUS-UEFS scores was analyzed. Results Ten patients were included in the study. After use of the 3D-printed myoelectric single electromyography channel prosthesis for 3 months, the average OPUS-UEFS score significantly increased from 45.50 to 60.10. The Spearman correlation coefficient (r) of the correlation between radius length and OPUS-UEFS at the 3rd month of prosthetic use was 0.815. Conclusions This low-cost 3D-printed myoelectric-interface prosthetic hand with a single reliable myoelectrical signal shows the potential to positively impact amputees' quality of life through daily usage. The emergence of a low-cost 3D-printed myoelectric prosthesis could lead to new market trends, with such a device gaining popularity via reduced production costs and increased market demand.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
• /
• v.25 no.1
• /
• pp.63-70
• /
• 2019

Background: The purpose of this study was to determine the effects of a pelvic compression belt on gait abilities and balance in subacute stroke patients. Methods: Twenty two patients with subacute were recruited and randomly assigned into two group: Two group offered conventional physical therapy and occupational therapy for five day. The group was composed of twelve patients. Participants in the experimental group were given the pelvic compression belt and conventional physical therapy, conventional occupational therapy, although conventional physical therapy and occupational therapy provided in the subjects in the control group. To assess the gait ability, the GAITRITE system was used and the Balance system SD was used to test balance. All measurements were performed before and after intervention. Results: The experimental group shows a significant improvement the cadence, velocity, step length and stride length in gait (p<.05) and show significant increase in the dynamic standing balance (p<.05). However, control group shows a significant improvement the cadence, velocity, step length and stride length in gait (p<.05), but shows no significant differences in dynamic standing balance. Furthermore, there were significant differences gait velocity, dynamic standing balance between two groups (p<.05). Conclusions: The results demonstrated that the elastic pelvic belt application is effective to improve gait velocity, dynamic balance in the subacute stroke patients. Thus, the elastic pelvic belt is seemed to be one of the potential methods to facilitate the active rehabilitation program for hemiplegia patients.

• The Journal of Korean Academy of Prosthodontics
• /
• v.57 no.3
• /
• pp.232-237
• /
• 2019

CAD/CAM technology has already been used in most areas of prosthetics. The range of CAD/CAM application in denture fabricating process has been gradually increasing since the CAD/CAM technology was introduced for the fabrication of complete dentures in 1994. This paper describes a technique that combines conventional and CAD/CAM technology for the fabrication of complete dentures: the master casts from a conventional impression techniques were scanned first, and the wax denture was fabricated using Amann Girrbach's Ceramill full denture system (fds). The purpose of this paper is to introduce the case in which making an esthetically and functionally satisfied denture in shorter time is possible with CAD/CAM technology.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
• /
• v.27 no.1
• /
• pp.1-11
• /
• 2021

Background: The purpose of this study is to identify the elements for the construction of the Korean academy of orthopedic manipulative physical therapy's (KAOMPT's) non-face-to-face lecture system using the Delphi method. Methods: The Delphi method was applied to 50 expert panel members of the Central Committee and the Provincial Branch of the KAOMPT. The Delphi survey was conducted in two rounds, and the first Delphi survey collected opinions on 40 questions on 12 topics. The second Delphi survey was collected into 25 questions on 4 topics. As a result of the survey, the content validity ratio (CVR), consensus and convergence were measured. Referring to the number of expert panels and previous studies were determine a CVR of at least 2.29, a consensus of at least .75 and a convergence of 0 to .5. Result: In the first Delphi result, out of the total 40 items, 20 items with high content validity ratio were found, and 10 items found double agreement. In the second Delphi result, 13 out of the total 25 items had a content validity ratio higher than 2.29, and 5 items found a double agreement. Conclusion: This study derived items on the role of central and municipal councils, lecture support and lecture room construction, non-face regular course and special lecture operation and personnel for the establishment of non-face-to-face lecture system. Based on this content, it is expected that it will help establish a non-face-to-face lecture system in 2021 through a pilot non-face-to-face lecture that will be implemented in the future.

• Journal of Technologic Dentistry
• /
• v.43 no.2
• /
• pp.56-61
• /
• 2021

Purpose: This study aimed to produce resin prosthetics using a dental automatic barrel finishing. Surface roughness and surface topography of resins were observed according to the grinding time of the dental automatic barrel finishing. Methods: This study was performed with thermopolymer, autopolymer, and photopolymer resins. The dimensions of the specimen were 10×10×2 mm. Each specimen was polymerized according to the manufacturer's instructions. The polymerized resin was honed for 30 minutes at 5-min intervals in a dental automatic barrel finishing. The specimen was observed using a three-dimensional (3D) optical microscope, and the surface roughness was measured. Results: After the polishing with the dental automatic barrel finishing, the heat-cured (HC) specimen showed the highest and lowest values of Ra after 10 and 15 minutes, respectively. The self-cured (SC) specimen showed the highest and lowest values of Ra after 10 and 25 minutes, respectively. Finally, the 3D specimen showed the highest and lowest values of Ra after 5 and 20 minutes, respectively. Conclusion: After measuring the surface roughness of the three types of resins according to the grinding time of the dental automatic barrel finishing, the lowest Ra values for the HC, SC, and 3D specimens were measured after 15, 25, and 20 minutes, respectively. Therefore, we concluded that a limit on the grinding time of the resin using a dental automatic barrel finishing is needed.

• Journal of The Korean Society of Integrative Medicine
• /
• v.8 no.4
• /
• pp.125-131
• /
• 2020

Purpose : Lower extremity orthoses have been used as conservative methods to recover gait of the stroke patients. The purpose of this study is to examine how newly designed pelvic belt orthosis can improve gait ability and dynamic balance of adults with Hemiparesis after stroke. Methods : 22 patients who had hemiparesis after stroke participated in this study. Two groups were randomly created by assigning 10 subjects to the experimental group and the rest of the 12 subjects to the control group. The control group was treated by conventional physical therapy and occupational therapy. Identical therapy protocols were used to treat the experimental group who were assigned to wear the pelvic belt orthosis during post measurement. This study has a group of independent variables including group, gender, age, height, MAS, lesion side, cause and a group of dependent variables including gait speed, cadence, step length, stride length, and dynamic balance. The GAITRite system was used to measure spatial-temporal gain parameters and the balance system SD to measure dynamic balance. The data was analyzed using R version 3.3.1. Random forest, boosting algorithm, and MANOVA test were conducted to determine the effects of independent variables on dependent variables. Results : This study has a group of independent variables including group, gender, age, height, MAS, lesion side, cause and a group of dependent variables including gait speed, cadence, step length, stride length, and dynamic balance. The independent variable "group" has the most important value, which is approximately 25.42 (%IncMSE) representing a value three times greater than the second important predictor "height." Conclusion : As a result of this research, the hypothesis is validated with conclusion that Pelvic Belt orthosis could be effectively used for improving gait ability and balance of the patients with post-stroke hemiparesis.