• Biomolecules & Therapeutics
• /
• v.26 no.2
• /
• pp.146-156
• /
• 2018

Spermidine is a naturally occurring polyamine compound that has recently emerged with anti-aging properties and suppresses inflammation and oxidation. However, its mechanisms of action on anti-inflammatory and antioxidant effects have not been fully elucidated. In this study, the potential of spermidine for reducing pro-inflammatory and oxidative effects in lipopolysaccharide (LPS)-stimulated macrophages and zebrafish was explored. Our data indicate that spermidine significantly inhibited the production of pro-inflammatory mediators such as nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$), and cytokines including tumor necrosis $factor-{\alpha}$ and $interleukin-1{\beta}$ in RAW 264.7 macrophages without any significant cytotoxicity. The protective effects of spermidine accompanied by a marked suppression in their regulatory gene expression at the transcription levels. Spermidine also attenuated the nuclear translocation of $NF-{\kappa}B$ p65 subunit and reduced LPS-induced intracellular accumulation of reactive oxygen species (ROS) in RAW 264.7 macrophages. Moreover, spermidine prevented the LPS-induced NO production and ROS accumulation in zebrafish larvae and was found to be associated with a diminished recruitment of neutrophils and macrophages. Although more work is needed to fully understand the critical role of spermidine on the inhibition of inflammation-associated migration of immune cells, our findings clearly demonstrate that spermidine may be a potential therapeutic intervention for the treatment of inflammatory and oxidative disorders.

• Applied Chemistry for Engineering
• /
• v.17 no.1
• /
• pp.73-81
• /
• 2006

Heat treatment condition for the stabilization of foamed glass block through the foaming process of the hydrolized waste glass was investigated and scale-up test for the manufacturing of foamed glass was also attempted for the actual foaming process. Proper heat treatment condition was quenching from the foaming temperature to $550{\sim}600^{\circ}C$ for stabilization, and then annealing from stabilization temperature to $200^{\circ}C$ and holding up at $200^{\circ}C$ for removal thermal stress, and then annealing to the room temperature with cooling speed of $0.3^{\circ}C/min$. Through this heat treatment conditions, foamed glass block with size of $250mm{\times}250mm{\times}90mm$ was produced successfully. The properties of this foamed glass block showed density of $0.28{\pm}0.06g/cm^3$, thermal conductivity of $0.048{\pm}0.005kcal/hm^{\circ}C$, moisture absorption of $0.5{\pm}0.09vol%$, linear expansion coefficient of $(8.6{\pm}0.2){\times}10^{-6}m/m^{\circ}C$($400^{\circ}C$), flexural strength of $15.0{\pm}0.6kg/cm^2$, and compression strength of $39.5{\pm}0.6kg/cm^2$.

• Journal of the Korean Wood Science and Technology
• /
• v.37 no.3
• /
• pp.184-191
• /
• 2009

In the southern part of the Korean Peninsula including Jeju-island, the production amount of domestic cedar has increased gradually. However, their low qualities, expected to be caused by the low density and frequent knots, have restricted their practical utilization as the high value-added products. In this study, it is aimed to look for the new uses of domestic cedar and to examine the applicability for lamination lumbers of structural glued laminated timber (glulam). Above all, machine stress ratings for individual sawn lumbers confirmed that modulus of elasticity (MOE) of cedar lumber was lower than that of other common softwood species in Korea. On the other hand, cedar lumbers have enough stiffness to manufacture the structural glulam in accordance with Korean Industrial Standard (KS). The bonding strength and durability also met the KS limitation. Nevertheless, from the result of bending tests for cedar glulam, it was shown that the modulus of elasticity (MOE) did not meet the KS limitation. Therefore, it was concluded that additional researches were needed for reinforcing the stiffness of cedar glulam.

• Proceedings of the Korean Institute of Surface Engineering Conference
• /
• 2003.10a
• /
• pp.134-135
• /
• 2003

The dental implant materials required good mechanical properties, such as fatigue strength, combined with a high resistance to corrosion. For increasing fatigue resistance and delaying onset of stress corrosion cracking, shot peening has been used for > 50 years to extend service life of metal components. However, there is no information on the electrochemical behavior of shot peened and hydroxyapatite(HA) coated Ti-6Al-4V alloys. To increase fatigue strength, good corrosion resistance, and biocompatibility, the electrochemical characteristics of Ti/TiN/HA coated and shot peened Ti-6Al-4V alloys by electron beam physical vapor deposition(EB-PVD) have been researched by various electrochemical method in 0.9%NaCl. Ti-6Al-4V alloys were prepared under the condition of hydrogen and vacuum arc furnace. The produced materials were quenched at 1000$^{\circ}C$ under high purity dried Ar atmosphere and were hold at 500$^{\circ}C$ for 2 hrs to achieve the fatigue strength(1140㎫) of materials. Ti-6Al-4V alloys were prepared under the condition of hydrogen and vacuum arc furnace. Shot peening(SP) and sand blasting treatment was carried out for 1, 5, and 10min. On the surface of Ti-6Al-4V alloys using the steel balls of 0.5mm and alumina sand of 40$\mu\textrm{m}$ size. Ti/TiN/HA multilayer coatings were carried out by using electron-beam deposition method(EB-PVD) as shown Fig. 1. Bulk Ti, powder TiN and hydroxyapatite were used as the source of the deposition materials. Electrons were accelerated by high voltage of 4.2kV with 80 - 120mA on the deposition materials at 350$^{\circ}C$ in 2.0 X 10-6 torr vacuum. Ti/TiN/HA multilayer coated surfaces and layers were investigated by SEM and XRD. A saturated calomel electrode as a reference electrode, and high density carbon electrode as a counter electrode, were set according to ASTM GS-87. The potentials were controlled at a scan rate of 100 mV/min. by a potentiostat (EG&G Co.273A) connected to a computer system. Electrochemical tests were used to investigate the electrochemical characteristics of Ti/TiN/HA coated and shot peened materials in 0.9% NaCl solution at 36.5$^{\circ}C$. After each electrochemical measurement, the corrosion surface of each sample was investigated by SEM.

• Journal of the Korean Vacuum Society
• /
• v.22 no.4
• /
• pp.188-192
• /
• 2013

Many studies have been conducted for preventing from diffusion between silicon wafer and metallic thin film due to a decrease of line-width and multi-layer thin film for miniaturization and high integration of semiconductor. This paper has focused on the nano-mechanical property of diffusion barrier which sample is prepared for various gas flow rate of nitrogen with tungsten (W) base from 2.5 to 10 sccm. The deposition rate, resistivity and crystallographic properties were measured by a ${\beta}$-ray back-scattering spectroscopy, 4-point probe and x-ray diffraction (XRD), respectively. We also has investigated the nano-mechanical property using the nano-indenter. As a result, the surface hardness of W-N thin film was increased rapidly from 10.07 to 15.55 GPa when the nitrogen gas flow was increased from 2.5 to 5 sccm. And the surface hardness of W-N thin film had 12.65 and 12.77 GPa at the nitrogen gas flow of 7.5 and 10 sccm respectively. These results were decreased by the comparison with the W-N thin film at nitrogen gas flow of 5 sccm. It was inferred that these severe changes were caused by the stoichiometric difference between the crystalline and amorphous state in W-N thin film. In addition, these results were caused by increased compressive stress.

• Fire Science and Engineering
• /
• v.23 no.6
• /
• pp.66-74
• /
• 2009

When a fire occurs, the concrete structure's strength decreases by the increasing temperature under the fire in certain condition of constant load. And, the ratio of the axial force is changed by such decreased strength so that the structure is deformed. In this research, considering such case, we have conducted an actual fire test for the concrete lining with constant loading condition and various fire conditions. The specimen adopts the shape condition for small practical specimen defined by the EFNARC and we used 24MPa, 40MPa and 50MPa to analyze the thermal properties by the strength. The ratio of loading is imposed by a certain loading condition based on 20% and 40% of the sectional stress in concrete and MHC Fire is selected to realize the thermal impact of the concrete by rapid increasing temperature. As the result of the experiment, in the same ratio of loading, the 50MPa specimen shows more cracks and spalling as time goes on. The area damaged by the fire, according to the functional criteria of the concrete lining under the fire in ITA, does not satisfy with the standard in lack of 50mm depth from the heating surface at total 200mm lining.

• Korean Journal of Construction Engineering and Management
• /
• v.22 no.2
• /
• pp.31-41
• /
• 2021

The purpose of this study is to analyze the properties of previous studies related to vocations in the construction field. The results of the analysis are as follows. First, The paper has not been published at the beginning of the establishment of the academic foundation for vocational studies, but there was a marked increase over the next 15 years. Second, research related to vocations in the construction field has been more active in engineering than in social science. Third, the primary data method was used much more than the secondary data method, and the quantitative research method through a questionnaire was the most common research method. Fourth, human objects showed the highest frequency as 78.9%, and among them, technicians was the most. Fifth, as the research topic, psychological and behavioral aspects such as job satisfaction, job stress, turnover intention, and organizational commitment were dealt with most, and structural and environmental aspects such as national job competency standards, job analysis, construction accidents, and career development. It was also found that the topic of the research was actively being dealt with.

• Journal of the Microelectronics and Packaging Society
• /
• v.28 no.1
• /
• pp.55-60
• /
• 2021

In order to produce wearable displays with high adhesion while maintaining flexible characteristics, the adhesive method using electro plating method was carried out. Laser lift-off (LLO) transcription was also used to remove sapphire substrates from LEDs bonded to fibers. Afterwards, the SEM and EDS data of the sample, which conducted the adhesion method using electro plating, confirmed that copper actually grows through the lattice of the fiber fabric to secure the light source and fiber. The adhesion characteristics of copper were checked using Universal testing machine (UTM). After plating adhesion, the characteristics of the LLO transcription process completed and the LED without the transcription process were compared using probe station. The electroluminescence (EL) according to the enhanced current was measured to check the characteristics of the light source after the process. As the current increases, the temperature rises and the bandgap decreases, so it was confirmed that the spectrum shifted. In addition, the change in the electrical characteristics of the samples according to the radius change is confirmed using probe station. The radius strain also had mechanical strength that copper could withstand bending stress, so the Vf variation was measured below 6%. Based on these results, it is expected that it will be applied to batteries, catalysts, and solar cells that require flexibility as well as wearable displays, contributing to the development of wearable devices.

• Tunnel and Underground Space
• /
• v.31 no.6
• /
• pp.561-577
• /
• 2021

The compacted bentonite buffer in a geological repository for high-level radioactive waste disposal is saturated due to groundwater inflow. Saturation of the bentonite buffer results in bentonite swelling and bentonite penetration into the rock discontinuities present around the disposal hole. The penetrated bentonite is exposed to groundwater flow and can be eroded out of the repository, resulting in bentonite mass loss which can affect the physical integrity of the engineered barrier system. Hence, the evaluation of buffer-rock interactions and coupled behavior due to groundwater inflow and bentonite penetration is necessary to ensure long-term disposal safety. In this study, the effects of the bentonite penetration and swelling on the physical properties of jointed rock mass were evaluated using the quasi-static resonant column test. Jointed rock specimens with bentonite penetration were manufactured using Gyeongju bentonite and hollow cylindrical granite rock discs obtained from the KAERI underground research tunnel. The effects of vertical stress and saturation were assessed using the P-wave and S-wave velocities for intact rock, jointed rock and jointed rock with bentonite penetration specimens. The joint normal and joint shear stiffnesses of each joint condition were inferred from the wave velocity results assuming an equivalent continuum. The joint normal and joint shear stiffnesses obtained from this study can be used as input factors for future numerical analysis on the performance evaluation of geological waste disposal considering rock discontinuities.

• Journal of the Korean Geotechnical Society
• /
• v.24 no.8
• /
• pp.25-34
• /
• 2008

A new hybrid oedometer cell is designed and manufactured to investigate a behavior of soft soils by using elastic and electromagnetic waves during consolidation test. Bender elements, which generate and detect shear waves, are placed in the top cap and the bottom plate and mounted on the oedometer wall. Double wedge type electrical resistance probe, which measures local void ratio change, is positioned onto the top cap of the oedometer cell. The bender elements and the electrical resistance probe are anchored into a nylon set screw with epoxy resin. The nylon set screw with epoxy resin minimizes directly transmited elastic waves through the oedometer cell due to impedence mismatch and allows for easy replacement of defected bender elements and electrical resistance probe. Primary consolidation time can be estimated from the slope of electrical resistance versus log time curve and the evolution of shear wave velocity. The shear wave velocity can be used to assess inherent anisotropy when disturbance effects are minimized because particle alignment affects the shear wave velocity. The void ratios evaluated by the electrical resistance probe are similar to those by the settlement during consolidation. This study suggests that the shear wave velocity and the electrical resistance can provide complementary imformations to understand consolidation characteristics such as primary consolidation, anisotropy, and void ratio.