• Molecules and Cells
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• v.45 no.11
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• pp.763-770
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• 2022

Caenorhabditis elegans has been used as a major model organism to identify genetic factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) regulates aging in many species, ranging from nematodes to humans. C. elegans is a nonpathogenic genetic nematode model, which has been extensively utilized to identify molecular and cellular components that function in organismal aging and longevity. Here, we review the recent progress in the role of IIS in aging and longevity, which involves direct regulation of protein and RNA homeostasis, stress resistance, metabolism and the activities of the endocrine system. We also discuss recently identified genetic factors that interact with canonical IIS components to regulate aging and health span in C. elegans. We expect this review to provide valuable insights into understanding animal aging, which could eventually help develop anti-aging drugs for humans.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.2665-2669
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• 2003

A wearable device to assist fingering function for disabled is developed in this study. This is the second paper to report the progress in development of this assisting device. The device is developed for a patient who suffers from cervical spinal cord injury. In the first paper, it was reported that the patient could successfully pick up several types of objects with his paralyzed fingers by using this device. As a next step, the maneuverability of the device under grasping operation is discussed in this paper. Maneuverability of the system is experimentally evaluated. The dexterity in controlling finger force is compared between the cases that non-disabled examinees operate their finger with inherent abilities and that a disabled examinee operates his finger by using the assisting device.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.1741-1744
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• 2005

In this paper, we proposed an adaptive skill element based on error signal. We assume that human progress their skills of actions based on errors, then an inverse dynamic of human motion have to changes. Human controller consists from feedback element (FB) and feed forward element (FF) and their elements cooperate to control actions. Under the assumption, we vary the connection of FF and FB by error signal. We propose the index function for change of a skill parameter. From results of the numerical simulations for the varying skill parameter with index function, we consider that the position error given by our vision changes the skill element and we confirm that the position error is the one of the estimate function for the improvement in our skill.

• Journal of Electrical Engineering and Technology
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• v.8 no.3
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• pp.428-435
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• 2013

Flexible AC Transmission System (FACTS) application study on enhancing the flexibility of AC power system has continued to make progress. A thyristor-controlled series capacitor (TCSC) is a useful FACTS device that can control the power flow by adjusting line impedances and minimize the loss of power flow and voltage drop in a transmission system by adjusting line impedances. Reduced power flow loss leads to increased loadability, low system loss, and improved stability of the power system. This study proposes the optimal location and compensation rate method for TCSCs, by considering both the power system loss and voltage drop of transmission systems. The proposed method applies a multi-objective function consisting of a minimizing function for power flow loss and voltage drop. The effectiveness of the proposed method is demonstrated using IEEE 14- and a 30-bus system.

• Progress in Medical Physics
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• v.3 no.2
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• pp.67-81
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• 1992

Lots of physical phenomena which deteriorate the faithfulness of radiological images exist. The most common types of degradation are a loss of resolution and an increase in noise. This article deals with resolution. factors that influence it. and its characterisation. The problem of resolution failure due to a generic blurring phenomenum is described diagramatically and mathematically. for both one dimensional and two dimensional signals. The definition of the point spread function. the line spread function. the convolution integral and the modulation transfer function are made. The concept of frequency domain operations using the Fourier Transform is also discussed.

• Osteoporosis and Sarcopenia
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• v.3 no.3
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• pp.117-122
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• 2017

Sarcopenia is the degenerative loss of muscle mass and function with aging. Recently sarcopenia was recognized as a clinical disease by the International Classification of Disease, 10th revision, Clinical Modification. An imbalance between protein synthesis and degradation causes a gradual loss of muscle mass, resulting in a decline of muscle function as a progress of sarcopenia. Many mechanisms involved in the onset of sarcopenia include age-related factors as well as activity-, disease-, and nutrition-related factors. The stage of sarcopenia reflecting the severity of conditions assists clinical management of sarcopenia. It is important that systemic descriptions of the disease conditions include age, sex, and other environmental risk factors as well as levels of physical function. To develop a new therapeutic intervention needed is the detailed understanding of molecular and cellular mechanisms by which apoptosis, autophagy, atrophy, and hypertrophy occur in the muscle stem cells, myotubes, and/or neuromuscular junction. The new strategy to managing sarcopenia will be signal-modulating small molecules, natural compounds, repurposing of old drugs, and muscle-specific microRNAs.

• Progress in Superconductivity and Cryogenics
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• v.21 no.3
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• pp.6-12
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• 2019

Extended Drude model has been used to obtain information of correlations from measured optical spectra of strongly correlated electron systems. The optical self-energy can be defined by the extended Drude model formalism. One can extract the optical self-energy and the electron-boson spectral density function from measured reflectance spectra using a well-developed usual process, which is consistent with several steps including the extended Drude model and generalized Allen's formulas. Here we used a reverse process of the usual process to investigate the extended Drude analysis when an additional low-energy interband transition is included. We considered two typical electron-boson spectral density model functions for two different (normal and d-wave superconducting) material states. Our results show that the low-energy interband transition might give significant effects on the electron-boson spectral density function obtained using the usual process. However, we expect that the low-energy interband transition can be removed from measured spectra in a proper way if the transition is well-defined or well-known.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2019.11a
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• pp.60-61
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• 2019

Concrete carbonation is one of the factors that reduce the durability of concrete. In modern times, due to industrialization, the carbon dioxide concentration in the atmosphere is increasing, and the impact of carbonation is increasing. So, it is important to understand the carbonation resistance according to the concrete compounding to secure the concrete durability life. In this study, we want to predict the concrete carbonation velocity coefficient, which is an indicator of the carbonation resistance of concrete, through the deep learning algorithm, and to find the activation function suitable for the prediction of carbonation rate coefficient as a process to determine the learning accuracy through the deep learning algorithm. In the scope of this study, using the ReLU function showed better accuracy than using other activation functions.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2021.05a
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• pp.255-256
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• 2021

The performance measurement of construction projects has traditionally been evaluated as a prerequisite for successful project completion. Considering this importance, the UK and the US are operating quantitative performance measurement systems for construction projects. However, in the case of Korea, there is a limit to the use of existing methods due to the limitation of data collection. Recently, in consideration of the domestic situation, research is being conducted to measure the quantitative performance of a project by using big data including progress and project attribute information. Therefore, this study aims to present the design direction of a performance monitoring system using Quality Function Deployment.

• The Journal of Internal Korean Medicine
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• v.25 no.2
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• pp.368-378
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• 2004

In Oriental Medical theory, origin of kidney's weakness or atrophy is shen qi(腎氣) and function of san jiao(三焦) deteriorate, it result in a passage of evacuation is blocked. - In Oriental Medicine, Shen(腎) take charge of storing and evacuating function, by taking qi(氣) of the five viscera and the six bowels. - The cause of reducing of shen qi and san jiao's evacuative function is xu han(Emptiness and Coldness) of the five viscera and the six bowels' activity. So we do not treat only kidney, but we also must focus the five viscera and the six bowels' organic function and ying wei's function. A Renal Failure is similar in symptom to Kwan-kyuk(關格), oliguria or anuria, edema, Hu-son(虛損), Sin-pung(腎風) and Yuk-kuk(六極) in chenxiang(沈香). We grasp symptom of 7 cases of chronic renal failure, and diagnose its pathology based on Sa-jin(四診), and prescribed herbal medicines. And in the point of the chenxiang, we separate two group, Ater one is taken herbal medicine with chenxiang and the other is only taken herbal medicine with no using chenxiang, we compared the rate of treating with only herbal and herbal compounded chenxiang. We repeat medical examination for continuation of effective result, report clinical progress and result which based on this examination.