• The Korean Journal of Nuclear Medicine
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• v.25 no.2
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• pp.177-185
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• 1991

Dipyridamole thallium imaging is one of the most widely accepted means of evaluating patients with suspected or known coronay artery disease. The results of thallium imaging help diagnose coronary artery disesse (CAD), determine the hemodynamic significance of coronary stenosis, evaluate viability of myocardium, assess the outcome of therapeutic interventions and stratify patients according to their risk for luther cardiac events. An increased lung thallium uptake and transient LV dilation has been reported as poor prognostic indicator and associated with extensive and severe coronary artery disease. We quantitated lung/heart uptake ratio (l/HUR) and transient left ventricular dilation ratio in 44 patients and 17 controls undertaking dipyridamole thallium-201 scintigraphy. The results are as follows: 1) The lung/heart uptake ratio was high in patients with CAD and which became higher according to increasing number of diseased vessel. The L/HUR of patients with low LVEF (<35%) was lower than those with normal LVEF. 2) Transient left ventricular dilation ratio of CAD patients had no close relation between numbers of diseased vessels and was not higher than normals. But transient left ventricular dilation ratio of patients with myocardial infartion was higher than normals. We concluded that lung/heart uptake ratio seems to be sensitive marker for severity of CAD and myocardial function, but transient left ventricular dilation ratio alone is not sufficient to be a marker for severe and extensive CAD.

• Journal of fish pathology
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• v.33 no.1
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• pp.35-43
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• 2020

Hypoxia is a serious problem in the marine ecosystem causing a decline in aquatic resources. MicroRNAs (miRNAs) regulate the expression of genes through binding to the corresponding sequences of their target mRNAs. Especially, miRNAs in the cytoplasm can be secreted into body fluids, which called circulating miRNAs, and the availability of circulating miRNAs as biomarkers for hypoxia has been demonstrated in mammals. However, there has been no report on the hypoxia-mediated changes in the circulating miRNAs in fish. miR-210 is known as the representative hypoxia-responsive circulating miRNA in mammals. To know whether fish miR-210 also respond to hypoxia, we analyzed the change of circulating miR-210 quantity in the serum of olive flounder (Paralichthys olivaceus) in response to hypoxia. The expression of hypoxia related genes, hypoxia inducible factor 1α (HIF-1α) and the heat shock protein 90α (HSP90α) was also analyzed. Similar to the reports from mammals, miR-210-5p and miR-210-3p were significantly increased in the serum of olive flounder in response to hypoxia, suggesting that circulating miR-210 levels in the serum can be used as a noninvasive prognostic biomarker for fish suffered hypoxia. The target genes of miR-210 were related to various biological processes, which explains the major regulatory role of miR-210 in response to hypoxia. The expression of HIF-1α and HSP90α in the tissues was also up-regulated by hypoxia. Considering the critical role of HIF-1α in miR-210 expression and HSP90 in miRNAs function, the present up-regulation of HIF-1α and HSP90α might be related to the increase of circulatory miR-210, and the interaction mechanism among HIF-1α, HSP90α, and hypoxia-responsive microRNAs in fish should be further studied.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.40 no.1
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• pp.57-64
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• 2017

In order to reduce damages to major railroad components, which have the potential to cause interruptions to railroad services and safety accidents and to generate unnecessary maintenance costs, the development of rolling stock maintenance technology is switching from preventive maintenance based on the inspection period to predictive maintenance technology, led by advanced countries. Furthermore, to enhance trust in accordance with the speedup of system and reduce maintenances cost simultaneously, the demand for fault diagnosis and prognostic health management technology is increasing. The objective of this paper is to propose a highly reliable learning model using various machine learning algorithms that can be applied to critical rolling stock components. This paper presents a model for railway rolling stock component fault diagnosis and conducts a mechanical failure diagnosis of motor components by applying the machine learning technique in order to ensure efficient maintenance support along with a data preprocessing plan for component fault diagnosis. This paper first defines a failure diagnosis model for rolling stock components. Function-based algorithms ANFIS and SMO were used as machine learning techniques for generating the failure diagnosis model. Two tree-based algorithms, RadomForest and CART, were also employed. In order to evaluate the performance of the algorithms to be used for diagnosing failures in motors as a critical railroad component, an experiment was carried out on 2 data sets with different classes (includes 6 classes and 3 class levels). According to the results of the experiment, the random forest algorithm, a tree-based machine learning technique, showed the best performance.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.2
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• pp.223-232
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• 2006

Background : Many doctors are under a bias toward clinical severity in patients with atopic dermatitis. But the various studios show that atopic dermatitis may produce a range of impacts on the qualify of lift . Nevertheless there is much to be desired about the association between the quality of lift and atopic dermatitis in the department of Dermatology in Korean medicine. Objective : This study was conducted to investigate the impact of the atopic dermatitis on quality of life and explore prognostic factors that influence outcomes. Methods : 70 patients were recruited in this study rho write out more than 90% of Skindex-29 questionnaires. The function of total scores and three domain scores and SCORAD index was investigated and the correlation of each domain scores also . Result : The total scores, showed significant correlation with three domain scores in atopic dermatitis. The correlation of each three domain scores were significant. SCORAD index showed significant correlation with three domain scores and total scores. Conclusion : In this study atopic dermatitis efface of the quality of life in physical, social, and psychological factors. So we considered to the quality of life as well as clinical severity in patient with atopic dermatitis.

• International Journal of Vascular Biomedical Engineering
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• v.4 no.1
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• pp.27-30
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• 2006

Background; Pleural micro-metastasis of lung cancer is detected by touch print cytology or pleural lavage cytology, but its prognostic impact has not elucidated yet. We hypothesize that recurrence may depend on the amount of tumor cells disseminated in pleural cavity, if the invasiveness of all cancer is the same. To predict the amount of tumor cells disseminated in pleural cavity, we need pleural surface area, distributed pattern of cells and concentration of cells per unit area. Human pleural surface area has not reported yet. In this report, we calculate the normal human pleural surface area using CT image data processing. Methods; Twenty persons were checked CT scan, and we obtained the data from each image. In order to calculate the pleural surface, the outline of lung was firstly extruded from CT image data using home-made Digitizer program. And the distance between CT images was calculated from the extruded outline. Finally a normal human pleural surface was calculated from function between the distance of consecutive CT images and the calculated length. Results; Their mean age is $65{\pm}12$ years old (range $26{\sim}77$), body weight is $62{\pm}9\;kg\;(48{\sim}80)$, and height is $167{\pm}6\;cm\;(156{\sim}176)$. The number of images used is $36{\pm}7\;(24{\sim}51)$. Pleural surface area is $211,888{\pm}35,756\;mm^2\;(143,880{\sim}279,576)$. Right-side pleural surface area is $107,932\;mm^2$ and Lt is $103,955\;mm^2$. Costal, mediastinal and diaphragmatic surfaces of right-side pleura are $77,483\;mm^2,\;39,057\;mm^2,\;and\;8,608\;mm^2$ respectively, and left-side are $72,497\;mm^2,\;35,578\;mm^2,\;and\;4,120\;mm^2$ respectively. Conclusion; Normal human pleural surface area is calculated using CT image data at first and the result is about $0.212\;m^2$.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1539-1544
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• 2014

Purpose: Alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), and Golgi protein 73 (GP73) levels have been widely used as tumor markers for the diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to investigate whether these tumor markers could be used to monitor short-term treatment response and recurrence of HCC in patients undergoing radiofrequency ablation (RFA). Methods: Between July 2012 and July 2013, 53 consecutive patients with newly diagnosed HCC were prospectively enrolled in this study. Among these, 32 patients underwent RFA, after which they were followed up prospectively at the First Hospital of Jilin University in China. Results: AFP, AFP-L3, and GP-73 values pre-RFA were not associated with tumor size, whereas AFP and GP-73 levels tended to be associated with tumor number, the presence of vascular invasion, deterioration of liver function, advanced-stage disease, and a poor performance status. GP-73 levels were dramatically elevated in the patients with hepatitis C-associated HCC. Neither pre-RFA nor 1-month post-RFA tumor marker values were associated with short-term outcome. The short-term recurrence rate of AFP-positive patients measured 1 month post-RFA was obviously higher than that of AFP-negative patients. Conclusions: AFP and GP-73 values were associated with clinical variables representing tumor growth and invasiveness, and the AFP value measured 1 month post-RFA was a strong predictor of short-term recurrence in patients with HCC.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.291-297
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• 2015

The Homeobox B13 (HOXB13):Interleukin 17 Receptor B (IL17BR) index of estrogen receptor (ER)-positive breast cancer (ER (+) BC) patients may be a potential biomarker of recurrence/ metastasis. However, effects of microRNA (miRNA) binding to the 3' untranslated region (3' UTR) of HOXB13 and IL17BR and its function on recurrence/metastasis in ER (+) BC remains elusive. The aims of this study were to determine the expression of miRNAs that bind to 3' UTR of HOXB13 and IL17BR in ER (+) BC patients and asess the effects of these miRNAs on recurrence/metastasis. The expression profiles of HOXB13 and IL17BR were evaluated using RT-PCR in tumors and normal tissue samples from 40 ER (+) BC patients. The expression level of 4 miRNAs, which were predicted to bind the 3' UTR of HOXB13 and IL17BR using TargetScan, microRNA.org and miRDB online databases, were further evaluated with RT-PCR. Our findings demonstrated that high miR-1266 levels might be significant prognostic factor for recurrence/metastasis occurrence (3.05 fold p=0.004) and tamoxifen response (3.90 fold; p=0.2514) in ER (+) BC cases. Although we suggest that modulation of miR-1266 expression may be an important mechanism underlying the chemoresistance of ER (+) BC, advanced studies and validation are required.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2219-2224
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• 2012

Background: Circulating lymphocyte subsets reflect the immunological status and might therefore be a prognostic indicator in cancer patients. Our aim was to evaluate the clinical significance of circulating lymphocyte subset in gastric cancer (GC) cases. Methods: A retrospective study on a prevalent cohort of 846 GC patients hospitalized at Hospital from Aug 2006 to Jul 2010 was conducted. We calculated the patient's disease free survival (DFS) after first hospital admission, and hazard ratios (HR) from the Cox proportional hazards model. Results: Our findings indicated a significantly decreased percentage of CD3+, and CD8+ cells, a significantly increased proportion of $CD4^+$, $CD19^+$, $CD44^+$, $CD25^+$, NK cells, and an increased $CD4^+/CD8^+$ ratio in GC patients as compared with healthy controls (all P < 0.05). Alteration of lymphocyte subsets was positively correlated with sex, age, smoking, tumor stage and distant metastasis of GC patients (all P<0.05). Follow-up analysis indicated significantly higher DFS for patients with high circulating $CD19^+$ lymphocytes compared to those with low $CD19^+$ lymphocytes (P=0.037), with $CD19^+$ showing an important cutoff of $7.91{\pm}2.98%$ Conclusion: Circulating lymphocyte subsets in GC patients are significantly changed, and elevated CD19+ cells may predict a favorable survival.

• The Journal of Korean Medicine
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• v.26 no.3 s.63
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• pp.43-54
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• 2005

Backgrounds : Many people think that ski disease has littel influence on the quality of life in patient, but various studios show that skin disease may produce a range of impacts on QOL. Nevertheless, there is much to be learned about the association between the duality of life and skin disease in the area of Oriental dermatology. Objectives : This study was conducted fe investigate the impact of the various skin diseases on QOL and explore prognostic factors that influence outcomes. Methods : 103 patients were recruited who filled out more than $90\%$ of the skindex-29 questionnaire. The function of sum scores and three domain scores with each skin disease were investigated, as well as the correlation of each domain scores. Results : The disease with the lowest qualify of life was atopic dermatitis. followed by eczematous dermatitis, seborrheic dermatitis and acne vulgaris in order. The sum scales showed significant correlation with three domain scores in atopic dermatitis, urticaria, allergodermia, acne vulgaris, psoriasis and seborrheic dermatitis, The correlation of all three domain scores was significant in atopic dermatitis, urticaria, allergodermia, and psoriasis. Conclusions : Tn this study, skin disease affects the quality of life in physical, social, and psychological factors- Thus, we must consider the quality of life as well as clinical severity inpatients with skin disease.

• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 1999.10c
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• pp.155-161
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• 1999

The land reclamation area of Saemangeum(Kunsan) is located between 126$^{\circ}$10' E~126$^{\circ}$50' E and 35$^{\circ}$35' N~356$^{\circ}$05'N at the western coast of the Korean peninsula. The are many small islands including extensive areas of semi-diurnally flooded and dewatered tidal flats. The reclamation area of Saemangeum has a range of 5.6m spring tide and the maximum tidal current speed is about 1.41m s-1 in ordinary spring tide. Most of the sediments deposited on the tidal flats are transported from the Geum river, the Manjyung river and The Dongjin river. The soil in this area consists of silty sand with the depth of 10m to 30m . The wind in winter is strong from the direction of northwest. In the past twenty years, land reclamation projects for agricutural purpose or industrial cocmplex have been mostly implemented along the western coast of Korea. Saemangeum coastal area is being constructed the33km sea dike and 40, 100ha reclamation area. The purpose of this study is to find the residual circulations in four seasons after the dike construction by a robust diagnostic and prognostic numerical model. Heat flux at the sea surface in January ,May , August , October was asopted on the basis on the daily inflow of solar radiation at the earth surface, assuming an average atomospheric transmission and no clouds , as a function of latitude and time of year(George L.P.J.E William, 1990). The discharge from the Geum , the Mankyung and the Dongjin rivers was adopted on the basis of experience formula of river flow in January , May ,August, October (The M. of C.Korea, 1993) . Water temperature and salinity along the open boundaries are obtained from the results of field observation s.