• BMB Reports
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• v.45 no.12
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• pp.742-747
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• 2012

Granulocyte colony-stimulating factor (G-CSF) is used for heart failure therapy and promotes myocardial regeneration by inducing mobilization of bone marrow stem cells to the injured heart after myocardial infarction; however, this treatment has one weakness in that its biological effect is transient. In our previous report, we generated 5 mutants harboring N-linked glycosylation to improve its antiapoptotic activities. Among them, one mutant (Phe140Asn) had higher cell viability than wild-type hG-CSF in rat cardiomyocytes, even after treatment with an apoptotic agent ($H_2O_2$). Cells treated with this mutant significantly upregulated the antiapoptotic proteins, and experienced reductions in caspase 3 activity and PARP cleavage. Moreover, the total number of apoptotic cells was dramatically lower in cultures treated with mutant hG-CSF. Taken together, these results suggest that the addition of an N-linked glycosylation was successful in improving the antiapoptotic activity of hG-CSF, and that this mutated product will be a feasible therapy for patients who have experienced heart failure.

• Journal of the Korea Society for Simulation
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• v.17 no.2
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• pp.63-74
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• 2008

The design of best efficient production process is common requirements of the production strategy department and the process planning department to maximize the revenue and accomplish target production volumes in the production periods. And they use several general methods for that-line-balancing, removing of the bottle-neck process, facility ramp-up, increasing of the worker's utilization, etc. But, those methods have depended on analytic, static and arithmetic calculations, yet. So, irregular work-waiting time causing the delay time isn't include in extracting production capacity, especially in the line production process. The work-waiting time is changed irregularly along the variation of each machine and very important for calculate real product lead-time and forecasting target production volumes. At this thesis, i'm going to mention the importance of the delay time of conveyor system which can be extracted by discrete-event simulation. And suggest it as a new main variable that must be considered at designing new production system. Then experimented and tested that's effects in the H-company case, conveyor based line production process.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.362-362
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• 2017

Dissemination of IPB3S rice variety combined with cultivation technology named IPB Prima was aimed to introduce IPB research product particularly for IPB rice variety with high-yield character that is IPB3S. The rice variety IPB3S and IPB Prima cultivation technology was expected to be one of solution to improve rice productivity and accelerate to food self-sufficiency in Indonesia. Research sctivity was consist of three main research unit i.e. (1) Dissemination of IPB3S rice variety and IPB Prima production technology; (2) The development of Information and management web-based system (IMS) for planning and monitoring IPB3S and IPB Prima application distribution; and (3) The development of High-capacity grain drying system in Fluidized-bed drying ang in-store drying system. The objective of main research i.e. to introduce IPB high-yield rice variety, to accelerate rice productivity to support self-sufficiency, to develop integrated system model through fluidized and in-store drying, and to develop web-based management-information system in result analyzing IPB3S and IPB Prima distribution and technology application. The dissemination activities was arranged in two location. The first location was in Banyuwangi, East Java with total area 10.87 ha, consist of 8.91 ha planting area for IPB3S and 1.96 ha planting area for Ciherang. The second location is in Tegal, Middle Java with total planting area in 5 ha. The experiment was arranged in different treatment of varieties and cultivation method. The experiment consist of (1) rice variety Ciherang with conventional cultivation technology (P0); (2) rice variety Ciherang with IPB Prima cultivation technology (P1); (3) rice variety IPB3S with conventional cultivation technology (P2); (4) rice variety IPB3S with IPB Prima cultivation technology (P3). Planting distance for twin rows system is $50cm{\times}25cm{\times}12.5cm$. Planting distance for single row system is $25cm{\times}25cm$. The research result elucidated that productivity result in two location has different grades in similar trend. Experiment in Tegal resulted P0 result is $6.18ton\;ha^{-1}$, P1 result is $6.30ton\;ha^{-1}$, P2 result is $6.82ton\;ha^{-1}$, P3 result is $7.31ton\;ha^{-1}$. Experiment in Banyuwangi resulted optimum production of IPB3S variety productivity number are $7.29ton\;ha^{-1}$, while Ciherang are $6.73ton\;ha^{-1}$.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.61-61
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• 2017

Dissemination of IPB3S rice variety combined with cultivation technology named IPB Prima was aimed to introduce IPB research product particularly for IPB rice variety with high-yield character that is IPB3S. The rice variety IPB3S and IPB Prima cultivation technology was expected to be one of solution to improve rice productivity and accelerate to food self-sufficiency in Indonesia. Research sctivity was consist of three main research unit i.e. (1) Dissemination of IPB3S rice variety and IPB Prima production technology; (2) The development of Information and management web-based system (IMS) for planning and monitoring IPB3S and IPB Prima application distribution; and (3) The development of High-capacity grain drying system in Fluidized-bed drying ang in-store drying system. The objective of main research i.e. to introduce IPB high-yield rice variety, to accelerate rice productivity to support self-sufficiency, to develop integrated system model through fluidized and in-store drying, and to develop web-based management-information system in result analyzing IPB3S and IPB Prima distribution and technology application. The dissemination activities was arranged in two location. The first location was in Banyuwangi, East Java with total area 10.87 ha, consist of 8.91 ha planting area for IPB3S and 1.96 ha planting area for Ciherang. The second location is in Tegal, Middle Java with total planting area in 5 ha. The experiment was arranged in different treatment of varieties and cultivation method. The experiment consist of (1) rice variety Ciherang with conventional cultivation technology (P0); (2) rice variety Ciherang with IPB Prima cultivation technology (P1); (3) rice variety IPB3S with conventional cultivation technology (P2); (4) rice variety IPB3S with IPB Prima cultivation technology (P3). Planting distance for twin rows system is $50cm{\times}25cm{\times}12.5cm$. Planting distance for single row system is $25cm{\times}25{\times}cm$. The research result elucidated that productivity result in two location has different grades in similar trend. Experiment in Tegal resulted P0 result is $6.18ton\;ha^{-1}$, P1 result is $630ton\;ha^{-1}$, P2 result is $6.82ton\;ha^{-1}$, P3 result is $7.31ton\;ha^{-1}$. Experiment in Banyuwangi resulted optimum production of IPB3S variety productivity number are 7.29 ton ha-1, while Ciherang are $6.73ton\;ha^{-1}$.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.382-390
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• 2018

This study developed a model to evaluate the quality management system of a medical device manufacturing company, and applied it to medical device manufacturers to understand the impact on business performance in response to international regulations and industry's change. This study prepared preliminary items, defined four (4) major factors (Plan-Do-Check-Act) that consist of the evaluation layers and items per category according to prior research review and expert interview, and calculated the weight and importance using AHP. The study results showed that responsibility & authority and quality objective in Planning Category, product-related requirement and R&D in Doing Category, Measuring and monitoring in Check Category, and review of meeting Regulatory and regulation in Action Category are relatively more important factors. The evaluation model developed based on the calculated weight and importance to business performance was applied to medical device manufacturers to investigate and analyze the implementation level of QMS and its impact on business performance according to each category. Most medical device manufacturers to be studied showed a reasonable level of QMS and effective business performance. Almost all the evaluation layers and items in the four (4) factors had a significant influence on business performance. Although the medical device quality management system is aimed mainly at license acquisition, it is important that management environment factors not related directly to licensing and authorization are important to business performance, and it is effective when these factors are integrated and operated within and outside the manufacturer.

• Journal of Korean Library and Information Science Society
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• v.28
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• pp.447-475
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• 1998

We are seeing a shift of the focus of information service from system-centered(data-centered or intermediary-centered) a n.0, pproach to user-centered a n.0, pproach. Sense-making theory is one of the user- centered a n.0, pproaches. This study focused on user-centered information service paradigm concepts of Dervin's sense-making theory and interpreting sense-making theory in the practical context of library services. The sense-making theory is basically a cognitive a n.0, pproach to information-seeking, in that it recognizes information as something that involves internal cognitive processes. The user of information becomes the focus in this sense-making model. The sense-making theory sees information as subjective, situational, and cognitive. It focuses on understanding information within specific contexts and on understanding how information needs develop and how they are satisfied. It regards the user not as a passive receive of external information but as the center in a active, ongoing process of change. It related to the information needs of users. Dervin's method for studying information needs employs the 'situation-gap-use' metaphor. All information needs stem from a discontinuity or 'gap! in one's knowledge. Dervin believes that information needs can be addressed by understanding the process that each individual goes through in experiencing a gap, in trying to resolve it, and in gaining something (especially new knowledge) from the experience. Sense-making is a process; 'sense' is the product of this process. Sense includes 'knowledge'. However, it includes a host of other subjective factors that reflect an individual's interpretations of a situation including intuitions, opinions, hunches, effective responses, evaluations, questions, etc. For several reasons, however, difficulties are encountered if one attempts a more substantial assessment of the theory. First, it has not yet crystallized into a well-defined theory. Secondly, though the theory has aroused general interest, e.g. within LIS, detailed discussion of its strong and weak points is still lacking. A third source of difficulty is that the basic assumptions of the theory have been explicated metaphorically. If sense-making theory is to be really useful, it needs to be interpreted for library settings. But we have found no attempt to construct an information service based on the theory. Because the research tradition is still relatively young, there are many unanswered questions connected, e.g. with the design of information systems. In any case, e.g. intermediary access systems would be more efficient and effective it their planning could be founded on the user-centered a n.0, pproach.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.9
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• pp.261-268
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• 2018

The use of electric cable was limited due to the installation time and large space as the increase of power demand and load quantity in side line. In order to solve these problems, the application of busway system which can supply the large current was increasing. But it was lack of methods of performance tests to evaluate the reliability and results of test for busway system. In this paper, we presented items to evaluate the reliability test for epoxy coated busway system with reference to IEC 61349-6. In addition, we proposed items to evaluate the reliability and long term life cycle test for the epoxy coated busway system. The combined acceleration deterioration test that reflects actual conditions of the survey as much as possible was conducted considering both thermal and electrical stresses. The deterioration condition was selected to satisfy fifty years life expectation and the insulation performance verification test of the busway system confirmed the long term life prediction. Furthermore, as test items for reliability assessment of compliance with the environment for the use of temperature, humidity and load current where busway system was installed, thermal overload test, water immersion test, cold shock temperature test and thermal cycle test were performed. And we examined changes in characteristics and abnormality after tests. From results, the test items presented to evaluate performance and reliability of the epoxy insulated busway system were confirmed to be appropriate in this paper, and the performance of the product was also confirmed to be excellent for reliability tests.

• Korean Journal of Agricultural and Forest Meteorology
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• v.9 no.4
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• pp.247-259
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• 2007

In this study, we examined the flux of carbon and water using an eco-hydrological model, Regional Hydro-Ecologic Simulation System (RHESSys). Our purposes were to develop a set of parameters optimized for a well-designed experimental watershed (Gwangneung Research Watershed, GN) and then, to test suitability of the parameters for predicting carbon and water fluxes of other watershed with different regimes of climate, topography, and vegetation structure (i.e Gangseonry Watershed in Mt. Jumbong, GS). Field datasets of stream flow, soil water content (SWC), and wood biomass product (WBP) were utilized for model parameterization and validation. After laborious parameterization processes, RHESSys was validated with the field observations from the GN watershed. The parameter set identified at the GN watershed was then applied to the GS watershed in Mt. Jumbong, which resulted in good agreement for SWC but poor predictability for WBP. Our study showed that RHESSys simulated reliable SWC at the GS by adjusting site-specific porosity only. In contrast, vegetation productivity would require more rigorous site-specific parameterization and hence, further study is necessary to identify primary field ecophysiological variables for enhancing model parameterization and application to multiple watersheds.

• The Journal of the Korea Contents Association
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• v.12 no.9
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• pp.340-347
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• 2012

In Korea, the game software and service industry is the core cultural industry from it's significant academic and policy. However, recent growth is slowing down because of increasing competition in the industry. In other words, most of the companies growth have reached limit caused by focusing only on short-term revenue-generating management, Therefore, the game software and service companies are needed to emphasize strategic planning of R&D and product development based on the long-term perspective. The purpose of this analysis is to measure the efficiency of management by data envelopment analysis(DEA), using data from 20 companies in the game software and service industry. Input variances are number of labor, total asset, and total investment and output variances are total sale and enterprise value. The results are followings: First, There was a different efficiency between the companies in the game software and service industry. The eight companies was inefficiency. Second, six inefficiency companies were excessive number of the employees and investment assets. third, four companies were CRS, five companies were IRS and eleven companies were DRS. From the result, five companies have to increase the scale of input variance and eleven companies also have to improve efficiency of input variance.

• Proceedings of the Safety Management and Science Conference
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• 2011.04a
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• pp.731-746
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• 2011

The successful and sustainable growth of SMEs depends on their ability of strengthen their competitiveness in quality and cost and service more than anything else as a fundamental of operation. Among these key competitive factors of SMEs, quality is the most critical factor in manufacturing business fields. Because quality strongly influence cost and service performance on this manufacturing business field. There are many different ways to improve the quality performance but it needs proper management decision to choose the best way what can maximize outputs with minimum inputs. And it needs effective measurement methods and some indicators to analysis the quality performance properly. The quality cost is one of the simplest key indicators to measure the quality performance and the effectiveness of quality related management decisions. The major purpose of this study is to diagnose the categorized current level of actual quality cost of local SMEs to maximize their quality management effectiveness through comparing their level with others what's expressed in early studies. In this study, through survey on local SMEs, we found that their average annual quality cost ratio versus turnover - Total amount of annual quality cost divided by annual turnover - is around 3.69% excluded some SME's performances what have different quality control measures with others. And we found some results what corresponded with the early studies on the correlations between those categorized quality costs factors and some discrepancies between some of the literature model and the early case study results as follows. There were negative correlations between the Prevention costs and the External failure costs, and the Appraisal costs and the External failure costs, and there was positive correlation between the Appraisal costs and Internal failure costs same as early studies. But, we couldn't found any strong negative correlations between the Cost of control - Preventive costs & Appraisal costs - and the Cost of Failure of control - Internal & External failure costs -. It reveals not only the lack of effectiveness on their preventive or appraisal activities but also it can reveal there were so many effective ways to prevent the failure costs properly such as some innovative investment on Factory automation includes Error Proofing and more preventive actions to improve the effectiveness of the typical management methods likes CE (Concurrent Engineering), APQP (Advanced Product Quality Planning), FMEA (Failure Mode & Effect Analysis) etc.