• Journal of Acupuncture Research
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• 제34권3호
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• pp.91-100
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• 2017

Objectives : We conducted a literature search to identify trends with respect to miniscalpel acupuncture points (MAPs) of the cervical region with the aim of providing guidance regarding miniscalpel acupuncture (MA) in the cervical region. Methods : We searched 2 overseas sites (PubMed and Google Scholar) and 5 domestic sites (NDSL, RISS, KISS, OASIS and Korean Traditional Knowledge Portal) for clinical trials of MA of the cervical region. The search terms used were "acupotomy or miniscalpel acupuncture or miniscalpel" and "cervical." Of 73 studies found, 11 were included in this review, 6 of which presented exact MAPs. Owing to the lack of data, we refer to 1 Korean and 4 Chinese articles to analyze the exact location and meaning of the MAPs used in the published studies and to propose other clinically applicable MAPs. Results : We identified 10 of the most commonly used MAPs in the published studies, including those located below the external occipital protuberance, 2-2.5 cm both side down of the external occipital protuberance, 4.5-5 cm both side down of the external occipital protuberance and C3-7 spinous process. Furthermore, we proposed 13 additional MAPs that can be used clinically. Conclusion : We hope that this study will form a basis for the development of MA and hope to improve the safety and reproducibility in future MA studies of the cervical region.

• 한국정보통신학회논문지
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• 제21권11호
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• pp.2167-2175
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• 2017

최근 사물인터넷은 인공지능의 발전, 연결된 기기의 증가와 클라우드 시스템의 높은 성능으로 인해 급격하게 발전하고 있다. 많은 기기와 센서로부터 생산되는 엄청난 양의 데이터들은 지능적 진단, 추천 서비스 뿐 아니라 스마트 관제 서비스와 같이 서비스 영역의 확대를 이끌고 있다. 엣지 컴퓨팅(Edge Computing)에 대한 연구는 높은 성능을 지닌 하드웨어를 바탕으로 작은 또 하나의 서버로써의 역할에 국한되어 연구되고 있다. 그러나 데이터를 분석하고 의미성에 따른 서비스를 구현하기 위해서는 범용적 서버로써의 역할보다는 도메인에 특화된 기능과 요구사항을 지녀야 한다. 스마트 팩토리에서의 엣지는 제한적 필터링, 사전 포맷팅을 포함하는 전처리와 그룹 컨텍스트 융합, 지역적 룰의 관리 등을 필요로 한다. 따라서 본 논문에서는 공장 특성에 맞는 효율성과 강건함 측면을 강조하는 요구사항들을 도출하고, 클라우드와 학습된 요소 공유 방법을 기반으로 하는 엣지 컴퓨팅의 구조를 제안하고자 한다. 이 엣지는 네트워크 자원 소모를 감소시키고 룰과 학습화된 모델의 변경을 쉽게 할 수 있도록 한다.

• 대한교통학회지
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• 제25권3호
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• pp.123-135
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• 2007

본 연구에서는 고속도로 트럼펫 인터체인지상에서 연결로 형식별로 일어나는 교통사고와 도로 기하구조 및 교통량등의 교통사고 요인들과의 관계를 분석하기 위해 교통사고의 분포의 특성을 분석하여 적합도 검증을 통해 모형추정시 가장 적절한 분포를 찾은 결과 음이항분포(Negative binomial distribution)가 선택되었다. 선택된 분포에 기반하여 트럼펫 인터체인지 연결로 전체, 연결로 형식별(직결, 준직결, 루프연결로) 각각의 음이항회귀모형 (Negative binomial regression model)을 개발하였다. 총 4개의 모형을 개발하고 그것의 적합도를 판단하는 여러 가지 통계값과 모형에서 예측한 값과 실제 관측값과의 차이를 분석한 결과 예측모형이 적합하게 구축되었음을 보였다. 추정된 모형의 통계적으로 유의한 변수들을 분석하여 교통사고를 설명하는데 유의한 변수들을 판단하고 이러한 변수들을 도로의 설계자가 도로 설계 및 운영에 적용하거나 교통안전계획 수립시 해당도로의 교통특성을 반영한 교통사고 절감 대책 등에 이용할 수 있을 것이다.

• 한국지능시스템학회논문지
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• 제14권5호
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• pp.545-550
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• 2004

생태학, 환경공학, 임상진단 등 생물학 분야에서 미생물의 다양성 연구의 중요성이 대두되고 그 연구가 점증하고 있다. 특히 16S rRNA를 분자지표로한 DNA 염기서열 분석방법이 널리 사용되고 있다. 본 논문에서는 16S rRNA의 염기서열 분석과정을 각 단계별로 자동화하고, 생물학자들의 결과 판단이나 사용상의 편의를 도모하기 위하여 웹기반의 미생물 다양성 분석 어플리케이션을 개발하였다. 이를 위하여 단계별 자동화 및 인터페이스 개발에 적합한 폴더-프로세스-필터 모델을 고안하고 적용하였다. 제공되는 생물정보분석도구는 서열입력, 서열방향교정, 다중서열정렬 및 가시화, 서열동정 등의 분석이 있으며, 각 결과는 계통분류도구와 호환 가능하도록 하였다. 또한 신생아의 장내 세균총에 대한 분석을 수행하여 개발된 도구의 유용성을 확인하였다. 개발된 웹 어플리케이션은 리눅스 시스템 상에서 Perl 과 CGI를 이용하였으며, http://home.pusan.ac.kr/～genome/tools/rat.htm으로 접속하여 사용할 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7935-7941
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• 2015

The aim of this study was to implement massive parallel sequencing (MPS) technology in clinical genetics testing. We developed and tested an amplicon-based method for resequencing the BRCA1 and BRCA2 genes on an Illumina MiSeq to identify disease-causing mutations in patients with hereditary breast or ovarian cancer (HBOC). The coding regions of BRCA1 and BRCA2 were resequenced in 96 HBOC patient DNA samples obtained from different sample types: peripheral blood leukocytes, whole blood drops dried on paper, and buccal wash epithelia. A total of 16 random DNA samples were characterized using standard Sanger sequencing and applied to optimize the variant calling process and evaluate the accuracy of the MPS-method. The best bioinformatics workflow included the filtration of variants using GATK with the following cut-offs: variant frequency >14%, coverage ($>25{\times}$) and presence in both the forward and reverse reads. The MPS method had 100% sensitivity and 94.4% specificity. Similar accuracy levels were achieved for DNA obtained from the different sample types. The workflow presented herein requires low amounts of DNA samples (170 ng) and is cost-effective due to the elimination of DNA and PCR product normalization steps.

• 한국수정란이식학회지
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• 제28권3호
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• pp.163-168
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• 2013

Embryo transfer (ET) technology is of high importance in modern cattle breeding programs. ET is one step in the process of removing one or more embryos from the reproductive tract of an outstanding donor female and transferring them to one or more recipient females. Embryos also can be produced in the laboratory via techniques such as in vitro fertilization (IVF). But the actual transfer of an embryo is only one step in a series of processes that may include some or all of the following: superovulation and insemination of donors, collection of embryos, isolation, evaluation and short-term storage of embryos, micromanipulation and genetic testing of embryos, freezing of embryos and embryo transfer. Cryopreservation and direct transfer of frozen-thawed embryos is common-place with pregnancy rates near that of fresh embryos. Polymerase chain reaction (PCR) technology is currently being used for sexing embryos, and this technology will be used for "embryo diagnostics" and "embryo genomics" in the future. Although, many limitations and problems remain to overcome, these and other new technologies promise to change livestock breeding drastically in the next decade.

• 대한한의학원전학회지
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• 제23권1호
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• pp.133-142
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• 2010

Preconditions for the separation of prescribing and dispensing medicinal herbs in Traditional Korean Medicine are classification of medicinal herbs for general public and special medical uses, establishment of national medicinal herb distribution company of governmental base, restriction in purchase of medicinal herbs for special medical use, partnership between doctors and pharmacists of Traditional Korean Medicine, and coverage of herbal medicine-based medication in national health insurance, etc. The number of Traditional Korean Medicine Pharmacists which was born during 'the herbal medicine conflict' initiated in 1993, goes over 1,000 and will increase by 120 annually. The number of Traditional Korean Medical Doctors is over 17,000 and increases by 850 annually. So in order to engage partnership between two groups, the government have to arrange the number of outputs of each group. Standardization and classification of diagnosis and diseases in Traditional Korean Medicine is a matter of course in the separation of prescribing and dispensing medicinal herbs. Related societies and academies need to do researches with governmental fund first. After these works, we can launch a task force team for implementation of process for the separation of prescribing and dispensing medicinal herbs in Traditional Korean Medicine properly. Entering the national health insurance system for full coverage of Korean Medicine care service will be essential for the patients. Implementation the separation of prescribing and dispensing medicinal herbs in Traditional Korean Medicine would be the core of health insurance coverage for medication.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
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• pp.218.1-218.1
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• 2014

In order to measure the absolute plasma density, various probes are proposed and investigated and microwave probes are widely used for its advantages (Insensitivity to thin non-conducting material deposited by processing plasmas, High reliability, Simple process for determination of plasma density, no complicate assumptions and so forth). There are representative microwave probes such as the cutoff probe, the hairpin probe, the impedance probe, the absorption probe and the plasma transmission probe. These probes utilize the microwave interactions with the plasma-sheath and inserted structure (probe), but frequency range used by each probe and specific mechanisms for determining the plasma density for each probe are different. In the recent studies, behaviors of each microwave probe with respect to the plasma parameters of the plasma density, the pressure (the collision frequency), and the sheath width is abundant and reasonably investigated, whereas relative diagnostic characteristics of the probes by a comparative study is insufficient in spite of importance for comprehensive applications of the probes. However, experimental comparative study suffers from spatially different plasma characteristics in the same discharge chamber, a low-reproducibility of ignited plasma for an uncertainty in external discharge parameters (the power, the pressure, the flow rate and so forth), impossibility of independently control of the density, the pressure, and the sheath width as well as expensive and complicate experimental setup. In this paper, various microwave probes are simulated by finite-different time-domain simulation and the error between the input plasma density in FDTD simulations and the measured that by the unique microwave spectrums of each probe is obtained under possible conditions of plasma density, pressure, and sheath width for general low-temperature plasmas. This result shows that the each probe has an optimum applicable plasma condition and reliability of plasma density measurement using the microwave probes can be improved by the complementary use of each probe.

• 생약학회지
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• 제51권3호
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• pp.151-157
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• 2020

When blood vessels are damaged, a rapid hemostatic reaction occurs to minimize blood loss and maintain normal circulation. Platelet activation and aggregation is essential in this process. However, excessive platelet aggregation or abnormal platelet aggregation may be the cause of cardiovascular disease, such as thrombosis, stroke and atherosclerosis. Therefore, it is important to prevent and treat cardiovascular disease by finding substances that can regulate platelet activation and suppress aggregation reactions. Isoscopoletin, which is mainly found in the roots of plants Artemisia or Scopolia, has been reported to have potential pharmacological effects on anticancer and Alzheimer's disease, but its role and mechanisms for platelet aggregation and thrombus formation are unknown. This study confirmed the effect of isoscopoletin on major regulation of collageninduced human platelet aggregation, TXA₂ production and intracellular granular secretion (ATP and serotonin release). In addition, the effects of isoscopoletin on phosphorylation of phosphorylated proteins PI3K/Akt and MAPK involved in signal transduction in platelet aggregation was studied. As a result, isoscopoletin significantly inhibited the phosphorylation of PI3K/Akt and MAPK, significantly inhibiting platelet aggregation through TXA₂ production and intracellular granular secretion (ATP and serotonin release). Therefore, we suggest that isoscopoletin is an anti-platelet substance that regulates phosphorylation of phosphorus proteins such as PI3K/Akt and MAPK and is valuable as a preventive and therapeutic agent for platelet-derived cardiovascular disease.

• 동의생리병리학회지
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• 제28권6호
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• pp.668-673
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• 2014

Cold and Heat pattern identification(CHPI) in traditional East Asian medicine(TEAM) is one of the major indicator to distinguish characteristics of disease and to determine treatment method. Basic parameters to determine CHPI include the pulse rate, respiration rate, and pulse power. Studies to associate physiological responses of human body by cold stress(CS) with CHPI in TEAM were rarely done so far. This study aims to explore the effects of cold stress on pulse signal via a feasibility study for three subjects and investigate some indices which can reflect autonomic nerve reaction(ANR). We measured radial pulse signals and respiration signal of the investigated subjects before the CS, during the CS which continues for 5 minutes, and immediately after the CS, respectively. Finally, we analyzed the pulse rate (P), respiration rate (R), pulse power, pulse depth, and pulse rate per respiration (P/R ratio). As a result, the P/R ratio showed a consistently decreasing tendency through the CS stimulation process, while other parameters behaved more complex and in subject-specific ways. It implies that, among candidate parameters, the P/R ratio is a simple but the most probable parameter that can be used as the ANR indicator. This result is also consistent with the theory in TEAM scripts, in which the P/R ratio is predicted to be a direct indicator for the CHPI. This pilot study shows that P/R ratio can be more appropriately associated with the ANR than heart rate or respiration rate alone. Extensive studies will be necessary to verify or confirm the P/R ratio as an appropriate and well defined parameter for ANR.