• Archives of Pharmacal Research
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• v.21 no.4
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• pp.398-405
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• 1998

We investigated the effects of triterpene acids (TAs), ursolic acid (UA) and oleanolic acid (OA), on the induction of proliferation and differentiation of normal rat mammary epithelial cells (RMEC) or organoids cultured in Matrigel or primary culture system. To elucidate the effects, we tested their differentiation inducing activities with intercellular communication ability, cell cycle patterns, induction of apoptosis, and morphological differentiation in the three dimensional extracellular culture system. To study the changes of RMEC subpopulation in culture, the cultured cells were isolated, immunostained with peanut lectin (PNA) and anti-Thy-1.1 antibody and then analyzed with flow cytometry. Four different subpopulations, such as PNA and Thy-1.1 negative cells (B-), PNA positive cells (PNA+), Thy-1.1 positive cells (Thy-1.1+), PNA and Thy-1.1 positive cells (B+), were obtained and the size of each subpopulation was changed in culture with time in the presence of TAs. Intercellular communication was observed in culture for 7 days in TAs-treated cells, but not in culture for 4 days with scrape-loading dye transfer technique. $G_2$/M phase cells and the number of apoptotic population were increased in TAs-treated groups in cell cycle analyses. S phase fractions were reduced and the change of $G_1$ phase cells was not observed. The colonies with distinct multicelfular structures, such as stellate, ductal, webbed, squamous, lobulo-ductal colonies, were observed in Matrigel culture and the frequencies of each colony were changed in the presence of TAs. These results suggest that UA and OA have differentiation inducing effects on rat mammary epithelial cells in primary or in Matrigel culture.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.49 no.1
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• pp.13-20
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• 2023

Objectives: Ultra-wide implants may be used as a replacement if existing implants fail. This study was conducted to evaluate the factors influencing the prognosis and failure of ultra-wide implants. Patients and Methods: This study evaluated whether sex, age, site, diameter, length, additional surgery, implant stability (primary and secondary), and reason for ultra-wide implant placement affect the 5-year survival and success rates and marginal bone loss (MBL) of ultra-wide implants. Seventy-eight ultra-wide implants that were placed in 71 patients (39 males and 32 females) from 2008 to 2010 were studied. One-way ANOVA analysis was conducted to evaluate the statistical significance of MBL according to the patient's sex, implant site, and diameter. Independent sample t-tests were used to determine the statistical significance of MBL analysis which was used to determine the significance of the 5-year success and survival rates related to the variables. One-way ANOVA was conducted to evaluate the statistical significance of sex, implantation site, diameter, and MBL. Independent sample t-tests were used to evaluate the correlation between implantability and MBL for implantation reasons, while additional surgery, length, and Kaplan-Meier analysis were used to evaluate 5-year survival and success rates. Results: The mean age of patients was 54.2 years with a survival rate of 92.3% and a success rate of 83.3% over a mean 97.8-month period of observation. MBL averaged 0.2 mm after one year of prosthetic function loading and 0.54 mm at the time of final observation. Success rates correlated with primary stability (P=0.045), survival rates correlated with secondary stability (P=0.036), and MBL did not correlate with any variables. Conclusion: Ultra-wide implants can be used to achieve secure initial fixation in the maxillary and mandibular molar regions with poor bone quality or for alternative purposes in cases of previous implant failure.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.26 no.2
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• pp.165-171
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• 2013

Due to the difficulty in considering dynamic load in the view point of a computer resource and computing time, it is common that external load is assumed as ideal static loads. However, structural analysis under static load cannot guarantee the safety of design of the structures under dynamic loadings. Recently, the systematic method to construct equivalent static load from the given dynamic load has been proposed. Previous study has calculated equivalent static load through the optimization procedure under displacement constraints. However, previously reported works to distribute equivalent static load were based on ad-hoc methods. Improper selection of equivalent static loading positions may results in unreliable prediction of structural design. The present study proposes the selection method of the proper locations of equivalent static loads to dynamically applied loads when we consider transient dynamic structural problems. Moreover, it is appropriate to take into account the stress constraint as well as displacement constraint condition for the safety design. But the previously reported studies of equivalent static load design methods considered only displacement constraint conditions but not stress constraint conditions. In the present study we consider not only displacement constraint but also stress constraint conditions. Through a few numerical examples, the efficiency and reliability of proposed scheme is verified by comparison of the equivalent stress between equivalent static loading and dynamic loading.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.2
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• pp.34-45
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• 2017

Cyclic loading tests for a total of nine test specimens were performed to evaluate the seismic performance of the exposed steel column-base plate connections. From the tests, flexural strength, deformation capacity, energy dissipation, and initial stiffness were investigated. The primary test parameters were the thickness of base-plate, embedment length of anchor bolt, the presence of hook, and rib plates. Test results showed that flexural behavior of column base-plate connection was substantially affected by the base-plate thickness, embedment length and the number of anchor bolts. On the other hand, the effect of rib plates on the increase of the flexural performance was not observed. The initial stiffness of the test specimens was about 15% of the flexural stiffness obtained by assuming that the support is fixed. As a result, even if the exposed column base-plate is designed in accordance with current design recommendations, in case that bond strength between concrete and the anchor bolts is not sufficient, the base-plate connection showed an unaccceptable load-displacement behavior.

• Journal of the Korean Recycled Construction Resources Institute
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• v.2 no.3
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• pp.196-201
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• 2014

As political circumstances in oversea countries and Korea varies, the risk of vulnerability from unexpected extreme loading conditions, such as explosions or extreme impacts, also increased. In addition, construction companies in Korea recently have taken chances of overseas expansion to countries where their domestic situations are not in rest. Therefore, the resistance of construction materials for blast or impact loading become taking more consideration from engineering field. This study is a part of the research to develop a high performance fiber reinforced cementitious composite materials with high volume steel fibers and primary purpose of this study is to find an optimum mix proportions of in-fill slurry. In order to accomplish the tasks this study performed experimental investigations on the slurry for consistency, compressive strength, flowability, J-penetration, bleeding and rheology properties as well as mechanical properties, compressive and flexural strength, with respect to different mix proportions.

• Magazine of the Korea Concrete Institute
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• v.3 no.2
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• pp.123-132
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• 1991

The purpose of this study was to Investigate the effects of bent - up bar Within beam - column 1lint core with High - Strength Concrete up to 800kg/$cm^2$. To achieve these objectives, 5 specimens were designed and tested under monotoric loading and reversed cyclic loadings. The primary variables were the number of bent-up bars, compressive strength of concrete and loading patterns. The results showed that the load capacity of specimen subjected to monotonic loading had more large than that of specirnn subjected to reversed cyclic loadings and the bent - up bar within joint core could prevented the crack at the joint face from propagating into the pint core but the failure was concentrated at the face of beam - column pint. Thus the study on flexural strength ratio should be accomplished before using bent - up bars within the joint core.

• Composites Research
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• v.20 no.4
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• pp.31-41
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• 2007

Dome shape design methods of Filament Winding (FW) composite pressure vessel, which can suggest various dome contour according to the external loading conditions, were investigated analytically and numerically. The performance indices(PV/W) of the pressure vessels with same cylinder radius and boss opening but different dome shape were evaluated by finite element analysis under the internal pressure loading condition. The analysis results showed that as the dome shape becomes flat, the performance index decreases significantly due to the reduced burst pressure. Especially, for the case of the high value of the parameter ro, the ratio between the radii of the cylinder part and the boss opening, the flat dome is disadvantageous in the aspect of the weight reduction, and additional reinforcing dome design technique should be required to increase the burst pressure. For example, above ro=0.54 condition, the dome shape change according to the loading condition could cause the low burst pressure and increase of composite weight in dome region and is not recommendable except for the special case that maximum inner volume or sufficient space between skirt and dome is the primary design objective. However, at ro=0.35, the dome shape change brings not so significant differences in the performance of FW vessel.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.30 no.3
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• pp.249-257
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• 2008

The authors performed the clinical and radiographic evaluation in the 29 patients with sinus bone graft and $Osstem^{(R)}$ implant placement between Sep 2003 and Jan 2006 and got the following results. 1. Fifteen complications developed in the 13 patients. Intraoperative sinus membrane perforation and postoperative maxillary sinusitis developed frequently. 2. The mean preoperative residual alveolar bone height was 4.5 mm, postoperative height 18.5 mm, height 1 year after operation 16.9 mm. 3. Three primary osseointegration failures(3.7%) developed in 3 patients. 4. The survival rate of prosthodontics was 100% at the final follow up. The mean marginal bone resorption around the implants was 0.69 mm 1 year after prosthodontic loading. Marginal bone resorption more than 1.5 mm developed in nine implants and the success rate was 88%.

• Journal of the Korean Geotechnical Society
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• v.15 no.4
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• pp.3-17
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• 1999

Torsion shear tests under various stress paths were performed to study the behavior of sand during large stress reversal. The stress paths can be classified into the clockwise and the counterclockwise according to torque applied to specimen, and the directions of plastic strain incremental on the stress paths including large stress reversal are compared with the direction of stress state and stress incremental. From test results, the isotropic hardening theory using the principle of St. Venant desirably showed that direction of plastic strain incremental coincided with stress state on primary loading part and nearby failure point, but it might result in a rough approximation on part of unloading and reloading by stress reversal.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2002.10b
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• pp.289-290
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• 2002

Stainless steel ball bearings are used in the control element drive mechanism and driving mechanisms such as step motor and gear boxes for the integral nuclear reactor, SMART. The bearings operate in pressurized pure water (primary coolant) at high temperature and should be lubricated with only this water because it is impossible to supply greases or any additional lubricant since the whole nuclear rector system should be perfectly sealed and the coolant cannot contain ingredients for bearing lubrication. Temperature of water changes from room temperature to about 120 degree Celsius and pressure rises up to 15MPa in the nuclear reactor. It can be anticipated that the frictional characteristics of the ball bearings changes according to the operating conditions, however little data are available in the literature. It is found that friction coefficient of 440C stainless steel itself does not change sharply according to temperature variation from the former research, and the friction coefficient is about 0.45 at low speed range. In this research frictional characteristics of the assembled ball bearings are investigated. A special tribometer is used to simulate the axial loading and the bearing operating conditions, temperature and pressure in the driving mechanism in the nuclear reactor. Highly purified water is used as lubricant ‘ and the water is heated up to 120 degree Celsius and pressurized to 15MPa. Friction force is monitored by the torque transducer.