• 한국응용과학기술학회지
• /
• 제39권3호
• /
• pp.377-385
• /
• 2022

본 연구는 지역사회 거주 독거노인의 치매에 대한 지식 및 태도가 치매예방행위에 미치는 영향을 파악하기 위한 조사연구이다. 연구 대상자는 지역사회 거주 독거노인 101명이었으며 자료 수집은 2020년 1월 2일부터 1월 16일까지 수행되었다. 분석방법은 SPSS/ WIN 24.0을 이용하여 기술통계, 상관관계 및 다중회귀분석으로 실시하였다. 연구결과, 지역사회 거주 독거노인의 치매예방행위는 치매지식(r=.42, p<.001)과 유의한 정적 상관관계를 보였다. 치매예방행위에 영향을 미치는 요인은 운동(β=-.26, p=003), 주관적 건강상태(β=.26, p=.003), 치매에 대한 지식(β=.37, p<.001)으로 나타났으며 모형의 설명력은 28.7%이었다. 이에 지역사회 거주 독거노인의 치매예방행위를 향상시키기 위해서는 운동과 주관적 건강상태 및 치매에 대한 지식을 향상시킬 수 있는 치매예방교육 중재 개발을 제안하는 바이다.

• Journal of Preventive Medicine and Public Health
• /
• 제49권6호
• /
• pp.349-366
• /
• 2016

Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs). Results: Thirty-two studies had parity categories of 1, 2, and ${\geq}3$. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q = 59.46; $I^2=47.9%$). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p = 0.17; Q = 18.79, $I^2=25.5%$). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.

• 기본간호학회지
• /
• 제7권3호
• /
• pp.391-400
• /
• 2000

A long-term bed rest results in an inevitable foot drop. Yet preventive device such as a foot board and high-neck tennis shoes, are not widely used. This study was conducted to compare the effects of a pillow-type foot board with that of the band-type device. The band-type device of a resonable price is designed for an effective prevention of foot drop, and the convenience for it use. Among the non-equivalent control group design, foot drop preventive effects, usefulness of the device, as well as its cost effectiveness were examined. The study was carried out for four months from December 1999, and its subject had been patients and nurses of two intensive care units at K medical center in Seoul. According to the study purpose, the data collected were analyzed by $x^2-test$ and t-test. The results are as follow : 1. The ROM of ankle joint is promoted in the experimental group with a band-type device comparing the control group with a pillow type one. Dorsiflexion is particularly increased in the experimental group as compared with the control group, while planterflexion hardly shows any change. 2. The usefulness score of the experimental group nurses using the band-type device (23.97) is higher than that of the control group nurses (18.88). 3. In an aspect of the unit production cost, band-type devices are low-priced compare with pillow-type or other foot board (wooden) or high-neck tennis shoes. In summary, the newly developed band-type device is both useful and preventive for a foot drop. It is also desirable regarding to the production cost and the cost effectiveness. This fact proves that the new anti-foot drop device could be practical both for clinical care and home care. Yet the results were obtained by some subjects, it should be used after a further examination. More effective nursing intervention could be observed throughout general studies, including proper positioning and foot and ankle exercises which are the important variables of the foot drop prevention.

• 한국환경보건학회지
• /
• 제39권3호
• /
• pp.197-210
• /
• 2013

Several US veterans stationed in Korea have told the press that around 250 fifty-five gallon drums of herbicides, including Agent Orange, were buried at Camp Carroll in 1978. Joint Korean-US Agent Orange investigation and environmental and health studies were started in July 2011. Korean soldiers and military personnel who served in Vietnam during 1964-1973 or near the demilitarized zone in Korea during 1967-1970 were exposed to dioxincontaminated Agent Orange. The joint Korean-US Agent Orange investigation team found that herbicides, pesticides, solvents and other chemicals -not Agent Orange- were buried at Camp Carroll. However, there remains the possibility that Agent Orange was stored and buried at Camp Carroll or other military camps in Korea. Adverse health effects have not been clearly explained despite a number of health studies among veterans in Korea with potential Agent Orange exposure. Although the Korean government has been compensating veterans and military personnel with 18 presumptive-service-connected-diseases and their offspring with three diseases, there are many veterans, military personnel and civilians who require the government°Øs support. The environmental study on contaminated sites and health studies among veterans and civilians were initiated three or four decades after possible Agent Orange contamination and exposure. Several toxic chemicals, including dioxin-contaminated Agent Orange, could remain in the environment and could have hazardous effects on the health of exposed people for more than several decades. Further environmental investigations and health studies are needed to ensure public safety and health, and government support should be guaranteed for people potentially exposed to these toxic chemicals.

• Journal of Preventive Medicine and Public Health
• /
• 제49권5호
• /
• pp.253-259
• /
• 2016

Objectives: Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity. Although several large-scale genome-wide association studies have reported susceptibility genes for central adiposity, the effects of interactions between genes and psychosocial stress on central adiposity have rarely been examined. A recent study focusing on Caucasians discovered the novel gene early B-cell factor 1 (EBF1), which was associated with central obesity-related traits via interactions with stress levels. We aimed to evaluate EBF1 gene-by-stress interaction effects on central adiposity traits, including visceral adipose tissue (VAT), in Korean adults. Methods: A total of 1467 Korean adults were included in this study. We selected 22 single-nucleotide polymorphisms (SNPs) in the EBF1 gene and analyzed their interactions with stress on central adiposity using additive, dominant, and recessive genetic modeling. Results: The four SNPs that had strong linkage disequilibrium relationships (rs10061900, rs10070743, rs4704967, and rs10056564) demonstrated significant interactions with the waist-hip ratio in the dominant model ($p_{int}$<0.007). In addition, two other SNPs (rs6556377 and rs13180086) were associated with VAT by interactions with stress levels, especially in the recessive genetic model ($p_{int}$<0.007). As stress levels increased, the mean values of central adiposity traits according to SNP genotypes exhibited gradual but significant changes (p<0.05). Conclusions: These results suggest that the common genetic variants for EBF1 are associated with central adiposity through interactions with stress levels, emphasizing the importance of managing stress in the prevention of central obesity.

• 한국어병학회지
• /
• 제20권2호
• /
• pp.179-187
• /
• 2007

손바닥선인장 가수분해 추출물을 양식어류의 사료에 첨가 투여하였을 때 어류의 체내 생리활성변화 유도 또는 세균성질병에 대한 예방효과를 가져오는지를 검토하였다. 체중, HSI, Ht수치, 혈장성분분석, 조직학적 검사에서 대조구와 첨가사료 투여구 사이에서 유의한 차이는 인정되지 않았으나, 면역활성 조사에서 첨가사료 투여구의 4주째 CL수치가 대조구와 비교하여 유의성을 나타내었다. 그러나 라이소자임 활성에는 변화가 없었다. 어병세균으로 대표적인 E. tarda와 S. iniae에 대한 공격실험에서도 4주째 첨가사료를 먹인 처리구가 대조구와의 상대생존율에서 각각 82.0%와 13.5% 수치를 나타내었다

• Journal of Nutrition and Health
• /
• 제38권9호
• /
• pp.689-697
• /
• 2005

This study was conducted to fine out the preventive effects of chitosan and chitosan oligomer on the disorders of hepatic functions and lipid metabolism induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) using adult male rats (SD) for four weeks. Rats were fed chitosan ($4\%$) or chitosan oligomer ($4\%$) diets respectively before 3weeks of TCDD treatment (50 ug/kg BW) by intraperitoneal injection and then continually supplied these diets for one week until being sacrificed. The elevation of serum total and LDL cholesterol levels induced by TCDD treatment was significantly reduced in the rats fed chitosan diets. The increment of liver triglyceride levels caused by TCDD treatment was tended to suppress in all rats fed chitosan and chitosan oligomer diets. Fecal total lipid and cholesterol excretion were high levels in the rats fed chitosan diets. The hepatic cytosolic catalase activities significantly decreased by TCDD treatment appeared recovering trend by chitosan diets. In hepatic microsomal cytochrome p-450, NADPH cytochrome p-450 reductase, ethoxycoumarin-o-deethylase (ECOD) and benzphetamin N-demethylase (BPND) chitosan than chitosan oligomer diets apparently decreased the increasing levels by TCDD treatment. In histochemical observation the fat droplets and apoptosis of hepatocytes by TCDD treatment were markedly alleviated by chitosan and chitosan oligomer diets. These results indicate that chitosan, more than chitosan oligomer can exert preventive effects on some disorders of hepatic functions and lipids accumulation by TCDD.

• Toxicological Research
• /
• 제15권1호
• /
• pp.39-45
• /
• 1999

To investigate the preventive effects of melatonin (MLT) on the immunotoxicity of cadmium acetate[Cd(AC)2] in ICR mice, Mlt(10,50mg/kg as cadmium) were orally administered to mice once a day (5:00, PM) for 28 consecutive days. Cadmium(Cd) test solution was also administered at 25mg/kg of cadmium through the same route 2hr after administration of MLT daily, Mice were immunized and challenged with sheep red blood cells (SRBC). Immune functions evaluated were delayed type hypersensitivity (DTH) response, mitogenic response, and flow cytometry analysis. The results of these studies were summarized as follows ; DTH response was abnormally increased in mice treated with Cd alone. DTH response was normally depressed in mice treated with Cd plus MLT along with the increase of MLT doses. The mitogenic response of splenic T cell to Con A and that of B cells to LPS was remarkably increased by MLT treatment as compared with treatment of Cd alone In case of CD 8+ cells, the slight increase was observed in MLT treatment. Splenic T cells and B cells were significantly increased by MLT treatment as compared with treatment with Cd alone. These results suggest that MLT has significant preventive effects on the immunotoxic status induced by Cd exposure.

• 약학회지
• /
• 제51권5호
• /
• pp.296-300
• /
• 2007

The purpose of this study was to investigate the preventive effects of Lycii fructus Extract (LFE) against the acute hepatotoxicity-inducing lipopolysaccharide (LPS) in the liver. LFE of 100 mg/kg concentration was intraperitoneally administered into rats at dose of 1.5 ml/kg for 20 days. On the day 21, 1.5 ml/kg of LPS dissolved in saline was injected 4 hours before anesthetization. We examined the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), lactate dehydrogenase (LDH) in serum of rats, superoxide dismutase (SOD) in mitochondrial fraction, and malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPx) in liver homogenate. LPS-treatment markedly increased the levels of GOT, GPT, LDH and MDA, and significantly decreased those of SOD, CAT and GPx. But LFE-pretreatment decreased the levels of GOT, GPT, LDH and MDA, by 17.7%, 27.5%, 40.7% and 56.9%, respectively and increased those of SOD, CAT and GPx, by 90.5%, 78.9% and 83.8%, respectively. These results showed that the LFE had the preventive effects against the acute hepatotoxicity-inducing LPS in the liver.

• 대한본초학회지
• /
• 제21권3호
• /
• pp.47-54
• /
• 2006

Objectives : This study was performed to compare the preventive effect of water extracts from Injinho-tang and Haninjinho-tang on hyperlipidemia and liver damage induced by alcohol. Methods : Except for the normal group, we fed rat on 25% alcohol for 55 days. And each extract was administrated for the same period. We measured the serum component in rat's blood, body weight and weight of liver. Results : 1. At first, we observed effects of Injinho-tang and Haninjinho-tang on hyperlipidemia induced by alcohol. Injinho-tang group showed significant decrease of triglyceride, body weight in comparison with those of the control group. Haninjinho-tang group showed significant decrease of total cholesterol, triglyceride in comparison with those of the control group. I 2. At second, we observed effects of Injinho-tang and Haninjinho-tang on liver damage induced by alcohol. lnjinho-tang group showed significant decrease of AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), liver weight in comparison with those of the control group. Haninjinho-tang group showed significant decrease of AST (aspartate aminotransferase), ALT (alanine aminotransferase) in comparison with those of the control group. Conclusion : Reviewing these experimental results, it appears that water extracts from Injinho-tang and Haninjinho-tang have pharmaceutical preventive efficacy on hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of these.