• Title/Summary/Keyword: preventive effects

Search Result 2,606, Processing Time 0.027 seconds

High Incidence of Breast Cancer in Light-Polluted Areas with Spatial Effects in Korea

  • Kim, Yun Jeong;Park, Man Sik;Lee, Eunil;Choi, Jae Wook
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.17 no.1
    • /
    • pp.361-367
    • /
    • 2016
  • We have reported a high prevalence of breast cancer in light-polluted areas in Korea. However, it is necessary to analyze the spatial effects of light polluted areas on breast cancer because light pollution levels are correlated with region proximity to central urbanized areas in studied cities. In this study, we applied a spatial regression method (an intrinsic conditional autoregressive [iCAR] model) to analyze the relationship between the incidence of breast cancer and artificial light at night (ALAN) levels in 25 regions including central city, urbanized, and rural areas. By Poisson regression analysis, there was a significant correlation between ALAN, alcohol consumption rates, and the incidence of breast cancer. We also found significant spatial effects between ALAN and the incidence of breast cancer, with an increase in the deviance information criterion (DIC) from 374.3 to 348.6 and an increase in $R^2$ from 0.574 to 0.667. Therefore, spatial analysis (an iCAR model) is more appropriate for assessing ALAN effects on breast cancer. To our knowledge, this study is the first to show spatial effects of light pollution on breast cancer, despite the limitations of an ecological study. We suggest that a decrease in ALAN could reduce breast cancer more than expected because of spatial effects.

A Study on the Existing State of Preventive Maintenance and the Improvement Measures for a Point Machine (선로전환기 예방정비 현황 및 개선 방안에 관한 연구)

  • Lee, In-Hyun;Kim, Dae-Hyun;Kim, Min-Ho;Seo, Jung-Wook;Kim, Du-Ill;Jung, Ho-Hung
    • Proceedings of the KSR Conference
    • /
    • 2011.05a
    • /
    • pp.1174-1181
    • /
    • 2011
  • This paper investigates the current established preventive maintenance and its corresponding data on a point machine among railway signalling facilities and suggests a part of considerable plans when the policy of the preventive maintenance is modified. It is not appropriated to apply the optimized preventive replacement period considered with the cost simply. In that case, it is suggested that the reliability should be analyzed failure mode and effects through collecting the on-site failure data sufficiently. Then, that result can be proposed to adjust the proper criteria into the rational way by comparing the initial maintenance criteria. In this paper, the alternative way to determine the feasibility of the inspection period using failure probability is introduced.

  • PDF

Effects of environmental carcinogens and genetic polymorphisms on the hypermethylation of hMLH1 gene promoter, microsatellite instability and mutations of the p53 and Ki-ras genes in gastric cancer (환경성 발암물질 및 유전자 다형성이 위암의 hMLH1 유전자 promoter의 과메틸화와 반복 서열 불안정성, 그리고 p53 및 Ki-ras 돌연변이에 미치는 영향에 대한 분자역학적 연구)

  • Nan Hong-Mei;Park Joo-Seung;Yun Hyo-Yung;Song Young-Jin;Hyun Tai-Sun;Kang Jong-Won;Kim Heon
    • 대한예방의학회:학술대회논문집
    • /
    • 2001.10a
    • /
    • pp.314-315
    • /
    • 2001
  • PDF

The Effects of Cuscuta japonica Chois on Gene Expression in RANKL-induced RAW 264.7 Cell (도사자(菟絲子)가 RANKL 유도 파골세포(破骨細胞)에 미치는 영향)

  • Kim, Joon-Yeon;Hwang, Gwi-Seo
    • Journal of Society of Preventive Korean Medicine
    • /
    • v.14 no.2
    • /
    • pp.77-89
    • /
    • 2010
  • Objectives : This study was performed to evaluate the effect of CJ(Cuscuta japonica Chois) on osteoclast differentiation and gene expression. Methods : The osteoclastogenesis and gene expression were determined in RANKL(receptor activator of nuclear factor kappa B ligand)-stimulated RAW 264.7. The results were summarized as followes. Results : CJ decreased the number of TRAP positive cell in RANKL-stimulated RAW264.7 cell. CJ decreased the expression of RANK(receptor activator of nuclear factor kappa B), $TNF{\alpha}$, and IL-6 in RANKL-stimulated RAW264.7 cell. CJ decreased the expression of iNOS and COX-2 in RANKL-stimulated RAW264.7 cell. CJ decreased the expression of Cathepsin K in RANKL-stimulated RAW264.7 cell. Conclusions : It is concluded that CJ might decrease the bone resorption resulted from decrease of osteoclast differentiation and it's related gene expression.

A Study of Decreasing Critical Disaterous Accidents in Small Construction Sites (소규모 건설현장의 중대재해 저감 방안 도출을 위한 연구)

  • Paik, Sin-Won;Kim, Han-Joong;Choi, Don-Heung
    • Journal of The Korean Society of Agricultural Engineers
    • /
    • v.54 no.6
    • /
    • pp.121-131
    • /
    • 2012
  • Many of the falling which is the number one risk factor in lethal accidents in construction could have been prevented if the right activity or supervising had been taken in time. All other measures do not preventive the fall, but rather intercept the fallen itself or preventive severe injury. The most common and the bets measures on the preventive measures are guardrails which are to be worn on the site. Workers always exposed the risk of serious accidents induced by causal effects related with environments around construction sites. In order to represent how to decrease the risk of workers, this study was accomplished with a number of interview with experienced site director, cheief of instructors, workers. And the questionaire survey (2012. 5~2012. 10) were used to make proposed policies which are expected to reduce critical disastrous accidents and strength authorized limits of director's management automatically.

Effects of Securinega suffructicosa(SS) Extract on Osteoclastogenesis and Gene Expression in RANKL-induced RAW Cell (일엽추 추출물이 RANKL 유도 RAW264.7 Cell의 유전자 발현에 미치는 영향)

  • Lee, Hyo-Keun;Hwang, Gwi-Seo
    • Journal of Society of Preventive Korean Medicine
    • /
    • v.14 no.3
    • /
    • pp.13-26
    • /
    • 2010
  • Objectives : This study was performed to evaluate the effect of Securinega suffructicosa Rehder (SS) on osteoclast differentiation and gene expression. Methods : The osteoclastogenesis and gene expression were determined in RANKL-stimulated RAW 264.7. The results were summarized as followes. Results : SS decreased the number of TRAP positive cell in RANKL-stimulated RAW264.7 cell. SS decreased the expression of RANK, TNF${\alpha}$, and IL-6 in RANKL-stimulated RAW264.7 cell. SS decreased the expression of iNOS and COX-2 in RANKL-stimulated RAW264.7 cell. SS decreased the expression of Cathepsin K in RANKL-stimulated RAW264.7 cell. Conclusions : It is concluded that SS might decrease the bone resorption resulted from decrease of osteoclast differentiation and it's related gene expression.

Quantitative Analysis on the Electrical Fire Preventive Effect of Safety Inspection for Electrical Facilities for General Use (일반용 전기설비 안전점검의 전기화재 예방효과에 대한 정량적 분석)

  • Kim, Taek-Hee;Yoo, Jae-Geun;Jeon, Jeong-Chay
    • The Transactions of the Korean Institute of Electrical Engineers P
    • /
    • v.64 no.2
    • /
    • pp.45-49
    • /
    • 2015
  • This paper presents a quantitative analysis method to quantitatively indicate a electrical fire preventive effect of safety inspection for electrical facilities for general use. Logic model was developed based on whether enforcement of safety inspection for electrical facilities, and then the developed analysis model was converted to hydraulic model by using mathematical logic. The electrical fire preventive effect of safety inspection for electrical facilities was quantitatively calculated by applying electrical safety inspection results and fire statistics for five years to the developed hydraulic model. The results show that electrical fire preventive effects of 5,542 cases on annual average for five years.