• 융합정보논문지
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• 제7권6호
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• pp.89-95
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• 2017

암을 유발하는 PMA는 세포를 자극하여 전사인자 C-Jun/C-fos의 발현을 증가시키며 핵 내의 AP-1의 활성을 증가하게 되고 결과적으로 각종 암이 발생된다고 보고되고 있다. 본 연구에서는 천연물 지표성분의 안전성을 보기위한 세포독성과 암예방 효과를 예측할 수 있는 Activator protein(AP-1) 활성억제를 관찰하였다. 천연물 지표성분 38종을 대상으로 세포독성과 AP-1 활성억제를 관찰한 결과 섬수의 지표성분인 Bufogein 과 Cinobufagin에서는 세포독성을 보이며 AP-1 활성 억제와 비교 시 5배 정도 차이를 보임을 알 수가 있다. 반면에 Arctigenin, Manassantin A, B에서는 AP-1 활성 억제 농도는 $2{\mu}M$ 이하이면서 세포독성과의 비율은 15배 이상임을 알 수 있다. 본 실험의 결과를 통해 우방자와 삼백초의 지표성분인 Arctigenin, Manassantin A,B는 암 예방 연구의 가능성을 시사하였다.

• 대한물리치료과학회지
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• 제15권4호
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• pp.1-9
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• 2008

Background: This study was to investigate effects of falls prevention exercise on functional fitness in elderly. Methods: A total of 45 healthy over 65years old adults (men=15, women=30) who were participated in this study. Exercise were involved in the period of 12 week complex physical training for around 50 minutes a day, three times per week. We measured subjects' physical activity levels by short physical performance battery(SPPB) test, timed up & go(TUG) test, one leg standing test(OLST) with closed eyes and maximal step length (MSL) test. Results: After falls prevention exercise, there were statically significant differences in SPPB, TUG, OLST and MSL test (P<.01) between pre and post test. There were statically significant differences in SPPB, TUG, OLST, MSL between pre and post test in men and women. There were statically significant differences between men and women in SPPB, TUG, OLST and MSL test. Conclusion: Falls prevention exercise had significant effects on physical fitness level in elderly, with a result increase muscle strength, balance ability and it might prevent falls.

• Geomechanics and Engineering
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• 제13권1호
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• pp.63-77
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• 2017

The failure mechanism of a deep hard rock tunnel under high geostress and high geothermalactivity is extremely complex. Uniaxial compression tests of granite at different temperatures were conducted. The complete stress-strain curves, mechanical parameters and macroscopic failure types of the rock were analyzed in detail. The brittleness index, which represents the possibility of a severe brittleness hazard, is proposed in this paperby comparing the peak stress and the expansion stress. The results show that the temperature range from 20 to $60^{\circ}C$ is able to aggravate the brittle failure of hard rock based on the brittleness index. The closure of internal micro cracks by thermal stress can improve the strength of hard rock and the storage capacity of elastic strain energy. The failure mode ofthe samples changes from shear failure to tensile failure as the temperature increases. In conclusion, the brittle failure mechanism of hard rock under the action of thermal coupling is revealed, and the analysis result offers significant guidance for deep buried tunnels at high temperatures and under high geostress.

• Child Health Nursing Research
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• 제15권2호
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• pp.145-154
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• 2009

Purpose: The purpose of this study was to develop a guide book on safety education for teachers to use in education classes for elementary school students. Methods: Dick & Carey's teaching model and Keller's ARCS theory were used in the development of this guide book. Results: This guide book was developed for lower grade (1st$\sim$3rd) and higher grade (4th$\sim$6th) elementary school students. The content consisted of subjects, worksheets, content for teachers, statistical data, case studies, and a safety letter to the parents. The 10 subjects were as follows: "Importance of injury prevention", "Safety at home", "Accident prevention at school", "Violence prevention", "Vehicles safety", "Water safety", "Prevention of Fires & Burns", "Safety of Toys & home supplies", "Safety in Sports & Recreation activity", "Prevention of injury caused by animals". Statistical data was presented by graphs and case studies were presented of cases of real occurrences of accidents. Worksheets contain various activities for students. Safety letters were composed for each student's parents. Conclusion: This guide book presents effective material for safety education classes in elementary school and the authors hope it will be widely used in elementary schools.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6207-6213
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• 2015

The supportive care of patients receiving antineoplastic treatment has dramatically improved over the past few years and development of effective measures to prevent nausea and vomiting after chemotherapy serves as one of the most important examples of this progress. A patient who starts cancer treatment with chemotherapy lists chemotherapy-induced nausea and vomiting as among their greatest fears. Inadequately controlled emesis impairs functional activity and quality of life, increases the use of health care resources, and may occasionally compromise adherence to treatment. New insights into the pathophysiology of chemotherapy-induced nausea and vomiting, a better understanding of the risk factors for these effects, and the availability of new antiemetic agents have all contributed to substantial improvements in emetic control. This review focuses on current understanding of chemotherapy-induced nausea and vomiting and the status of pharmacological interventions for their prevention and treatment.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6465-6468
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• 2013

This study aimed to assess body features, and alimentary and lifestyle behavior related to cancer prevention among Romanian adults having relatives with cancer. The study was performed in 2010/2011 in an oncological hospital in Cluj-Napoca, Romania. It involved 320 adults who had relatives with cancer. An anonymous questionnaire was filled in by each participants; their weights and heights were measured and body mass index (BMI) was calculated, 56.6% of the participants having a value higher than 24.9. Almost all subjects ate less than 400g of fruits and vegetables daily and 56% of the participants consumed more than 500 g of red meat weekly. One quarter of the study sample was performing less than 30 minutes of moderate physical activity daily. Some 28.1% of the subjects were smokers. These data call for comprehensive actions to help Romanian cancer patient relatives to respect the recommendations regarding healthy lifestyle promotion and cancer prevention. Health professionals should periodically assess body composition and lifestyle components of adults who have relatives with cancer in order to identify unhealthy behavior and offer them personalized education and counseling.

• 여성건강간호학회지
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• 제11권2호
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• pp.156-162
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• 2005

Purpose: The study was done to identify the relationship of symptoms of stress, cancer prevention behavior, the quality of life in women, and the factors influencing the quality of life. Method: The subjects of this study were 210 married women. They were living in Gyeonggi Province and Busan Metropolitan City. Symptoms of stress were measured by the Park's Stress Scale. Cancer preventive behavior was measured by Suh's Korean scale, and Smith Kline Beecham Quality of life' Scale by Dunbar. Data was analyzed with the SPSS program by ANOVA, Pearson's correlation, and Multiple Regression Analysis. Result: The higher scores of physical stress correlated with lower practice scores of cancer prevention behavior. Psychological and physical stress revealed negative correlations among sub-items of the QOL such as competence, psychological well-being, stability, physical well-being and activity. Multiple regression analysis revealed that the predictor of quality of life in the women was stress. A combination of symptoms of stress and cancer prevention behaviors accounted for 35.3% of the variance in the quality of life in the women. Conclusion: The most important factor influencing the quality of life of women was stress. Thus the study's findings can be useful in directing a comprehensive nursing care plan to improve the QOL of women.

• 동서간호학연구지
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• 제27권1호
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• pp.61-69
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• 2021

Purpose: This study aims to determine the association between fear of falling, falls efficacy, and fall prevention behaviors in older adults in outpatient and identify the factors affecting fall prevention behaviors. Methods: This was a descriptive study. A total of 137 older adults aged 60 or older with more than one disease in an outpatients setting were recruited from a university hospital in Seoul. Data were collected from March 11 through April 8, 2016. Results: The experience of a fall was significantly associated with age (t=-2.71, p=.008), gender (𝛘²=14.32, p<.001), education (𝛘²=6.05, p=.049), income (𝛘²=9.93, p=.019), physical activity status (𝛘²=16.84, p<.001), and the number of diseases (t=-2.89, p=.004). Fall experience was not significantly associated with marital status (𝛘²=3.79, p=.285). Multiple regression analysis revealed that the most influential factor of fall prevention behaviors was the fear of falls (β=-.37, p<.001), followed by the number of diseases (β=-.20, p=.013). Conclusion: It is necessary to provide preventive fall education with older adults in outpatients settings considering the fear level of falling and the numbers of accompanying diseases.

• 보건교육건강증진학회지
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• 제24권4호
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• pp.241-249
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• 2007

Health education aims at behavior change rather than just delivering health knowledge to people. In Korea health education activities in public sector began in 1960 and they were included in the primary prevention program in communities. This article reviewed current health education programs in healthy living practice programs provided by local public health centers in Korea and drew implications for the future role of health education in community setting. Health education has been a core function of the National Health Promotion programs in the nation since the enactment of the National Health Promotion Law in 1995. The National Health Promotion programs are funded by the National Health Promotion Fund which are drawn from tobacco tax. The National Health Promotion programs include healthy living practice programs (smoking prevention and cessation programs, moderate alcohol use programs, physical activity promotion programs, and nutrition programs), chronic disease prevention programs, oral health programs and public hygiene programs. Methods of the National Health Promotion programs include health education, health counseling, health class, health information management, survey and research. Smoking prevention and cessation programs include smoking cessation clinic, smoking cessation education, non-smoking environment program, and non-smoking campaign. Moderate alcohol use programs include alcohol use education, moderate alcohol use campaign, alcohol use counseling, and alcohol free environment programs. Physical activity promotion programs include obesity control, targeted exercise program, and exercise civic group programs. Nutrition programs include nutrition management, obesity management, nutrition education, breakfast eating program, and nutrition counseling and treatment programs. The health education programs in community are not efficient today because there are many overlapping contents and short term goals. Community health education programs needs to be more comprehensive. Workforce development is another big issue at the moment because the National credential program will begin in 2009. Variety of community health education programs should be developed and funded by the national health promotion fund.

• 한국산학기술학회논문지
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• 제21권3호
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• pp.360-369
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• 2020

본 연구는 요양병원 종사자들의 비말감염 예방 활동과 기침예절 지식을 비교하기 위해 시행되었다. 대상자는 A시의 3개 요양병원 종사자 177명이었다(의료인: 간호사 61명, 비의료인: 간호조무사와 요양보호사 116명). 자료는 2019년 3월 4일부터 29일까지 구조화된 질문지를 이용하여 수집되었다. 자료분석방법은 x²-test, Fisher exact test, independent t-test, ANOVA를 이용하였다. 분석결과, 의료인과 비의료인의 일반적 특성은 성별과 연령에서 두 집단간 유의한 차이를 나타냈다. 의료인과 비의료인의 비말감염 예방 활동은 평상 시 티슈 휴대, 평상 시 손수건 휴대, 평상시 마스크 휴대, 호흡기 증상 시 손수건 휴대, 손씻기 횟수, 기침예절 준수에서 통계적으로 두 집단 간 유의한 차이를 나타냈다. 기침예절 지식은 통계적으로 두 집단 간 유의한 차이를 나타냈다. 비의료인의 비말감염 예방 활동에 따른 기침 예절 지식 정도의 차이에서 평상 시 마스크 휴대, 기침예절 교육 유무에서 통계적으로 유의한 차이를 나타냈다. 본 연구를 통해 요양병원 종사자별로 기침예절에 관한 지식을 높이고 기침예절의 습관화를 위한 전략 마련이 필요하다.