• 대한약침학회지
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• 제3권2호
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• pp.1-25
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• 2000

We were trying to study the validity of Puffer fish's poison(Tetrodotoxin- TTX) to make a traditional Korean Medical treatment. The following conclusions were made after literary studies. 1. The first record of the puffer fish dates back 2000 years ago in the Chinese text Book of Mountain and Sea and other texts from the similar period. 2. Puffer fish's poison IS known as tetrodotoxin which is an amino perhydroquinazoline compound. It has a chemical formula of $C_{11}H_{17}N_3O_8$ in the hemiacetal structure and has the molecular weight of 319. 3. Tetrodotoxin (TTX) plays a role as potent neurotransmitter blocker by blocking the $Na^+$ -gate channel which hinders the influx of $Na^+$ ion into the cell. 4. Symptoms of the puffer fish poisoning ranges from blunted sense in the lips and tongue, occasional vomiting in the first degree to sudden descending of the blood pressure, apnea, and other critical conditions in the fourth degree. Intoxication of the puffer fish poison progresses at a rapid pace as death may occur after an hour and half up to eight hours in maximum. Typical death occurs after four to six hours. 5. Ways to treat the puffer fish poisoning include gastric irrigation, induce vomiting, purgation, intravenous fluid injection, and correcting electrolytic imbalance and acidosis. In cases of dyspnea, apply oxygen inhalation and conduct artificial respiration. 6. Tetrodotoxin (TTX) may be applied in treating brain disorders, ocular pain, excess pain in the large intestine and ileum, and relieving tension of the skeletal museles, neuralgia, rheumatism, arthritis, and etc. 7. In terms of Oriental medicine, the puffer fish poison has characteristics of sweet, warm, and poisonous. It's known efficacies are to tonify weakness, dispel damp, benefit the lower back, relieve hemorrhoid, kills parasites, remove edema, and so forth. And the puffer fish eggs processed with ginger are said to be effective against tuberculosis and lung cancer, thus, it's validity must be investigated and further research should be followed.

• 한국지반공학회논문집
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• 제18권5호
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• pp.229-236
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• 2002

본 논문은 실용화된 지반개량용 마이크로시멘트 및 보통포틀랜드시멘트의 주입특성에 관한 연구로서 기초물성, 고결율, 침투성과 같이 실험적으로 주입재의 입도와 다짐정도를 조정하고, 주입대상 토사지반의 투수계수를 3종류로 변화시컥 약액주입의 주요 특성을 검토한 것이다. 주입재의 적용성을 평가하기 위하여 고결성 시험 및 침투성 시험을 실시한 결과, 모형토사지반의 상대밀도에 따른 투수계수를 $10^{-4}$~$10^{-2}$cm/sec로 변화시킨 경우, 마이크로시멘트는 투수 계수 $10^{-4}$cm/sec에서 유효고결율 75%, 침투주입율 86%로서 침투성 및 고결성이 우수한 결과를 나타낸 반면, OPC는 $10^{-2}$cm/sec에서 유효고결율 및 침투주입율이 50% 미만으로서 원활한 침투주입이 될 수 없음을 알 수 있었다. 댐 기초 지반 및 연약지반의 보강을 위해 주입재의 침투성이 요구되는 경우에는 마이크로시멘트가 적용성이 매우 우수한 것으로 판단된다. 동수지중 모형시험 결과 유속이 상대적으로 느린 경우 주입압이 높을수록, 완결형 주입재가 고결효과가 우수한 반면, 유속이 빠른 경우에는 완결형의 경우 주입재의 대부분이 외부로 유출되는 등 유효고결율이 매우 낮아 고결효과가 불량함을 알 수 있었다.

• 가정∙방문간호학회지
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• 제16권1호
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• pp.49-58
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• 2009

Purpose: This study aimed to clarify the needs for hospital-based home care nursing medical services in elder care institutions by analyzing the details and frequency of medical services provided by, and the needs for, hospital based home care nursing in select institutions in Korea. Methods: Seventy-seven staffs at elderly care institutions located throughout the country completed self-report questionnaires between February 1 and May 31, 2009. SPSS ver. 14.0 was used for data analysis regarding frequency and percentage, mean and standard deviation. Results: Forty-eight hospital-based home care nursing medical services in eight domains were identified as being needed in elderly care institutions. The most commonly used medical services were providing instruction in oral drug administration, checking drug beneficial/adverse effects, and administering blood glucose test, while the most needed medical services requiring hospital based home care nursing were complex pressure ulcer care, followed by diabetic foot ulcer management and nutrient injection. Conclusion: The present results should provide fundamental data for better healthcare services with hospital based home care nursing at elderly care institutions as part of a 'win-win' strategy through which medical expenses are reduced, insurance costs are kept stable, and safe and high-quality medical services are provided for residents of elder care institutions. Political decisions intended to promote visits by hospital based home care nurses to elder care institutions would be a prudent course.

• 한국수소및신에너지학회논문집
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• 제23권5호
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• pp.530-537
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• 2012

This work experimentally investigates that Diesel-DME blended fuel influences combustion characteristics and emissions (NOx, CO, HC, smoke) in a single-cylinder DI diesel engine. Diesel is used as a main fuel and DME is blended for the use of its quick evaporating characteristics. Diesel and DME are blended by the method of weight ratio. Weight ratios for Diesel and DME are 95:5 and 90:10 respectively and the both ratios have been used altogether in blended fuel. The experiments are conducted in this study single cylinder engine is equipped with common rail and injection pressure is 700 bar at 1200 rpm. The amount of injected fuels is adjusted to obtain the fixed input calorie value as 972.2 J/cycle in order to compare with the fuel conditions. DME is compressed to 15 bar by using nitrogen gas thus it can be maintained the liquid phase. In this study, different system compared others paper is common rail system, also there is combustion and emission about compared DME and diesel fuel. It is expected to be utilized about blended fuel.

• Journal of Mechanical Science and Technology
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• 제20권10호
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• pp.1765-1772
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• 2006

High-pressure die casting such as thixocasting and rheocasting is an effective process in the manufacturing automotive parts. Following the recent trend in the automotive manufacturing technologies, the product design subject to the die casting becomes more and more complex. Simultaneously the injection speed is also designed to be very high to establish a short cycletime. Thus, the requirement of the die design becomes more demanding than ever before. In some cases the product's shape can have multiple slender manifolds. In such cases, design of the inlet and outlet parts of the die is very important in the whole manufacturing process. The main issues required for the qualified products are to attain gentle and uniform flow of the molten liquid within the passages of the die. To satisfy such issues, the inlet cylinder ('bed cylinder' in this paper) must be as large as possible and simultaneously the outlet opening at the end of each passage must be as small as possible. However these in turn obviously bring additional manufacturing costs caused by re-melting of the bed cylinder and increased power due to the small outlet-openings. The purpose of this paper is to develop effective simulation methods of calculation for fluid flows in multiple columns, which mimic the actual complex design, and to get some useful information which can give some contributions to the die-casting industry. We have used a commercial code CFX in the numerical simulation. The primary parameter involved is the size of the bed cylinder. We will show how the very small opening of the outlet can be treated with the aid of the porous model provided in the code. To check the validity of the numerical results we have also conducted a simple experiment by using water.

• 한국산학기술학회논문지
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• 제17권1호
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• pp.244-251
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• 2016

본 연구에서는 폼 모니터의 유로 형상에 따라 유동 특성 및 분사거리에 비치는 영향을 수치적 해석기법인 유동해석을 통해 예측, 비교하고 실제 분사 성능 시험을 통해 검증하였다. 폼 모니터의 유로 형상에 따라 유체의 유동 양상이 달라지며, 유동손실이 발생함에 따라 분사거리에 영향을 미치는 것을 수치해석을 통해 계산하였다. 폼 모니터의 기본 형상은 N사에서 설계한 형상을 사용 하였고, 변경모델은 유로의 길이를 증가시킨 모델과 직선형태의 모델을 사용하였다. 입구압력은 6.5bar를 주었고, 계산 결과 유로의 길이를 증가시킨 모델과 직선형상 모델 모두 노즐에서의 분사거리가 향상되었다. 분사 성능시험결과와 비교한 결과 오차율은 7.43%로 비교적 잘 일치 하여 해석 기법의 타당성을 검증하였다.

• 한국주조공학회지
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• 제27권1호
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• pp.31-35
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• 2007

본 연구에서는 Mg합금의 반응고성형 공정기술을 개발하기 위하여 여러 가지 전단속도와 냉각속도에 따른 Mg합금의 점도와 딕소트러픽 거동을 분석하였으며, 이를 전산모사연구와 비교 검토하였다. 전산모사연구에서는 미세조직과 공정변수를 고려한 반응고 슬러리의 유변학적 거동을 분석하였다. 반응고 온도영역에서의 Mg합금(AZ91D) 슬러리의 점도는 고상율에 따라 지수함수적으로 증가하였으며, 전단속도가 증가하면 감소하는 경향을 나타났다. Mg합금 슬러리의 유변학적 거동을 정확하게 분석하기 위하여 Carreau 모델을 사용하여 ANYCAST 프로그램에서 고압다이캐스팅용 금형으로의 Mg합금 반응고 슬러리의 충진거동을 모사하였다. 전산모사된 결과는 동일한 조건에서의 실제 실험결과와 잘 일치하였다.

• 한국가스학회지
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• 제19권6호
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• pp.28-33
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• 2015

2012년 7월부터 우리나라 천연가스 열량에 대한 기준이 기존의 표준열량제에서 열량범위제로 변경되면서 가정이나 산업체로 공급되는 가스 열량 변화가 가스기기 성능에 미치는 영향을 규명하고자 하는 노력이 이루어지고 있다. 특히 천연가스를 주 연료로 사용하는 열병합 발전용 엔진의 경우 이러한 열량 변화에 의해 엔진 성능 전반에 걸쳐 영향이 있을 것으로 예상된다. 따라서 이번 연구에서는 열량범위제를 고려한 CNG 열량 변화가 디젤-CNG 혼소엔진의 효율 및 연소특성에 미치는 영향에 대해 조사하였다. CNG 모사 연료의 발열량은 $10,400kcal/Nm^3$에서 $9,400kcal/Nm^3$까지 질소 가스를 CNG에 희석하는 방식으로 변경을 하였다. 우선 디젤연료의 분사시기와 혼소율을 80%로 고정한 조건에서 가스연료의 발열량 변화가 엔진 효율 및 출력 변화에 미치는 영향을 살펴보았으며, 열방출율 및 연소압력 등의 변화를 측정하였다. 실험 결과로부터 가스 열량이 낮아질수록 엔진 출력과 효율이 모두 감소함을 알 수 있었으며, 점화지연시간과 연소기간은 가스 열량 감소에 관계없이 일정하게 유지되는 반면 최대연소압력은 낮아짐을 볼 수 있었다.

• Biomolecules & Therapeutics
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• 제3권4호
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• pp.316-321
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• 1995

All the pharmacological studies of LB17522 described here were carried out with high doses (fifteen to sixty times of the therapeutic dose) to determine an indication of potential side effects in clinical use in terms of the acute clinical signs, cardiovascular and central nervous system. LB10522 does not produce any observable clinical signs except for the symptoms such as moist eye, skin rash, slight salivation, vomitting, and slightly reduced activity. The effects of LB10522 on the hemodynamics and cardiac function of anesthetized beagle dogs are as follows; heart rates and mean arterial blood pressure had a tendency to increase mildly, which is a normal finding in anesthetized dogs. All the animals except for one showed relatively stable respiratory rates throughout the observation period. Each animal treated with LB10522 showed slight increase in the left cardiac work and left ventricular stroke work which are mainly related to corresponding increases in cardiac output. Femoral blood flow were shown to be increased in some animals treated with LB10522. The epileptogenic activities of various cephalosporins were assessed by a direct intracerebral injection of appropriate concentration of test articles. The CD$_{50}$ values (nmol) obtained from the analysis of the dose-response data are as follows; 78.2, 175.3, 156.3, and 53.5 for cefazolin, cephaloridine, ceftazidime, and LB 10522, respectively. LB10522 seems to be equipotent with cefazolin or to be three times more potent than cephaloridine and ceftazidime in causing adverse CNS stimulation. Taken into consideration all the information obtained, LB10522 is not supposed to induce much changes in the functions examined in these studies in man at therapeutic doses.s.

• Biomolecules & Therapeutics
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• 제3권4호
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• pp.322-326
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• 1995

General pharmacology of LB20304, a quinolone antibiotic, were examined in terms of general behaviour, cardiovascular, and central nervous system. LB20304 at oral dose of 2,000 mg/kg did not induce significant behavioural changes in mice. In contrast with ciprofloxacin, LB20304 at dose of 20 mg/kg, iv. did not show any observable effects on the blood pressure in rats. Displacement of [$^3$H]muscimol binding to the rat brain synaptic membranes was measured. LB20304 was shown to be about five times less potent than ciprofloxacin in specific GABA receptor binding. Drug interaction between LB20304 and 4-biphenyl acetic acid, an active metabolite of fenbufen, was assessed in mice by measuring convulsion and/or subsequent death. A single oral pretreatment with 4-BPA at 400 mg/kg increased the incidence of convulsion and death after oral administration of ciprofloxacin at the doses of 25, 50, and 100 from zero of five to three of five, two of five, and four of five, respectively, whereas LB20304 alone or combination with 4-BPA caused neither convulsions nor death at the doses of 12.5, 25, 50, and 100 mg/kg, respectively. Quinolones-induced epileptogenic activities were assessed by a direct intracerebral injection of test articles. The CD$_{50}$ values (nmole) are as follows; 169.47, 35.36, 105.29, and 88.67 for LB20304, ciprofloxacin, of loxacin, and lomefloxacin, respectively. From these data, LB 20304 at therapeutic doses seems to be much more safe than any other quinolones tested.d.