• 한국융합학회논문지
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• 제8권7호
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• pp.349-356
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• 2017

본 연구는 골관절염을 앓고 있는 여성을 대상으로 24주간의 수동적 수중재활운동을 통하여 효율적인 골관절염 예방 재활 프로그램 및 운동처방의 양식에 지침을 제공하는데 목적이 있다. 본 연구의 대상자는 K 정형외과 전문의에게 골관절염이라는 진단 받고 골관절염으로 인한 통증으로 병원을 3회 이상 내원한 자 중 실험군은 수동적 수중재활 운동집단(CG, n=10)과 비교군(AREG, n=10)으로 선정하였다. 연구결과 집단 내 좌우 어깨 높이(shoulder height) 변화는 수동적 수중재활운동군에서 유의한 차이가 있었다(p<.001). 집단 내 좌우 견갑골 하각 무늬의(sacpula patterns inferior) 변화는 수동적 수중재활운동군에서 유의한 차이가 있었다(p<.001). 집단 내 좌우 골반 하각 무늬의(pelvis patterns inferior) 변화는 수동적 수중재활운동군에서 유의한 차이가 있었다(p<.001).

• 대한한방내과학회지
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• 제42권4호
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• pp.532-546
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• 2021

Objective: This study investigated the perception, diagnosis, and treatment of irritable bowel syndrome (IBS) in the general population, in patients, and in Korean medicine doctors (KMDs) in order to provide basic information for the development of Korean medicine clinical practice guidelines for IBS. Methods: A questionnaire was developed in two versions, one for the general population/patients and one for KMDs. The questions were about the general perception, diagnosis, and treatment of IBS. Both online and offline surveys were conducted using these questionnaires. Results: In total, 213 general population/patients and 435 KMDs responded to the survey. The results of the analysis were as follows. Most of the KMDs diagnosed IBS based on clinical aspects. Acupuncture was the most common treatment, followed by prescription herbal medicine, moxibustion, and manufactured herbal medicine. 34.3% of KMDs used clinical practice guidelines for IBS patient treatment. 57.8% of patients were diagnosed with IBS by doctors at primary medical institutions, and 53.1% were diagnosed with colonoscopy. More than half of the IBS patients who have been treated with Korean medicine said they experienced improvement of symptoms and prevention of recurrence, but more than 70% of the respondents said future safety and effectiveness studies of Korean medicine were needed. Conclusions: In spite of the positive perception of IBS treatment with Korean medicine, actual utilization was relatively low. The development and promotion of, as well as education about, appropriate and reasonable Korean medicine practice guidelines for IBS is necessary.

• 한국임상약학회지
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• 제29권2호
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• pp.79-88
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• 2019

Backgrounds: Inflammatory bowel disease (IBD) including ulcerative colitis (UC) and Crohn's disease (CD) increased prevalence and economic burden. Objectives: This study aimed to investigate drug use pattern in IBD patients in a real world. Methods: National Health Insurance claim data from 2010 to 2014 were used in this population-based study. All IBD patients diagnosed during study period were enrolled. IBD medications included 5-aminosalicylic acid (ASA), glucocorticoid, immunomodulator and anti-tumor necrosis factor-${\alpha}$ agent(anti TNF-${\alpha}$). Growth rate of IBD prevalence, prescribed drug classes, duration of drug therapy and medication cost were analyzed. Number and percentage of patients for categorical variables, and mean and median for continuous variables were presented. Results: Total numbers of patients were 131,158 and 57,286 during 5 years, and their annual growth rate were 3.2 and 5.7% for UC and CD. UC and CD were prevalent in the 40-50 (41.2%) and 20-30 age groups (36.0%). About 60% of IBD patients was prescribed any of medications. 5-ASA was the most frequently prescribed, followed by corticosteroid and immunomodulator. Anti TNF-${\alpha}$ use was the lowest, but 5 times higher than UC in CD. Combination therapies with different class of drugs were in 29% for UC and 62% for CD. Mean prescription days per patient per year were 306 and 378, and the median medication cost per patient per year was KRW 420,000 (USD 383) and KRW 830,000 (USD755), for UC and CD, respectively. Conclusions: Increasing prevalence of IBD requires further studies to contribute to achieve better clinical outcomes of drug therapy.

• 한국융합학회논문지
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• 제12권3호
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• pp.53-59
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• 2021

의약품 정보검색 서비스를 사용할 때 대표적인 검색방법은 ATC(Anatomic Therapeutic Chemical Classification) 코드를 사용하는 것이다. 기존의 ATC코드 기반 의약정보 검색은 주요 성분이 한가지인 단일제 검색에는 매우 유용하다. 하지만 복합제의 경우에는 검색 오류가 종종 발생하고 있다. 이 문제의 원인은 ATC코드 기반 검색은 단일제 ATC 코드를 패턴매칭하여 진행 된다는 것이다. 본 연구는 ATC코드기반 검색 시 주성분을 기준으로 복합제를 검색하는 요구사항 시나리오를 분석하여 ATC코드기반 매핑 스키마를 설계하였다. ATC코드기반 매핑 스키마는 복합제의 ATC코드와 복합제에 포함된 모든 단일제의 ATC코드를 저장한 스키마를 의미한다. 이 스키마를 사용한 ATC코드기반 검색은 단일제의 주성분으로 복합제를 검색하므로 기존 방법보다 높은 정확도를 가진다. ATC코드기반 매핑 스키마는 의사의 환자 처방 효율을 높일 수 있고 의약품 안전 사용 서비스의 정확도를 올릴 수 있을 것으로 기대된다.

• The Korean Journal of Pain
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• 제35권4호
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• pp.361-382
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• 2022

The third opium war may have already started, not only due to illicit opioid trafficking from the Golden Crescent and Golden Triangle on the international front but also through indiscriminate opioid prescription and opioid diversion at home. Opioid use disorder (OUD), among unintentional injuries, has become one of the top 4 causes of death in the United States (U.S.). An OUD is defined as a problematic pattern of opioid use resulting in clinically significant impairment or distress, consisting of 2 or more of 11 problems within 1 year, as described by the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition. Observation of aberrant behaviors of OUD is also helpful for overworked clinicians. For the prevention of OUD, the Opioid Risk Tool and the Current Opioid Misuse Measure are appropriate screening tests before and during opioid administration, respectively. Treatment of OUD consists of 3 opioid-based U.S. Food and Drug Administration-approved medications, including methadone, buprenorphine, and naltrexone, and non-opioid-based symptomatic medications for reducing opioid withdrawal syndromes, such as α₂ agonists, β-blockers, antidiarrheals, antiemetics, non-steroidal anti-inflammatory drugs, and benzodiazepines. There are at least 6 recommendable guidelines and essential terms related to OUD. Opioid stewardship programs are now critical to promoting appropriate use of opioid medications, improving patient outcomes, and reducing misuse of opioids, influenced by the successful implementation of antimicrobial stewardship programs. Despite the lack of previous motivation, now is the critical time for trying to reduce the risk of OUD.

• 대한한방부인과학회지
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• 제35권4호
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• pp.143-160
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• 2022

Objectives: This study aimed to lay the foundation for the Korean medicine infertility treatment support program to be implemented in the future by analyzing the results of the Korean medicine infertility treatment support program implemented by Incheon metropolitan city. Methods: 224 patients applied for the Korean medicine infertility treatment support program conducted by Incheon metropolitan city and had three months of herbal medicine treatment and three months of follow-up time. Information on general, demographic, and infertility-related characteristics of patients before treatment was collected. Information on treatment contents performed by Korean medical doctors during treatment, and information on results and satisfaction after treatment was collected. In order to evaluate the safety of treatment, blood tests were performed before and after treatment, and abnormal reactions were monitored. Results: Of 224 patients, 211 ended treatment, of which 45 (21.33%) succeeded in pregnancy. The characteristics of the successful and failure groups of pregnancy were found to be statistically significant differences in age, therapeutic history, parity, anti-müllerian hormone test results, and type of infertility of the patients and spouses. The most common pattern identification was kidney deficiency, and the most widely used prescription was Jogyeongjongok-tang. Patients were highly satisfied with the treatment of Korean medicine infertility. As a result of the safety evaluation, herbal medicine treatment was confirmed to be a safe treatment. Conclusions: In this study, clinical information on the Incheon metropolitan city Korean medicine infertility treatment support program was obtained. Based on this study, it is expected that the Korean medicine infertility treatment program in the future will guarantee more extensive treatments such as extending the treatment period or supporting korean herbal medicine to spouses.

• 대한한방내과학회지
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• 제44권4호
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• pp.703-725
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• 2023

Objectives: This study investigated Korean medicine doctors' perspectives on clinical practice patterns in the process of developing Korean medicine clinical practice guidelines for benign prostatic hyperplasia. Methods: A questionnaire was developed for Korean medicine doctors. A total of 323 oriental medicine doctors participated in the survey, which was live for a total of 9 days from September 22, 2022, to September 30, 2022. Results: Regarding awareness of treatments for benign prostatic hyperplasia, 63.8% of respondents showed high awareness of Korean medical treatments. However, items such as diagnostic criteria (17.7%), evaluation methods (17.0%), and Western medical treatments (22.9%) showed low recognition rates. In clinical practice, 76.2% of respondents were found to treat five or fewer patients with benign prostatic hyperplasia per month, and the average treatment period was 1 to 3 months for most at 41.2%. Korean medicine doctors diagnosed benign prostatic hyperplasia based on clinical features. The main interventions used were acupuncture, herbal medicine (prescription medicine), and moxibustion. This study has several limitations because of the low response rate for this survey; therefore, the participants are not representative of all Korean medicine doctors. In addition, because the study was conducted broadly on various topics related to benign prostatic hyperplasia, sufficient quality management was not carried out. Further studies that include a larger sample size and more in-depth studies on benign prostatic hyperplasia are needed. Conclusions: It is necessary to develop appropriate and reasonable Korean medicine clinical practice guidelines for benign prostatic hyperplasia.

• Korean Circulation Journal
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• 제53권5호
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• pp.313-327
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• 2023

Background and Objectives: Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Recent advances in PAH-specific drugs have improved its outcomes, although the healthcare burden of novel therapeutics may lead to a discrepancy in outcomes between developing and developed countries. We analyzed how the epidemiology and clinical features of PAH has changed through the rapidly advancing healthcare infrastructure in South Korea. Methods: PAH was defined according to a newly devised 3-component algorithm. Using a nationwide health insurance claims database, we delineated annual trends in the prevalence, incidence, medication prescription pattern, and 5-year survival of PAH in Korea. Cumulative survival and potential predictors of mortality were also assessed among 2,151 incident PAH cases. Results: Between 2002 or 2004 and 2018, the prevalence and incidence of PAH increased 75-fold (0.4 to 29.9 per million people) and 12-fold (0.5 to 6.3 per million person-years), respectively. The proportion of patients on combination PAH-specific drug therapy has also steadily increased up to 29.0% in 2018. Among 2,151 incident PAH cases (median [interquartile range] age, 50 [37-62] years; 67.2% female), the 5-year survival rate and median survival duration were 71.8% and 13.1 years, respectively. Independent predictors of mortality were age, sex, etiology of PAH, diabetes, dyslipidemia, and chronic kidney disease. Conclusions: This nationwide study delineated that the prevalence and incidence of PAH have grown rapidly in Korea since the early 2000s. The use of combination therapy has also increased, and the 5-year survival rate of PAH in Korea was similar to those in western countries.

• 한국안광학회지
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• 제19권3호
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• pp.323-329
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• 2014

목적: 본 연구는 최근 4년간 대한민국의 안경원에서 판매된 콘택트렌즈를 조사하여 처방되는 추세를 알아보고자 하였다. 방법: 매년 100개의 설문지를 무작위로 전국 안경원에 우편 발송하였다. 각 설문지의 작성은 안경원에서 설문지를 받은 후에 판매된 처음 10건의 콘택트렌즈에 대한 정보를 기재하도록 하였고, 우편이나 이메일로 반송하도록 요청하였다. 결과: 총 400개의 설문지 중에 209개의 설문지가 반송되었고, 훼손이 없고 분석에 적합한 처방건수가 1937건이었다. 콘택트렌즈를 처방 받은 고객들의 평균 나이는 2010년에는 $26.2{\pm}7.0$세, 2011년에는 $26.1{\pm}7.6$세, 2012년에는 $24.7{\pm}.6$세, 2013년에는 $24.8{\pm}7.2$세로 나타났으며, 착용자의 대부분은 여성이었다(75%). 소프트콘택트 렌즈 중에서 실리콘 하이드로겔 렌즈의 비율은 평균 18%를 차지하였고, 디자인별로 분류했을 때, 토릭렌즈의 비율은 평균 17%였으며, 이 비율은 4년간 꾸준히 증가하였다(2010년:10%, 2011년:18%, 2012년:16%, 2013년:22%). 미용렌즈는 29%의 비율을 나타내었다. 일회용 렌즈의 비율은 29%이고, 3~6개월 교체용이 가장 많은 40%로 조사되었다. 결론: 콘택트렌즈 착용자의 대부분이 여성이었으며, 평균나이는 4년간 적은 비율로 차츰 감소하였다. 나이가 어린 여성 착용자가 증가한 것은 미용렌즈의 처방이 갈수록 증가한 것과 연관된다. 또한 미용렌즈의 처방 비율(29%)은 전세계의 미용렌즈 처방 평균(7%)보다 훨씬 높게 나타났다. 이러한 미용렌즈의 성장은 한국의 미용관련 시장의 상승세와 관련 있는 것으로 생각된다.

• 한국의학물리학회지:의학물리
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• 제29권1호
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• pp.1-7
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• 2018

The $TomoTherapy^{(R)}$ beam-delivery method creates helical beam-junctioning patterns in the dose distribution within the target. In addition, the dose discrepancy results in the particular region where the resonance by pattern of dose delivery occurs owing to the change in the position and shape of internal organs with a patient's respiration during long treatment times. In this study, we evaluated the dose pattern of the longitudinal profile with the change in respiration. The superior-inferior motion signal of the programmable respiratory motion phantom was obtained using AbChes as a four-dimensional computed tomography (4DCT) original moving signal. We delineated virtual targets in the phantom and planned to deliver the prescription dose of 300 cGy using field widths of 1.0 cm, 2.5 cm, and 5.0 cm. An original moving signal was fitted to reflecting the beam delivery time of the $TomoTherapy^{(R)}$. The EBT3 film was inserted into the phantom movement cassette, and static, without the movement and with the original movement, was measured with signal changes of 2.0 s, 4.0 s, and 5.0 s periods, and 2.0 mm and 4.0 mm amplitudes. It was found that a dose fluctuation within ${\pm}4.0%$ occurred in all longitudinal profiles. Compared with the original movement, the region of the gamma index above 1 partially appeared within the target and the border of the target when the period and amplitude were changed. Gamma passing rates were 95.00% or more. However, cases for a 5.0 s period and 4.0 mm amplitude at a field width of 2.5 cm and for 2.0 s and 5.0 s periods at a field width of 5.0 cm have gamma passing rates of 92.73%, 90.31%, 90.31%, and 93.60%. $TomoTherapy^{(R)}$ shows a small difference in dose distribution according to the changes of period and amplitude of respiration. Therefore, to treat a variable respiratory motion region, a margin reflecting the degree of change of respiration signal is required.