• 대한토목학회논문집
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• 제8권1호
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• pp.127-140
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• 1988

도시의 급속한 팽창에 따라 하수 및 우수관리에 대한 문제가 점점 대두되고 있다. 도시내의 가정과 공장 등에서 나오는 오수 및 폐수들은 지하의 하수관거를 통하여 처리장이나 일반하천으로 방출되는데, 합류식 관거의 경우에는 강우로 인한 유출수까지도 이동시키는 역할을 담당하게 된다. 그런데 강우로 인한 유출수는 폐수나 오수처럼 인위적인 비율로 취급될 성질의 것이 아니므로 강우강도의 차이나 강우량에 따라서 가용적을 초과하여 관거내 압력류(surcharge)나 맨홀상부 범람 현상(overflow)을 발생시키게 된다. 따라서 어느 정도의 하수나 우수량은 감당할 수 있지만 장마철과 같이 강도가 높은 강우가 발생할 때에는 관경이 작거나 경사가 완만한 곳으로부터 지표면상으로 하수 및 우수가 동시에 범람되어 지대가 낮은 지역의 침수현상을 흔히 볼 수가 있다. 이번 연구는 하수관거의 이러한 흐름특성(flow characteristic)을 수치해석방법을 이용하여 해석함으로써, 설계된 관거에 있어서 관경 및 관경사등의 보정에 참고자료로서의 가능성을 찾는데 있었다. 본 연구는 유한차분법(finite difference method) 중 4점 음해법(four point implicit method)을 이용하며 Preissmann Slot Concept를 컴퓨터 용량에 제약이 없는 중첩분할법(Overlapping Segment Method)에 도입함으로써 압력류(surcharge) 및 맨홀의 범람 현상을 용이하게 파악할 수 있도록 시도하였다. 가상관망에 대한 모델의 실행결과 각 관거내의 수위 및 유량곡선의 시간적 분포를 통해 Slot의 적용의 실효성을 확인할 수 있었으며, 관거의 입구 및 출구에서의 유량보존이 성립함으로써 모델의 합리성이 제시되었다.

• 응용통계연구
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• 제27권4호
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• pp.645-653
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• 2014

p-값은 관측 표본과 관측 결과보다 심하게 대안가설의 방향으로 영가설을 이탈하는 표본들이 영가설 하에서 갖는 확률이다. p-값이 일정 ${\alpha}$(= 0:05)보다 작게 나타나면 연구자는 대안가설이 지지된 것으로 본다. 그런 경우라고 하더라도 그의 가설이 향후 연구에서 번복될 수 있는데 그 이유는 p-값이 표본에 따라 변동하는 통계량이기 때문이다. Boos와 Stefanski (2011)는 붓스트랩 방법으로 p-값의 예측분포를 구할 수 있음을 보였다. 그들은 그 분포의 상위 10-20% 분위수가 ${\alpha}$보다 작은가를 확인할 필요가 있음을 강조한다. 만약 그렇지 않은 경우에는 "지지"된 가설의 재현성이 문제될 수 있기 때문이다. 가설검정에서 일정 수준의 재현율을 확보하기 위해서는 표본의 증대가 요구된다. 이 연구는 k배 확대 붓스트랩 표본추출(boosted bootstrap sampling)로써 필요한 표본크기를 계산할 수 있음을 두 표본의 비교와 다중선형회귀의 수치 예에서 보인다. k 값을 정하기 위해서는 몇 차례 시행착오를 해야 하지만 계산적 부담은 크지 않다. 95% 신뢰구간은 독립적인 표본들로부터 같은 방식으로 산출되는 구간이 미지의 모수를 포함할 확률이 95%가 되도록 설정된다. 이 연구는 한 관측표본으로부터 얻어진 95% 신뢰구간 내 개별 점이 미래 연구의 신뢰구간에도 포함될 것인지 그 재현성을 붓스트랩 재표본들에서 평가한다. 이 연구는 개별 점에서 산출한 신뢰구간 재현율을 그래프로 보인다.

• 대한환경공학회지
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• 제38권10호
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• pp.551-557
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• 2016

여러 환경요인을 예측하는데 위성영상과 측정데이터의 접목은 정확도를 향상시킬 수 있는 잠재력을 가지고 있다. 하지만 습지 토양에 포함되어있는 영양염류의 성분 등을 예측함에 있어 위성영상의 활용 효과는 잘 알려져 있지 않다. 따라서, 본 연구에서는 지구통계학 중 블록크리깅과 회귀크리깅을 자연습지인 에버글레이드에 위치한 수자원관리유역의 토양 내 총인 예측에 적용하였다. 토양시료의 측정된 총인농도를 이용하여 블록크리깅을, 측정값 외에 30 m의 공간해상도를 가지고 있는 위성영상인 Landsat ETM+로부터 추출한 스펙트럼 데이터 및 분광지수 등을 독립변인으로 하여 회귀크리깅을 실시한 결과, 블록크리깅의 결정계수는 0.59, 회귀크리깅의 결정계수는 0.49로 나타났다. 측정 자료만을 이용한 블록크리깅의 예측 오차가 위성영상을 이용한 회귀크리깅의 예측 오차보다 더 작았으나, 각각의 방법을 이용하여 총인 농도를 수자원관리유역에 매핑한 결과 두 경우 모두 비슷한 경향을 보였고, 회귀크리깅의 경우 연구대상유역의 독특하고 복잡한 경관요소들을 더욱 잘 표현할 수 있었다.

• The Korean Journal of Physiology and Pharmacology
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• 제16권4호
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• pp.273-279
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• 2012

Busulfan is an antineoplastic agent with a narrow therapeutic window. A post-hoc population pharmacokinetic analysis of a prospective randomized trial for comparison of four-times daily versus once-daily intravenous busulfan was carried out to search for predictive factors of intravenous busulfan (iBu) pharmacokinetics (PK). In this study the population PK of iBu was characterized to provide suitable dosing recommendations. Patients were randomized to receive iBu, either as 0.8 mg/kg every 6 h or 3.2 mg/kg daily over 4 days prior to hematopoietic stem cell transplantation. In total, 295 busulfan concentrations were analyzed with NONMEM. Actual body weight and sex were significant covariates affecting the PK of iBu. Sixty patients were included in the study (all Korean; 23 women, 37 men; mean [SD] age, 36.5 [10.9] years; weight, 66.5 [11.3] kg). Population estimates for a typical patient weighing 65 kg were: clearance (CL) 7.6 l/h and volume of distribution (Vd) 32.2 l for men and 29.1 L for women. Inter-individual random variabilities of CL and $V_d$ were 16% and 9%. Based on a CL estimate from the final PK model, a simple dosage scheme to achieve the target $AUC_{0-inf}$ (defined as median AUC0-inf with a once-daily dosage) of 26.18 $mg/l{\cdot}hr$, was proposed: $24.79{\cdot}ABW^{0.5}mg$ q24h, where ABW represents the actual body weight in kilograms. The dosing scheme reduced the unexplained interindividual variabilities of CL and Vd of iBu with ABW being a significant covariate affecting clearance of iBU. We propose a new simple dosing scheme for iBu based only on ABW.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10451-10456
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• 2015

Background: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6%) cases were male, 730 (46.4%) cases were female. One thousand four hundred forty-seven (92%) cases were invasive melanoma and 127 (8%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9%). It was followed by nodular melanoma in 379 (26.2%), acral lentiginous melanoma (ALM) in 191 (13.2%) and lentigo maligna melanoma in 132 (9.1%), respectively. On univariate analysis, lymphovascular invasion (p<0.001), tumor thickness (p<0.001), histopathological subtype (p<0.001), Clark level (p=0.001), ulceration (p<0.001), ${\geq}6/mm^2$ mitosis (p=0.005), satellite formation (p=0.001) and gender (p=0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p=0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index; most of the melanoma lesions' thickness were greater than 2 mm, corresponding Clark IV. Vascular invasion and tumor thickness are the most important factors for sentinel lymph node involvement.

• Journal of Nutrition and Health
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• 제31권1호
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• pp.96-101
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• 1998

The prevalence of iron deficiency in later infancy and the toddler years(25% to 40% at 1 year of age) has not decreased remarkably , except in Western countries. The purpose of this study was to 1) determine the relationship between current feeding practices and iron status, and 2) assess compliance to infant feeding instructions. Two groupsof infants were examined. The first group of 302 infants aged 6 to 24months was seen at a well baby clinic while the second group of 135 infants of the same age group was assessed by venipuncture. Cutoff values for laboratory tests were as follows ; hemoglobin<11g/dL, mean corpuscular volume (MCV) <72fl ; red cell distribution width(RDW)>15% ; serum ferritin level<10ng/ml ; and transferrin saturation (serum iron(TIBC)<10%. The diagnosis of iron deficiency anemia (IDA) was made when a low hemoglobin level was associated with either low ferritin orlow transferrin saturation . Of the 302 children brought to the well baby clinic , 12.3%(n=37) were found to have anemia (hemoglobin<11.0/dL). In terms of children grouped according to feeding practices, it was found that children with anemial comprised 32.0% (24/75) of the prolonged breast-fed group (Group A), significantly more than the 4.0%(7/176) of the artificial milk feeding group(Group B). and 3.9%(2/51) of the switched from breast milk to iron -fortified weaning foods group(Group C).Among the 107 children with IDA , iron deficiency in 105 children(98.1%) was suggested by their dietary histories ; exclusive or prolonged breast-feeding for more than 6 months without iron fortification in 98 infants ; cow's milk consumption> 500ml/day without iron fortification during infancy(n=12), or >800ml without iron-fortified foods after infancy(n=15) ; and the use of unfortified forumula or unbalanced diets, mainly limited to rice gruel. Despite the relatively high (79.6%) motivation on the part of the infants mothers and supervison by professional personnel, the poor results in the infants receiving iron fortified foods were due to poor compliance(85.75). Among the mothers of 98 IDA patients who were contacted by telephone , it was revealed that 29% did not give the oral iron preparation for more than 2 months. Furthermore, negligence or disregard by the parents occurred in 14% of the case , discontinuance of the oral iron preparation by the parents due to side effects occurred in 6%, and the children's refusal or poor oral intake and no further trial occurred in 6%. The dietary history of a large group of infants was highly predictive of their risk for anemia . Continued consumption of breast milk until the age of 1 year is not warranted unless iron-fortified foods are given concomitantly. Because there is a problem with compliance, more successful and safe strategies for preventing iron deficiency woold included dual coverage in the from of therapeutic iron supplementation as well use of iron-fortified foods for teddlers who are at risk of iron deficiency.

• 한국빅데이터학회지
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• 제4권1호
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• pp.63-72
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• 2019

전력 에너지의 경우 발전 및 송전 과정을 거쳐 사용자에게 제공된 이후에는 회수가 불가능하기 때문에 정확한 수요 예측에 기반한 최적 발전 및 송배전 계획이 필요하다. 전력 수요 예측의 실패는 2011년 9월에 발생한 대규모 정전사태와 같이 다양한 사회적·경제적 문제를 야기할 수 있다. 전력 수요 예측 관련 기존 연구에서는 ARIMA, 신경망모형 등 다양한 방법으로 개발이 되었다. 하지만 전국 단위의 평균 외기온도를 사용한다는 점과, 계절성을 구분하기 위한 획일적 기준을 적용하는 한계점으로 인해 데이터의 왜곡이나 예측모형의 성능 저하를 초래하고 있다. 이에 본 연구에서는 전력 수요 예측 모형의 성능을 향상하기 위해 전국을 5대 권역으로 구분하여 지역적 특성과 이동 기간 학습 기법을 통해 계절적 특성을 반영한 선형회귀모형과 신경망 모형의 장기적 전력 수요 예측 모형을 개발하였다. 이를 통해 중장기부터 단기에 이르기까지 다양한 범위의 수요 예측에 해당 모델을 활용할 수 있을 뿐만 아니라 특정 기간 중에 발생하는 다양한 이벤트와 예외 상황을 고려할 수 있을 것이다.

• 한국토양환경학회지
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• 제1권2호
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• pp.91-101
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• 1996

최근에 식물을 이용한 탄화수소화합물의 정화방법은 특히, 넓은 범위에 거쳐 저농도로 오염되어 있는 토양인 경우에 앞으로 각광을 받을 가능성이 높은 새로운 연구분야로 주목을 받아왔다. 이의 기술을 실제 오염토양에 바로 적용하기전 적절한 설계에 필요한 예측 모델링의 필요성이 함께 요구되고 있다. 현재 녹지토양내의 용질과 식물과의 상호작용에 관한 많은 모델들이 나와있지만 대부분이 이온상태의 무기영향물이나 금속류의 경우에만 한정되어 있다. 본 연구에서는 토양내의 탄화수소화합물의 생물학적정화에 미치는 식물의 영향을 예측하기 위한 기본 수학적 모델식을 제안 하였다. 먼저 토양내의 식물뿌리가 토양수분과 오염물에게 미치는 영향과 비포화계층에서의 오염물의 이동현상 및 토양내 기/액상간의 물질전달을 수학적으로 나타내고자 하였으며 시간의 변화와 토양깊이별 식물의 오염물의 동태에 미치는 영향을 시뮬레이션하기 위하여 식물뿌리의 시간에 따른 양적성장과 깊이별 분포정도를 예측하기 위한 관계식도 아울러 모델링에 포함하였다. 오염물의 식물내의 흡수 및 생물막이론을 이용한 식물뿌리근처에서의 생물학적 분해에 관한 현상도 관계식을 이용 설명하고자 하였다. 본 연구에서 제시한 식물영향하의 탄화수소화합물의 토양내의 동태해석을 위한 모델식은 실제로 탄화수소화합물에 의해 오염된 토양을 식물을 이용하여 정화하고자 할때, 필요한 기본설계도구로서 유용하게 쓰여질 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3253-3256
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• 2015

Background: Chronic hepatitis B virus (HBV) infection related hepatocellular carcinoma (HCC) is a major health problem in the Asia-Pacific region including Thailand. Several factors have been proposed as contributing to hepatocarcinogenesis. This study was aimed to investigate the impact of CYP2C19 genotypic polymorphism in HCC related to chronic HBV infection in Thailand. Materials and Methods: A cross-sectional study was performed between April 2014 and January 2015. Chronic HBV patients with HCC (n=50) and without HCC (n=50) were included. Clinical information and blood samples of all patients were collected. The CYP2C19 genotype was determined by polymerase chain reaction-restriction fragment length polymorphism method, and was classified as rapid metabolizer (RM), intermediate metabolizer (IM) or poor metabolizer (PM). Results: The CYP2C19 genotype frequencies of RM, IM and PM in HBV patients were found to be 19/50 (38%), 25/50 (50%) and 6/50 (12%), respectively. The CYP2C19 genotype frequencies of RM, IM and PM in HBV with HCC patients were 21/50 (42%), 25/50 (50%) and 4/50 (8%), respectively. The distribution of CYP2C19 genotype was not different between patients with and without HCC. Interestingly, among HBV with HCC patients, the RM genotype of CYP2C19 tended to increase risk of aggressive manifestation (OR=2.89, 95%CI=0.76-11.25, P-value=0.07), compared with non RM genotype carriers. Conclusions: CYP2C19 genotype IM was the most common genotype in Thai patients with chronic HBV infection. In addition, genotype RM could be an associated factor for aggressive presentation in HCC related to chronic HBV infection.

• 한국과학교육학회지
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• 제16권1호
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• pp.61-76
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• 1996

The purpose of this study was to apply the instructional strategies for conceptual change prescribed by Posner et al(1982) to the astronomic content domain taught in the elementary and middle school and to analyze the characteristics of students' knowledge revealed in the test before, during and after the instruction. Also, it was to investigate the intercorrelation of cognitive levels, spatial ability and science achievement. The major findings of this study are as follows: 1. Students had a great variety of misconceptions related to the motion of the moon before the instruction, that is, the phases, the names of phases and the cause of changing phases by the moon's orbit about the earth, the moon's appearance and location at the given time, the relative positions of earth, moon and sun during a lunar eclipse, the cause that a full moon is not at the line of node once a month. In the analysis of students' responses concerning the cause of changing phases of the moon and a lunar eclipse, the results indicate that the great majority of students had rote learning rather than meaningful learning in the middle school. 2. Students' reponses during the instruction concerning the changing phases of the moon and the predictive knowledge about the motions of the earth and the moon were analyzed. 1) According to the results of the test given before and after experiment, after discussion, achievement score of the whole of subjects and groups in both preformal and formal cognitive levels appeared to increase linearly. 2) There was no statistically significant differences of achievement scores before and after experiment, after discussion between preformal group and formal group in cognitive levels. 3. Distribution of achievement scores according to the whole of subjects and groups in preformal and formal cognitive levels shows that there was a statistically significant difference between pretest and posttest. 4. Types of conceptual changes concerning the cause of changing phases of the moon that occurred from pretest to posttest were classified as accommodation, incomplete accommodation, assimilation, no change and no model. Six of the seven students starting instruction with alternative frameworks didn't sustain those alternative models throughout instruction. Five of these six students accommodated completely and the last one partially. Seventy-nine percentage of students taking instruction with fragmental models assimilated correct propositions at the end of the instruction. These results suggest that conceptual change model prescribed by Posner et al(1982) has promised the meaningful learning to students taking with fragmental models, especially in cases where students with misconception enter instruction. 5. High correlation between achievement score of simple-recall items and that of written items in pretest and posttest indicates that the higher students got the score in simple-recall items the better they also performed in written items. However, there was no statistically significant differences among cognitive levels, spatial ability and science achievement in the whole of subjects and groups according to the cognitive levels.