• Journal of Ginseng Research
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• v.47 no.6
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• pp.694-705
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• 2023

Panax ginseng Meyer is a traditional Chinese medicine that is widely used as tonic in Asia. The main pharmacologically active components of ginseng are the dammarane-type ginsenosides, which have been shown to have anti-cancer, anti-inflammatory, immunoregulatory, neuroprotective, and metabolic regulatory activities. Moreover, some of ginsenosides (eg, Rh2 and Rg3) have been developed into nutraceuticals. However, the utilization of ginsenosides in clinic is restrictive due to poor permeability in cells and low bioavailability in human body. Obviously, the dammarane skeleton and glycosyls of ginsenosides are responsible for these limitations. Therefore, improving the oral bioavailability of ginsenosides has become a pressing issue. Here, based on the structures of ginsenosides, we summarized the understanding of the factors affecting the oral bioavailability of ginsenosides, introduced the methods to enhance the oral bioavailability and proposed the future perspectives on improving the oral bioavailability of ginsenosides.

• Computers and Concrete
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• v.33 no.5
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• pp.545-557
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• 2024

A real-case incident occurred where a 9-meter-high segment of a pre-fabricated concrete separation wall unexpectedly collapsed. This collapse was triggered by improperly depositing excavated soil against the wall's back, a condition for which the wall segments were not designed to withstand lateral earth pressure, leading to a flexural failure. The event's analysis, integrating technical data and observational insights, revealed that internal forces at the time of failure significantly exceeded the wall's capacity per standard design. The Lattice Discrete Particle Model (LDPM) further replicates the collapse mechanism. Our approach involved defining various parameter sets to replicate the concrete's mechanical response, consistent with the tested compressive strength. Subsequent stages included calibrating these parameters across different scales and conducting full-scale simulations. These simulations carried out with various parameter sets, were thoroughly analyzed to identify the most representative failure mechanism. We developed an equation from this analysis that quickly correlates the parameters to the wall's load-carry capacity, aligned with the simulation. Additionally, our study examined the wall's post-peak behavior, extending up to the point of collapse. This aspect of the analysis was essential for preventing failure, providing crucial time for intervention, and potentially averting a disaster. However, the reinforced concrete residual state is far from being fully understood. While it's impractical for engineers to depend on the residual state of structural elements during the design phase, comprehending this state is essential for effective response and mitigation strategies after initial failure occurs.

• Structural Engineering and Mechanics
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• v.52 no.2
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• pp.323-349
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• 2014

In this paper, linear buckling analysis of a curved sandwich beam with a flexible core is investigated. Derivation of equations for face sheets is accomplished via the classical theory of curved beam, whereas for the flexible core, the elasticity equations in polar coordinates are implemented. Employing the von-Karman type geometrical non-linearity in strain-displacement relations, nonlinear governing equations are resulted. Linear pre-buckling analysis is performed neglecting the rotation effects in pre-buckling state. Stability equations are concluded based on the adjacent equilibrium criterion. Considering the movable simply supported type of boundary conditions, suitable trigonometric solutions are adopted which satisfy the assumed edge conditions. The critical uniform load of the beam is obtained as a closed-form expression. Numerical results cover the effects of various parameters on the critical buckling load of the curved beam. It is shown that, face thickness, core thickness, core module, fiber angle of faces, stacking sequence of faces and openin angle of the beam all affect greatly on the buckling pressure of the beam and its buckled shape.

• Research in Mathematical Education
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• v.8 no.4
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• pp.227-260
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• 2004

This article represents a survey on the Romanian mathematics education. we emphasize not only some of recent, specific and significant Romanian methods concerning the teaching and learning of mathematics, starting from the pre-school and primary level to the university mathematics education, but also the role of the national and international mathematical competitions, the education of mathematics teacher, the formation of the researchers in mathematics, their contributions and perspectives, the mathematics education in society and culture, the technology in mathematics education, links between research and practice, topical developments and for the future and other related topics.

• Journal of Korean Neurosurgical Society
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• v.40 no.4
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• pp.293-295
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• 2006

Infundibular dilatation is funnel-shaped symmetrical enlargement that occurs at the origin of cerebral arteries and which is apparent on 7 to 25% of normal angiograms. Infundibular dilatation is frequently considered a normal anatomic variation of no pathologic significance. The authors report a case in which an aneurysm developed on an infundibular dilatation of the posterior communicating artery [PComA]. A 72-year-old woman presented with severe headache, nausea, and vomiting. Digital subtraction angiography showed a saccular aneurysm arising from the origin of the left PComA. Operative findings revealed the aneurysm and infundibular widening of the right PComA. The aneurysm was successfully obliterated. Whether infundibular dilatation is a pre-aneurysmal state or a benign dilatation is controversial. However, we believe infundibular dilatation of the PComA in this case may have served as a pre-aneurysmal lesion.

• Journal of Chest Surgery
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• v.20 no.2
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• pp.384-392
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• 1987

The occlusive coronary artery disease presents a potential threat to a significant population in the United State. According to many case reports, the increasing incidence of coronary artery disease due to atherosclerosis is noted in Korean, recently. We experienced one case of coronary artery disease. He was a 68 year old male who had been suffered from hypertension since 1 5 years ago, and had intermittent conservative treatment at local clinic. He had been afflicted with severe chest pain on exertion, but this symptom was relieved on rest. Pre-operative EKG finding revealed no any other ischemic sign. Significant S-T segment depression was noted at lead II, aVF, V3, V4, and V5, and inverted T wave in V5 and V6 after Master`s test. Simple chest X-ray finding showed emphysematous field, bilaterally. Final pre-operative diagnosis was made by coronary angiogram, which showed almost 90% degree of occlusive lesion in the proximal part of left main coronary artery above the origin LAD artery. He was treated successfully by aorta-coronary saphenous vein graft under extra-corporeal circulation in May, 1987. He has been followed up with uneventful course.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.99.2-99.2
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• 2014

We investigate how a solar eruption occurs in an environment where a solar wind exists during a pre-eruptive phase. To understand it, we have performed three-dimensional simulations based on a zero-beta magnetohydrodynamic (MHD) equations in various ways to drive an eruption with a solar wind. A pre-eruptive state is derived by applying a nonlinear force-free reconstruction method to a flux emergence full MHD simulation. We discuss what is the most appropriate way to drive a solar wind-related eruption.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.4
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• pp.619-628
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• 2001

A viscoelastic constitutive equation of rubber is proposed under small oscillatory load superimposed on large static deformation. The proposed model is derived through linearization of Simos nonlinear viscoelastic constitutive model and reference configuration transformation. Statically pre-deformed state is used as reference configuration. The model is extended to a generalized viscoelastic constitutive equation including widely-used Mormans model. Static deformation correction factor is introduced to consider the influence of pre-strain on the relaxation function. The model is tested for dynamic behavior of rubbers with different carbon black fractions. It is shown that the constitutive equation with static deformation correction factor agrees well with test results.

• Structural Monitoring and Maintenance
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• v.3 no.2
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• pp.145-155
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• 2016

The Pulse-Pre Pump Brillouin Optical Time Domain Analysis (PPP-BOTDA) technique is introduced to implement the multi-direction strain measurement. The monitoring principle is stated. The layout scheme of optical fibers is proposed. The temperature compensation formula and its realizing method are given. The experiments, under tensile load, combined bending and tensile load, are implemented to validate the feasibility of the proposed method. It is shown that the PPP-BOTDA technique can be used to discriminate the multi-direction strains with high spatial resolution and precision.

• Smart Structures and Systems
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• v.4 no.2
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• pp.153-169
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• 2008

The use of pre-tensioned shape memory alloy (SMA) wires to retrofit historic masonry structures is investigated. A small wall, serving as a prototype masonry specimen, is constructed to undergo a series of shaking-table tests. It is first studied in its original state, and its dynamic characteristics (in terms of modal frequencies) are extracted from the recorded signals. The results are then compared with those obtained when an increasing number of couples of pre-stressed SMA wires are introduced in the specimen to link the bricks together. A three-dimensional finite element model of the specimen is developed and calibrated according to the modal parameters identified from each experimental test (with and without SMA wires). The calibration process is conducted by enhancing the masonry mechanical behaviour. The results and the effectiveness of the approach are presented.