• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제24권1호
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• pp.21-27
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• 2013

Objectives : Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre- and post-treatment cerebral perfusion according to the MspI polymorphisms of the alpha-2A-adrenergic receptor gene (ADRA2A) in children with ADHD. Methods : Thirty seven drug-naive ADHD children (8.9+1.8 years old, M=32, F=5) were genotyped. Baseline single-photon emission computed tomography (SPECT) and clinical assessments were performed for ADHD children. After treatment with methylphenidate for eight weeks, SPECT and clinical assessment were repeated. Results : No differences in baseline clinical assessments or cerebral perfusion were observed according to the MspI genotype. However, after treatment, ADHD children with the G/G genotype at the MspI polymorphism showed hyperperfusion in the right cerebellar declive (p=.001, uncorrected) and hypoperfusion in the left lentiform nucleus and left cingulate gyrus (p<.001 and p=.001, uncorrected), compared to children without the G/G genotype. Conclusion : Although the results of this study should be interpreted cautiously, they suggest a possible role of the MspI polymorphisms of the ADRA2A gene in methylphenidate-induced changes in cerebral perfusion.

• 대한물리치료과학회지
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• 제31권1호
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• pp.16-32
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• 2024

Background: Exercise equipments and assistive devices for the disabled are being developed, but improvements for usability are still needed. The purpose of this study was to improve and utilize the developed exercise equipment and assistance devices by conducting usability test for people with spinal cord injury. Design: Cross-sectional Study. Methods: Scenarios and usability indicators were derived by conducting a preliminary usability test, 5 non-disabled men and women aged 19 or older. In the scenario, a total of 9 tasks were sequentially performed, including 2 tasks of entry and exit, 5 tasks of assistance devices and weight stack adjustment, and 2 tasks of pre exercise and exercise. The usability indicators were task success (success or fail), execution time (sec), safety, and convenience. For safety, 7 questions (Likert scale, 1~5 point) related to safety, stability and hazard were derived, and for convenience, the system usability scale (SUS score) was used (range: 0~100, 50 percentile rank is 68 point). Results: As a result of the usability test of people with spinal cord injury, there was a large variation among subjects in the task of adjusting the position of the pulley and support in the execution time (11.64~25.44 seconds), and one person failed to adjust the pulley. The safety level showed a lower score (score = 3 points) than other items in the item of entrapment or skin pressure, and in the case of SUS, the average score was 64.5 points, which was close to the acceptable level. Conclusion: Through the usability test, it was confirmed that exercise equipment for the disabled needs improvement in operability, pinching, and pressure, and that it is necessary to develop an assistive device that provides unrestrained posture information (biofeedback) to maintain correct posture during exercise.

• 구강회복응용과학지
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• 제28권4호
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• pp.371-383
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• 2012

성공적인 근관치료를 위하여 원래 근관 형태를 따르는 근관 성형 과정이 중요하다. 그러나 대부분의 근관은 만곡되어 있고, 근관 성형 기구는 직선의 금속을 기본으로 만들어지기 때문에 근관 성형 후 만곡 근관이 원래 근관 형태를 벗어나는 오류가 나타날 수 있다. 이런 오류들로 인하여 근관 치료가 실패할 수 있으므로 근관 성형시 원래 만곡형태를 유지할 수 있는 다양한 기술과 방법들이 소개되고 있다. 본 연구의 목적은 만곡 근관 형태의 레진 모형을 이용하여 기구의 형태와 사용방법이 다른 세 가지 Ni-Ti 파일을 사용하여 Ni-Ti 파일 종류에 따른 만곡 근관에 대한 성형 후 형태 유지능을 비교하는 것이다. 직경과 경사도가 ISO 15, 0.02인 30개의 레진모형을 사용하였다. 그룹 1은 Profile을 이용하여 #20/.06까지 근관 성형하였고, 그룹 2는 Mtwo를 이용하여 #35/.04까지 근관 성형하였으며, 그룹 3은 PathFile을 이용하여 glide path를 만들어준 다음 WaveOne 파일 중 Primary을 사용하여 근관 성형하였다. 기구 사용 전과 후의 레진모형을 스캔하여 디지털 이미지로 만들었다. 각 이미지를 중첩시킨 다음 Matlab r2010b 소프트웨어를 이용하여 곡률반경의 비(CRr)를 계산하였다. 이를 바탕으로 Ni-Ti file 간 성형 후 형태 유지능을 비교하기 위하여 1-way ANOVA를 이용하여 세 그룹의 CRr의 차이에 대한 유의성 검정을 시행하였다.(P<.05) 또한 continuous rotary system과 single file system간의 형태 유지능을 비교하기 위하여 independent t-test를 이용하였다.(P<.05) 곡률반경의 비(CRr)를 이용하여 Ni-Ti 파일 종류에 따른 만곡 근관의 형태 유지능을 비교한 결과 Ni-Ti file 간에는 통계적으로 유의한 차이가 있었다.(P<0.05) ProFile과 WaveOne은 Mtwo에 비해서 만곡 근관에서의 형태 유지능이 우수하게 나타났다.Ni-Ti 기구 사용 방법에 따른 만곡 근관 형태 유지능을 비교한 결과 continuous rotary system과 single file system 간에는 통계적으로 유의한 차이를 보이지 않았다.(P>0.05) 본 연구결과에 따르면, ProFile과 WaveOne은 Mtwo에 비하여 만곡 근관에서의 형태 유지능이 통계적으로 유의하게 높게 나타났으므로, ProFile과 WaveOne이 만곡근관에 대한 형태 유지능이 우수하다고 할 수 있다. 만곡근관에서의 형태 유지능에 있어서 continuous rotary system과 single file system은 만곡근관에서의 형태 유지능에 차이가 없다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8573-8578
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• 2016

Background: This study was guided by principles of the theoretical system of evidence-based medicine. In particular, when searching for evidence of breast cancer, a measuring scale is an instrument for evaluating curative effects in accordance with the laws and characteristics of medicine and exploring the establishment of a system for medically assessing curative effects. At present, there exist few tools for evaluating curative effects. Patient-reported outcomes (PROs) refer to outcomes directly reported by patients (without input or explanations from doctors or other intermediaries) with respect to all aspects of their health. Data obtained from PROs provide evidence of treatment effects. Materials and Methods: In accordance with the tenets of theoretical medicine and ancient medical theory regarding breast cancer, principles for developing a PRO scale were established, and a theoretical model was developed and a literature review was performed, items from this pool were combined and split, and an initial scale was constructed. After a pilot survey and additional modifications, a pre-questionnaire scale was formed and used in a field investigation. After the application of statistical methods, the item pool was used to create a formal scale. The reliability, validity and feasibility of this formal scale were then assessed. Results: In a clinical investigation, 479 responses were recovered, with an acceptance rate of 95%. a combination of various methods was employed, and the items that were selected by all methods or more than half of the methods were employed in the questionnaire. In these cases, the screening methods were combined with certain features of the item, A total of four domains and 38 items were reserved. The reliability analysis indicated that the PRO scale was relatively reliable. Conclusions: Scientific assessment proved that the proposed scale exhibited good reliability and validity. This scale was readily accepted and could be used to assess the curative effects of medical therapy. However, given the limited scope of this investigation, the capacity for adapting this scale to incorporate other theories could not be determined.

• 말소리와 음성과학
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• 제12권2호
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• pp.73-80
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• 2020

갑상선 수술 후 음성변화를 보이는 경우가 흔하며 신경손상의 성대마비부터 심인성 음성장애까지 그 증상은 복합적이고 다양하다. 대부분 자연적으로 회복을 보이지만 환자에게 회복시점에 대한 자세한 정보가 부족하다. 호흡은 음성을 만드는 동력이면서 동시에 후두 기능과 효율에 대한 조절자 역할을 하는데, 갑상선 암 수술의 전신마취 부작용으로 호흡기능 부조화를 유발할 수 있다. 이에 본 연구에서는 갑상선 수술 전후 공기역학적 검사결과를 추적하여 갑상선 수술 후 음성회복에 실제적이고 보완적인 정보를 제공하고자 한다. 2014년 5월부터 2015년 7월까지 갑상선 유두암으로 진단받고 수술 받은 환자를 대상으로 술전 1주일, 술후1개월, 술후3개월에 공기역학 검사를 실시하였다. 성대마비, 보청기 착용자, 항우울증약 복용자, 호흡기 질환자, 뇌졸중 병력자 및 임신 대상자는 제외시켜 최종 34명을 대상자로 선정하였다. 공기역학 검사는 PAS 기계를 사용하였고 분석변수는 총 29개이며, 시간요인에 따른 최고호기류율(p=0.004), 평균음도(p<0.01), 호기류지속시간(p=0.001), 호기량(p=0.018) 변수가 통계적으로 유의미한 차이를 보였다. 이때 시간요인의 대응비교에서 최고호기류율과 평균음도 변수는 술전-술후1개월, 술전-술후3개월 간 차이를 보였고, 호기류지속시간과 호기량 변수는 술전-술후3개월, 술후1개월-술후3개월 간 차이를 보였다. 시간과 수술범위의 교호작용 효과는 호기량 (p=0.024) 변수에서만 유의하였다. 갑상선절제술을 받은 여성군에서 최고호기류율과 평균음도 변수의 차이가 있으며 이는 수술 후 호흡훈련의 필요성이 있으며 호기류지속시간과 호기량 변수의 변화는 수술 후 긍정적 생활습관의 반영으로 여겨진다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
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• pp.66-72
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• 2003

Toxicogenomics is now emerging as one of the most important genomics application because the toxicity test based on gene expression profiles is expected more precise and efficient than current histopathological approach in pre-clinical phase. One of the challenging points in Toxicogenomics is the construction of intelligent database management system which can deal with very heterogeneous and complex data from many different experimental and information sources. Here we present a new Toxicogenomics database developed as a part of 'Toxicogenomics for Efficient Safety Test (TEST) project'. The TEST database is especially focused on the connectivity of heterogeneous data and intelligent query system which enables users to get inspiration from the complex data sets. The database deals with four kinds of information; compound information, histopathological information, gene expression information, and annotation information. Currently, TEST database has Toxicogenomics information fer 12 molecules with 4 efficacy classes; anti cancer, antibiotic, hypotension, and gastric ulcer. Users can easily access all kinds of detailed information about there compounds and simultaneously, users can also check the confidence of retrieved information by browsing the quality of experimental data and toxicity grade of gene generated from our toxicology annotation system. Intelligent query system is designed for multiple comparisons of experimental data because the comparison of experimental data according to histopathological toxicity, compounds, efficacy, and individual variation is crucial to find common genetic characteristics .Our presented system can be a good information source for the study of toxicology mechanism in the genome-wide level and also can be utilized fur the design of toxicity test chip.

• Journal of Periodontal and Implant Science
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• 제31권2호
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• pp.401-420
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• 2001

A novel glucanhydrolase from a mutant of Lipomyces starkeyi(KSM 22)has been shown effective in hydrolysis of mutan, reduction of mutan formation by Streptococcus mutans and removal pre-formed sucrose-dependent adherent microbial film and Lipomyces starkeyi KSM 22 dextranase has been strongly bound to hydroxyapatitie. These in vitro properties of Lipomyces starkeyi KSM 22 dextranase are desirable for its application as a dental plaque control agent. This study was performed to determine oral hygiene benefits and safety of dextranase(Lipomyces starkeyi KSM 22 dextranase)-containing mouthwash in human experimental gingivitis. This 3-week clinical trial was placebo-controlled double-blind design evaluating 1U/ml dextranase mouthwash and 0.12% chlorhexidine mouthwash. A total 39 systemically healthy subjects, who had moderate levels of plaque and gingivitis were included. At baseline, 1, 2 and 3 weeks, subjects were scored for plaque(Silness and $L{\ddot{o}e$ plaque index and plaque severity index), gingivitis($L{\ddot{o}e$ and Silness gingival index), and at baseline and 3 weeks of experiment, subjects were scored for plaque(Turesky-Quingley-Hein's plaque index and plaque severity index), tooth stain(Area and severity index system by Lang et al). Additionally, oral mucosal examinations were performed and subjects questioned for adverse symptoms. Two weeks after pre-experiment examinations and a professional prophylaxis, the subjects provided with allocated mousewash and instructed to use 20-ml volumes for 30s twice dailywithout toothbrushing. All the groups showed significant increase in plaque accumulation since 1 week of experiment. During 3 weeks' period, the dextranase group showed the least increase in plaque accumulation of Silness and $L{\ddot{o}e$ plaque index, compared to the chlorhexidine and placebo groups, but chlorhexidine group showed the least increase inplaque accumulation of Turesky-Quingley-Hein's plaque index. As for gingival inflammation, all the groups showed significant increase during 3 weeks of experiment. The dextranase group also showed the least increase in gingival index score, compared to the chlorhexidine as well as the placebo groups. Whereas the tooth stain was increased significantly in the chlorhexidine group, compared to the baseline score and the placebo group since 3 weeks of mouthrinsing. It was significantly increased after 3 weeks in the dextranase group, still less severe than the chlorhexidine group. As for the oral side effect, the dextranase group showed less tongue accumulation, bad taste, compared to the chlorhexidine group. From these results, mouthrinsing with Lipomyces starkeyi KSM 22 dextranase was comparable to 0.12% chlorhexidine mouthwashin inhibition of plaque accumulation and gingival inflammation and local side effects were if anything less frequent and less intense than chlorhexidine, in human experimental gingivitis. All data had provided positive evidence for Lipomyces starkeyi KSM 22 dextranase as an antiplaque agent and suggested that further development of dextranase formulations for plaque control are warranted.

• 성인간호학회지
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• 제25권6호
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• pp.622-632
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• 2013

Purpose: This study was conducted to compare the nurse licensure examination system in Korea with that of the United States (US). Methods: Focus interviews with the administrative staff of the National Council of State Boards of Nursing (NCSBN) were held. two areas were explored in the interviews: the item development process and the general administrative operating procedures. Results: NCLEX-RN items are designed for entry-level practice. The items are subjected to a series of 12 steps including a item writing panel, a content and editorial review, a sensitivity panel, a pre-test, a Differential item functioning panel and a committee review. NCSBN is responsible for the test for registered nurses and one for practical nurses. In contrast the Korean National Health Personnel Licensing Board (KNHPLB) is responsible for nursing is and 21 other health related licensure. Another difference is that in Korea there is no consistent and specialized staff to develop question items. Items are developed by educators who are not active nurses (this last statemtne is not a finding but a point of view usually not given in findings.). Conclusion: Korean nurses form the largest group of health related job categories and the most direct to health care consumers. Therefore, the nursing licensure exam should be acknowledged as the most influential licensure exam in health care services. We recommend a nursing specialized licensing institution to be established with active nurse' participation in item development process to reflect clinical practice into licensure exam.

• Journal of Korean Neurosurgical Society
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• 제59권2호
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• pp.143-148
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• 2016

Objective : We evaluated postoperative outcomes in patients who have lumbar foraminal or extraforaminal disc herniation (FELDH) and suggested the risk factors for poor outcomes. Methods : A total of 234 patients were selected for this study. Pre- and post-operative Visual Analogue Scale (VAS) and Korean version Oswestry Disability Index (KODI) were evaluated and the changes of both score were calculated. Outcome was defined as excellent, good, fair, and poor based on Mcnab classification. The percentage of superior facetectomy was calculated by using the Maro-view 5.4 Picture Archiving Communication System (PACS). Results : Paramedian lumbar discectomy was performed in 180 patients and combined lumbar discectomy was performed in 54 patients. Paramedian lumbar discectomy group showed better outcome compared with combined discectomy group. p value of VAS change was 0.009 and KODI was 0.013. The average percentage of superior facetectomy was 33% (range, 0-79%) and it showed negative correlation with VAS and KODI changes (Pearson coefficient : -0.446 and -0.498, respectively). Excellent or good outcome cases (Group I) were 136 (58.1%) and fair or poor outcome cases (Group II) were 98 (41.9%). The percentage of superior facetectomy was 26.5% at Group I and 42.5% at Group II. There was significant difference in superior facetectomy percentage between Group I and II (p=0.000). Conclusion : This study demonstrated that paramedian lumbar discectomy with preservation of facet joints is an effective and good procedure for FELDH. At least 60% of facet should be preserved for excellent or good outcomes.

• 임상간호연구
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• 제24권1호
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• pp.113-126
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• 2018

Purpose: The purpose of this study was to revise the KPCS-1 and to standardize the three patient classification systems for general ward, ICU and NICU. The actual utilization of the KPCS-1 score and each nursing activity was evaluated and the relationships between KPCS-1 score and nursing related variables were reviewed. Methods: The 47,711 KPCS-1 scores of 6,931 patients who discharged from $1^{st}$ to $30^{th}$ April 2017 were analyzed and the statistical significance between KPCS-1 score and nursing related variables was reviewed by Generalized Estimating Equation. The revision of the KPCS-1 was carried out by Partial Least Square model. The 3 patient classification systems (KPCS-1,KPCSC and KPCSN) were standardized by professional reviews. Results: KPCS-1 was a valid instrument to express nursing condition adequately and was revised as a new version which has 34 nursing activity items. The names and terminologies of pre-existing 3 patient classification systems developed by KHNA were standardized as KPCS-GW, KPCS-ICU, KPCS-NICU. Conclusion: KPCS-1 was a valid instrument to represent diverse nursing conditions precisely and was revised as a 34-item KPCS-GW. The terminologies of the other patient classification systems by KHNA were standardized as KPCS-ICU and KPCS-NICU.