• Journal of Acupuncture Research
• /
• 제27권1호
• /
• pp.51-64
• /
• 2010

Objectives : To introduce and compare various headache measurement tools, in order to provide fundamental information for future clinical trials and development of oriental medicine measurement tools. Methods : Eight headache assessment scales, Migraine-Specific Quality of Life Questionnaire(MQoLQ), Migraine-Specific Quality of Life(MSQOL), Migraine-Specific Quality of Life Questionnaire(MSQ), The Headache Impact Questionnaire(HImQ), Headcahe Needs Assessment Survey(HANA), Henry Ford Headache disability Inventory(HDI), Migraine Disablity Assessment Scale(MIDAS) and Headache Impact Test(HIT-6), were searched through Pubmed. General character, the process of development, verification of reliability, internal consistency, responsiveness to patient's change and validity were reviewed. Results : In assessing the quality of life of migraine patients, MQoLQ can be used to measure the change within 24 hours, MSQ and MSQOL can be used to measure the change during a relatively longer period of time. The frequency and bothersomeness of headache can be easily measured by HANA. HImQ can be used to measure the intensity of headache and the influence on normal daily activities. HDI can measure the emotional difficulties of headache patients. HIT-6 and MIDAS makes measurements possible in a short period of time, and the reliability and validity have been verified numerously. HIT-6 and MIDAS are the most frequently used measurement tools because they are simple and easy for both the assessor and the patient to understand and use. Conclusions : In this study, various headache assessment tools have been reviewed. The assessed tools were widely used after being verified for their reliability and validity. We hope this study provides fundamental information in establishing future clinical trial and clinical practice guidelines. We also hope this study to contribute to the development of an oriental medicine assessment tool for headache.

• 대한간호학회지
• /
• 제28권1호
• /
• pp.81-92
• /
• 1998

This study is to define the caring experience of mothers with insulin-dependent diabetes mellitus children, by finding core category, contextual factors, ntervening factors, and the patterns of caring, and to velop a practice theory on it. Research method followed grounded theory methodology by Strauss & Corbin. Subjects were six mothers. whose children have had insulin-dependent diabetes mellitus for 4 months to 14 years by the interview time. They were selected by theoretical sampling. Data were collected from September, 1995 to January, 1996. Interview were done by long interview technique and observation. Each interview took 50 minutes to 2 hours. Content of interview was recorded and transcribed later. Based on the results of previous interview, content of next interview was planned until data reached to the saturation point. Results were as follows : One hundred and forty concepts were found. These concepts were grouped into thirty-three categories, and then to ten categories. Mothers with diabetic child were revealed to face “being overwhelmed by burden”. Overwhelming by burden is found to be progressed through the cycle production-coping-decrease or in crease process. Mothers showed four patterns of adaptation in caring the diabetic children. 1) If mothers felt large amount of overwhelming by burden because of difficulty of caring and unsympathizing but they had sufficient support, no condition of the child, and their coping mechanism was positive, most of them overcome with strong will, but some fell into burnout. 2) If mothers felt large amount of overwhelming by burden because of difficulty of caring, unsympathizing, insufficient support. serious condition of the child, and their coping mechanism was negative, they fell into burnout by coping with feeling. 3) If mothers felt small amount of overwhelming by burden because of little difficulty of caring and sympathizing, sufficient support. no serious condition of the child, but their coping was negative, most of them fell into burnout by coping with feeling, but some overcome. 4) If mothers felt small amount of overwhelming by burden because of little difficulty of caring and unsympathizing, sufficient support, no serious condition of the child, and their coping was positive, they overcome with strong will. On the basis of the above result, in order to help mothers take good care of their children, nursing assesment and intervention on life readjustment, and getting support should be required. Especially, through understanding mothers' personalities, individual support consistent with each of them should be required. Therefore education. counseling, mutual support and exchange of information will have to be accomplished.

• 한국수자원학회논문집
• /
• 제32권4호
• /
• pp.457-467
• /
• 1999

유역의 토양유실량을 정확하게 추정하는 방법은 아직 없으며 현재로서 가장 바람직한 유사한 지역의 토양유실량 실측자료를 이용하는 것이다. 이러한 실측자료가 없는 경우에는 범용토양유실공식(USLE, Universal Soil Loss Equation)과 같이 경험적으로 토양유실량을 추정하는 방법 등을 이용할 수 있다. 범용토양유실공식의 인자 중 지역의 수문 특성에 지배되는 되는 것으로 강우침식도(rainfall erosivity) {{{{{ R}_{}}}}} 이 있다. 본 연구에서는 지속기간 0.5, 1, 2, 3, 6, 12, 24-hr에 대한 재현기간 2, 5, 10, 20, 30, 50, 80, 100, 150, 200, 500-yr의 확률강우량을 구하였고 이를 이용하여 빈도별 지속기간 24-hr 설계호우의 지점별 {{{{ { R}_{ } }}}} 값을 구하였다. 지점별{{{{ { R}_{ } }}}} 값을 내삽하여 우리 나라 전역의 등{{{{ { R}_{ } }}}}선도를 작성하였다. 본 연구에서 구해진 재현기간 5-yr, 지속기간 24-hr 설계호우의 등{{{{ { R}_{ } }}}}선도는 연평균 등{{{{ { R}_{ } }}}}선도와 매우 유사하였고, 임의 재현기간에 해당하는 {{{{ { R}_{ } }}}}값은 재현기간 5-yr 또는 연평균{{{{ { R}_{ } }}}}값에 적절한 배율을 곱하여 추정할 수 있음을 알 수 있었다. 본 연구에서 구해진 재현기간별 지속시간 24-hr 설계호우의 등{{{{{R}_{}}}}} 선도는 침사지 등의 설계에 유용하게 이용될 수 있을 것으로 판단된다.

• Archives of Pharmacal Research
• /
• 제21권4호
• /
• pp.391-397
• /
• 1998

The toxicity evaluation of oriental herbal drugs is of great concern at present. Bojungchisup-tang (BCST, in Korean), a decocted medicine of oriental herbal mixture, is now well used in clinic at oriental hospitals for the treatment of edema of several diseases in practice. However, the toxicity of the oriental herbal decocted medicines such as genetic toxicity is not well defined until now. In this respect, to clarify the genetic toxicity of BCST, in vitro chromosome aberration assay with Chinese hamster lung (CHL) fibroblasts and in vivo supravital micronucleus assay with mouse peripheral reticulocytes were performed in this study. In the chromosome aberration assay, we used 5,000 $\mu\textrm{g}$/ml BCST as maximum concentration because no remarkable cytotoxicity in CHL cells was observed both in the presence and absence of S-9 metabolic activation system. No statistical significant differences of chromosome aberrations were observed in CHL cells treated with 5,000, 2,500 and 1,250 $\mu\textrm{g}$/ml BCST for 6 hour both in the presence and absence of S-9 metabolic activation. However, very weak positive result (6.5-8.0% aberration) of BCST was obtained in the absence of S-9 metabolic activation system at 5,000 $\mu\textrm{g}$/ml BCST when treated for 24 hour, i.e. 1.5 normal cell cycle time. And also, in vivo clastogenicity of BCST was studied by acridine orange-supravital staining micronucleus assay using mouse peripheral reticulocytes. We used 2,000 mg/kg as the highest oral dose in this micronucleus assay because no acute oral toxicity of BCST was observed in mice. The optimum induction time of micronucleated reticulocytes (MNRETS) was determined as 36 hours after oral administration of 2,000 mg/kg BCST. No significant differences of MNRETs between control and BCST treatment groups were observed in vivo micronucieus assay. From these results, BCST revealed very weak positive result in chromosome aberration assay in vitro with CHL cells and no clastogenicity in micronucieus assay in vivo.

• 한국약용작물학회지
• /
• 제5권2호
• /
• pp.139-146
• /
• 1997

본 연구는 전보(前報)에 이어 초롱꽃과 약용작물 중에서 농가에서 재배되고 있는 도라지, 더덕, 만삼 종자의 발아 및 유근신장에 미치는 priming 방법(재료, 농도, 기간)과 Priming 후 발아과정에서의 광질(光質) (적색광(赤色光), 백색광(白色光), 암상태(暗狀態)) 효과(效果)를 조사하여 입묘율 향상에 관한 정보를 제공하고자 실시하였던 바 그 결과를 요약하면 다음과 같다. 1. 평균발아율(平均發芽率)은 priming 후 발아시 암조건(暗條件)에서는 도라지, 만삼, 더덕 순으로 감소하였던 반면, Priming 후 광질처리(光質處理)로 인하여 만삼에서는 발아가 억제되고 더덕에서는 발아가 향상되어 도라지, 더덕, 만삼 순으로 감소하였다. 2. 암상태(暗狀態)로 수행된 priming 처리에서 처리기간 간에는 차이가 없었다 할지라도 $KNO_3$ 보다는 $Ca(NO_3)_2$가, 무처리(無處理) 또는 타처리농도(他處理濃度)에 비하여 $50{\sim}150mM$에서 발아율과 유근신장이 향상되었다.3. Priming 후 광질처리(光質處理)로 인한 발아율은 도라지에서는 priming 유무(有無)에는 차이가 없었던 반면, 더덕에서는 발아초기에, 만삼에는 시간이 경과할수록 발아율이 향상되었다. 4. 발아중 백색광(白色光) 처리(處理)는 더덕과 만삼에서 발아를 억제하였는데 이러한 경향은 만삼에서 큰 반면, 도라지에서는 초기발아가 조장되는 것으로 나타나 초롱꽃과 약용작물의 발아는 priming 후 주어지는 광질(光質)에 따라 변화됨을 알 수 있었다.

• 한국학교ㆍ지역보건교육학회지
• /
• 제6권
• /
• pp.89-107
• /
• 2005

The purposes of this study were to investigate the recognition and the needs and problems of in-service education for school nurse, and to suggest the desirable guidelines, for supples the basic data of in-service education for school nurse to upgraded the quality as school nurse's professional specialist. The subjects of this study were 376 school nurses who were working in Jollanamdo. The research instruments used in this study was 'Needs of In-service Education questionnaire'. 305 collected Data were analyzed with the frequency analysis, $x^2$-test. The conclusions were as follows; First of all, the most important motives for the school nurses to participate in-service education are the enhancement of their specialties on teaching profession, self-realizations as educators, and improvement of health teaching skill. However, the motives to obtain the skill for school management or to obtain a high rank qualification and promotion are quite low. School nurses are generally satisfied with duration, time, place of in-service education, But they are not satisfied with contents of in-service education, professional specialist and understanding of real educational situation of the instructors. On the urgent problem of school nurses, promotion of health teaching skill was highest in the rank, and establishment of firm educational philosophy and a sense of teaching profession, proceed to university and graduate school ranked next, respectively. Second, the need of a school nurses on in-service education direction ranked the application of teachers' character and need, practicable and concrete educational programs, planning of school health development, reinforcement of health education, expansion of practical knowledge and on reflection thought, respectively. The need of a school nurses on in-service education contents(major part) ranked health education, health promoting program of student, knowledge and practice of practical medicine and oriental medicine, consultation process, health education of advanced country, respectively. The need of in-service education supervisory organization, the need for a cities provinces educational office was highest in the rank. The need of in-service education type, duty training ranked high, and abroad training, qualification training, general training ranked next. the need for specialist for lecturer of in-serve education ranked among the highest, along with school nurses and university professor. The need of school nurses on education method(duplication answer), need for conference and discussion teaching was highest in the rank. The need on evaluation method, evaluation through a examination ranked the highest. On the needs of in-service education times, need for vacation during the winter and summer was the highest. As for the duration, 31 to 60 hours in duration of in-service education was need most, and most school nurses need cities and provinces in-service training institute as the location of in-service education. On the organization size, need for 21 to 30 people was the highest, where as need for 41 people was relatively low. Lastly, on the problem of in-service education for school nurses, lack of opportunity of in-service education for school nurses was highest in the rank, and improperness of in-service education contents and method, lack of incentive ranked next, respectively.

• 한국학교보건학회지
• /
• 제8권1호
• /
• pp.117-131
• /
• 1995

The purpose of this study is to grasp the nature of health behavior to pactice in order to keep and improve the optimal health in the current status of the cancer patients. The subjects were 21 cancer patients, who knew about their disease for themselves, could communicate without mental disease history, and could understand the purpose of this study and cooperate, in a university hospital in Seoul. The data were collected by direct interview from July 15 to Oct. 17, 1994. The interview took about 1~2hours per one time for each paitent by unstructural and open questions. And they were classified into some similar contents on the basis of the phenomenological analysis and categorized. The analyzed results are as follows: 1) In the daily life before and after diagnosis as cancer patients, they were categorized into 6 areas-the state of movement, sleeping, nutrition and diet, society and economy, drinking and somking, and recognition of their health. 2) In the experience of health behavior of cancer patents, they were categorized into 7 areas-the state of movement, sleeping, nutrition and diet, society and economy, drinking and smoking, recognition of their health, and psychology etc. According to the analyzed results of daily life before diagnosis as cancer patients, it turned out that they didn't recognize the problems for their health habit and made their disease state bad by irresolute characteristics which hesitated to practice rightly, renunciation, and irresponsibility and so on, even if they had much interests in their health and were motivated. Therefore, it is necessary to recognize and have an individual-centric interests in order to change the pattern of life for optimal health state to some extent. In the health behavior of cancer patients, it turned out that they had interests in the state of nutrition and diet the most. Even though they experienced the change of serious nutritive state due to the bad gastroenteric trouble by anticancer treatment, they were trying to have a regular eating habit refraining from irritant food and use folk remedies or healthy food temperating the taste food thoroughly, they also showed the sensitive response for nutrition. In addition, they appeared to use the traditional medical treatment or the folk remedies very seriously without abuse. In consideration of it, it is desirable to use them together with the modern medical treatment intercomplementarily and necessary to look into the types for cancer patients and their benefits.

• Safety and Health at Work
• /
• 제7권1호
• /
• pp.63-71
• /
• 2016

Background: Construction painters have not been studied well in terms of their hazards exposure. The objective of this study was to evaluate the exposure levels of total volatile organic compounds (TVOCs) for painters in the construction industry. Methods: Activity-specific personal air samplings were carried out in three waterproofing activities [polyurethane (PU), asphalt, and cement mortar] and three painting activities (epoxy, oil based, and water based) by using organic-vapor-monitor passive-sampling devices. Gas chromatograph with flame ionization detector could be used for identifying and quantifying individual organic chemicals. The levels of TVOCs, by summing up 15 targeted substances, were expressed in exposure-index (EI) values. Results: As arithmetic means in the order of concentration levels, the EIs of TVOCs in waterproofing works were 10.77, 2.42, 1.78, 1.68, 0.47, 0.07, and none detected (ND) for indoor PU-primer task, outdoor PU-primer task, outdoor PU-resin task, indoor PU-resin task, asphalt-primer task, asphalt-adhesive task, and cement-mortar task, respectively. The highest EI for painting works was 5.61 for indoor epoxyprimer task, followed by indoor epoxy-resin task (2.03), outdoor oil-based-spray-paint task (1.65), outdoor water-based-paint task (0.66), and indoor oil-based-paint task (0.15). Assuming that the operations were carried out continuously for 8 hours without breaks and by using the arithmetic means of EIs for each of the 12 tasks in this study, 58.3% (7 out of 12) exceeded the exposure limit of 100% (EI > 1.0), while 8.3% (1 out of 12) was in 50e100% of exposure limit (0.5 > EI > 1.0), and 4 tasks out of 12 were located in less than 50% of the limit range (EI < 0.5). Conclusion: From this study, we recognized that construction painters are exposed to various solvents, including carcinogens and reproductive toxins, and the levels of TVOC concentration in many of the painting tasks exceeded the exposure limits. Construction workers need to be protected from chemical agents during their painting works by using personal protective devices and/or work practice measures. Additional studies should focus on the exposure assessment of other hazards for construction workers, in order to identify high-risk tasks and to improve hazardous work environments.

• 한국잡초학회지
• /
• 제13권1호
• /
• pp.7-13
• /
• 1993

농산물(農産物) 수입개방화(輪入開放化)에 대처(對處)하여 농가(農家) 고소득(高所得) 작물중(作物中) 하나인 참깨의 수확(收穫)시 기계화(機械化) 작업(作業)에 의한 노동(勞動)의 효율(效率)과 대량생산(大量生産)에 따른 생산비(生産費) 절감(節減)을 위한 방법(方法)으로 비선택성(非選擇性) 제초제(除草劑)인 paraquat와 diquat를 예취(刈取) 3일전(日前)과 3시간전(時間前)에 각각(各各) 처리(處理)하여 참깨 수확(收穫)을 위한 건조제(乾燥劑)로서의 이용가능성(利用可能性)을 연구(硏究)할 목적(目的)으로 수행(遂行)한 실험결과(實驗結果)는 다음과 같다. 1. Paraquat와 diquat를 예취(刈取) 3일전(日前)과 3시간전(時間前)에 각각(各各) 처리(處理)한 결과(結果) 참깨 꼬투리의 수분함량(水分含量)은 무처리구(無處理區)에 비(比)해 빠르게 감소(減少)되어 건조효과(乾燦效果)가 뚜렷하였다. 2. 공시약제(供試藥劑)를 처리(處理)한 후(後) 수확(收穫)한 참깨의 수량(收量)과 참깨 종자(種子)의 발아율(發芽率)은 무처리구(無處理區)에 비(比)하여 유의차(有意差)가 없었다. 3. 참깨 종자중(種子中)의 약제(藥劑) 잔유량(殘留量)은 두 공시약제(供試藥劑) 모두 예취(刈取) 3일전(日前) 처리농도(處理濃度) 250ppm에서 검출(檢出)되지 않았다. 4. 예취후(刈取後) 일수(日數)에 따른 참깨꼬투리의 탈립율(脫粒率)은 건조제(乾燥劑) 처리(處理)로 무처리(無處理) 실행(慣行)에 비(比)하여 매우 높았다. 5. 탈곡회수(脫穀回數)에 따른 소요노동력(所要勞動力)도 크게 감소(減少)되었다.

• Biomolecules & Therapeutics
• /
• 제22권6호
• /
• pp.532-539
• /
• 2014

Peripheral neuropathy induced by human immunodeficiency virus (HIV) infection and antiretroviral therapy is not only difficult to distinguish in clinical practice, but also difficult to relieve the pain symptoms by analgesics because of the severity of the disease at the later stage. Hence, to explore the mechanisms of HIV-related neuropathy and find new therapeutic options are particularly important for relieving neuropathic pain symptoms of the patients. In the present study, primary cultured embryonic rat dorsal root ganglion (DRG) neurons were used to determine the neurotoxic effects of HIV-gp120 protein and/or antiretroviral drug dideoxycytidine (ddC) and the therapeutic actions of insulin-like growth factor-1 (IGF-1) on gp120- or ddC-induced neurotoxicity. DRG neurons were exposed to gp120 (500 pmol/L), ddC ($50{\mu}mol/L$), gp120 (500 pmol/L) plus ddC ($50{\mu}mol/L$), gp120 (500 pmol/L) plus IGF-1 (20 nmol/L), ddC ($50{\mu}mol/L$) plus IGF-1 (20 nmol/L), gp120 (500 pmol/L) plus ddC ($50{\mu}mol/L$) plus IGF-1 (20 nmol/L), respectively, for 72 hours. The results showed that gp120 and/or ddC caused neurotoxicity of primary cultured DRG neurons. Interestingly, the severity of neurotoxicity induced by gp120 and ddC was different in different subpopulation of DRG neurons. gp120 mainly affected large diameter DRG neurons (> $25{\mu}m$), whereas ddC mainly affected small diameter DRG neurons (${\leq}25{\mu}m$). IGF-1 could reverse the neurotoxicity induced by gp120 and/or ddC on small, but not large, DRG neurons. These data provide new insights in elucidating the pathogenesis of HIV infection- or antiretroviral therapy-related peripheral neuropathy and facilitating the development of novel treatment strategies.