• 한국안전학회지
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• 제37권5호
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• pp.80-88
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• 2022

The Korean nuclear industry had developed the SPACE (Safety and Performance Analysis Code for nuclear power plants) code, which adopts a two-fluid, three-field model that is comprised of gas, continuous liquid and droplet fields and has the capability to simulate three-dimensional models. According to the revised law by the Nuclear Safety and Security Commission (NSSC) in Korea, the multiple failure accidents that must be considered for the accident management plan of a nuclear power plant was determined based on the lessons learned from the Fukushima accident. Generally, to improve the reliability of the calculation results of a safety analysis code, verification is required for the separate and integral effect experiments. Therefore, the goal of this work is to verify the calculation capability of the SPACE code for multiple failure accidents. For this purpose, an experiment was conducted to simulate a Control Element Drive Mechanism (CEDM) break with a safety injection failure using the ATLAS test facility, which is operated by Korea Atomic Energy Research Institute (KAERI). This experiment focused on the comparison between the experiment results and code calculation results to verify the performance of the SPACE code. The results of the overall system transient response using the SPACE code showed similar trends with the experimental results for parameters such as the system pressure, mass flow rate, and collapsed water level in component. In conclusion, it can be concluded that the SPACE code has sufficient capability to simulate a CEDM break with a safety injection failure accident.

• 한국산업융합학회 논문집
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• 제20권4호
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• pp.257-263
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• 2017

The following thesis researched into the characteristics of electrolytic ion water with different levels of electrical conductivity by adding NaCl into tap water which is for experimental use in multi-layered electrolytic ion water generator. Electrolytic ion water is generated by underwater electrolysis and the electrolysis generator has a simple structure, is easy to control and is highly utilized in industries. Electrolytic ion water is useful in many areas since it has a superior sterilizing power, has no possibility of secondary pollution itself as water and removes active oxygen. In the experiment, we used tap water with NaCl excluded and water with three different levels of electrical conductivity by changing NaCl concentration levels into three levels. The features of current and voltage in electrolytic ion water represented a form of quadric instead of the linear characteristic following ohm's law. As well, as the electric conductivity of water and applied voltage increased, we were able to generate much stronger acid water and alkali water.

• 한국수산과학회지
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• 제40권1호
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• pp.1-7
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• 2007

The chemical and rheological properties of deproteinated porphyrans from laver Porphyra yezoensis were investigated to obtain basic data for the production of food materials with biological functionality. Deproteinated porphyran was prepared by acid extraction (pH 4.0, $80^{\circ}C$, 4 hr) and successive hydrolysis with 0.5% Alcalase and 0.5% Flavourzyme. The porphyran constituted 10.7% of the dry laver and consisted of 0.6% protein, 14.8% ester sulfate, 3.2% 6-O-methyl galactose, 16.0% 3,6-anhydro-L-galactose, and 67.3% galactose. The effects of concentration and temperature on the apparent viscosity were examined by applying the power law and Arrhenius equations. The porphyran solution showed the typical behavior of a pseudoplastic liquid and the flow behavior index decreased with increasing concentration. The activation energy of the deproteinated porphyran solution at a 1,000 L/s shear rate also increased from $1.4954{\times}10^{4}\;to\;1.9544{\times}10^{4}\;J/kg$ mol with the concentration.

• Molecules and Cells
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• 제37권12호
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• pp.888-898
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• 2014

Pancreatic cancer is one of the most fatal cancers and is associated with limited diagnostic and therapeutic modalities. Currently, gemcitabine is the only effective drug and represents the preferred first-line treatment for chemotherapy. However, a high level of intrinsic or acquired resistance of pancreatic cancer to gemcitabine can contribute to the failure of gemcitabine treatment. To investigate the underlying molecular mechanisms for gemcitabine resistance in pancreatic cancer, we performed label-free quantification of protein expression in intrinsic gemcitabine-resistant and -sensitive human pancreatic adenocarcinoma cell lines using our improved proteomic strategy, combined with filter-aided sample preparation, single-shot liquid chromatography-mass spectrometry, enhanced spectral counting, and a statistical method based on a power law global error model. We identified 1931 proteins and quantified 787 differentially expressed proteins in the BxPC3, PANC-1, and HPDE cell lines. Bioinformatics analysis identified 15 epithelial to mesenchymal transition (EMT) markers and 13 EMT-related proteins that were closely associated with drug resistance were differentially expressed. Interestingly, 8 of these proteins were involved in glutathione and cysteine/methionine metabolism. These results suggest that proteins related to the EMT and glutathione metabolism play important roles in the development of intrinsic gemcitabine resistance by pancreatic cancer cell lines.

• 한국식품과학회지
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• 제27권5호
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• pp.799-806
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• 1995

고유점도가 3.75 dL/g인 감귤류 펙틴 용액의 전단점도 및 점탄성에 대한 농도의존성을 연구하였다. 전형적인 자수법칙 흐름 현상이 2.0% 이상의 펙틴 농도에서 관찰되었으며, 전단점도의 전단속도 의존성은 농도의 증가에 따라 더욱 뚜렷하게 나타났다. ${\eta}_{sp.o}$ 대 $C[\eta]$를 양대수 좌표에 그렸을 때 묽은 영역에서 진한 영역으로의 전이를 나타내는 $C^{*}[\eta]$는 약 4.0이었으며, 이때 ${\eta}_{sp.o}$의 값은 약 10.0을 나타내었다. 묽은 용액$(C[\eta]과 진한 용액$(C[\eta]>C^{*}[\eta])$에서 ${\eta}_{sp.o}$ $C[\eta]$의 기울기는 각각 1.1과 4.5였다. 전단점도를 ${\eta}/{\eta_0}$ 대 ${\gamma}/{\gamma}_{0.8}$에 대하여 그렸을 때 $2{\sim}5%$의 농도에서는 잘 중첩되었으나, 6%의 고농도에서는 중첩곡선에서 벗어나는 현상을 보였다. 펙틴 용액의 점탄성을 조사한 결과 전 농도범위에서 손실탄성률$(G^{\prime\prime})$의 값이 저장탄성률$(G^\prime)$보다 훨씬 높은 값을 보여 점성이 전체 점탄성을 지배하는 것으로 나타났다. 저 농도에서 전단점도는 복소점도와 거의 비슷한 값을 보여 Cox-Merz 법칙에 잘 부합하였으나, 농도가 높아질수록 두 값은 차이를 보였다.