• IMMUNE NETWORK
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• 제6권2호
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• pp.93-101
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• 2006

Background: Memory T lymphocytes of the immune system provide long-term protection in response to bacterial or viral infections/immunization. Ag concentration has also been postulated to be important in determining whether T cell differentiation favors effector versus memory cell development. In the present study we hypothesized that naive Ag-specific $CD4^+$ T cells briefly stimulated with different Ag doses at the primary exposure could affect establishment of memory cell pool after secondary immunization. Methods: To assess this hypothesis, the response kinetics of DO11.10 TCR $CD4^+$ T cells primed with different Ag doses in vitro was measured after adoptive transfer to naive BALB/c mice. Results: Maximum expansion was shown in cells primarily stimulated with high doses of ovalbumin peptide $(OVA_{323-339})$, whereas cells in vitro stimulated with low dose were expanded slightly after in vivo secondary exposure. However, the cells primed with low $OVA_{323-339}$ peptide dose showed least contraction and established higher number of memory cells than other treated groups. When the cell division was analyzed after adoptive transfer, the high dose Ag-stimulated donor cells have undergone seven rounds of cell division at 3 days post-adoptive transfer. However, there was very few division in naive and low dose of peptide-treated group. Conclusion: These results suggest that primary stimulation with a low dose of Ag leads to better memory $CD4^+$ T cell generation after secondary immunization. Therefore, these facts imply that optimally primed $CD4^+$ T cells is necessary to support effective memory pool following administration of booster dose in prime-boost vaccination.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 한국해양정보통신학회 2010년도 추계학술대회
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• pp.84-87
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• 2010

We manufacture an antifuse OTP (One-time programmable) cell for analog trimming which will be used in power management ICs. For the antifuse cell using dual program voltage of VPP (=7V) and VNN (=-5V), the thin gate oxide is broken down by applying a voltage higher than the hard break-down voltage to the terminals of the antifuse. The area of the manufactured antifuse OTP cell using $0.18{\mu}m$ BCD process is $48.01{\mu}m^2$ and is about 44.6 percent of that of an eFuse cell. The post-program resistances of the antifuse are good with the values under several kilo ohms when we measure twenty test patterns.

• Journal of the Korea Institute of Information Security & Cryptology
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• 제29권4호
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• pp.697-708
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• 2019

In this paper, we propose and implement a method to optimize Rainbow for 8 bit MCU(Microcontroller Unit). As quantum computers have been developed, the security of existing cryptography, especially the signature algorithms, has been threatened, so it is necessary to apply a signature scheme with a quantum-resistance to IoT devices. Currently, the proposed PQC(Post Quantum Cryptography) are lattice-based, hash-based, code-based, and MQ(Multivariate Quadratic)-based cryptographic algorithms and signature schemes. In particular, MQ-based signature schemes are faster than conventional signature schemes and are suitable for IoT devices Do. However, it is difficult to apply 8-bit MCU, which has a large key length and large number of computations, to the memory and performance of IoT devices. In this paper, we propose a method of storing Rainbow, which is a MQ-based signing scheme, in 8-bit MCU by dividing the key and optimizing the computation method. By reducing the memory consumption and improving the algorithm speedily, Compare performance.

• PNF and Movement
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• 제11권2호
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• pp.9-19
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• 2013

Purpose : Study on the effects of attention(working memory) for normal adults by applying transcranial Direct Current Stimulation(tDCS). Methods : There are two groups of 10 random people aged between 20 to 30, one is an experimental group(stimulation) and the other is a comparison group(simulate stimulation). For the 1st da y, pre-stimulation test is executed, and for the 2nd day to the 4th day, tDCS is applied stimulated both on the right prefrontal lobe and the left occipital lobe through the electrode. The stimulation lasts for 15 minutes with voltage power of 1mA for each day. The post-stimulation test is executed on the day of 5th. In this paper, a FAIR attention test is used for measuring the attention. Results : As the result of the experiment, there are significant gaps both on the value of P, the ability of selective attention, and the value of C, the consistent ability after the stimulation on right prefrontal and left occipital lobe. And there is no significant gap on the value Q, the quality(Control). However, all the P, Q, and C values are increased according to the average value between the pre-stimulation test and the post-stimulation. Conclusion : Finally, ability of selective attention and self-control, and consistent attention is progressed by applying the tDCS to the normal people.

• Biomolecules & Therapeutics
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• 제23권3호
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• pp.251-260
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• 2015

Propofol is an anesthetic agent that gained wide use because of its fast induction of anesthesia and rapid recovery post-anesthesia. However, previous studies have reported immediate neurodegeneration and long-term impairment in spatial learning and memory from repeated neonatal propofol administration in animals. Yet, none of those studies has explored the sex-specific long-term physical changes and behavioral alterations such as social (sociability and social preference), emotional (anxiety), and other cognitive functions (spatial working, recognition, and avoidance memory) after neonatal propofol treatment. Seven-day-old Wistar-Kyoto (WKY) rats underwent repeated daily intraperitoneal injections of propofol or normal saline for 7 days. Starting fourth week of age and onwards, rats were subjected to behavior tests including open-field, elevated-plus-maze, Y-maze, 3-chamber social interaction, novel-object-recognition, passive-avoidance, and rotarod. Rats were sacrificed at 9 weeks and hippocampal protein expressions were analyzed by Western blot. Results revealed long-term body weight gain alterations in the growing rats and sex-specific impairments in spatial (female) and recognition (male) learning and memory paradigms. A markedly decreased expression of hippocampal NMDA receptor GluN1 subunit in female- and increased expression of AMPA GluR1 subunit protein expression in male rats were also found. Other aspects of behaviors such as locomotor activity and coordination, anxiety, sociability, social preference and avoidance learning and memory were not generally affected. These results suggest that neonatal repeated propofol administration disrupts normal growth and some aspects of neurodevelopment in rats in a sex-specific manner.

• The Korean Journal of Archival Studies
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• 제74호
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• pp.5-43
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• 2022

This study aims to explore the 'affective value' of records. Traditionally, records have been evaluated as having evidence value, information value, and artificial value. However, the 'affective turn' in the humanities and social sciences, which began in the 1990s, calls for discussion on the affective value of records. The overseas archive academia is in full swing discussing the emotional value of records after the 'affective turn'. However, there is no emotional discussion on records in the domestic archive academia. This study first conducts theoretical discussions to overcome these domestic limitations and explore the emotional value of archives in earnest. Following the theoretical discussion, a specific case will be dealt with next. As a representative storage of affect, which records the pain, sadness, and condolences of the domestic disaster era, this study investigates the record management case of the 4.16 Memory Storage. The Ferry Sewol disaster, which provided a dramatic opportunity to witness the unexpected ripple effect of affect in Korea, and the 4.16 Memory Storage as a recording activity, can be seen as a representative example of affective recording of the pain and sadness of survivors of the trauma incident. It will capture the differentiation of affet recording, which is different from the record management practice, and demonstrate empirically how this differentiation is implemented from collection to evaluation and service through the '4.16 Memory Storage'.

• Information Systems Review
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• 제18권3호
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• pp.51-71
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• 2016

Tourism products are intangible goods. Given this nature, tourist experience should be recorded and visualized through media, such as pictures, videos, and souvenir. Online platforms played the role of media given the growth of information and communication technology. Tourists post their travels for real-time documentation of their experiences, but they also tend to reminisce about past experiences that they posted on social media. Social media is not only a channel of self-presentation or a means of communication with other people, but it also serves as an archive of electronic records to bring back memories. Given this finding, we investigated the impact of social media on the autobiographical memory (recollection and vividness) of tourists and their intention to revisit a certain destination. The results showed social media interface and the impact of display quality on the recollection and vivid memory. The predictor of memory recollection of tourists is intention to revisit a destination. Social media is considered an archive of travel memory that indulges people to reminisce. Theoretical and practical implications were provided based on these results.

• The Journal of Korean Physical Therapy
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• 제27권5호
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• pp.375-380
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• 2015

Purpose: The purpose of this study was to evaluate the impact of differences in computer-aided cognitive rehabilitation aimed at stroke patients on cognitive function and daily life. Methods: The study subjects were Gwangju, Jeonnam including the attention group (group I), memory group (group II), and visual perception group (group III), who were randomly placed in each of a 10 by one problem solving group (group IV). The PSSCogRehab was applied to all subjects who underwent eight weeks once a week after 20 minutes in each group by strengthening mediation 10 minutes 30 minutes total, with a five minute break in the middle. Results: Cognitive function and activities of daily living is security and inter-group differences before intervention, and post-test results in the memory training group II, the intervention group I, III, IV and more on cognitive function and activities of daily living compared to it was effective. Conclusion: The results of computer-aided cognitive rehabilitation measuring cognitive function and ADL in patients with stroke in accordance with the group I, III, and IV group cognitive function and activities of daily living compared to IV showed that it was more effective.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• 제12권4호
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• pp.141-145
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• 2012

In a Ubiquitous sensor network environment, the sensor node is in general small and low price, and operating with power limited battery. The reliable TCP/IP protocol is used for transmitting sensed data from the sensor node. A new method was proposed in order to overcome the limitation of small embedded memory, but it is difficult to use for the case of frame error. In this paper, a new algorithm is proposed to manage the receiving frame error or loss, and it is appropriate to the sensor network to send sensed data periodically.

• International Journal of Contents
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• 제15권4호
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• pp.8-15
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• 2019

This paper presents a solution of the 'Quick, Draw! Doodle Recognition Challenge' hosted by Google. Doodles are drawings comprised of concrete representational meaning or abstract lines creatively expressed by individuals. In this challenge, a doodle is presented as a sequence of sketches. From the view of at the sketch level, to learn the pattern of strokes representing a doodle, we propose a sequential model stacked with multiple convolution layers and Long Short-Term Memory (LSTM) cells following the attention mechanism [15]. From the view at the image level, we use multiple models pre-trained on ImageNet to recognize the doodle. Finally, an ensemble and a post-processing method using the minimum cost flow algorithm are introduced to combine multiple models in achieving better results. In this challenge, our solutions garnered 11th place among 1,316 teams. Our performance was 0.95037 MAP@3, only 0.4% lower than the winner. It demonstrates that our method is very competitive. The source code for this competition is published at: https://github.com/ngxbac/Kaggle-QuickDraw.