• Radiation Oncology Journal
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• 제24권1호
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• pp.58-66
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• 2006

목적: 방사선에 의한 신장손상은 궁극적으로 신장 섬유화로 인한 신부전으로 나타나며 여기에는 세포외기질의 변화가 동반된다. 방사선 신장손상에서 신사구체 상피세포의 역할을 알아보기 위하여 방사선에 의한 세포외기질과 연관된 여러 유전자 발현의 변화를 알아보고자 하였다. 대상 및 방법 : 백서 사구체 상피세포 (rat glomerular epithelial cell: GEpC) 에 6 MV 선형가속기 (Siemens, USA)를 이용하여 0, 2, 5, 10, 20 Gy 의 단일 방사선량을 조사한 후 각각 6, 24, 48, 72 시간에 시료를 채취하였다. Northern blot, Western blot, Zymography를 이용하여 fibronectin (Fn), plasminogen activator inhibitor-1 (Pai-1), matrix metalloproteinases-2, 9 (MMP-2, 9), tissue inhibitor of matrix metallproteinase-2 (TIMP-2), tissue-type plasminogen activator (t-PA), Urokinase-type plasminogen activator (u-PA)의 발현을 측정하였다. 결과: GEpC 에 대한 10 Gy 단일 방사선 조사후 24 시간부터 Fn mRNA 가 유의한 증가를 나타냈으며 48 시간에 측정한 Fn 단백질은 5, 10 Gy 의 방사선량에서 유의하게 증가되었다. 방사선조사에 의해서 Pai-1 유전자의 발현도 mRNA 및 단백질 단계에서 증가되었으며, 특히 10Gy 조사 후 24, 48 시간에 측정한 mRNA 의 증가는 통계적으로 유의하였다. GEpC에 방사선조사 후 24 시간에 측정한 MMP-2 활성형은 방사선량에 따라 증가하였으나 통계학적 유의성은 없었다. 그밖의 MMP-9, TIMP-2, t-PA 와 u-PA 는 아무런 변화를 나타내지 않았다. 결론 : 방사선에 의하여 GEpC에서 세포외 기질과 관련된 유전자 발현의 번화가 관찰되었으며 이는 방사선 신장 손상에 GEpC가 관여함을 나타낸다.

• The Korean Journal of Physiology
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• 제4권2호
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• pp.45-51
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• 1970

In an attempt to better understand the effect of whole body irradiation on the spontaneous motility and oxygen consumption rate of the isolated mouse duodenum, a whole body X-irradiation of 1,000r. was given to albino mouse, and 1) the total length of contraction of isolated duodenum was recorded on kymograph every five minutes for 60 minutes, 2) glucose and 5-hydroxytryptamine(5-HT) were added to the reaction medium of Kreb's-Ringer-bicarbonate buffer(KRB) and response of the isolated duodenum to the drugs was observed, and 3) the oxygen consumption rate $(QO_2)$ of the isolated duodenum as well as the effect of glucose and 5-HT on $QO_2$ were measured by Warburg's standard manometric method and the comparison was made with the control(i.e. normal) group. The results thus obtained are summarized as follows. 1. The spontaneous motility of the isolated duodenum in the irradiated groups showed a significantly elevated pattern for the first 15 minutes comparing with the control. The motility, however, decreased after 15 minutes and remained so in the irradiated groups to the level of the nonirradiated control, but 24 hours post-irradiation group showed a tendency of an increased motility while one hour post-irradiation group showed no difference comparing with the control. 2. Addition of glucose produced generally elevated motility of the isolated duodenum in both irradiated and non-irradiated groups comparing with the control throughout the experiment, but no difference was observed in contractile amplitude between the irradiated and non·irradiated groups. 3. When 5-HT was added to the irradiated group, the contractile amplitude of isolated duodenum was similar to that of the control, and 5-HT alone caused a slight increase of the motility comparing with the control. 4. The oxygen consumption rate $(QO_2)$ of the isolated duodenum was found to be ,slightly increased in one hour post·irradiated group, but similar in 24 hour post·irradiated group comparing with the control. Glucose produced a significant increase of $QO_2$ in all the groups, but 5-HT produced a tendency of decrease of $QO_2$ in all the groups.

• Parasites, Hosts and Diseases
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• 제47권1호
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• pp.7-11
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• 2009

Cryptosporidium parvum is a well-known waterborne and opportunistic intracellular protozoan parasite that causes diarrheal illness. In this study, we quantitatively investigated reduction of the infectivity of C. parvum after gamma irradiation and repair of the infectivity during incubation time after irradiation. C. parvum oocysts were subjected to gamma irradiation at various doses (1, 5, 10, and 25 kGy), and the in vitro infectivity was measured by real-time PCR every day up to 7 days after irradiation. The in vitro infectivity of C. parvum on human ileocecal adenocarcinoma cells (HCT-8) was effectively reduced (> $2\;{\log}_{10}$) by irradiation at 10kGy or more. However, in the experiment to find out repair of the infectivity, recovery was not noted until day 7 post-incubation.

• 사상체질의학회지
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• 제10권1호
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• pp.269-284
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• 1998

The purpose of this study was to investigate the effect of ILIB(Intravenous Laser Irradiation of blood) on Meridian-Heart Circulation CMP and Hyperlipidemia. Circulatory symptom of 20 patients was treated with ILIB. After 10 times' treatment, changes of total cholesterol, HDL-cholesterol, triglyceride and Meridian-Heart Circulation CMP value were observed. The results were as follows : 1. In observation of Meridian-Heart Circulation CMP value, significant increase was observed in both pre-ID generation and post-ID generation. So, distinctive observation between pre-ID generation and post-ID generation became not relatively significant. 2. In observation of Meridian-Heart Circulation CMP value, significant increase was observed in both left and right. So, distinctive observation between left and right became not relatively significant. 3. In observation of Meridian-Heart CMP value, significant increase was not observed in control group, but significant increase close to normal value was observed in treatment group after treatment of Intravenous He-Ne Laser Irradiation. 4. In observation of Meridian-Circulation CMP value, significant increase was not observed in control group, but significant increase close to normal value was observed in treatment group after treatment of Intravenous He-Ne Laser Irradiation. 5. In concentration of plasma total cholesterol and plasma triglyceride, significant decrease was not observed in control group, but significant increase was observed in treatment group after treatment of Intravenous He-Ne laser Irradiation. 6. Significant concentration change of plasma HDL-cholesterol was not observed in both control group and treatment group. From above results, it was thought that Intravenous He-Ne Laser Irradiation was significant effect on heart circulatory system in human body.

• 열처리공학회지
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• 제36권5호
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• pp.298-302
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• 2023

Transparent and conducting tungsten (W) doped indium oxide (IWO) thin films were deposited on the glass substrate by using RF magnetron sputtering and then electron irradiation was conducted to investigate the effect of electron irradiation on the optical and electrical properties of the films. The electron irradiated films showed three x-ray diffraction peaks of the In₂O₃ (222), (431) and (046) planes and the full width at half maximum values are decreased as increased electron irradiation energy. In the atomic force microscope analysis, the surface roughness of as deposited films was 1.70 nm, while the films electron irradiated at 700 eV, show a lower roughness of 1.28 nm. In this study, the figure of merit (FOM) of as deposited films is 2.07 × 10^-3 Ω^-1, while the films electron irradiated at 700 eV show the higher FOM value of 5.53 × 10^-3 Ω^-1. Thus, it is concluded that the post-deposition electron beam irradiation is the one of effective methods to enhance optical and electrical performance of IWO thin films.

• 한국작물학회지
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• 제10권
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• pp.73-77
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• 1971

본 실험은 소맥품종 Weibull's Svenno종자(수분함량 11.3%)에 감마선과 속중성자를 조사한후 일정기간의 저장효과를 저장시 온도와 관련시켜 조사한 결과이다. 감마선이나 속중성자조사에 의하여 모두 묘생육은 저장기간의 연장에 따라서 감소되었고 선량구에서는 그 정도가 더욱 크게 나타났다. 저장온도효과에 대한 묘생육장해는 높은온도(4$0^{\circ}C$)구에서 크게 보였다. 이의 결과로서는 명확한 저장효과를 인정할 수 있었다.

• 구강회복응용과학지
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• 제36권4호
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• pp.282-288
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• 2020

구강방사선스텐트는 구강암의 방사선치료 시 종양조직에 적정 선량을 유도하거나 주변 정상 조직에 대한 불필요한 방사선을 최소화하는 보조 장치이며 환자상황에 따라 개별적으로 적용되므로 효율적인 적용을 위한 관련 외과의, 방사선 치료전문의 그리고 치과전문의들간의 전략적인 협진이 필수적이다. 본 보고에서는 2종의 방사선스텐트(볼러스합입형, 설압형)를 다학제 협진하에 제작하였고 방사선치료 시 선택적으로 적용하여 그 효율성을 경험하였기에 증례와 함께 보고하는 바이다.

• Nuclear Engineering and Technology
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• 제55권6호
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• pp.2195-2205
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• 2023

One of the salient nuclear fuel performance parameters for new fuel types under development is changes in fuel thickness. To test the new commercially fabricated U-10Mo monolithic plate-type fuel, an irradiation experiment was designed that consisted of multiple mini-plate capsules distributed within the Advanced Test Reactor (ATR) core, the mini-plate 1 (MP-1) experiment. Each capsule contains eight mini-plates that were either fueled or "dummy" plates. Fuel thickness changes within a fuel assembly can be characterized by measuring the gaps between the plates ultrasonically. The channel gap probe (CGP) system is designed to measure the gaps between the plates and will provide information that supports qualification of U-10Mo monolithic fuel. This study will discuss the design and the results from the use of a custom-designed CGP system for characterizing the gaps between mini-plates within the MP-1 capsules. To ensure accurate and repeatable data, acceptance and calibration procedures have been developed. Unfortunately, there is no "gold" standard measurement to compare to CGP measurements. An effort was made to use plate thickness obtained from post-irradiation measurements to derive channel gap estimates for comparison with the CGP characterization.

• Tribology and Lubricants
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• 제16권4호
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• pp.241-246
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• 2000

The effect of post-irradiation shelf-aging time on the wear of UHMWPE was investigated, and wear results were correlated with the time-dependent microstructural changes of polyethylene after gamma irradiation sterilization. The levels of oxidation and crosslinking in the shelf-aged acetabular liners were examined by FTIR and hot xylene extraction, respectively, and uni-directional repeat pass sliding wear tests were conducted by using a pin-on-disc wear tester. Gamma irradiation sterilization in the air environment caused an increase of oxidation, crosslinking, and wear resistance. With aging, however, oxidation progressed and decreased the level of crosslinking. This resulted in a decrease of wear resistance of UHMWPE that was accompanied with white bands and brittle cracking.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 1999년도 제30회 추계학술대회
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• pp.296-302
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• 1999

The effect of post-irradiation shelf-aging time on the wear of orthopaedic grade UHMWPE was investigated, and wear results were correlated with the time-dependent microstructural changes of polyethylene after gamma irradiation sterilization. The levels of oxidation and crosslinking in the shelf-aged acetabular liners were examined by FTIR and hot xylene extraction, respectively, and uni-directional repeat pass sliding wear tests were conducted by using a pin-on-disc wear tester. Gamma irradiation sterilization in the air environment caused an increase of oxidation, crosslinking, and wear resistance. With aging, however, oxidation progressed and decreased the level of crosslinking. This resulted in a decrease of wear resistance of UHMWPE that was accompanied with the existence of white bands and brittle cracking.