• Composites Research
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• 제27권6호
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• pp.236-241
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• 2014

본 연구에서는 공항 포장용 유지보수 재료로 사용되는 폴리머 콘크리트의 자외선 노출에 대한 기계적 물성 변화를 확인하기 위해 자외선 노출 전/후 시편의 압축강도 및 연성인자의 변화를 평가하였다. 현재 공항 포장용으로 사용되는 폴리머 콘크리트의 비율과 선행연구를 통해 얻은 최적 배합비율을 참고하여 시편을 제작하였다. 자외선 발생 램프의 출력을 고려하여 자연상태에서 노출되는 등가시간을 계산한 후 최대 3년에 해당하는 시간만큼의 등가시간 동안 시편을 노출시켰다. 실험결과, 자외선 노출 자체는 재료물성에 거의 영향을 주지 않았으며, 자외선 노출에 따른 온도상승에 의한 재료물성 변화가 주로 관찰되었다. 자외선에 의해 발생된 열에 노출된 후 모든 시편에서 인성은 감소하고, 압축강도는 증가하는 경향을 나타내었다.

• 대한한의학회지
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• 제17권2호
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• pp.418-426
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• 1996

Clinical studies were done 23 peoples who were treated with the auricular acupuncture therapy to the hypertension in the Dept. of the Acupuncture and Moxibution Hospital of Oriental Medicine in Won Kwang University. The following results have obtained. 1. Distribution of sex: male (52.0%), female (48.0%), 2. Distribution of age: 50s age group (30.0%), 70s(26.0%), 40s or 60s(22.0%). 3. Distribution of occupation: housewife (26.0%), farmer or commerce(22.0%), unemployed(13.0%), 4. Causes of illness: unknown origin(61.0%), stress(17.0%), drinking (13.0%), 5. Distribution according to symptom: headache(57.0%), non-symptom(17.0%), dizziness(9.0%). 6. Duration of onset: 3-5 years(26,0%), unknown(17.0%), 6 months, 5-10 years or 10 years (13.0%). 7. Cure rate of auricular acupuncture treatment according to differentiation symptoms: HLY(43.0%), DLK(30.0%), DYY(13.0%), HYD(9.0%). 8. Result grade on $pr{\`{e}}-freatment$ of auricular acupuncture: Grade I(4.0%), GradeII(52.0%), Grade III(43.0%). Result grade on post-treaftment auricular acupuncture: Grade O(48.0%), Grade I(26.0%), Grade II(26.0%).

• Parasites, Hosts and Diseases
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• 제37권4호
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• pp.289-292
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• 1999

BALB/c mice infected with a high virulent strain of Trypanosoma brucei gambiense IL3707 were treated intraperitoneally (ip) with either Melarsoprol （Mel-B) or PSG(+) buffer as controls. The mice were subsequently monitored regularly for parasites by direct microscopic examination of their tail blood or buffy coat and by polymerase chain reaction (PCR). Mel-B was found to be an effective drug for treatment against T.b. gambiense because at the end of the first treatment schedule, all treated mice were negative for parasites even by PCR, while all the control animals were positive. Three of the five Mel-B treated mice, while parasitologically negative, were PCR positive between 53 and 80 days post infection (DPI), indicating that they still harbored an infection. All treated mice were subsequently negative for parasites even by PCR at 88 DPI. A combination of conventional microscopic examination and PCR offers a good prediction of cure following treatment of trypanosomosis.

• 한국치위생학회지
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• 제12권4호
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• pp.655-663
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• 2012

Objectives : This study was progressed a research with the aim of using it as basic data necessary for a plan in order to increase qualitatively medical level for patients who feel anxiety about dental treatment, and of offering basic data for improving the whole medical services by grasping conditions and satisfaction level with laser therapy in patients who visited dental clinic. Methods : The statistical analysis was carried out t-test and ANOVA by using SPSS(PASW statistics) 18.0. When there is statistically significant difference in analysis of variance, post-test was carried out by using Duncan multiple range test. Results : In therapy kinds of using laser, gingival treatment was the largest with 37.0%. It was the highest in likely seeming to be not painful with 32.9% as for a decisive factor, which came to receive laser therapy, and in having been enough to endure even if having been slightly tingling as for pain level. Conclusions : This study can be considered to have significance in changing recognition of medical cure by surveying patients satisfaction with using laser as a method for slightly solving elements of fear and anxiety about dental treatment and to have its value as basic data for seeking improvement plan for diverse medical services in the future.

• Journal of Microbiology and Biotechnology
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• 제19권6호
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• pp.622-628
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• 2009

In the present study, the therapeutic potential of purified and well-characterized bacteriophages was evaluated in thermally injured mice infected with Klebsiella pneumoniae B5055. The efficacy of five Klebsiella phages (Kpn5, Kpn12, Kpn13, Kpn17, and Kpn22) was evaluated on the basis of survival rate, decrease in bacterial counts in different organs of phage-treated animals, and regeneration of skin cells as observed by histopathological examination of phage-treated skin. Toxicity studies performed with all the phages showed them to be non-toxic, as no signs of morbidity and mortality were observed in phage-treated mice. The results of the study indicate that a single dose of phages, intraperitoneally (i.p.) at an MOI of 1.0, resulted in significant decrease in mortality, and this dose was found to be sufficient to completely cure K. pneumoniae infection in the burn wound model. Maximum decrease in bacterial counts in different organs was observed at 72 h post infection. Histopathological examination of skin of phage-treated mice showed complete recovery of burn infection. Kpn5 phage was found to be highly effective among all the phages and equally effective when compared with a cocktail of all the phages. From these results, it can be concluded that phage therapy may have the potential to be used as stand-alone therapy for K. pneumoniae induced burn wound infection, especially in situations where multiple antibiotic-resistant organisms are encountered.

• Macromolecular Research
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• 제11권5호
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• pp.382-386
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• 2003

Reductive amination of N-succinyl-chitosan (1) and lactose using sodium cyanoborohydride in 1/15 M phosphate buffer (pH 6.0) for 6 d was suitable for the preparation of lactosaminated N-succinyl-chitosan (2). At 8, 24 and 48 h after i.v. administration of fluorescently labeled 1 (1') or 2 (2'), Peyer's patch, mesenteric lymph nodes, testes, prostate, preputial grand, intestine (small intestine plus cecum), femoral muscle, backbone and peritoneum were taken. Peyer's patch and mesenteric lymph nodes were put together as lymph nodes. Over 10% of dose/g tissue was distributed to the prostate and lymph nodes at 48 h post-administration in both l' and 2'.2' was easily distributed into not only the liver but also prostate, intestine, preputial gland and lymph nodes. Although galactose receptors are known to exist not only on the liver parenchymal cells but also on prostate and testes, the selective distribution of 2' into the prostate and the testes were not observed clearly. This study suggested that 1 and 2 should have possibilities for both the prevention and cure of lymph node metastasis as drug carriers.

• The Journal of Advanced Prosthodontics
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• 제7권1호
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• pp.1-7
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• 2015

PURPOSE. This study was performed to evaluate shear bond strength (SBS) between three dual-cured resin cements and silica coated zirconia, before and after thermocycling treatment. MATERIALS AND METHODS. Sixty specimens were cut in $15{\times}2.75mm$ discs using zirconia. After air blasting of $50{\mu}m$ alumina, samples were prepared by tribochemical silica coating with $Rocatec^{TM}$ plus. The specimens were divided into three groups according to the dual-cure resin cement used: (1) Calibra silane+$Calibra^{(R)}$, (2) Monobond S+$Multilink^{(R)}$ N and (3) ESPN sil+$RelyX^{TM}$ Unicem Clicker. After the resin cement was bonded to the zirconia using a Teflon mold, photopolymerization was carried out. Only 10 specimens in each group were thermocycled 6,000 times. Depending on thermocycling treatment, each group was divided into two subgroups (n=10) and SBS was measured by applying force at the speed of 1 mm/min using a universal testing machine. To find out the differences in SBS according to the types of cements and thermocycling using the SPSS, two-way ANOVA was conducted and post-hoc analysis was performed by Turkey's test. RESULTS. In non-thermal aged groups, SBS of Multilink group (M1) was higher than that of Calibra (C1) and Unicem (U1) group (P<.05). Moreover, even after thermocycling treatment, SBS of Multilink group (M2) was higher than the other groups (C2 and U2). All three cements showed lower SBS after the thermocycling than before the treatments. But Multilink and Unicem had a significant difference (P<.05). CONCLUSION. In this experiment, Multilink showed the highest SBS before and after thermocycling. Also, bond strengths of all three cements decreased after thermocycling.

• 접착 및 계면
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• 제15권3호
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• pp.100-108
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• 2014

본 연구에서는 비스페놀 A 에폭시 수지/경화제(YD-128/DDM) 조성물의 비율을 조절하여 $170^{\circ}C$의 경화온도에서 접착성능 최적화 조성비를 얻기 위한 실험을 진행하였다. DSC, TGA, DMA, TMA 열분석 장비를 사용하여 YD-128/DDM 혼합물의 당량비 변화가 경화물의 열적 특성에 미치는 영향에 대하여 조사하였으며, 조성물의 경화시간은 YD-128/DDM (1 : 1.1) 조성물을 동적 DSC를 이용하여 측정된 시간당 누적 발열량을 총 발열량으로 나누어 계산한 전환율을 토대로 결정하였다. TGA를 이용한 분해 활성화 에너지 분석에서는 경화물의 DDM 당량비가 증가할수록 열안정성과 열분해 활성화 에너지가 높게 나타났고, DMA와 TMA를 이용한 경화물의 열적 특성 조사 결과에서는 당량비 1 : 1에서 다른 당량비 조건에 비해 우수한 탄성률 및 열팽창성이 관찰되었다. 또한 각기 다른 당량비의 조성물을 $170^{\circ}C$에서 경화하여 중첩 전단 강도를 측정하였다.

• Parasites, Hosts and Diseases
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• 제61권3호
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• pp.282-291
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• 2023

Despite the recent progress in public health measures, malaria remains a troublesome disease that needs to be eradicated. It is essential to develop new antimalarial medications that are reliable and secure. This report evaluated the pharmacokinetics and antimalarial activity of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the rodent malaria parasite Plasmodium berghei in vivo. After a single oral dose (75 mg /kg) of N-89, its pharmacokinetic parameters were measured, and t_1/2 was 0.97 h, T_max was 0.75 h, and bioavailability was 7.01%. A plasma concentration of 8.1 ng/ml of N-89 was maintained for 8 h but could not be detected at 10 h. The dose inhibiting 50% of parasite growth (ED₅₀) and ED₉₀ values of oral N-89 obtained following a 4-day suppressive test were 20 and 40 mg/kg, respectively. Based on the plasma concentration of N-89, we evaluated the antimalarial activity and cure effects of oral N-89 at a dose of 75 mg/kg 3 times daily for 3 consecutive days in mice harboring more than 0.5% parasitemia. In all the N-89-treated groups, the parasites were eliminated on day 5 post-treatment, and all mice recovered without a parasite recurrence for 30 days. Additionally, administering oral N-89 at a low dose of 50 mg/kg was sufficient to cure mice from day 6 without parasite recurrence. This work was the first to investigate the pharmacokinetic characteristics and antimalarial activity of N-89 as an oral drug. In the future, the following steps should be focused on developing N-89 for malaria treatments; its administration schedule and metabolic pathways should be investigated.

• Composites Research
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• 제36권3호
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• pp.186-192
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• 2023

최근, 철도차량 분야에서는 경량화 및 운송 효율화를 위해 복합재 활용에 대한 관심이 높아지고 있다. 이에 따라 다양한 차량 부품에 복합재를 적용하고자 하는 연구 및 상용화 개발이 활발히 이루어지고 있으며, 복합재 적용에 대한 품질 검증을 위해 완성품의 기계적 성능 평가와 같은 사후 측정을 중심으로 평가가 이루어지고 있다. 하지만, 제작 품질에 큰 영향을 미치는 요소인 복합재 성형 과정에서 발생하는 열과 응력에 대한 분석은 미비한 상황이다. 따라서, 본 연구에서는 철도차량용 복합재 부품의 성형 품질을 검증하기 위하여 가장 활발히 사용되는 복합재 내장재 패널 2종(라미네이트 패널, 샌드위치 패널)에 대한 성형 품질 분석을 진행하였다. 이를 위해 복합재 내부 적용에 용이한 FBG 광섬유 센서를 이용하여 성형 과정 동안 온도 및 변형률 변화를 모니터링 하고, 성형 완료 후 발생하는 잔류 변형률 값을 측정하였다. 결과적으로, 과열 현상과 과도 잔류응력이 발생하지 않은 것을 확인함으로써 철도차량용 복합재 내장재 패널의 우수한 성형 품질을 검증하였다.