• Title/Summary/Keyword: possible hazard

Search Result 326, Processing Time 0.026 seconds

Development and Application of a Scenario Analysis System for CBRN Hazard Prediction (화생방 오염확산 시나리오 분석 시스템 구축 및 활용)

  • Byungheon Lee;Jiyun Seo;Hyunwoo Nam
    • Journal of the Korea Society for Simulation
    • /
    • v.33 no.3
    • /
    • pp.13-26
    • /
    • 2024
  • The CBRN(Chemical, Biological, Radiological, and Nuclear) hazard prediction model is a system that supports commanders in making better decisions by creating contamination distribution and damage prediction areas based on the weapons used, terrain, and weather information in the events of biochemical and radiological accidents. NBC_RAMS(Nuclear, Biological and Chemical Reporting And Modeling S/W System) developed by ADD (Agency for Defense Development) is used not only supporting for decision making plan for various military operations and exercises but also for post analyzing CBRN related events. With the NBC_RAMS's core engine, we introduced a CBR hazard assessment scenario analysis system that can generate contaminant distribution prediction results reflecting various CBR scenarios, and described how to apply it in specific purposes in terms of input information, meteorological data, land data with land coverage and DEM, and building data with pologon form. As a practical use case, a technology development case is addressed that tracks the origin location of contaminant source with artificial intelligence and a technology that selects the optimal location of a CBR detection sensor with score data by analyzing large amounts of data generated using the CBRN scenario analysis system. Through this system, it is possible to generate AI-specialized CBRN related to training and analysis data and support planning of operation and exercise by predicting battle field.

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

  • Paradkar, Prajakta Hemant;Joshi, Jayashree Vinay;Mertia, Priyanka Nirmalsingh;Agashe, Shubhada Vidyadhar;Vaidya, Rama Ashok
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.15 no.9
    • /
    • pp.3851-3864
    • /
    • 2014
  • Cytokine research is currently at the forefront in cancer research. Deciphering the functions of these multiple small molecules, discovered within the cell and in intercellular spaces, with their abundance and pleotrophism, was initially a great challenge. Advances in analytical chemistry and molecular biology have made it possible to unravel the pathophysiological functions of these polypeptides/proteins which are called interleukins, chemokines, monokines, lymphokines and growth factors. With more than 5 million women contracting cervical cancer every year this cancer is a major cause of mortality and morbidity the world over, particularly in the developing countries. In more than 95% of cases it is associated with human papilloma virus (HPV) infection which is persistent, particularly in those with a defective immune system. Although preventable, the mere magnitude of prevalence of HPV in the world population makes it a dominating current health hazard. The discovery of cytokine dysregulation in cervical cancer has spurted investigation into the possibility of using them as biomarkers in the early diagnosis of cases at high risk of developing cancer. Their critical role in carcinogenesis and progression of cervical cancer is now being revealed to a great extent. From diagnostics to prognosis, and now with a possible role in therapeutics and prevention of cervical cancer, the cytokines are being evaluated in all anticancer approaches. This review endeavours to capture the essence of the astonishing journey of cytokine research in cervical neoplasia.

Quantitative and Qualitative Extrapolation of Carcinogenesis Between Species

  • Gold Lois Swirsky;Manley Neela B.;Ames Bruce N.
    • 대한예방의학회:학술대회논문집
    • /
    • 1994.02a
    • /
    • pp.431-438
    • /
    • 1994
  • As currently conducted, standard rodent bioassays do not provide sufficient information to assess carcinogenic risk to humans at doses thousands of times below the maximum tolerated dose. Recent analyses indicate that measures of carcinogenic potency from these tests are restricted to a narrow range about the maximum tolerated dose and that information on shape of the dose-response is limited in experiments with only two doses and a control. Extrapolation from high to low doses should be based on an understanding of the mechanisms of carcinogenesis. We have postulated that administration of the maximum tolerated dose can increase mitogenesis which, in turn. increases rates of mutagenesis and, thus, carcinogenesis. The animal data are consistent with this mechanism, because about half of all chemicals tested are indeed rodent carcinogens, and about 40% of the positives are not detectably mutagenic. Thus, at low doses where cell killing does not occur, the hazards to humans of rodent carcinogens may be much lower than commonly assumed. In contrast, for high-dose exposures in the workplace, assessment of hazard requires comparatively little extrapolation. Nevertheless. permitted workplace exposures are sometimes close to the tumorigenic dose-rate in animal tests. Regulatory policy to prevent human cancer has primarily addressed synthetic chemicals, yet similar proportions of natural chemicals and synthetic chemicals test positive in rodent studies as expected from an understanding of toxicological defenses, and the vast proportion of human exposures are to natural chemicals. Thus, human exposures to rodent carcinogens are common. The natural chemicals are the control to evaluate regulatory strategies, and the possible hazards from synthetic chemicals should be compared to the possible hazards from natural chemicals. Qualitative extrapolation of the carcinogenic response between species has been investigated by comparing two closely related species: rats and mice. Overall predictive values provide moderate confidence in interspecies extrapolation; however, knowing that a chemical is positive at any site in one species gives only about a 50% chance that it will be positive at the same site in the other species.

  • PDF

Reproductive History and Hip Fracture in the Elderly Women in Korea : A Cohort Study (여성 노인에서 출산력과 고관절 골절 발생간의 관련성 : 코호트 연구)

  • Lee, Seung-Mi;Kim, Yoon-I;Youn, Koung-Eun;Park, Byung-Joo
    • Journal of Preventive Medicine and Public Health
    • /
    • v.35 no.4
    • /
    • pp.305-312
    • /
    • 2002
  • Objectives : The reproductive history of women has been suggested to have a possible influence on the risk of osteoporotic fractures. The purpose of this study was to assess the association between reproductive history and hip fractures in the elderly women. Methods : The study subjects were drawn from women members of the Korean Elderly Pharmacoepidemiologic Cohort (KEPEC), aged 65 years or over, whose reproductive histories were available, and who were beneficiaries of the Korea Medical Insurance Corporation (KMIC) in 1993 and lived in Busan city, Korea. The information on reproductive histories, and possible confounders, were collected from mailed questionnaires. Potential hip fracture cases were collected from the claims data obtained between 1993 and 1998, with a hospital survey conducted to confirm the final diagnoses. Rate ratios and their 95% confidence intervals, were calculated using a Cox's proportional hazard model. Results : Following up 5,215 women for 6 years, 51 cases were confirmed with hip fractures. When adjusted for age, weight and physical activity, the rate ratio of hip fractures in women who had given birth three or more times was 0.56 (95% CI: 0.25-1.25), compared with those who had given birth two or less times. When adjusted for age, number of births, weight and physical activity, the rate ratio in women who first gave birth when younger than 22 years was 0.60 (95% CI: 0.34-1.08) compared with those who had giving birth at 22 years or older. Conclusions : According to these findings, an early age when first giving birth might decrease the risk of hip fractures in elderly Korean women.

Three-Dimensional Simulation of Seismic Wave Propagation in Elastic Media Using Finite-Difference Method (유한차분법을 이용한 3차원 지진파 전파 모의)

  • 강태섭
    • Proceedings of the Earthquake Engineering Society of Korea Conference
    • /
    • 2000.10a
    • /
    • pp.81-88
    • /
    • 2000
  • The elastic wave equation is solved using the finite-difference method in 3D space to simulate the seismic wave propagation. It is based on the velocity-stress formulation of the equation of motion on a staggered grid. The nonreflecting boundary conditions are used to attenuate the wave field close to the numerical boundary. To satisfy the stress-free conditions at the free-surface boundary, a new formulation combining the zero-stress formalism with the vacuum one is applied. The effective media parameters are employed to satisfy the traction continuity condition across the media interface. With use of the moment-tensor components, the wide range of source mechanism parameters can be specified. The numerical experiments are carried out in order to test the applicability and accuracy of this scheme and to understand the fundamental features of the wave propagation under the generalized elastic media structure. Computational results show that the scheme is sufficiently accurate for modeling wave propagation in 3D elastic media and generates all the possible phases appropriately in under the given heterogeneous velocity structure. Also the characteristics of the ground motion in an sedimentary basin such as the amplification, trapping, and focusing of the elastic wave energy are well represented. These results demonstrate the use of this simulation method will be helpful for modeling the ground motion of seismological and engineering purpose like earthquake hazard assessment, seismic design, city planning, and etc..

  • PDF

A study of performing Fall-Back operation in RF-CBTC signalling system (RF-CBTC 신호방식에서 Fall-Back 시스템 구축방안)

  • Jeon, Jae-Hun;Kang, Deok-Won;Lee, Jong-Seong
    • Proceedings of the KSR Conference
    • /
    • 2011.05a
    • /
    • pp.145-153
    • /
    • 2011
  • In the system necessary for safety such as the train control system, to make train control information be sent correctly is very important to enable organic movement between trains. In the case of the system such as RF-CBTC (Radio Frequency Communication Based Train Control) the control related information is sent through wireless transmission between on-board system of a train and wayside transmitter. The wayside transmitter collects the running information such as location, velocity from the on-board system and operates the optimizing control by sending the control information such as the target, limited velocity to the on-board system. But, when the communication disconnect or train failure, the critical hazard such as train collision or derailment may be possible because the RF-CBTC depends on the information through wireless communication. This paper discribes of performing Fall-Back system to detect train position in the case of rail break or communication failure to avoid train accident and allows train to be operated safely. It can be implemented with ATP function through track circuits using active-type transformers and axle counters, and allows train to be operated manually in emergency status.

  • PDF

Aggregate Risk Assessment on Xylene and Ethylbenzene (자일렌과 에틸벤젠에 대한 매체통합위해성평가 연구)

  • Seo, Jung-Kwan;Kim, Taksoo;Kim, Pilje
    • Journal of Environmental Science International
    • /
    • v.22 no.2
    • /
    • pp.163-171
    • /
    • 2013
  • The aggregate risk assessment on xylene and ethylbenzene was carried out according to the guidance established newly in 2010 with the purpose of providing information for risk management. In human exposure assessment, the results indicated that lower ages were exposed more and that, in the interior space at home, the highest level of human exposure occurred via inhalation. At outdoor spaces, exposures via inhalation and drinking were less than 1%. In human health risk characterization, xylene showed HI(Hazard Index) < 1 in all ages. When reasonable maximum exposure(RME) was applied, HI for young children was 0.64. The HI of ethylbenzene was also below 1(0.02~0.04) in all ages, indicating no potential risk. From this study, it is considered that xylene need to be continous monitoring with interest because this substance may be more sensitive on young age group. In additon, to reduce the uncertainty of the risk assessment, the korean exposure factors on young age group such as infant, children had to be established as soon as possible.

A Study on the Space Planing for Restaurant Kitchens to Improve Hygiene (식당 주방의 위생 향상을 위한 공간계획에 관한 연구)

  • Lee, Jong-Ran
    • Journal of The Korean Digital Architecture Interior Association
    • /
    • v.11 no.1
    • /
    • pp.5-13
    • /
    • 2011
  • This research proposed the space planing methode and diagrams of restaurant kitchens to improve hygiene by analyzing the related contents collected from books and researches in interior design and HACCP (Hazard Analysis and Critical Control Point). HACCP is an effective and scientific hygiene system for food safety in order to prevent cross-contamination from food hazards. Based on the analyses, improvement of food production environments like restaurant kitchens is necessary for food hygiene. The space planing methode of restaurant kitchens to improve hygiene are followings: The circulation planing is that the direction of movement of the food, workers, waste, and dishes should be fractionated and managed for cross-contamination prevention. The space separation planing is that the spaces in the kitchen should be classified and divided into contaminated area and non-contaminated and clean area depending on the degree of cleanliness. The zoning is space arrangement with feed-back process to check the possible points of cross-contamination and correct space arrangement until the possibility of cross-contamination disappear in kitchen. However, if cross-contamination is unavoidable in some points in restaurant kitchens, hygiene facilities such as washing rooms, pass rooms, and double doors with air-shower should be located in order to remove contamination.

S100A14 Promotes the Growth and Metastasis of Hepatocellular Carcinoma

  • Zhao, Fu-Tao;Jia, Zhan-Sheng;Yang, Qun;Song, Le;Jiang, Xiao-Jing
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.14 no.6
    • /
    • pp.3831-3836
    • /
    • 2013
  • Background: S100A14 has recently been implicated in the progress of several types of cancers. This study aimed to investigate the clinical significance and possible mechanisms of action of S100A14 in the invasion and metastasis of hepatocellular carcinoma (HCC). Methods: S100A14 expression in HCC was detected at mRNA and protein levels and its prognostic significance was assessed. Functional roles of S100A14 in HCC were investigated using MTT, BrdU, wound healing, transwell invasion assay and HCC metastatic mouse model. Results: S100A14 was significantly elevated in HCC tissues, correlated with multiple tumor nodes, high Edmondson-Steiner grade and vascular invasion. Multivariate Cox analysis showed that the S100A14 expression level was a significant and independent prognostic factor for overall survival (OS) of HCC patients (hazard ratio=1.98, 95% confidence interval=1.14-3.46, P=0.013). S100A14 promoted cell proliferation, invasion and metastasis of HCC in vitro and in vivo. Conclusion: These results suggest S100A14 is a novel prognostic marker and therapeutic target for HCC.

The humidifier disinfectant case and the legislative challenges of the 20th Congress

  • Park, Taehyun
    • Environmental Analysis Health and Toxicology
    • /
    • v.31
    • /
    • pp.15.1-15.6
    • /
    • 2016
  • A number of absurdities surrounding the humidifier disinfectant (HD) incident may have occurred because 1) a judicial system operates on the underlying false assumption that the involved parties are equals in knowledge, information and resource mobilization capabilities, regardless of respective real status as company or individual; 2) there is a lack of a system that mandates a company to prevent and actively manage possible catastrophes; 3) the regulatory scheme makes companies believe that as long as they are complying with the existing regulations, they have satisfied all of their responsibilities. I believe that this issue is an opportunity to bring about changes in the judicial redress system, the system of internal management of manufacturers, and the regulatory system of the government. The following regulation amendments are needed to move towards the changes stated above. First, legislation relating to victim relief that is applicable to the HD incident must be established. Second, a risk management system must be formed within the manufacturing company and to this end an institutional environment for the system must be established within regulatory framework. Furthermore, legislation must be passed that could punish companies themselves that have caused severe damage to individuals because they had failed to take necessary actions to avoid foreseeable harm. Finally, the framework of regulation must be changed so that the company, who has the necessary information regarding the product and the component chemicals used in the product, must self-directed experiment and assessment of the safety of their own products.