• The Journal of the Korea Contents Association
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• v.15 no.12
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• pp.212-221
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• 2015

This study searched the effect of volunteering activity on democratic citizen consciousness as a mediation of adolescents' leadership living technique. For this, it has been conducted that a survey for 386 middle and high school students in Chungcheongbuk-do. Main analysis results are as follows. First, searching the effect on democratic citizen consciousness, it is analyzed that volunteering activity participation satisfaction level(${\beta}=.215$), learning ability technique(${\beta}=.297$), group activity technique(${\beta}=.145$) have a positive(+) effect. Second, as a result of mediation effect, volunteering activity is confirmed that is meaningful as both a direct effect(.35) on democratic citizen consciousness and an indirect effect($.42{\times}.65=.29$) as leadership living technique and it is appeared as an partial mediation effect. Therefore, in order to improve adolescents' democratic citizen consciousness, active support for volunteering activity and overall efforts which are able to activate the leadership technique in real youth everyday life are necessary.

• Journal of the Korean Association of Geographic Information Studies
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• v.11 no.4
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• pp.161-171
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• 2008

Nowdays the need of modeling a real world using computers leads to increase the importance of GIS. Moreover, the wide spread of the Internet service has brought about Web GIS Development. Especially, the tuning of Web GIS system has a crucial role in improving the performance of high resolution image Web GIS system. Thus, this study provides a variety of ways to improve the performance of high resolution image Web GIS system. We have tuned IBM AIX operation system, Oracle, ArcSDE in the database level and Tomcat, ArcIMS in the application level. What is more, we propose ways of coding which can have a positive impact on performance. As a result, the proposed methods guarantee high resolution image Web GIS system to improve performance.

• Journal of Korean Society of Rural Planning
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• v.15 no.4
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• pp.135-146
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• 2009

Urban forest area in South Korea has been increased up to 20.8% of national land as of 2007 by the mergence of municipalities and counties. The rate of park and green tract among urban forest averages out to about 4% nationally but the Capital, Seoul, almost 105% level, not easy to split the two. Park and green has positive management system because of its infrastructure attribute and relevant security obligation standard while urban forest left alone with no such concerns. The most important reason of the negligence comes from institutional inertia although it is possible to be managed functionally by forest laws as like forests of park, landscape, wind and noise protection, and timber product. As a results, it reaches below than 92.64% of the national average level of the timber stockpile especially in the metropolitan areas and loses broad acres rapidly due to the easy conversion system to the urban land usage. Therefore, there must be required some alternative methodologies to conserve and foster it. The paper proposes the four urban forest management types and their control methods. The four types divide into conservation, foster, development, and reservation ones. Also it suggests the five furtherance tract types with the combination among the four earlier types, optionally having one of the six aim climaxes and recommends the standardization of operation design. The total green quantity index of urban forest also suggested by the weight method according to location and DBH class. The case study of the suggested model was executed on the Daejon Metropolitan area and its index calculated as 110.4% level compared with the acreage.

• Parasites, Hosts and Diseases
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• v.47 no.4
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• pp.353-357
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• 2009

Cryptosporidium can cause gastrointestinal diseases worldwide, consequently posing public health problems and economic burden. Effective techniques for detecting contaminated oocysts in water are important to prevent and control the contamination. Immunomagnetic separation (IMS) method has been widely employed recently due to its efficiency, but, it is costly. Sucrose floatation technique is generally used for separating organisms by using their different specific gravity. It is effective and cheap but time consuming as well as requiring highly skilled personnel. Water turbidity and parasite load in water sample are additional factors affecting to the recovery rate of those 2 methods. We compared the efficiency of IMS and sucrose floatation methods to recover the spiked Cryptosporidium oocysts in various turbidity water samples. Cryptosporidium oocysts concentration at 1, $10^1$, $10^2$, and $10^3$ per $10{\mu}l$ were spiked into 3 sets of 10 ml-water turbidity (5, 50, and 500 NTU). The recovery rate of the 2 methods was not different. Oocyst load at the concentration < $10^2$ per 10 ml yielded unreliable results. Water turbidity at 500 NTU decreased the recovery rate of both techniques. The combination of sucrose floatation and immunofluorescense assay techniques (SF-FA) showed higher recovery rate than IMS and immunofluorescense assay (IMS-FA). We used this SF-FA to detect Cryptosporidium and Giardia from the river water samples and found 9 and 19 out of 30 (30% and 63.3%) positive, respectively. Our results favored sucrose floatation technique enhanced with immunofluorescense assay for detecting contaminated protozoa in water samples in general laboratories and in the real practical setting.

• Biomolecules & Therapeutics
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• v.28 no.4
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• pp.337-343
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• 2020

Activation of osteoclast and inactivation of osteoblast result in loss of bone mass with bone resorption, leading to the pathological progression of osteoporosis. The receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily, and is a key mediator of osteoclast differentiation. A flavanone glycoside isolated from the fruit of Poncirus trifoliata, poncirin has anti-allergic, hypocholesterolemic, anti-inflammatory and anti-platelet activities. The present study investigates the effect of poncirin on osteoclast differentiation of RANKL-stimulated RAW264.7 cells. We observed reduced formation of RANKL-stimulated TRAP-positive multinucleated cells (a morphological feature of osteoclasts) after poncirin exposure. Real-time qPCR analysis showed suppression of the RANKL-mediated induction of key osteoclastogenic molecules such as NFATc1, TRAP, c-Fos, MMP9 and cathepsin K after poncirin treatment. Poncirin also inhibited the RANKL-mediated activation of NF-κB and, notably, JNK, without changes in ERK and p38 expression in RAW264.7 cells. Furthermore, we assessed the in vivo efficacy of poncirin in the lipopolysaccharide (LPS)-induced bone erosion model. Evaluating the micro-CT of femurs revealed that bone erosion in poncirin treated mice was markedly attenuated. Our results indicate that poncirin exerts anti-osteoclastic effects in vitro and in vivo by suppressing osteoclast differentiation. We believe that poncirin is a promising candidate for inflammatory bone loss therapeutics.

• Journal of the Korean School Mathematics Society
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• v.16 no.2
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• pp.337-362
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• 2013

The purposes of the study were to develop STEM instructional materials for teaching and learning mathematics and to investigate how the STEM based approach affects on students' learning of mathematics in cognitive and affective domain and career choice. STEM instructional materials were designed for learning of mathematical concepts in the contexts of science, technology, and engineering as well as real world. According to the results of the study, STEM instructional materials for teaching and learning mathematics were effective for improving students' problem solving ability and affective achievement such as self-regulation, self-efficacy, and value of mathematics. In addition, STEM program played a positive role in tempting students' career choice into science and engineering fields including mathematics.

• Journal of Educational Research in Mathematics
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• v.21 no.4
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• pp.399-422
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• 2011

There has been an agreement on the necessity for each citizen is to be educated, so called, to develop quantitative literacy or statistical literacy, dealing with real world data. For this reason, it is highly demanded to improve traditional statistics education. In particular, critical thought and statistical communication competency cultivation is becoming more crucial in statistics classes. In line with this reform movement in statistics education, we developed tasks facilitating statistical debate among students through inducing cognitive conflict. The tasks employed for this study resulted in playing crucial role to activate statistical debate. Including aforementioned feature about the tasks for this study, we obtained several positive results such as promoting critical thought and conceptual extension by designed teaching experiment focusing on statistical debate.

• Journal of Applied Biological Chemistry
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• v.63 no.2
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• pp.169-174
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• 2020

The objective of this study was to investigate the effects of a hypodermic injectable solution comprised of an LPM LB meso solution containing Melissa officinalis L. leaf extract (LPM) on the lipogenesis in the 3T3-L1 cells line. The lipid accumulation measured by oil red o staining in the 3T3-L1 adipocytes treated with LPM, which was reduced in a dose dependent manner and showed 91.7 to 62.9% compared to control group. Its effectiveness with a 50% solution was significantly higher than the hydroxycitric acid (positive control) treatment without showing cell cytotoxicity. In a quantitative real-time PCR, it was demonstrated that the LPM treatment appeared to upregulate the mRNA expression of the adipogenesis-related genes, which included the peroxisome proliferator-activated receptor gamma (50% concentration) while down-regulating the CCAAT-enhancer binding protein alpha (50% concentration) and the sterol regulatory element-binding protein 1c (10, 25, and 50% concentrations). The results from the current study suggest that the LPM could be useful biomaterials that can inhibit obesity in the 3T3-L1 cells, which could possibly be by regulating the specific adipogenic gene transcription factors.

• Proceedings of the KAIS Fall Conference
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• 2008.11a
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• pp.484-487
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• 2008

This study investigates and analyzed to whole public offering listed company whether enterprise's integration information system exercises some influence on business users. Many medium and small enterprise introduce and operate new integrated system, but there was difficulty in Productivity Analysis that is real by unstableness of system, preservation and insufficiency of management control etc. Therefore, in this study, designed study model and research hypothesis laying stress on information strategy, system quality, information quality of information support agents to measure integration information system to relative stable enterprise. This study may become data that is useful in stable system introduction in various field of industry hereafter medium and small enterprises. This study Was construed by thing which degree that give influence of positive in user satisfaction as findings information system quality, quality of service, information support agents is good in study analysis is very high. The other side, information strategy was expose for factor that do not exert big influence on user's satisfaction, and got sequence that is affected in some degree if user satisfaction is high in details article.

• Biomolecules & Therapeutics
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• v.26 no.2
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• pp.218-223
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• 2018

The liver is an essential organ for the detoxification of exogenous xenobiotics, drugs and toxic substances. The incidence rate of non-alcoholic liver injury increases due to dietary habit change and drug use increase. Our previous study demonstrated that Ecklonia stolonifera (ES) formulation has hepatoprotective effect against alcohol-induced liver injury in rat and tacrine-induced hepatotoxicity in HepG2 cells. This present study was designated to elucidate hepatoprotective effects of ES formulation against carbon tetrachloride ($CCl_4$)-induced liver injury in Sprague Dawley rat. Sixty rats were randomly divided into six groups. The rats were treated orally with ES formulation and silymarin (served as positive control, only 100 mg/kg/day) at a dose of 50, 100, or 200 mg/kg/day for 21 days. Seven days after treatment, liver injury was induced by intraperitoneal injection of $CCl_4$ (1.5 ml/kg, twice a week for 14 days). The administration of $CCl_4$ exhibited significant elevation of hepatic enzymes (like AST and ALT), and decrease of antioxidant related enzymes (superoxide dismutase, glutathione peroxidase and catalase) and glutathione. Then, it leaded to DNA damages (8-oxo-2'-deoxyguanosine) and lipid peroxidation (malondialdehyde). Administration of ES formulation inhibited imbalance of above factors compared to $CCl_4$ induced rat in a dose dependent manner. Real time PCR analysis indicates that CYP2E1 was upregulated in $CCl_4$ induced rat. However, increased gene expression was compromised by ES formulation treatment. These findings suggests that ES formulation could protect hepatotoxicity caused by $CCl_4$ via two pathways: elevation of antioxidant enzymes and normalization of CYP2E1 enzyme.