• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.5
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• pp.1325-1329
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• 2003

The preventive effect of Salvia miltiorrhiza extracts (SMEs) on the progress of bone loss induced by ovariectomy (OVX) was studied in rats. We measured body weight and bone histomorphometry in sham, OVX or SMEs-administered OVX rats. From light microscopic analyses, a porous or erosive appearances were observed on the surface of trabecular bone of tibia in OVX rats, whereas those of the same bone in sham rats and in SMEs-administered rats were composed of fine particles. The trabecular bone area and trabecular thickness in OVX rats decreased by 50% from those in sham rats, these decreases were completely inhibited by administration of SMEs for 7 weeks. In this study, the mechanical strength in femur neck was significantly enhanced by the treatment of SMEs for 7 weeks. In OVX rats, free T3 was normal in all cases, whereas free T4 was significantly increased. Although there was no difference between OVX and SMEs-administered rats in T3 level, we have found significant difference between them in T4 level. These results strongly suggest that SMEs are effective in preventing the development of bone loss induced by OVX in rats.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2017.05a
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• pp.160-160
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• 2017

Commercially pure titanium (Cp-Ti) and Ti alloys (typically Ti-6Al-4V) display excellent corrosion resistance and biocompatibility. Although the chemical composition and topography are considered important, the mechanical properties of the material and the loading conditions in the host have, conventionally. Ti and its alloys are not bioactive. Therefore, they do not chemically bond to the bone, whereas they physically bond with bone tissue. The electrochemical deposition process provides an effective surface for biocompatibility because large surface area can be served to cell proliferation. Plasma electrolyte oxidation (PEO) enables control in the chemical composition, porous structure, and thickness of the TiO2 layer on Ti surface. Silicon (Si) in particular has been found to be essential for normal bone and cartilage growth and development. Zinc (Zn) plays very important roles in bone formation and immune system regulation, and is also the most abundant trace element in bone. The objective of this work was to study on electrochemical behaviors of PEO-treated Ti-6Al-4V Alloy in solution containing Zn and Si ions. The morphology, the chemical composition, and the microstructure analysis of the sample were examined using FE-SEM, EDS, and XRD. The potentiodynamic polarization and AC impedance tests for corrosion behaviors were carried out in 0.9% NaCl solution at similar body temperature using a potentiostat. The promising results successfully demonstrated the immense potential of Si/Zn-TiO2 coatings in dental and biomaterials applications.

• Korean Journal of Materials Research
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• v.25 no.5
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• pp.238-246
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• 2015

$H_2S$ is a flammable toxic gas that can be produced in plants, mines, and industries and is especially fatal to human body. In this study, CuO nanowire structure with high porosity was fabricated by deposition of copper on highly porous singlewall carbon nanotube (SWCNT) template followed by oxidation. The SWCNT template was formed on alumina substrates by the arc-discharge method. The oxidation temperatures for Cu nanowires were varied from 400 to $800^{\circ}C$. The morphology and sensing properties of the CuO nanowire sensor were characterized by FESEM, Raman spectroscopy, XPS, XRD, and currentvoltage examination. The $H_2S$ gas sensing properties were carried out at different operating temperatures using dry air as the carrier gas. The CuO nanowire structure oxidized at $800^{\circ}C$ showed the highest response at the lowest operating temperature of $150^{\circ}C$. The optimum operating temperature was shifted to higher temperature to $300^{\circ}C$ as the oxidation temperature was lowered. The results were discussed based on the mechanisms of the reaction with ionosorbed oxygen and the CuS formation reaction on the surface.

• The Korean Journal of Ceramics
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• v.6 no.3
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• pp.214-218
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• 2000

Hydroxyapatite (HA) and $\beta$-tricalcium phosphate ($\beta$-TCP) are bio-compatible materials with bones and teeth. HA has been widely applied as bone substitutes because of chemical stability in vivo, while $\beta$-TCP has higher resorbability than HA when the material is implanted in a bone defect. In the present study, both HA and $\beta$-TCP porous ceramics were soaked in the simulated body fluid in order to investigate the reaction between the materials and the fluid. After the soaking test, carbonate hydroxyapatite was formed on HA surface at 1 week, and then the amount of precipitates increased with increasing period of the soaking test. While $\beta$-TCP was not dissolved in the fluid, carbonate hydroxyaopatite was also formed on $\beta$-TCP surface after 12 weeks, and the amount of precipitates was less than that on HA. In vitro behavior of HA was similar to that in vivo, but in vitro behavior of $\beta$-TCP was not similar to that in vivo.

• International Journal of Industrial Entomology and Biomaterials
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• v.28 no.2
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• pp.66-70
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• 2014

In order to the feasibility of silk materials as protein delivery system, silk beads incorporated with bovine serum albumin (BSA) were prepared by dropping silk fibroin extract into dope solution composed of ethanol and dichloromethane. Structural and morphological characteristics of silk beads were examined using scanning electron microscopy (SEM), infrared spectrometry, and X-ray diffractometry. Swelling ratio of silk beads was also measured. Release behavior of prototypical protein, BSA, was studied by observing the electropheretic phenomenon and release profile. SEM showed that silk beads are spherical with porous interior structure. Infrared spectrometry and X-ray diffraction confirm that the silk beads have a ${\beta}$-sheet conformation. The swelling capability of silk beads increased with the incorporation of the protein. The protein was released from the beads with slow release following an initial burst release. Therefore, silk beads show promise as materials for encasing protein drugs to be delivered to targets in the human body.

• Preventive Nutrition and Food Science
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• v.10 no.2
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• pp.156-160
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• 2005

Salvia miltiorrhiza Radix root extracts (SMR) was evaluated for inhibition of the progress of bone loss induced by ovariectomy (OVX) in rats. We measured body weight and bone histomorphometry in sham, OVX and SMR-administered OVX rats. From light microscopic analyses, porous or erosive appearances were observed on the surface of trabecular bone of tibia in OVX rats, whereas those of the same bone in sham rats and in SMR-administered rats were composed of fine particles. The trabecular bone area and trabecular thickness in OVX rats were decreased by $50\%$ from those in sham rats, and these decreases were completely inhibited by administration of SMR for 7 weeks. In this study, the mechanical strength in femur neck was significantly enhanced by the treatment of SMR for 7 weeks. In OVX rats, free $T_3$ was normal in all cases, whereas free $T_4$ was significantly increased. Although there was no difference between OVX and SMR-administered rat in $T_3$ levels, we have found significant difference between them in $T_4$ level. These results strongly suggest that SMR may be beneficial for preventing bone loss in OVX rats.

• Journal of the Korean Society of Industry Convergence
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• v.24 no.5
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• pp.573-579
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• 2021

In this study, flow analysis was performed on three types of strainers for ships with different flow rates to predict the pressure drop of the strainer due to the filter of strainer. In the case of flow analysis, the flow analysis was performed by applying the porous media method by applying the resistance value derived by Ergun's equation to the filter position. As a result of the analysis, it was found that when the dimensions of the strainer body were small, the influence of the flow rate on the pressure drop was large. In addition, the amount of pressure drop and the flow rate are almost linearly proportional, and an analysis formula that can predict the amount of pressure drop was derived. In order to predict the amount of pressure drop of the strainer when blockage exist in the strainer filter, the analysis was performed by introducing the resistance ratio to derive the prediction equation. Using this equation, it is thought that it will be possible to predict the performance of the strainer due to blockage in the future strainer design and field application.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2019.11a
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• pp.172-173
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• 2019

As the damage to fine dust increased, the Republic of Korea designated fine dust as a social disaster. The composition of the fine dust is composed of carbon, sulfate, nitrate, ammonium and minerals. The cause of fine dust is naturally generated by dirt, pollen, etc. In addition, there are artificial causes such as gaseous vehicle exhaust gas emitted from the use of fossil fuel. When fine dust enters the human body through breathing, it causes various respiratory diseases and skin diseases. In IARC, fine dust was designated as a carcinogen group 1. In this research, we tried to adsorb fine dust by physical adsorption using powdered activate carbon. Powdered activate carbon is a powdered activated carbon activated in a carbonized state. Porous material with high specific surface area and low density. Experimental items were tested for density, water absorption, and fine dust concentration according to the PAC addition ratio. Basic experiments were carried out to fabricate the fine dust adsorption matrix.

• Korean Journal of Metals and Materials
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• v.47 no.12
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• pp.881-886
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• 2009

Research into the replacement of injured systems and tissue in the human body is advancing rapidly. Recently, Ti-Ni shape memory alloys have shown excellent biofunctionality related to their shape memory effect and superelasticity. In this study, the effect of an acid or an alkali treatment on the bioactivity in 49Ti-Ni and 51.5Ti-48.5Ni alloys is investigated in an effort to utilize Ti-Ni alloy as a biomaterial. In addition, the biocompatibility in a SBF solution is assessed through in vitro testing. A porous surface was formed on the surface of both alloys after a chemical treatment. According to the in vitro test, apatite formed on the surfaces of both alloys. The forming rate of apatite in the Ti-rich alloy was faster that in the Ni-rich alloy. The formation of apatite provided proof of the bioactivity of the Ti-Ni alloy. A small quantity of Ni was eluted at the initial stage, whereas Ni was not found for 12 days in the Ti-rich alloy and for 8 days in the Ni-rich alloy. In the case of the treated 51.5Ti-Ni alloy, the shape memory property was worsened but the biocompatibility was improved.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2021.05a
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• pp.146-147
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• 2021

An increase in carbon emissions leads to the problem of global warming and is an issue to be solved in other countries. The problem of carbon dioxide has many effects not only on global warming but also on people. According to the World Health Organization (WHO), 4.3 million people have died because harmful substances generated indoors cannot be discharged to the outside and accumulate in the human body through the respiratory tract. In response to this situation, in order to reduce the generation of pollutants in the building itself, soak into lightweight bubble concrete to adsorb and purify indoor pollutants, mix charcoal, investigate the appropriate amount and physical characteristics, and check carbon dioxide This is an experiment for grasping the adsorption capacity, and the results are as follows. As the replacement rate of rice husk charcoal increased, the compressive strength tended to decrease, and the carbon dioxide reduction rate tended to increase. It is judged that the charcoal of rice husks shows a low density and the physical adsorption is smooth due to the porous structure. Since it is excellent in the basic physical properties and carbon dioxide adsorption surface of this experiment, it is judged that it has sufficient potential for use as an indoor finishing material.