• Title/Summary/Keyword: polyethylene glycol

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Enhancement of Dissolution from Pharmaceutical Preparation of Hydrophobic Drugs ( I ) -Characteristics of Sulpiride-Polyethylene Glycol Coprecipitates-

  • Ku, Young-Soon
    • Journal of Pharmaceutical Investigation
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    • v.12 no.4
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    • pp.145-152
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    • 1982
  • Data from IR spectroscopy and X-ray diffractometry were used for the characterization of sulpiride polyethylene glycol coprecipitates related with polymorphism of sulpiride. Sulpiride Form II transformed to Form I during coprecipitating with polyethylene glycol and the transformation rate is increased in proportion to molecular size of polyethylene glycol and the content of polyethylene glycol in coprecipitate.

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Effect of Polyethylene Glycol on Release of Heparin from Silicone Segment Devices (실리콘 segment device로부터의 헤파린 방출에 미치는 폴리에틸렌글리콜의 영향)

  • 김성호
    • YAKHAK HOEJI
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    • v.29 no.2
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    • pp.70-75
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    • 1985
  • The influence of polyethylene glycol derivatives on heparin release from cylindrical monolithic type silicone segment devices was examined in physical saline solution. This water-soluble carrier caused the devices to absorb the water in aqueous media. The release rate of heparin from the devices was increased as molecular weight of polyethylene glycol was increased. Water soluble carrier incorporated into silitone segment devices permits controlled release of heparin that otherwise would be released extremly slowly from the polymer. Heparin released from the silicone segment containing polyethylene glycol showed the first-order kinetics. Without changing the release-pattern, the release rate of heparin could be controlled by varing molecular weight of polyethylene glycol, the water-soluble carrier and depleting polyethylene glycol on the outlayer of devices. The mechanism of release probably showed the creation of pore or microdomine through the devices secondary to the swelling.

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Polyethylene Glycol을 이용한 수침목재의 보존처리

  • Kim, Yong-Han
    • 보존과학연구
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    • s.5
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    • pp.179-188
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    • 1984
  • 본문은 Conservation of Water logged Wood(1979, Netherlands National Commission for UNESCO)중의 "The Use of Polyethylene glycol for the Treatment of Waterlogged wood-its Past and Future(Dr.C.Pearson)" 및 "The Conservation of ship wrecks by impregnation with Polyethylene glycol (Dr.J.deJong)"을 역편한 것임.

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Synthesis of block copolymer of polystyrene and polyethylene glycol methyl ether methacrylate(PEGMA) by ATRP (atom transfer radical polymerization) (ATRP(atom transfer radical polymerization)에 의한 polystyrene과 poly ethylene glycol methyl ether methacrylate(PEGMA)의 블록 공중합체의 합성)

  • Kim, Sang-Hern
    • Journal of the Korean Applied Science and Technology
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    • v.26 no.3
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    • pp.306-316
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    • 2009
  • In this study, block copolymer of polystyrene and polyethylene glycol methyl ether methacrylate(PEGMA) by ATRP(atom transfer radical polymerization) method was synthesized. 4 arm-molecule which contained halogen atom was synthesized for an initiator. With 4 arm-molecule monodispered polystyrene were synthesized by ATRP method. The molecular change of synthesized monodispersed polystyrene with respect to time was investigated and living polymer characteristic was confirmed. Block copolymer of polystyrene and polyethylene glycol methyl ether methacrylate(PEGMA) was synthesized by ATRP with macroinitiator which was synthesized from the monodispersed polystyrene(Mn=12000). The molecular weight of obtained PS-b-PEGMA was 22,000.

Effects of Drought by Polythylene glycol Solution on Seven Grasses Germination (Polythylene glycol을 이용한 모의적 토양수분 조절방법이 목초의 발아에 미치는 영향과 유효성)

  • 윤세형
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.10 no.2
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    • pp.70-76
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    • 1990
  • The present study elucidates the effect of drught by polyethylene glycol solution on germination of five temperate and two tropical grasses. The results obtained can be summarized as follows: 1. The germination percentage of seven grasses decreased with increasing concentration of polythylene glycol. 2. The germination pattern hi higher concentration of polyethylene glycol showed similar trends to the emergence pattern under drought stress in soil condition. 3. The treatment of 30g is most useful at this study. Therefore, polythlene glycol was the appropriate to creat the drought condition of soil.

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Comparison of polyethylene glycol 4000 and lactulose for treatment of chronic functional constipation in children (소아의 만성 기능성 변비 치료에 polyethylene clycol 4000과 락툴로스의 효과 비교)

  • Uhm, Ji Hyun
    • Clinical and Experimental Pediatrics
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    • v.50 no.8
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    • pp.752-756
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    • 2007
  • Purpose : The aim of this study was to compare 2 laxatives, namely, polyethylene glycol 4000 without electrolytes and lactulose, evaluating the efficacy and safety for the treatment of constipation in children. Methods : Fifty-six children with chronic functional constipation were randomly assigned to receive polyethylene glycol 4000 (24 patients) or lactulose (32 patients). Patients or their parents reported defecation frequency, stool consistency, abdominal pain, stool incontinence and side effects after 1, 3, 6 and 12 months of treatment. Percentage of recovered patients were compared with each group. Results : Defecation frequency, abdominal pain and stool incontinence were improved in each group. At 12 months of follow up, 60% of patients treated with polyethylene glycol and 57.7% of patients treated with lactulose were considered as recovered. Conclusion : In this study, both polyethylene glycol and lactulose were equally effective and safe in the long-term treatment of constipation in children. There were no significant differences in recovery rates between 2 groups.

The Effect of Polyethylene Glycol on the Trivalent Chromium Electroplating (Polyethylene glycol이 3가크롬 전기도금에 미치는 효과)

  • Lee, Joo-Yul;Phuong, Nguyen Van;Lim, Sung-Hwan;Han, Seung-Zeon;Kwon, Sik-Chol
    • Journal of the Korean institute of surface engineering
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    • v.44 no.1
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    • pp.7-12
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    • 2011
  • The effect of organic additives, polyethylene glycol (PEG), on the trivalent chromium electroplating was analysed in the view point of current efficiency, solution stability and metallurgical structure. It was measured that PEG-containing trivalent chromium solution had about 10% higher current efficiency than pure solution and controlled the micro-crack density of electrodeposits. PEG exhibited profound effect on the solution stability by reducing the consumption rate of formic acid which acts as a complexant to lower the activation energy required for electrochemical reduction of trivalent chromium ions. It was also revealed that the formation of chromium carbide layer was facilitated in the presence of polyethylene glycol, which meant easier electrochemical codeposition of chromium and carbon, not single chromium deposition. Trivalent chromium layer formed from PEG-containing solution was amorphous with local nano-crystalline particles, which were prominently developed on the entire surface after non-oxidative heat treatment.

Production of $\alpha$-Amylase using Aqueous Two-Phase System (수성 2상계를 이용한 알파-아밀라제의 생산)

  • Choi, J.S.;Yoo, Y.J.
    • Microbiology and Biotechnology Letters
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    • v.16 no.5
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    • pp.358-362
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    • 1988
  • Aqueous two-phase fermentation system was tested for the overproduction of extracellular enzyme through $\alpha$-amylase fermentation by Bacillus amyloliquefaciens. By employing aqueous two-phase system $\alpha$-amylase activity showed 25% increase compared to the result using regular medium and no deactivation of the enzyme was observed. The presence of polyethylene glycol was observed to promote the enzyme production, while to inhibit the growth of the microorganism. It is recommended that polyethylene glycol be added during the log-growth phase and dextran be added after the enzyme activity reaches Its maximum for efficient $\alpha$-amylase fermentation and in situ recovery of the enzyme.

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Enhancement of Dissolution from Pharmaceutical Preparation of Hydrophobic Drugs ( II ) -Dissolution Rates of Sulpiride-Polyethylene Glycol Coprecipitates- (Sulpiride-Polyethylene Glycol Coprecipitates의 용출속도(溶出速度)에 관한 연구(硏究))

  • Ku, Young-Soon
    • Journal of Pharmaceutical Investigation
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    • v.13 no.3
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    • pp.100-103
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    • 1983
  • Coprecipitates of sulpiride and polyethylene glycol (PEG) decrease the dissolution rate of sulpiride and the degree of decrease is reversely proportional to molecular size of PEG and proportional to increase of PEG ratios in coprecipitates. The physical mixtures of sulpiride and PEG increase the dissolution rate of sulpiride.

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The Stability of Chlorobutanol Solution in Polyethylene and Glycol-modified Polyethylene Terephthalate Containers (Polyethylene과 Glycol-modified Polyethylene Terephthalate 용기내에서의 Chlorobutanol용액의 안정성)

  • Min, Shin-Hong;Kwon, Jong-Won;Jheong, Gu-Choong
    • Journal of Pharmaceutical Investigation
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    • v.16 no.1
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    • pp.8-11
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    • 1986
  • There have been many difficulties in utilization of polyethylene (PE) container for volatile ingredients because of its high permeability. We selected glycol-modified polyethylene terephthalate (PETG) lately being used and evaluated the stability of 0.5% chlorobutanol solution for PETG. We used PE bottle, glass flask and rubber stoppered vial for comparison and assayed chlorobutanol contents of the samples stored at various temperatures for nine weeks by HPLC method. The results indicated that the stability of chlorobutanol in PETG container was almost similar to that in glass flask, and was superior to that in PE bottle and rubber stoppered vial.

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