• Korean Journal of Pharmacognosy
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• v.40 no.1
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• pp.6-12
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• 2009

Thirty five methanol extracts from 19 natural local plants, which have been used as traditional anti-cancer medicine, were prepared. They were analyzed the cytotoxic effects on primary fibroblast cells and carcinoma cells. The root extract of Solanum nigrum were highly toxic in both cell lines with $IC_{50}$ values of less than $0.01{\mu}g/{\mu}l$, and 26 of 35 extracts were toxic in all cells with $IC_{50}$ values of $0.1{\sim}2{\mu}g/{\mu}l$. Three extracts including the fruit extracts of Solanum nigrum and Morus alba had no cytotoxic activity in both cell lines. Five of 35 extracts were highly toxic in cancer cells than in primary cells. Because primary cells were more resistant on these extracts, the five extracts were selected for anti-cancer agent candidates. Apoptosis or programmed cell death has an essential role in chemotherapy-induced tumor cell killing. Recently, inducers of apoptosis have been used in cancer therapy. When two of 5 cancer cell-specific cytotoxic extracts (Ulmus parvifolia and Zelkova serrata) were treated in concentration of $0.02{\sim}0.1{\mu}g/{\mu}l$, apoptosis were increased at 3-5 times in cancer cell lines. Finally, the apoptotic effects of these extracts were confirmed by cleavages of both poly-(ADP-ribose)-polymerase and caspase-3 as apoptotic markers. In this report, we suggested that two of 35 medicinal herb extracts can be useful anti-cancer drug candidates inducing apoptosis in several carcinoma cell lines.

• Polymer(Korea)
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• v.24 no.3
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• pp.326-332
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• 2000

The effects of sizing agent on the final mechanical properties of the glass fiber/unsaturated polyester composites were investigated by contact angle measurements at room temperature. In this work, glass fibers were coated by poly(vinyl alcohol), polyester, and epoxy type sizing agent and each property was compared. Contact angles of the sized glass fiber were measured by the wicking method based on Washburn equation using deionized water and diiodomethane as testing liquids. As an experimental result, the surface free energy calculated from contact angle showed the highest value in case of the glass fiber coated by epoxy sizing agent. From measurements of interlaminar shear strength (ILSS) and fracture toughness ( $K_{IC}$ ) of the composites, it was found that the sizing treatment on fibers could improve the fiber/matrix interfacial adhesion, resulting in growing the final mechanical properties. This was due to the enhanced surface free energy of glass fibers in a composite system.

• Applied Chemistry for Engineering
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• v.35 no.3
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• pp.260-265
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• 2024

To synthesize an antistatic material for use in semiconductor wafer transport trays, in-situ polymerization of poly(methyl methacrylate) (PMMA) and polyurethane (PU) incorporating carbon nanotubes was designed and conducted. The newly synthesized composites were evaluated for their thermal and electrical conductivity properties under conditions mimicking commercial device manufacturing processes. Comparative analysis of their respective performances revealed that both PMMA and PU containing carbon nanotubes exhibited enhanced thermal properties and superior electrical conductivity as the nanotube content increased. Morphology of the composites synthesized via in-situ polymerization was confirmed to be excellent through FE-SEM analysis, demonstrating good dispersibility. Both PMMA and PU incorporating carbon nanotubes showed outstanding surface resistance values of 10³ Ω/□, indicating their suitability as antistatic materials for semiconductor applications.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.42 no.5 s.305
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• pp.43-50
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• 2005

This paper describes some IC(integrated circuits) design and implementation techniques of low power multi-band Gm-C bandpass filter for body composition analyzer. Proposed BPF(bandpass filter) can be selected from three bands(20 KHz, 50 KHz, 100 KHz) by control signal. To minimize die area, a simple center frequency tuning scheme is used. And to reduce power consumption, operational transconductance amplifier operated in the sub-threshold region is adopted. The proposed BPF is implemented with 0.35 um 2-poly 3-metal standard CMOS technology Chip area is $626.42um\;{\times}\;475.8um$ and power consumption is 700 nW@100 KHz.

• The Journal of the Korea Contents Association
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• v.7 no.1
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• pp.116-123
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• 2007

This paper proposed a new amplitude width modulation for OLED data driver IC. The data driver controls brightness of OLED by adjusting amplitude and width of the data drive current pulse. There were two conventional methods; pulse amplitude modulation(PAM) and pulse width modulation(PWM). The PWM method suffered from lower light emitting time efficiency at low luminance signal. The PAM method suffered from large chip area using DACs for each column. The proposed method was aiming at accurately controlling of the current level by MSB data and light emitting efficiency by LSB data to improve the inefficiencies of the PAM and a PWM. The proposed AWM driver circuit implemented using $0.35-{\mu}m$ 3-poly 4-metal CMOS high voltage process. The simulation result shows the improvement in the accuracy of the gray level control even though the driver circuit is smaller than the PAM.

• Journal of IKEEE
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• v.2 no.2 s.3
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• pp.309-315
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• 1998

This paper describes an 8b 52 MHz CMOS subranging analog-to-digital converter (ADC) for Integrated Services Digital Network (ISDN) applications. The proposed ADC based on the improved time-interleaved architecture removes the holding time which is typically observed in the conventional double-channel subranging ADCs to increase throughput rate. Moreover, the ADC employs the interpolation technique in the back-end subranging ADCs far residue signal processing to minimize die area and power consumption. The fabricated and measured prototype ADC in a 0.8 um n-well double-poly double-metal CMOS process typically shows a 52 MHz sampling rate at a 5 V supply voltage with 230 mW, and a 40 MHz sampling rate at a 3 V power supply with 60 mW power consumption.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.3
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• pp.51-59
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• 2009

This paper presents the design of continuous-time sigma-delta modulator for acoustic sensor. The feedforward structure without summing block is used to reduce power consumption of sigma-delta modulator. A high-linearity active-RC filter is used to improve resolution of sigma-delta modulator. Excess loop delay problem in conventional continuous-time sigma-delta modulators is solved by our proposed architecture. A low power, high resolution fourth-order continuous-time sigma-delta modulator with 1-bit quantization was realized in a 0.13-${\mu}m$ 1-Poly 8-metal CMOS technology, with a core area of $0.58\;mm^2$. Simulation results show that the modulator achieves 91.3-dB SNR over a 25-kHz signal bandwidth with an oversampling ratio of 64, while dissipating $290{\mu}W$ from a 3.3-V supply.

• Journal of IKEEE
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• v.9 no.1 s.16
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• pp.57-64
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• 2005

This paper presents a built-in current sensor(BICS) that detects defects in CMOS integrated circuits using the current testing technique. This circuit employs a cross-coupled connected PMOS transistors, it is used as a current comparator. The proposed circuit has a negligible impact on the performance of the circuit under test (CUT) and high speed detection time. In addition, in the operation of the normal mode, the BlCS does not have dissipation of extra power, and it can be applied to the deep submicron process. The validity and effectiveness are verified through the HSPICE simulation on circuits with defects. The area overhead of a BlCS versus the entire chip is about 9.2%. The chip was fabricated with Hynix $0.35{\mu}m$ 2-poly 4-metal N-well CMOS standard technology.

• Korean Journal of Food Science and Technology
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• v.43 no.4
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• pp.464-468
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• 2011

Halocynthia roretzi is one of the most important cultured marine species on the southern coast of Korea. Samples were extracted using methanol (ME), ethanol (EE) and water (WE) to evaluate the antioxidant activities and antilipase activity in Halocynthia roretzi extracts. Antioxidant potentials of the samples were determined by poly-phenol content, flavonoid content, free radical scavenging activity, reducing potential, and chelating activity. The ME showed significant scavenging activity (1176 ${\mu}g/mL$ IC50 for DPPH, and 895 ${\mu}g/mL$ IC50 for ABTS assay). The IC50 for lipase inhibition activity was 12,021, 6,004, and 14,979 ${\mu}g/mL$ in the ME, EE, and WE, respectively. In conclusion, Halocynthia roretzi extracts exhibited antioxidant activities and anti-lipase activity. These results suggest that Halocynthia roretzi extracts can be potentially used as a source of antioxidant and antiobesity agents.

• Journal of Genetic Medicine
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• v.10 no.2
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• pp.124-127
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• 2013

Among cause of carcinogenesis, heredity is believed to take about 10 percent in ovarian cancer. BRCA1 or BRCA2 account for largest portion of Hereditary Breast and Ovary Cancer (HBOC). Frequency of BRCA1/2 germ line mutations varies according to region and ethnicity from 1.1-39.7 percent. The identification of ovarian cancers with a BRCA mutation is will be more and important due to the possibility to offer a genetic counseling and also due to potential beneficial treatment effects with a poly-ADP-ribose polymerase inhibitor in some individuals. We report the case of a 41 year old woman with a stage Ic mucinous ovarian adenocarcinoma and carrier daughter found on family genetic counseling. We indentified other family members with a history of breast cancer of 1st degree and pancreatic cancer of 2nd degree relative. After a screening with immunohistochemistry, the absence of nuclear expression for BRCA1 and BRCA2 was revealed. The gene sequencing confirmed heterozygous mutations of BRCA2 gene. The daughter of the case subject consented for a test. This test was shown the daughter is positive for BRCA2 mutation. Regular surveillance, chemoprophylaxis with oral contraceptive and prophylactic surgery after childbearing were offered to her.