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A Study on the Liquid Crystal Formed in PLO Gel Containing Ceramide NP (Ceramide NP 를 함유한 PLO Gel 에서 형성되는 액정에 관한 연구)

  • Heo, Min Geun;Yoon, Kyung-Sup
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.47 no.1
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    • pp.85-92
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    • 2021
  • The stratum corneum is formed from keratinocytes and intercellular lipids, with ceramide as the main component of intercellular lipids. Ceramides are one of the important components of the intercellular lipids to form a lamellar structure, but they are insoluble and therefore are not suitable for direct application to the skin. Thus, it was intended to apply ceramide to the formulation of pluronic lecithin organogel (PLO gel), which received constant attention among drug delivery systems. A suitable oil for formulation was selected and a PLO gel containing ceramide was manufactured. Liquid crystal formation and variation were observed using polarized microscopes, and viscoelastic analysis was performed to find out the viscoelastic behavior of the PLO gel. Small-angle X-ray scattering (SAXS) and wide-angle X-ray scattering (WAXS) analysis were performed to confirm the structures in the formulation. Results showed that the size and stability of the liquid crystal differed depending on the content ratio of ceramide and lecithin in the PLO gel containing ceramide. Furthermore, viscoelastic analysis showed the stability of the formulation, and SAXS/WAXS analysis confirmed that the PLO gel without ceramide had hexagonal structure of the quadrilateral system array, and the PLO gel with ceramide had the lamellar structure of the quadrilateral system array.

Geophysical Logging of Frequency-domain Induced Polarization for Mineral Exploration (광물탐사를 위한 진동수영역 유도분극 물리검층)

  • Shin, Seungwook
    • Geophysics and Geophysical Exploration
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    • v.24 no.3
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    • pp.73-77
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    • 2021
  • Induced polarization (IP) is useful for mineral exploration and hydrogeological studies by visualizing the electrochemical reactions at the interface between polarized minerals and groundwater. Frequency-domain IP (FDIP) is not actively applied to field surveys because it takes longer to acquire data, despite its higher data quality than conventional time-domain IP. However, data quality is more important in current mineral exploration as the targets gradually shift to deep or low-grade ore bodies. In addition, the measurement time reduced by automated instrumentation increases the potential for FDIP field applications. Therefore, we demonstrate that FDIP can detect mineral exploration targets by performing geophysical logging in the boreholes of a skarn deposit, in South Korea. Alternating current (AC) resistivity, percent frequency effect (PFE) and metal factor (MF) were calculated from impedance values obtained at two different frequencies. Skarn zones containing magnetite or pyrite showed relatively low AC resistivity, high PFE, and high MF compared to other zones. Therefore, FDIP surveys are considered to be useful for mineral exploration.

Evaluating the Effectiveness of an Artificial Intelligence Model for Classification of Basic Volcanic Rocks Based on Polarized Microscope Image (편광현미경 이미지 기반 염기성 화산암 분류를 위한 인공지능 모델의 효용성 평가)

  • Sim, Ho;Jung, Wonwoo;Hong, Seongsik;Seo, Jaewon;Park, Changyun;Song, Yungoo
    • Economic and Environmental Geology
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    • v.55 no.3
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    • pp.309-316
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    • 2022
  • In order to minimize the human and time consumption required for rock classification, research on rock classification using artificial intelligence (AI) has recently developed. In this study, basic volcanic rocks were subdivided by using polarizing microscope thin section images. A convolutional neural network (CNN) model based on Tensorflow and Keras libraries was self-producted for rock classification. A total of 720 images of olivine basalt, basaltic andesite, olivine tholeiite, trachytic olivine basalt reference specimens were mounted with open nicol, cross nicol, and adding gypsum plates, and trained at the training : test = 7 : 3 ratio. As a result of machine learning, the classification accuracy was over 80-90%. When we confirmed the classification accuracy of each AI model, it is expected that the rock classification method of this model will not be much different from the rock classification process of a geologist. Furthermore, if not only this model but also models that subdivide more diverse rock types are produced and integrated, the AI model that satisfies both the speed of data classification and the accessibility of non-experts can be developed, thereby providing a new framework for basic petrology research.

Village Museum Establishment Process, Characteristics and Tasks in Jeonju Urban Regeneration Projects (문화적 도시재생사업에서 마을박물관 설립운영과 과제 : 전주노송늬우스박물관 사례를 중심으로)

  • Cho, Sungsil;Lee, Jungwoo
    • 지역과문화
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    • v.8 no.3
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    • pp.1-25
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    • 2021
  • Nosong-dong is used to be center of the administration, education and transportation in Jeonju. It has ironically been the location of the city's prostitution quarter 'called Seonmichon'. This place is recently selected as an area of urban regeneration by Jeonju. The project has involved numerous programs which gradually transfer this place for the women's rights and arts. This paper focuses on exploring the socio-cultural meanings of a community museum, an archive for gender equality, and an exhibition site for local artists. The Seonmichon quarter has long been stigmatized as an area of ill repute and regarded with contempt by the surrounding neighborhood. It is space where polarized interests are entangled. City authority has tried to reflect this by presenting a variety of perspectives on the Seonmichon district. An initiative of the community museum has been its hosting of several exhibitions around the themes of women's rights and community arts. The most remarkable aspect of the exhibitions that have taken place in the heart of the Seonmichon district has been the active participation of local community residents as a catalyst for progressive social change. The paper's overall purpose is to provide an introduction and analyze the process of development of the exhibition initiative, and further examine the social role and meaning of the community museum in Nosong-dong, as well as its future tasks and directions.

Growth and Photocurrent Properties of $CuGaSe_2$ Single Crystal ($CuGaSe_2$ 단결정 박막 성장과 광전류 특성)

  • K.J. Hong
    • Proceedings of the Materials Research Society of Korea Conference
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    • 2003.03a
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    • pp.81-81
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    • 2003
  • The stochiometric mixture of evaporating materials for the CuGaSe$_2$ single crystal thin films were prepared from horizontal furnace. Using extrapolation method of X-ray diffraction patterns for the polycrystal CuGaSe$_2$, it was found tetragonal structure whose lattice constant no and co were 5.615$\AA$ and 11.025$\AA$, respectively. To obtains the single crystal thin films, CuGaSe$_2$ mixed crystal was deposited on throughly etched GaAs(100) by the Hot Wall Epitaxy(HWE) system. The source and substrate temperature were 61$0^{\circ}C$ and 45$0^{\circ}C$ respectively, and the growth rate of the single crystal thin films was about 0.5${\mu}{\textrm}{m}$/h. The crystalline structure of single crystal thin films was investigated by the double crystal X-ray diffraction(DCXD). Hall effect on this sample was measured by the method of van der pauw and studied on carrier density and mobility depending on temperature. From Hall data, the mobility was likely to be decreased by pizoelectric scattering in the temperature range 30K to 150K and by polar optical scattering in the temperature range 150K to 293K. The optical energy gaps were found to be 1.68eV for CuGaSe$_2$ single crystal thin films at room temperature. The temperature dependence of the photocurrent peak energy is well explained by the Varshni equation then the constants in the Varshni equation are given by a=9.615$\times$ 10$^{-4}$ eV/K, and $\beta$=335K. From the photocurrent spectra by illumination of polarized light of the CuGaSe$_2$ single crystal thin films. We have found that values of spin orbit coupling ΔSo and crystal field splitting ΔCr was 0.0900eV and 0.2498eV, respectively. From the PL spectra at 20K, the peaks corresponding to free bound excitons and D-A pair and a broad emission band due to SA is identified. The binding energy of the free excitons are determined to be 0.0626eV and the dissipation energy of the acceptor-bound exciton and donor-bound exciton to be 0.0352eV, 0.0932eV, respectively.

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Study on Constituent Minerals and Illitization Characteristics of Yeongdong Illite Ore (영동 일라이트 광체의 구성광물 및 일라이트화 특성 연구)

  • EunJi Baek;Yu Na Lee;Byeongyong Yu;Dongbok Shin;Youngseuk Keehm;Sun Young Park;Hyun Na Kim
    • Korean Journal of Mineralogy and Petrology
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    • v.36 no.1
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    • pp.41-54
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    • 2023
  • Illite is a common mineral that forms readily from feldspar and mica via hydrothermal alteration and exhibits various characteristics depending on the degree of hydrothermal alteration. To ensure continued mining of high-quality illite ore, it is crucial to understand the illitization. Thus, this study collected ores from two illite ore deposit and their surrounding alteration zones in Yeongdong-gun, Chungcheongbuk-do, a significant source of illite in the Republic of Korea, to determine the constituent mineral contents and textural characteristics. Polarized light microscopy analyses revealed that the illite ore deposit were highly illitized with little remaining textural characteristics of the parent mica schist, and only some quartz was present. The ore zone contained illite, muscovite, quartz, and feldspar, with illitization primarily occurring around feldspar and quartz. X-ray diffraction analyses identified that the content of illite/muscovite was approximately 50-75 wt.%, with a maximum of 75 wt.%. Additionally, X-ray fluorescence analyses indicated a linear increase in K2O content with increasing illite content, showing the highest correlation among the major components analyzed. It is suggested that the illite in the Yeongdong area results from feldspar and quartz alteration by hydrothermal fluids along the fault, with illitization of feldspar occurring before that of quartz. The results of this study are expected to contribute to the development of high-quality illite ore deposit in Yeongdong, Chungcheongbuk-do.

The effect of similarity, time of release, and message type on the evaluation of extended brand in the era of consumption polarization (소비 양극화 시대에 확장 유사성, 출시 시기, 메시지 유형이 확장 브랜드 평가에 미치는 영향)

  • Kwak, Junsik
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.7 no.9
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    • pp.141-149
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    • 2017
  • Numerous products are on the market every day and consumption is becoming increasingly polarized. Some products have been introduced to the market for the first time and others are the existing products that have upgraded performance. For companies, new products must be released constantly to prevent losing existing customers and to increase loyalty. However, when companies released new product, they communicate consumer brand name and core benefits of the new product. Moreover, if a new product fails, the amount that the company has to pay is bound to grow. So companies often use brand extension strategies that use the names of famous brands that are already loved by their customers for new products. In this study, the effect of extension similarity, time of release, and message type on brand extension was investigated. Result shows that using abstract messages rather than specific messages is more effective when similarities with existing brands are poor. In particular, the closer the release period is, the more effective these effects are. However, in case of extending the brand with high similarity products, it is effective to focus on concrete messages when the release time is near, and to communicate abstract messages when the release time is long. This result suggests that companies should take into consideration not only the similarity of extension but also the timing and characteristics of messages when extending the brand.

Recombinant human KAI1/CD82 attenuates M1 macrophage polarization on LPS-stimulated RAW264.7 cells via blocking TLR4/JNK/NF-κB signal pathway

  • Hyesook Lee;Jung-Hwa Han;Kangbin An;Yun Jeong Kang;Hyun Hwangbo;Ji Hye Heo;Byung Hyun Choi;Jae-Joon Kim;Seo Rin Kim;Soo Yong Lee;Jin Hur
    • BMB Reports
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    • v.56 no.6
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    • pp.359-364
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    • 2023
  • KAI1/CD82, a membrane tetraspanin protein, can prevent various cancers and retinal disorders through its anti-angiogenic and anti-metastatic capacity. However, little is known about its anti-inflammatory effect and molecular mechanism. Therefore, the present study aimed to inLPSvestigate effect of a recombinant protein of the large extracellular domain of human KAI1 (Gly 111-Leu 228, rhKAI1) on lipopolysaccharides (LPS)-stimulated RAW264.7 macrophage-like cells and mouse bone marrow-derived macrophages (BMDM) and to identify its underlying mechanism. Our data showed that rhKAI1 suppressed expression levels of classically macrophages (M1) phenotype-related surface markers F4/80+CD86+ in LPS-stimulated BMDM and RAW264.7 cells. In addition, LPS markedly increased mRNA expression and release levels of pro-inflammatory cytokines and mediators such as interleukin (IL)-1β, IL-6, tumor necrosis factor-α, cyclooxygenase-2, nitric oxide and prostaglandin E2, whereas these increases were substantially down-regulated by rhKAI1. Furthermore, LPS strongly increased expression of NF-κB p65 in the nuclei and phosphorylation of ERK, JNK, and p38 MAPK. However, nuclear translocation of NF-κB p65 and phosphorylation of JNK were greatly reversed in the presence of rhKAI1. Especially, rhKAI1 markedly suppressed expression of toll-like receptor (TLR4) and prevented binding of LPS with TLR4 through molecular docking predict analysis. Importantly, Glu 214 of rhKAI1 residue strongly interacted with Lys 360 of TLR4 residue, with a binding distance of 2.9 Å. Taken together, these findings suggest that rhKAI1 has an anti-inflammatory effect on LPS-polarized macrophages by interacting with TLR4 and down-regulating the JNK/NF-κB signaling pathway.

A Study on the High Content Ceramide Stabilization Formulation with Cyclodextrin (사이클로덱스트린을 함유한 고함량 세라마이드 안정화 제형 연구)

  • Ye Ji Kim;Sang Woo Han;So Min Lee;Byungsun Cha;Hyojin Heo;Sofia Brito;Lei Lei;Sang Hun Lee;You-Yeon Chun;Ha Hyeon Jo;Hyung Mook Kim;Byeong-Mun Kwak;Bum-Ho Bin
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.49 no.2
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    • pp.97-106
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    • 2023
  • In this study, we would like to study the stabilization of the high content of ceramide formulation by containing cyclodextrin. Ceramide, which constitutes the intercellular lipid, a human skin barrier, is a very important ingredient in moisturizing maintenance by protecting moisture in the skin and strengthening the skin barrier. However, since ceramide is poorly soluble, even if it is included in the cosmetic formulation, it has a problem that it is slowly gelled or crystallized and deposited over time, making it difficult to containing a high amount of ceramide. Cyclodextrin is a cyclic oligosaccharide connected with glucose molecules and has a cylindrical structure with hydrophilic outer surface and hydrophobic inner surface, which is known to improve the physicochemical properties of drugs such as improving solubility and absorption of poorly soluble drugs. We demonstrated the stability of the formulation containing high amount of ceramide by measuring hardness and observing emulsion drops with polarized microscope. This study also demonstrated that the high-content ceramide formulation containing cyclodextrin has the effect of preventing gelation or crystallization of ceramide, thus having excellent environmental conditions stability and skin moisturization.

Evaluation Study of Performance for Solar Energy Blocking of Smart Windows based on Phase Retardation Film (Phase Retardation 필름 기반 스마트윈도우의 태양열차단 성능 평가 시험 연구)

  • Il-Gu Kim;Ho-Chang Yang;Young-Min Park;Yo-Han Suh;Seung Hyun Lee;Young Kyu Hong
    • Journal of the Microelectronics and Packaging Society
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    • v.31 no.3
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    • pp.67-71
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    • 2024
  • A smart window based on a retarder can transmit or block polarized lights by overlapping two smart windows. In the study, tests were conducted to evaluate the performance of blocking solar heat using smart windows with a size of 300×300 mm2. Solar heat gain coefficient (SHGC) values were derived through simulation using transmission and reflectance data of the smart windows. As a result of the simulation, it showed that SGHC is effective in blocking solar heat by obtaining values of 0.722 and 0.615 in transmission and blocking mode of smart windows, respectively. The test boxes were fabricated in order to verify the effect of suppressing temperature rise when applying smart windows, the inside temperature in test boxes, which are installed bare glass (reference) and two smart windows with transmission and blocking mode, were measured at 10 minutes-interval for 7 days. As of 1 p.m., the inside temperature of the test boxes with the smart windows applied showed lower temperature compared to the reference. In particular, on the day when the temperature of reference box was the highest at 66.1℃, the temperature of the test box with the smart window applied showed 61.0℃, which was lowered by 5.1℃.