• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1241-1245
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• 2014

Cinobufacin is used clinically to treat patients with many solid malignant tumors. However, the mechanisms underlying action remain to be detailed. Our study focused on miRNAs involved in cinobufacin inhibition of GC cell proliferation. miRNA microarray analysis and real time PCR identified miR-494 as a significant cinobufacin-associated miRNA. In vivo, ectopic expression of miR-494 inhibited the proliferation and induced apoptosis of BGC-823 cells on CCK-8 and flow cytometry analysis. Further study verified BAG-1 (anti-apoptosis gene) to bea target of miR-494 by luciferase reporter assay and Western blotting. In summary, our study demonstrated that cinobufacin may inhibit the proliferation and promote the apoptosis of BGC-823 cells. Cinobufacin-associated miR-494 may indirectly be involved in cell proliferation and apoptosis by targeting BAG-1, pointing to use as a potential molecular target of cinobufacin in gastric cancer therapy.

• The Journal of the Korea Contents Association
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• v.10 no.6
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• pp.378-385
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• 2010

The purpose of this study is finding the way of vitalizing local festival of Chung-buk through successful local festivals and local festivals of Chung-buk. Therefore this study analyzed case of local festivals Young dong with reference definitude, participation, foundation, organizing, capability of calling the people. And It is pointing out the problems of the local festivals and suggesting the ways of vitalizing local festival in Chung-buk.

• Journal of Astronomy and Space Sciences
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• v.22 no.1
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• pp.35-46
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• 2005

This paper addresses the design and analysis results of a 2-axes magnetometer for attitude determination of small satellite. A low-cost and efficient 2-axes fluxgate magnetometer was selected as the most suitable attitude sensor for LEO microsatellites which require a low-to-medium level pointing accuracy. An optimization trade-off study has been performed for the development of 2-axes fluxgate magnetometer. All the relevant parameters such as permeability, demagnetization factor, coil diameter, core thickness, and number of coil turns were considered for the sizing of a small satellite magnetometer. The magnetometer which is designed, manufactured, and tested in-house as described in this paper satisfies linearity requirement for determining attitude position of small satellites. On the basis of magnetometer which is designed in Space System Research Lab. (SSRL), commercial magnetometer will be developed.

• Journal of Astronomy and Space Sciences
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• v.22 no.1
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• pp.47-58
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• 2005

This paper addresses development of the ultra-light analog sun sensors for small satellite applications. The sun sensor is suitable for attitude determination for small satellite because of its small, light, low-cost, and low power consumption characteristics. The sun sensor is designed, manufactured and characteristic-tested with the target requirements of ${\pm}60^{\circ}$ FOV (Field of View) and pointing accuracy of ${\pm}2^{\circ}$. Since the sun sensor has nonlinear characteristics between output measurement voltage and incident angle of sunlight, a higher order calibration equation is required for error correction. The error was calculated by using a polynomial calibration equation that was computed by the least square method obtained from the measured voltages vs. angles characteristics. Finally, the accuracies of 1-axis and 2-axes sun sensors, which consist of 2 detectors, are compared.

• Journal of Astronomy and Space Sciences
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• v.25 no.3
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• pp.239-244
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• 2008

Two kinds of important issues on Titius-Bode's relation have been discussed up to now: one is if there is a simple mathematical relation between distances of natural bodies orbiting a central body, and the other is if there is any physical basis for such a relation. These may be tackled by answering a question whether Titius-Bode's relation is valid universally in exo-planetary systems. We have examined whether Titius Bode's relation is also applicable to exo-planetary systems by statistically studying the distribution of the ratio of rotational periods of two planets in an exo-planetary system, 55 Cnc, by comparing it with that derived from Titius-Bode's relation. We find that the distribution of the ratio of rotational periods of randomly chosen two planets in the 55 Cnc system is apparently inconsistent with that derived from Titius-Bode's relation. The probability that two data sets are drawn from the same distribution function is 50%. We also find that the Fourier power spectra show that the distribution of the semi-major axis of planets in the 55 Cnc system seems to be stretched. We conclude by pointing out that large numbers of planets should be examined to more convincingly explain the distribution of the distance of planetary formation regions.

• Journal of Astronomy and Space Sciences
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• v.26 no.3
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• pp.287-294
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• 2009

In helioseismology it is normally assumed that p-mode oscillations are excited in a statistically independent fashion. Unfortunately, however, this issue is not clearly settled down in that two experiments exist, which apparently look in discrepancy. That is, Appourchaux et al. (2000) looked at bin-to-bin correlation and found no evidence that the assumption is invalid. On the other hand, Roth (2001) reported that p-mode pairs with nearby frequencies tend to be anti-correlated, possibly by a mode-coupling effect. This work is motivated by an idea that one may test if there exists an excess of anticorrelated power variations of pairs of solar p-modes. We have analyzed a 72-day MDI spherical-harmonic time series to examine temporal variations of p-mode power and their correlation. The power variation is computed by a running-window method after the previous study by Roth (2001), and then distribution function of power correlation between mode pairs is produced. We have confirmed Roth's result that there is an excess of anti-correlated p-mode pairs with nearby frequencies. On the other hand, the amount of excess was somewhat smaller than the previous study. Moreover, the distribution function does not exhibit significant change when we paired modes with non-nearby frequencies, implying that the excess is not due to mode coupling. We conclude that the origin of this excess of anticorrelations may not be a solar physical process, by pointing out the possibility of statistical bias playing the central role in producing the excess.

• Journal of the Korea Computer Industry Society
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• v.6 no.5
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• pp.697-714
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• 2005

In this paper, we made a windows-based interactive presentation system using a laser pointer mouse. The system provides that a speaker controls the presentation interactively by means of a laser pointer. During the presentation, a display PC generates on its local display a bitmap corresponding to the presentation. This bitmap is then transmitted to the projector and the bitmap is then projected onto the screen. The display of the presentation is controlled by the monitoring of the laser spots that are also projected onto the screen. Laser spot control is achieved through a control system. When the processing section matches the successive laser spot positions with a pre-established spatial pattern, the corresponding display command is issued. The display command may be transmitted to the display computer which responds by an action like mouse function.

• Journal of Korean Medical classics
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• v.23 no.4
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• pp.1-11
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• 2010

"Gyeongbangsilheomrok(經方實驗錄)" is a book that was written for the propagation of the thought of Gyeongbang(經方) theory in the early 20th century. Gyeongbang means the medicine in "Sanghanron(傷寒雜病論)" which was written by Jangjonggyeong(張仲景), who is known as a great doctor of ancient times in China. Gyeongbang had worked as a good model of medicine for a long time, but as time goes by, there appeared some physicians pointing out the limit of Gyeongbang and trying to overcome it. Through the effort like this, there gradually had appeared so many physicians carrying out the medical treatment which was getting out of the boundary of Gyeongbang. And There also had appeared a group of physicians, called Gyeongbangpa(經方派), opposing the opinion like this and defending the academic value of Gyeongbang. "Gyeongbangsilheomrok" had been estimated as a meaningful achievement of Gyeongbangpa tradition, and also had been regarded as a good book comprising copious basic theory about Bangje(方劑). The most significant assertion in this book is that it explained the Onbyeong(溫病) theory as a component itself in "Sanghanron(傷寒論)", which had been argued by many other medicians thinking that "Sanghanron" did not cover the treatment of Onbyeong. In regarding to this problem, "Gyeongbangsilheomrok" argued that the concept of Onbyeong in "Sanghanron" belongs to the category of Taeyangbyeong(太陽病) and also suggested that Galgeuntang(葛根湯) would be the main recipe for Onbyeong.

• Proceedings of the Korea Contents Association Conference
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• 2009.05a
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• pp.587-592
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• 2009

The purpose of this study is finding the way of vitalizing local festival of Chung-buk through successful local festivals and local festivals of Chung-buk. Therefore this study analyzed case of local festivals Young dong with reference definitude, participation, foundation, organizing, capability of calling the people. And It is pointing out the problems of the local festivals and suggesting the ways of vitalizing local festival in Chung-buk.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.05a
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• pp.131-134
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• 2018

Structural equation modeling is pointing to statistical procedures that simultaneously perform path analysis and confirmatory factor analysis. Today, this statistical procedure is an essential tool for researchers in the social sciences. There are as (AMOS, LISREL and PLS) representative tools that can perform structural equation modeling analysis. AMOS provides a convenient graphical user interface for beginners to use. PLS has the advantage of not having a constraint on normal distribution as well as a graphical user interface. Therefore, we compared and analyzed the three most commonly used tools in social sciences. This study suggests practical and theoretical implications based on the results.