• Journal of Pharmaceutical Investigation
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• 제39권4호
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• pp.233-242
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• 2009

Bioequivalence (BE) studies provide important information in the overall set of data that ensure the availability of safe and effective medicines to patients and practitioners. Thus its determination of proper criterion for assessing BE is very important. BE is frequently expressed or measured by estimating area under the plasma concentration-time curve (AUC) and maximum concentration ($C_{max}$) that are reflective of systemic exposure. In all countries except Canada, the acceptance criteria of BE is that the 90% confidence interval of difference in the average values of logarithmic AUC and $C_{max}$ between test and reference products is within the acceptable range of log(0.8) ${\sim}$ log(1.25). In Canada, unlike other countries, point estimation instead of applying 90% confidence interval is applied to assess $C_{max}$ which is, in essence, more variable than AUC. We also compared other parts of BE guidelines which include a fed study, average BE (ABE), scaled-ABE, population BE (PBE), individual BE (IBE), dropout & withdrawal, sampling frequency & time and number of subjects. This article reviews the most recent BE guidelines of Korea, USA, Europe, Canada and Japan, highlighting the differences focused on Korean BE guidelines compared to other countries. It will help us to revise BE guideline of Korea reflecting international trends. Finally, it is strongly recommended that the extended acceptance criterion for the highly variable drug among all the considering aspects for the revision of current BE guideline has to be adopted into Korea BE guideline in the nearest future.

• 대한약침학회지
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• 제4권3호
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• pp.101-103
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• 2001

Objective : This study is designed to find out the effects of the Bee-Venom Acupuncture on knee joint with osteoarthritis. Methods :We are investigated that outpatients suffer from knee joint pain deciphered at the division of Acupuncture in Jaseng oriental medicine hospital from the 13, July 1999 to until 11, November 2000. We make an estimated of the score from both before or after its treatment about 70 cases of diagnostic patient with the osteoarthritis of knee joints by biochemical method and X-RAY analysis, we observed in the progress of symptoms. Results: These results found that sex. distinction with a disease caused much more female than male at the ratio of 1 to 5.36 in the proportion of males to females, jobs is mainly ranked with a housewife and approximately 82.9% of cases before our hospital have ever treated at the other clinics or hospitals. On the hand. the distribution interval of a case history is mainly followed by disease in below 6 month, interval of the period-treatment is mainly gone within 3 month and frequency of treatment is examined into 11 to 15 times, more than 16 times and below 10 times, respectively. We are estimated with the score of functional barrier from both before or after its treatment against osteoarthritis' patients and produced in the usefulness from the totally point of fields except the aid-device after its treatment. In summary, these results demonstrated that Bee Venom, Acupuncture enhanced more than 82.9% to the improvement of treatment and P<0.05 considered to be statistically significant. Conclusion: These results suggest that Bee-venom Acupuncture may be playa role in the significant usefulness and have need of actively application for the clinical trials against osteoarthritis' patients.

• Journal of Acupuncture Research
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• 제18권3호
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• pp.35-47
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• 2001

Objective : This study is designed to find out the effects of the Bee Venom-Acupuncture on knee joint with osteoarthritis. Methods : We are investigated that outpatients suffer from knee joint pain deciphered at the division of Acupuncture in Jaseng oriental medicine hospital from the 13, July 1999 to until 11, November 2000. We make an estimated of the score from both before or after its treatment about 70 cases of diagnostic patient with the osteoarthritis of knee joints by biochemical method and X-RAY analysis, we observed in the progress of symptoms. Results : These results found that sex distinction with a disease caused much more female than male at the ratio of 1 to 5.36 in the proportion of males to females, jobs is mainly ranked with a housewife and approximately 82.9% of cases before our hospital have ever treated at the other clinics or hospitals. On the hand, the distribution interval of a case history is mainly followed by disease in below 6 month, interval of the period-treatment is mainly gone within 3 month and frequency of treatment is examined into 11 to 15 times, more than 16 times and below 10 times, respectively. We are estimated with the score of functional barrier from both before or after its treatment aganist osteoarthritis' patients and produced in the usefulness from the totally point of fields except the aid-device after its treatment. In summary, these results demonstrated that Bee Venom, Acupuncture enhanced more than 82.9% to the improvement of treatment and P<0.05 considered to be statistically significant. Conclusion : These results suggest that Bee-venom Acupuncture may be play a role in the significant usefulness and have need of actively application for the clinical trials against osteoarthritis'patients.

• 한국측량학회지
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• 제28권4호
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• pp.441-448
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• 2010

본 논문은 계절별로 획득된 항공라이다 자료로부터 수고를 추정하여 수관울폐도와 자료융합에 따른 영향을 분석하였다. 수고추정은 수목에서 반사되는 신호(First Return : FR)와 지표에서 반사되는 신호(Last Return : LR)를 추출하고, 영상분할을 통해 수목개체를 가정하여 개체목별 수고를 획득하는 방법을 적용하였다. 계절별 자료를 통해 획득한 각 수고 자료와 융합자료로부터 획득한 수고의 결과를 비교하였으며, 수고측정기를 사용하여 현지 측정을 하여 정확성을 비교하고, 항공라이다를 통해 획득한 자료들을 융합한 결과에 대한 그 활용성을 검토하였다. 실험 결과, 수목개체를 위한 영상분할 결과는 0.5미터 점군간격보다 1미터 간격이 현지조사 결과와 가까웠으며, 수목고의 경우 각 계절별 자료보다 융합자료를 활용한 결과가 현지 측정 결과에 접근하고 있음을 알 수 있었다.

• 대한전기학회논문지:시스템및제어부문D
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• 제55권7호
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• pp.335-343
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• 2006

We have designed the system that measure one channel ECG by two electrode and extract real-time EDR with more related resipiration and comportable to subject by using conductive textile. On the assumption that relation between RL electrode and potential measurement electrode is coupled with RC connected model, we designed RL drive output to feedback two electrode for reduction of common mode signal. The conductive textile which was used for two ECG electrode was offered more comfort during night sleep in bed than any other method using attachments. In the method of single-lead EDR, R wave point or QRS interval area could be used for EDR estimation in traditional method, it is, so to speak, the amplitude modulation(AM) method for EDR. Alternatively, R-R interval could be used for frequency modulation(FM) method based on Respiratory Sinus Arrhythmia(RSA). For evaluation of performance on AM EDR and FM EDR from 14 subject, ECG lead III was measured. Each EDR was compared with both temperature around nose(direct measurement of respiration) and respiration signal from thoracic belt(indirect measurement of respiration) on mean squared error(MSE), cross correlation(Xcorr), and Coherence. The upsampling interpolation technique of multirate signal processing is applied to interpolating data instead of cubic spline interpolation. As a result, we showed the real-time EDR extraction processing to be implemented at micro-controller.

• 생물환경조절학회지
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• 제11권2호
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• pp.93-100
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• 2002

본 연구에서는 포그냉방시스템을 수치적으로 시뮬레이션하기 위한 CFD 모델을 개발하였으며, 포그냉방온실에서 측정된 데이터에 의해 개발된 모델의 유효성을 검증하였다. 또한 분무수온, 분무수량, 분무정지시간과 분무입자의 증발률이 포그냉방시스템의 성능에 미치는 영향을 알아보기 위해 개발된 모델을 적용하였다. 시뮬레이션 결과에 의하면, 각 측점에서 실측치와 예측치의 온도차가 무차광조건에서는 $0.1~1.4^{\circ}C$, 차광조건에서는 $0.2~2.3^{\circ}C$였으며, 상대습도차는 무차광조건에서는 0.3~6.0%, 차광조건에서는 0.7~10.6%였다. 예측치가 실측치와 비교적 잘 일치하는 것으로 나타나 개발된 모델이 포그냉방시스템의 냉방효과를 예측할수 있는 것으로 판단된다. 포그냉방시스템 성능은 분무수량, 분무정지시간과 분무입자의 증발률의 영향을 많이 받지만 분무수온의 영향은 받지 않는 것으로 나타났다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권6호
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• pp.3086-3103
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• 2017

Video images captured by vehicle cameras often contain blurry or dithering frames due to inadvertent motion from bumps in the road or by insufficient illumination during the morning or evening, which greatly reduces the perception of objects expression and recognition from the records. Therefore, a real-time electronic stabilization method to correct fuzzy video from driving recorders has been proposed. In the first stage of feature detection, a coarse-to-fine inspection policy and a scale nonlinear diffusion filter are proposed to provide more accurate keypoints. Second, a new antiblurry binary descriptor and a feature point selection strategy for unintentional estimation are proposed, which brought more discriminative power. In addition, a new evaluation criterion for affine region detectors is presented based on the percentage interval of repeatability. The experiments show that the proposed method exhibits improvement in detecting blurry corner points. Moreover, it improves the performance of the algorithm and guarantees high processing speed at the same time.

• 소성∙가공
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• 제27권2호
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• pp.115-122
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• 2018

Most domestic and international standards on the forming limit diagram (FLD) including ISO 12004-2, use a 'position-dependent method,' which determines the forming limit from a strain distribution measured on the specimen after necking or fracture. However, the position-dependent method has inherent problems such as the incidence of asymmetry of a strain distribution, the estimation of missing data near fracture, the termination time of test, and the deformation due to the new stress equilibrium after a fracture, which is blamed for causing sometimes a significant lab-to-lab variation. The 'time-dependent method,' which is anticipated to be a new international standard for evaluating the forming limit, is expected to greatly improve these intrinsic disadvantages of the position-dependent method. It is because the time-dependent method makes it possible to identify and accurately determine the forming limit, just before the necking point from the strain data as continuously measured in a short time interval. In this study, we propose a new time-dependent method based on a Gaussian fitting of strain acceleration with the introduction of 'normalized correlation coefficient.' It has been shown in this study that this method can determine the forming limit very stably and gives a higher value, which is in comparison with the results of the previously studied position-dependent and time-dependent methods.

• Journal of Biosystems Engineering
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• 제29권6호
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• pp.515-520
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• 2004

A device far estimating the optimal artificial insemination time consisted of a computer, RS module, and six direct-reflex photo-sensors. Program was written in LabWindows CVI. In order to establish references for estimating optimal artificial insemination time, lying rate of the thirty three $Berkshire{\times}Hampshire crossbred sows (parity 5 to 6) was recorded from 2 days after moving into stalls to artificial insemination using a time lapse VCR and was measured every hour with one minute interval using the scan point sampling method. Twenty low hours in a day were divided into three comparing periods : 21:00 to 06:59, 07:00 to 13:59, and 14:00 to 20:59. If sum of the percentages of tying during a comparing period was less than the reference value, the starting hour of the comparing period was considered as onset of estrus and the optimal artificial insemination time was estimated at 20 to 24 hours after onset of estrus. The experimental device was evaluated with twenty five $Berkshire{\times}Hampshire$ crossbred sows (parity 2 to 7) and 23 of 25 sows $(92\%)$ were pregnant. This result suggests that the experimental device is excellent in performance for estimating optimal artificial insemination time.

• 수산경영론집
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• 제45권1호
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• pp.63-77
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• 2014

This study is to estimate the recent changes in total factor productivity of 15 Korean adjacent water fisheries based on Malmquist productivity indices. The study adopted both input and output oriented productivity measures utilizing a hyperbola distance function. In addition to this point, the study also calculated the 95% confidence interval for the various components of the productivities in order to access the statistical significance of estimates using 2000 times of re-sampling process through the smoothed bootstraping. The results of the study showed us that there was 18% reduction in the overall total factor productivity during the study period from 2007 to 2011, which turned out to be 5% of annual decrease in productivity. The study found that the main reason of this decrease in total productivity is about 22% downward shift of a fisheries production function due to recent conditions of a devastated fishing ground. When we evaluated the statistical significance of changes in technical efficiency combining both pure technical and scale efficiency based on the 95% confidence intervals, we could not find any evidence of changes in those components of total factor productivity. When we accessed the productivity of the each of 15 adjacent water fisheries methods, only the large danish seine fisheries showed us about 7% increase in productivity. Even though the large trawling and the large tow-boat trawling revealed no changes in productivity, all of the other 12 fisheries suffered the decreases in productivities.