• Journal of Microbiology and Biotechnology
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• 제18권2호
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• pp.369-376
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• 2008

In the present study, we investigated the radioprotective effect of cyclo(L-phenylalanyl-L-prolyl) on irradiated rat lungs to determine its potential as a radioprotective agent. We found that early lung damage induced by irradiation was reduced by treatment with 40mg/kg of cyclo(L-phenylalanyl-L-prolyl) in the latent and early pneumonitis phases. Expression of $TNF-{\alpha}\;and\;TGF-{\beta}1$ at 2 and TGF-${\beta}1$ at 8 weeks post-irradiation was decreased in animals that received both radiation and cyclo(L-phenylalanyl-L-prolyl) compared with animals that received radiation alone. Evidence indicated that the proinflammatory cytokine TNF-${\alpha}$ and the fibrogenic cytokine TGF-${\beta}1$ likely play a role in the radioprotective effect of cyclo(L-phenylalanyl-L-prolyl). However, besides TNF-${\alpha}$ and TGF-${\beta}1$ expressions, the precise mechanism by which cyclo(L-phenylalanyl-L-prolyl) ameliorates the induced radiation damage is not clear.

• 대한기관식도과학회지
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• 제16권1호
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• pp.51-54
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• 2010

Occult bronchial foreign body is that long-standing foreign body lodge in bronchial tree. Occult bronchial foreign bodies arc rare in adults, whereas tracheobronchial aspiration of foreign bodies occurs commonly in children. A 65-year-old man with chronic cough, sputum production, and fever was transferred for treatment of right middle and lower lobc collapse and obstructive pneumonitis as evidenced by imaging studies. The patient was treated with right middle-lower bilobectomy because fiberoptic bronchoscopic removal of the foreign body failed. We report this case with review of literatures.

• 한국임상수의학회지
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• 제16권2호
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• pp.492-496
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• 1999

A 3-year old male Maltese, which had enlarged and ballooned superficial lymph-nodes, was admitted to the Veterinary Teaching Hospital, College of Veterinary Medicine, Kyung-pook National University. Radiographic findings indicated cranial mediastinal mass, interstitial pneumonitis, conspicuous splenomegaly and liver enlargement. The patient showed anorexia, depression and anemia. It was autopsied following its death 2 days after admittance. There were copious hemoperitoneum, lymphomatous mass in the spleen, torsion of the mesenterium and stenosis of the duodenum. On the microscopic observation, there was the increase of the amount of lymphocytic cytoplasm and numbers of nucleus-devided lymphocytes followed by their diffused infiltration in lymph nodule. Based on the physical, histological and pathological findings, this case was diagnosed as a multicentric form of lymphosarcoma.

• Journal of Yeungnam Medical Science
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• 제25권1호
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• pp.72-77
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• 2008

Liver abscess in children is rare in developed countries; the incidence is 25 per 100,000 admissions in USA. Common complications are pleural effusion, empyema, pneumonitis, hepatopleural or hepatobronchial fistula, intraperitoneal or intrapericardiac rupture, septic shock, cerebral amebiasis, etc. These complications may lead to death if the management is delayed. However, recent management results in a mortality of less than 15%. We report a case of liver abscess in a child. He manifested with fever and abdominal pain in the right upper quadrant. On computerized tomography scans, multiple cystic lesions were seen in both lobes of the liver and were 5 to 55 mm in size. In laboratory findings, neutrophilic leukocytosis, peripheral eosinophila, elevated values of ESR, C-reactive protein, and elevated serum AST, ALT, ALP and GGT were detected. Furthermore, we determined the organisms in the blood culture and serum. Blood culture was positive for Streptococcus spp., and amebic indirect hemagglutination antibody titer was increased to 1:512.

• Journal of Chest Surgery
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• 제36권4호
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• pp.285-288
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• 2003

거대세포바이러스(CMV： Cytomegalovirus)에 의한 폐렴은 기관지계의 염증 및 폐쇄로 인해 폐실질의 낭종성 변화를 유발할 수 있다. 본 교실에서는 심한 호흡부전을 동반한 생후 2주된 유아에서 선천성 폐낭종 질환 진단하에 폐구역 절제술을 시행하였다. 수술 후 병리소견 및 혈청학적 검사를 통해 선천성 감염에 의한 거대세포바이러스(CMV) 세기관지폐렴을 확인하였기에 보고하는 바이다.

• Journal of Chest Surgery
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• 제5권1호
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• pp.1-8
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• 1972

On the study of surface activity in excized lung extracts of various pulmonary diseases, following facts were concluded. 1]The minimum surface tension measured in lung extracts of tuberculous tissue surrounding cavitary lesion was 26.3dyne/cm and its stability index was 0.53. 2]Macroscopically almost normal lung tissue at a distance of tuberculous lesion in same lobe revealed 21.3 dyne/cm of minimum surface tension in extracts and its stability index showed 0.66. This low surface activity may be due to the chronic pneumonitis microscopically. 3] In the atelectatic lung which had been collapsed by chronic empyema the extracts revealed much higher minimum surface tension in 27.3 dyne/cm and its stabillry index revealed the least value of 0.47 without correlation of duration of disease. This suggests that the longstanding collapsed lung may be soon collapsed even after mechanical full expansion because of lack of surfactant.

• Applied Microscopy
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• 제12권2호
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• pp.1-10
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• 1982

P. carinii is a protozoan which induces an often fatal pneumonitis in a variety of compromised patients. The ultrastructure of P. carinii was studied in a male infant with pneumocystitis pneumonia associated with hypogammaglobulinemia. Four principal structural varieties-small trophozoites, large trophozoites, mature cyst and empty cyst were identified. The ultrastructure of these organisms was similar to the cases previously reported. Relevance of the morphologic findings to the functional aspect were discussed.

• 한국임상수의학회지
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• 제21권4호
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• pp.413-415
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• 2004

A male Blue-fronted amazon parrot suddenly died after having a history of depression, anorexia and emaciation. At necropsy, numerous well-demarcated yellow to white firm nodules were scattered throughout the left caudal lung lobes and adjacent air sac. Histologically, the wall of air sac was significantly thickened due to necrosis and infiltration of large numbers of fungi and degenerated heterophils. Multifocal necrotizing granulomatous lesions with numerous fungal hypae as well as vasculitis and thrombosis were found in tl1e lung. The fungi had conidiophore, vesicle, phialides and conidia which were characteristic of Aspergillus sp. This is tl1e first report of mycotic air sacculitis and pneumonitis caused by Aspergillus in a parrot in Korea.

• Tuberculosis and Respiratory Diseases
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• 제77권2호
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• pp.81-84
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• 2014

A patient treated with venlafaxine for major depression developed an interstitial lung disease (ILD) with the characteristic clinical, radiological and pathological features of chronic hypersensitivity pneumonitis. A high resolution computed tomography scan demonstrated ground glass opacity, mosaic perfusion with air-trapping and traction bronchiectasis in both lungs. The pathological findings were consistent with a nonspecific interstitial pneumonia pattern. Clinical and radiological improvements were noted after the discontinuation of venlafaxine and the administration of a corticosteroid. This report provides further evidence that the anti-depressant venlafaxine can cause ILD.

• Korean Journal of Radiology
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• 제24권8호
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• pp.795-806
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• 2023

Occupational lung diseases (OLD) are a group of preventable conditions caused by noxious inhalation exposure in the workplace. Workers in various industries are at a higher risk of developing OLD. Despite regulations contributing to a decreased incidence, OLD remain among the most frequently diagnosed work-related conditions, contributing to significant morbidity and mortality. A multidisciplinary discussion (MDD) is necessary for a timely diagnosis. Imaging, particularly computed tomography, plays a central role in diagnosing OLD and excluding other inhalational lung diseases. OLD can be broadly classified into fibrotic and non-fibrotic forms. Imaging reflects variable degrees of inflammation and fibrosis involving the airways, parenchyma, and pleura. Common manifestations include classical pneumoconioses, chronic granulomatous diseases (CGD), and small and large airway diseases. Imaging is influenced by the type of inciting exposure. The findings of airway disease may be subtle or solely uncovered upon expiration. High-resolution chest CT, including expiratory-phase imaging, should be performed in all patients with suspected OLD. Radiologists should familiarize themselves with these imaging features to improve diagnostic accuracy.