• 분석과학
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• 제37권5호
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• pp.261-270
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• 2024

This study examines portable Gas Chromatography (GC) for the quantitative analysis of oxygen and impurities, focusing on the development and validation of a method to determine oxygen, carbon monoxide, carbon dioxide, methane, and nitrogen in medical compressed oxygen gas. The goal is to ensure the quality of medicalgrade oxygen. The method's validation assessed its metrological characteristics, demonstrating specificity through clear chromatographic separation of the target gases and the absence of these peaks in the carrier gas chromatogram. It exhibited linearity within the designated concentration ranges, while precision met permissible standards, with the relative standard deviation for intermediate precision being less than 4% for carbon monoxide (0.00025 - 0.00099 %), less than 3 % for methane (0.0005 - 0.00246%) and carbon dioxide (0.0050 - 0.0150 %), less than 2% for nitrogen (0.1 - 0.7 %), and less than 0.01% for oxygen (99.27 - 99.98%). Overall, the validation results confirm the suitability of this analytical method for the quantitative determination of the aforementioned gases in medical compressed oxygen using portable GC with microchromatographic columns and detectors.