• Polymer(Korea)
• /
• v.31 no.1
• /
• pp.58-67
• /
• 2007

Fully cholesteryloxycarbonated and (8-cholesteryloxycarbonyl) heptanoated disaccharide derivatives were synthesized by reacting cellobiose, maltose, and lactose with cholesteryl chloroformate or 8- cholesteryloxycarbonylheptanoyl chloride, and their thermotropic liquid crystalline properties were investigated. All the cholesteryloxycarbonated derivatives (CH1DSs) formed enantiotropic cholesteric phases, whereas all the (8-cholesteryloxycarbonyl) heptanoated derivatives (CH8DSs) exhibited monotropic cholesteric phases with left-handed helicoidal structures whose optical pitches (${\lambda}m's$) decrease with increasing temperature. All the CH1DSs, contrast with the CH8DSs, did not display reflection colors over the full cholesteric range, suggesting that the helicoidal twisting power of the cholesteryl group highly depends on the length of the spacer joining the cholesteryl group to the disaccharide chain. The thermal stability and degree of order in the mesophase and the temperature dependence of the ${\lambda}m$ observed for EH8DSs were entirely different from those reported for the cholesterol-bearing dimers and triplet and the (8-cholesteryloxycarbonyl) heptanoated polysaccharide derivatives. The results were discussed in terms of the difference in the number of the mesogenic units per mole of repeating unit and the flexibility of the main chain.

• Polymer(Korea)
• /
• v.31 no.4
• /
• pp.356-367
• /
• 2007

Three kinds of amylose derivatives such as: cholesteryloxycarbonated amyloses(CAMs) with degree of esterification(DE) ranging from 1.8 to 3, (6-cholesteryloxycarbonyl)pentanoated amyloses(PAMs) with DE ranging from 0.3 to 3, and fully cholesteryloxycarbonated PAMs(CPAMs) were synthesized, and their thermotropic liquid crystalline properties were investigated. CAMs with $DE{\geq}2.6$, PAM with DE=1.6 and all the CPAMs formed enantiotropic cholesteric phases, whereas PAM with $DE{\geq}2.2$ exhibited monotropic cholesteric phases. PAM with $DE{\geq}2.2$ and CPAMs with (6-cholesteryloxycarbonyl)pentanoyl DE (DS) more than 1.0 formed cholesteric phases with left-handed helical structures whose optical pitches (${\lambda}_{m'}s$) decrease with increasing temperature. However, the ${\lambda}_{m'}s$ of these samples decreased with increasing DS at the same temperature. On the other hand, CAMs, PAM with DE=1.6, and CPAM with DS=0.3 did not display reflection colors over the full cholesteric range, suggesting that the helicoidal twisting power of the cholesteryl group highly depends on the length of the spacer joining the cholesteryl group to the main chain and DS. The thermal stability and degree of order in the mesophase observed for the amylose derivatives highly depended on DE or DS. The results were discussed in terms of the difference ul the hydrogen bond, the internal plasticization, and the decoupling of the motion of side group with the main chain.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.36 no.7
• /
• pp.689-695
• /
• 2012

The friction factor in a rod bundle and the loss coefficient at a spacer grid were examined. As a test section, 25 smooth rods, 9.5 mm in diameter and 2000 mm in length, were prepared and installed in a $5{\times}5$ square array in a square channel. In this case, the P/D (Pitch-to-Diameter ratio) was 1.35. In this work, plain (i.e., no mixing vanes), split-vane, and hybrid-vane spacer grids were tested. In a bare rod bundle (i.e., no spacer grid), the measured friction factors were in good agreement with the previous correlations. Among the spacer grids tested, the hybrid-vane spacer grid presented the largest friction factor in the rod bundle and loss coefficient. This may be because of the flow pattern change induced by large relative plugging of the flow cross section and mixing vane geometry. At Re=$5{\times}10^5$, the predicted loss coefficients of plain, splitvane, and hybrid-vane spacer grids were approximately 0.79, 0.80, and 0.88, respectively.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.16 no.11
• /
• pp.1999-2010
• /
• 1992

The fixed slab analogy device which can measure stress intensity factors(S.I.F) experimentally by slab analogy theory is developed in this paper. The margin of errors resulted from the new testing apparatus are between 0.02% and 8.25%. Therefore, it is assured that this one can be effectively used for the more accurate measurement of S.I.F.( $k_{I}$, $k_{I I}$) than conventional apparatus. The pitch of master grating used in this experiment is 0.1mm It is known that the ratio of the distance from crack tip to the crack length on obtaining the accurate stress intensity factor is between 0.4 and 0.7. The optimum curvature radius of slab is about 125mm. The thickness of slab(plate) used in the fixed slab analogy device is 0.05mm(P.V.C. ; E = 64 MN/ $m^{2}$, .nu.=0.38), which is proved to be suitable for the test. The optimum material for the frame(slab`s external boundary) is a alloy tool steel(SKS 5) plate and its thickness is 1mm. In this research, the rigid cracks are directly bonded to the slab surface by cyanoacrylate adhesive for the easiness of slab making and conformity to the practical crack figure. The material of rigid crack is thin steel plate. It is expected that the developed method can be used effectively for the analysis of $k_{I}$ and $k_{I I}$ of arbitrary shaped or distributed cracks.cks.

• The Journal of the Acoustical Society of Korea
• /
• v.20 no.3
• /
• pp.24-33
• /
• 2001

this paper describes a baseline for an implementation of a corpus-based Korean TTS system. The conventional TTS systems using small-sized speech still generate machine-like synthetic speech. To overcome this problem we introduce the corpus-based TTS system which enables to generate natural synthetic speech without prosodic modifications. The corpus should be composed of a natural prosody of source speech and multiple instances of synthesis units. To make a phone level synthesis unit, we train a speech recognizer with the target speech, and then perform an automatic phoneme segmentation. We also detect the fine pitch period using Laryngo graph signals, which is used for prosodic feature extraction. For break strength allocation, 4 levels of break indices are decided as pause length and also attached to phones to reflect prosodic variations in phrase boundaries. To predict the break strength on texts, we utilize the statistical information of POS (Part-of-Speech) sequences. The best triphone sequences are selected by Viterbi search considering the minimization of accumulative Euclidean distance of concatenating distortion. To get high quality synthesis speech applicable to commercial purpose, we introduce a domain specific database. By adding domain specific database to general domain database, we can greatly improve the quality of synthetic speech on specific domain. From the subjective evaluation, the new Korean corpus-based TTS system shows better naturalness than the conventional demisyllable-based one.

• Clinical and Experimental Pediatrics
• /
• v.60 no.7
• /
• pp.227-231
• /
• 2017

Purpose: This study aimed to verify the safety of low-dose topiramate on language development in pediatric patients with migraine. Methods: Thirty newly diagnosed pediatric patients with migraine who needed topiramate were enrolled and assessed twice with standard language tests, including the Test of Language Problem Solving Abilities (TOPs), Receptive and Expressive Vocabulary Test, Urimal Test of Articulation and Phonology, and computerized speech laboratory analysis. Data were collected before treatment, and topiramate as monotherapy was sustained for at least 3 months. The mean follow-up period was $4.3{\pm}2.7months$. The mean topiramate dosage was 0.9 mg/kg/day. Results: The patient's mean age was $144.1{\pm}42.3months$ (male-to-female ratio, 9:21). The values of all the language parameters of the TOPs were not changed significantly after the topiramate treatment as follows: Determine cause, from $15.0{\pm}4.4$ to $15.4{\pm}4.8$ (P>0.05); making inference, from $17.6{\pm}5.6$ to $17.5{\pm}6.6$ (P>0.05); predicting, from $11.5{\pm}4.5$ to $12.3{\pm}4.0$ (P>0.05); and total TOPs score, from $44.1{\pm}13.4$ to $45.3{\pm}13.6$ (P>0.05). The total mean length of utterance in words during the test decreased from $44.1{\pm}13.4$ to $45.3{\pm}13.6$ (P<0.05). The Receptive and Expressive Vocabulary Test results decreased from $97.7{\pm}22.1$ to $96.3{\pm}19.9months$, and from $81.8{\pm}23.4$ to $82.3{\pm}25.4months$, respectively (P>0.05). In the articulation and phonology validation in both groups, speech pitch and energy were not significant, and all the vowel test results showed no other significant values. Conclusion: No significant difference was found in the language-speaking ability between the patients; however, the number of vocabularies used decreased. Therefore, topiramate should be used cautiously for children with migraine.

• Journal of Korea Water Resources Association
• /
• v.46 no.9
• /
• pp.947-956
• /
• 2013

Most of flood protection walls built on the impingement in mountain rivers have been made of concrete. It may cause flood disasters because the smooth wall surface could increase flow velocity. In this study the hydraulic experiments was carried out to evaluate the effect of one side wall with rectangular vertical ribs on flow resistance in open channel. The ratio of the pitch between vertical ribs to its depth, ${\lambda}_{nv}$, was designed so that it include the so-called d type and k type roughness. The range of Froude number, $F_r$, based on hydraulic radius is 0.81~1.12. Flow resistance in the open channel with a rib sidewall depends on the interval length of each ribs and the flow discharge. Maximum flow resistance occurred when ${\lambda}_{nv}$ is 9. In the d type roughness which ${\lambda}_{nv}$ is less than 3, the flow resistance decreases with increase of flow discharge. In the k type roughness which ${\lambda}_{nv}$ is greater than 3, the flow resistance increases with increase of flow discharge. The increments of flow resistance are especially great when ${\lambda}_{nv}$ are 9 and 12. The resistance due to vertical rib is mostly by the shape resistance and the vertical rib on one sidewall of open channel affects on the flow resistance so that the equivalent roughness heights of vertical rib may occur in scale of flow depth. Therefore the vertical ribs may be used to reduce the flow velocity and to move the location of maximum flow velocity from the rib sidewall to the centerward in a cross section of channels.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.33 no.2
• /
• pp.131-138
• /
• 2007

The purpose of this study was to observe the effect of calcium and vitamin D to the titanium implant osseointegration in animal model. 32 rats, 10 weeks of age, were divided into two group: additional calcium and vitamin D supplementation group and a control group. Titanium screw implant(diameter, 2.0mm; length, 3.5mm; pitch-height 0.4mm) were placed into tibia of 32 rats, 16 in the control group and 16 in the experimental group. The rats were sacrificed at different time interval(1, 2, 4, and 8 weeks after implantation) for histopathologic observation, histomorphometric analysis and immunohistochemistry with osteocalcin and osteopontin antibody. Histopathologically findings, newly formed bone was seen at 1 weeks and became lamellar bone at 2 weeks, and mature trabecullar bone was seen at 4 weeks experimental group. In control group, thickness of regenerated bone increased till 4 weeks gradually and trabecullar bone was seen at 8 weeks. By histomorphometric analysis, bone marrow density was increased significantly at 1 and 2 weeks in experimental group compared to control group. Osteocalcin immunoreactivity was strong at 1 week experimental group and reduced after 4 weeks gradually. But it was continuously weakly from 1 to 4 weeks in control group. Osteopontin immunoreactivity was very strong in newly formed bone from 2 to 8 weeks experimental group. And the amount of osteopontin expression was more abundant in experimental group. The results of this study suggest that calcium and vitamin D supplementation promotes bone healing around dental implants

• Polymer(Korea)
• /
• v.33 no.3
• /
• pp.254-262
• /
• 2009

Nine kinds of hydroxypropyl celluloses (HPCs) with degree of substitution (DS) and molar substitution (MS) ranging from 2.10 to 2.71 and 2.3 to 6.7, respectively and seven kinds of fully butanoated HPCs (BPCs) based on the HPCs with $2.3\;{\le}\;MS\;{\le}\;6.7$ were synthesized, and the molecular characteristics of HPCs and the thermotropic liquid crystalline properties of the derivatives were investigated. MS was nearly equal to DS for small value of DS, but it became exceedly larger than DS for $DS{\gtrsim}1$, showing that in the later stages of reaction, propylene oxide preferentially adds to the side chains rather than the main chain. All the derivatives formed enantiotropic cholesteric phases with right-handed helical structures. The glass and clearing transition temperatures of both HPCs and BPCs were decreased with increasing MS. The optical pitches (${\lambda}_m'S$) of BPCs, as well as HPCs themselves, increased with increasing temperature. However, the ${\lambda}_m'S$ of both HPCs and BPCs at the same temperature increased with increasing MS. Moreover, the temperature dependence of ${\lambda}_m$ of HPCs was weaker than that of BPCs, suggesting that the helical twisting power of the cellulose chain highly depends on the length and chemical structure of the side chain introduced in cellulose chain.

• The Journal of Korean Academy of Prosthodontics
• /
• v.39 no.1
• /
• pp.71-83
• /
• 2001

The purpose of this study was to compare the effects of various surface treatments by measuring removal torque on bone healing around titanium implants. 40 Screw-shaped cp titanium implants with length of 4mm, outer diameter of 3.75mm, and pitch-height of 0.5mm were used Group 1 was left as machined(control), Group 2 was blasted with $50{\mu}m\;Al_2O_3$, group 3 was blasted and etched in etching solution($NH_4OH : H_2O_2:H_2O= 1 : 1 : 5$) at $90^{\circ}C$ for 1 minute group 4 was blasted and oxidated under pure oxygen at $800^{\circ}C$. The implant surface roughness was analyzed with SEM and CLSM(Confocal Laser Scanning Microscope) and implants were placed in proximal tibial metaphysis of 10 New Zealand White rabbits. After 3 months of healing period, removal torque of each implant was measured to compare bone healing around implant. The results obtained were as follows 1. In SEM view, blasting increased the roughness of the surface, but etching of that rough surface decreased the roughness due to the removal of the tip of the peak. Oxidation also decreased the roughness due to formation of needle-like oxide grains on the implant surface. 2. The Sa value from CLSM was least in the machined group($0.47{\mu}m$), greatest in blasted group($1.25{\mu}m$), and the value decreased after etching($0.91{\mu}m$) and oxidation($0.94{\mu}m$). 3. The removal torque of etched group(24.5Ncm) was greater than that of machined group(16.7Ncm) (P<0.05), and was greatest in the oxidated group(40.3Ncm) and the blasted group(34.7Ncm).